Article
Immunology
Zhipeng Ning, Pan Gu, Jialing Zhang, Chi Wai Cheung, Lixing Lao, Haiyong Chen, Zhang-Jin Zhang
Summary: This study revealed a novel mechanism that acupuncture produces analgesic effects at least partially via the APN/AdipoR2-AMPK pathway in the spinal cord. The deletion of APN significantly reduced the acupuncture analgesia, while intrathecal administration of APN mimicked the analgesic effects of acupuncture. The study suggests that acupuncture may increase APN accumulation in the spinal cord through the blood circulation.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Cell Biology
Ling Li, Muhammad Aslam, Benedikt H. Siegler, Bernd Niemann, Susanne Rohrbach
Summary: This study showed that C1q/tumor necrosis factor-alpha related proteins (CTRPs) have effects on glucose and fatty acid metabolism in cardiomyocytes, primarily through AMP-activated protein kinase (AMPK) and Akt signaling pathways. CTRP2, 7, 9, and 13 were found to promote glucose uptake and regulate enzyme expression related to metabolism. Targeting the AMPK signaling pathway via CTRPs could be a therapeutic approach for restoring glucose homeostasis.
Article
Plant Sciences
Wenya Zheng, Jinxin Yang, Quanquan Zhang, Minghui Cheng, Horia Shaukat, Hong Qin
Summary: This study revealed that sesamol can alleviate liver insulin resistance by stimulating adiponectin secretion and activating the AMPK signaling pathway. Sesamol also has the ability to regulate the expression of related proteins, including glycogen synthase, phosphoenolpyruvate carboxykinase, and protein kinase B.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Article
Biology
Masato Iwabu, Miki Okada-Iwabu, Hiroaki Tanabe, Nozomi Ohuchi, Keiko Miyata, Toshiko Kobori, Sara Odawara, Yuri Kadowaki, Shigeyuki Yokoyama, Toshimasa Yamauchi, Takashi Kadowaki
Summary: Overexpressing human AdipoR1 in the muscles of diabetic mice increased insulin sensitivity and exercise endurance, suggesting a possible route for future clinical therapies. The small-molecule AdipoR agonist AdipoRon could exert its beneficial effects via human AdipoR1.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hee Young Yoo, So Yeon Park, Sun-Young Chang, So Hee Kim
Summary: The study found that chronic exposure to butyrates induced resistance in colon cancer cells. This resistance may be related to autophagy, as well as changes in the AMPK/ACC and Akt/mTOR signaling pathways. AMPK activation restored sensitivity to butyrates, suggesting it could be a therapeutic target for butyrate-resistant colon cancers.
Article
Medicine, Research & Experimental
Oscar Ka-Fai Ma, Simone Ronsisvalle, Livia Basile, Ariya Weiman Xiang, Cristina Tomasella, Federica Sipala, Matteo Pappalardo, Koon-Ho Chan, Danilo Milardi, Roy Chun-Laam Ng, Salvatore Guccione
Summary: Diabetic neuropathy is a long-term complication of diabetes mellitus, affecting peripheral nerve systems. High blood sugar is the major cause, leading to symptoms such as balance and coordination problems, insensitivity, muscle weakness, and limb numbness and pain. This study found a compound with dual activity on opioid receptors and adiponectin receptors that may have analgesic and neuroprotective effects for treating diabetic neuropathy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Xiaomeng Pei, Haolin Li, Hao Yu, Wei Wang, Dagan Mao
Summary: Adiponectin (APN) is a crucial adipokine for various reproductive processes. The structure and content of APN showed no significant differences in different luteal phases in both goat corpora lutea (CLs)and sera. However, high molecular weight APN was more abundant in serum, while low molecular weight APN was more present in CLs. APN and its receptors (AdipoR1/2 and T-Ca) were mainly expressed in goat luteal steroidogenic cells, and the regulation mainly relied on AMPK.
Article
Biochemistry & Molecular Biology
Xinlei Yao, Lei Liu, Wenjun Shao, Miao Bai, Xiaohan Ding, Geng Wang, Shuyue Wang, Lihua Zheng, Ying Sun, Guannan Wang, Yanxin Huang, Chunlei Yu, Zhenbo Song, Yongli Bao, Shaonian Yang, Luguo Sun
Summary: This study demonstrates that the natural compound tectorigenin (TG) enhances GLUT4 expression, glucose uptake, and insulin responsiveness by activating AMPK/MEF2 signaling. TG-mediated enhancement of AMPK signaling and GLUT4 expression in skeletal muscle improves insulin resistance and type 2 diabetes. This study suggests that TG could be a potential drug candidate for the treatment of insulin resistance and its related diseases and provides new insights into PKA signaling in glucose metabolism in skeletal muscle.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Neurosciences
Julien Clain, David Couret, Cynthia Planesse, Pascale Krejbich-Trotot, Olivier Meilhac, Christian Lefebvre D'Hellencourt, Wildriss Viranaicken, Nicolas Diotel
Summary: This study investigated the distribution of adiponectin receptors in the brain and the therapeutic effect of adiponectin receptor agonist AdipoRON in a stroke model. The results showed that adiponectin receptors AdipoR1 and AdipoR2 are widely distributed in the brain of adult mice, mainly expressed in neurons and blood vessels. However, a single injection of AdipoRON did not modulate infarct volume, cell death, or neuroinflammatory parameters in the stroke model.
Article
Nutrition & Dietetics
Yi-Zhen Tsai, Mei-Ling Tsai, Li-Yin Hsu, Chi-Tang Ho, Ching-Shu Lai
Summary: Studies have shown that tetrahydrocurcumin (THC) can attenuate adiposity, steatosis, and hyperglycemia in diabetic obese mice through upregulating UCP-1 in adipose tissue, increasing adiponectin levels in circulation, and activating the AdipoR1/R2-APPL1 pathway in the liver and skeletal muscle. This leads to improved insulin signaling, glucose utilization, and lipid metabolism, as well as preservation of islet mass and restoration of defective insulin expression in the pancreatic beta-cells.
Article
Biochemistry & Molecular Biology
Qi Guo, Shicheng Cao, Xiaohong Wang
Summary: Exercise can improve the pathogenic changes in adiponectin and betatrophin levels in insulin-resistant mice. This effect is achieved by increasing adiponectin levels and reducing betatrophin levels through exercise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Sourav Chattopadhyay, Amit Joharapurkar, Nabanita Das, Shamima Khatoon, Sapana Kushwaha, Anagha Ashok Gurjar, Abhishek Kumar Singh, Sonal Shree, Md Zohaib Ahmed, Shyamsundar Pal China, Subhashis Pal, Harish Kumar, Ravishankar Ramachandran, Vishal Patel, Arun Kumar Trivedi, Amit Lahiri, Mukul Rameshchandra Jain, Naibedya Chattopadhyay, Sabyasachi Sanyal
Summary: This study suggests that E2 may play a crucial role in modulating adiponectin sensitivity in type 2 diabetes, particularly in male mice. By downregulating PTB and miR-221, E2 treatment can rescue AdipoR1 protein expression and improve adiponectin resistance, potentially ameliorating insulin resistance in type 2 diabetes.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Neurosciences
Samira Rashtiani, Iran Goudarzi, Adele Jafari, Kambiz Rohampour
Summary: Adiponectin (APN) plays a crucial role in regulating insulin sensitivity and glucose homeostasis, while also positively affecting memory. Inhibition of AMPK may block the memory-enhancing effect of APN and impact the expression of IRS1. Overall, APN may improve memory through the AMPK pathway and boost insulin signaling by increasing IRS-1 expression in the hippocampus.
NEUROSCIENCE LETTERS
(2021)
Article
Multidisciplinary Sciences
Ying Mei, Hui Hu, Liangjun Deng, Xiaoou Sun, Wen Tan
Summary: This study found that STVNa can improve NAFLD by activating autophagy, reducing inflammation and lipid accumulation, and inhibiting hepatic oxidative stress and fibrosis. Therefore, STVNa may be an alternative therapeutic agent for NAFLD.
SCIENTIFIC REPORTS
(2022)
Article
Integrative & Complementary Medicine
Jiang Qi-Xin, Chen Yi-Meng, Ma Ling-lie, Wang Yu-Ping, Li Ping, Wen Xiao-Dong, Yang Lie
Summary: This study screened the antilipolytic fraction ESMW from the traditional Chinese formula Simiao Wan and investigated its mechanisms in improving insulin resistance and hepatic gluconeogenesis. ESMW was found to inhibit PKA-HSL related lipolysis by activating AMPK and reduce diacylglycerol accumulation in the liver, leading to improved insulin resistance and hepatic glucose production.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Nutrition & Dietetics
Leonie H. Bogl, Jaakko Kaprio, Kirsi H. Pietilainen
CLINICAL NUTRITION
(2020)
Article
Cardiac & Cardiovascular Systems
Lutgarda Bozzetto, Bram J. Berntzen, Jaakko Kaprio, Aila Rissanen, Marja-Riitta Taskinen, Kirsi H. Pietilainen
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2020)
Article
Genetics & Heredity
Benjamin Cogne, Xenia Latypova, Lokuliyanage Dona Samudita Senaratne, Ludovic Martin, Daniel C. Koboldt, Georgios Kellaris, Lorraine Fievet, Guylene Le Meur, Dominique Caldari, Dominique Debray, Mathilde Nizon, Eirik Frengen, Sara J. Bowne, Elizabeth L. Cadena, Stephen P. Daiger, Kinga M. Bujakowska, Eric A. Pierce, Michael Gorin, Nicholas Katsanis, Stephane Bezieau, Simon M. Petersen-Jones, Laurence M. Occelli, Leslie A. Lyons, Laurence Legeai-Mallet, Lori S. Sullivan, Erica E. Davis, Bertrand Isidor
AMERICAN JOURNAL OF HUMAN GENETICS
(2020)
Article
Genetics & Heredity
Dulika S. Sumathipala, Petter Stromme, Christian Gilissen, Ingunn Holm Einarsen, Hilde J. Bjorndalen, Andres Server, Jordi Corominas, Bjornar Hassel, Madeleine Fannemel, Doriana Misceo, Eirik Frengen
BMC MEDICAL GENETICS
(2020)
Article
Genetics & Heredity
Dulika S. Sumathipala, Doriana Misceo, Selma Mujezinovic Larsen, Tuva Baroy, Thilini H. Gamage, Eirik Frengen, Petter Stromme
CLINICAL DYSMORPHOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Anne Slavotinek, Doriana Misceo, Stephanie Htun, Linda Mathisen, Eirik Frengen, Michelle Foreman, Jennifer E. Hurtig, Liz Enyenihi, Maria C. Sterrett, Sara W. Leung, Dina Schneidman-Duhovny, Juvianee Estrada-Veras, Jacque L. Duncan, Charlotte A. Haaxma, Erik-Jan Kamsteeg, Vivian Xia, Daniah Beleford, Yue Si, Ganka Douglas, Hans Einar Treidene, Ambro van Hoof, Milo B. Fasken, Anita H. Corbett
HUMAN MOLECULAR GENETICS
(2020)
Article
Genetics & Heredity
Chun-An Chen, Emeline Crutcher, Harinder Gill, Tanya N. Nelson, Laurie A. Robak, Marjolijn C. J. Jongmans, Rolph Pfundt, Chitra Prasad, Roberta A. Berard, Madeleine Fannemel, Eirik Frengen, Doriana Misceo, Keri Ramsey, Yaping Yang, Christian P. Schaaf, Xia Wang
Article
Multidisciplinary Sciences
Milla Kibble, Suleiman A. Khan, Muhammad Ammad-ud-din, Sailalitha Bollepalli, Teemu Palviainen, Jaakko Kaprio, Kirsi H. Pietilainen, Miina Ollikainen
ROYAL SOCIETY OPEN SCIENCE
(2020)
Article
Microbiology
Joel Touma, Yan Liu, Afsar Rahbar, Mattia Russel Pantalone, Nerea Martin Almazan, Katja Vetvik, Cecilia Soderberg-Naucler, Jurgen Geisler, Torill Sauer
Summary: The study revealed a significant association between HCMV and human malignancies, specifically in breast cancer tumors, and emphasized the importance of automating diagnostic procedures to improve clinical value. The method developed for staining HCMV late antigen (LA) was shown to be highly sensitive and reproducible, making it useful for future diagnostics and scientific applications.
Article
Cell & Tissue Engineering
Elena Herbers, Mimmi Patrikoski, Anita Wagner, Riikka Jokinen, Antti Hassinen, Sini Heinonen, Susanna Miettinen, Hilkka Peltoniemi, Eija Pirinen, Kirsi H. Pietilainen
Summary: Mitochondrial dysfunction in white adipose tissue is associated with obesity. Human adipose-derived stromal/stem cells are a useful tool to study the underlying mechanisms of this dysfunction. Existing protocols for adipogenic differentiation alter the phenotype of white adipocytes and have varying effects on mitochondria. This study aims to find a protocol that can more faithfully recapitulate the white adipocyte phenotype observed in human adipose tissue.
STEM CELLS INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Matthias Blueher, Mohini Aras, Louis J. Aronne, Rachel L. Batterham, Francesco Giorgino, Linong Ji, Kirsi H. Pietilainen, Oliver Schnell, Elena Tonchevska, John P. H. Wilding
Summary: Obesity is a chronic disease with increasing prevalence worldwide and is associated with various health risks. The treatment of obesity includes behavioral interventions, pharmacotherapy, and bariatric surgery, but long-term weight maintenance is challenging. Recent advances in understanding the pathophysiology of obesity have led to the development of novel and effective therapies, such as semaglutide and tirzepatide, which have shown promising weight loss effects and improvement in cardiometabolic risk factors. These new agents may bridge the gap between traditional treatments and achieve better outcomes in obesity management.
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Sakris K. E. Kupila, Anu Joki, Laura-U. Suojanen, Kirsi H. Pietilaeinen
Summary: The study evaluates the effectiveness of eHealth interventions for weight loss and weight loss maintenance among adults with overweight or obesity. The findings suggest that eHealth interventions are more effective than control interventions or no care, and comparable to face-to-face interventions. However, interventions with human contact work better than fully automated interventions.
CURRENT OBESITY REPORTS
(2023)
Article
Endocrinology & Metabolism
Ruixin Zhu, Maija Huttunen-Lenz, Gareth Stratton, Teodora Handjieva-Darlenska, Svetoslav Handjiev, Jouko Sundvall, Marta P. Silvestre, Elli Jalo, Kirsi H. Pietilaeinen, Tanja C. Adam, Mathijs Drummen, Elizabeth J. Simpson, Moira A. Taylor, Sally D. Poppitt, Santiago Navas-Carretero, J. Alfredo Martinez, Wolfgang Schlicht, Mikael Fogelholm, Jennie Brand-Miller, Anne Raben
Summary: In this study, individuals with metabolically healthy overweight/obesity (MHO) were found to have better improvements in cardiometabolic risk factors and lower incidence of type 2 diabetes during long-term lifestyle intervention compared to those with metabolically unhealthy overweight/obesity (MUO).
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Health Care Sciences & Services
Sakris K. E. Kupila, Mikko S. Venalainen, Laura-Unnukka Suojanen, Milla Rosengard-Barlund, Aila J. Ahola, Laura L. Elo, Kirsi H. Pietilainen
Summary: Healthy weight coaching (HWC) is a web-based obesity management program integrated into standard clinical care. The program is a 12-month structured digital program based on acceptance and commitment therapy, providing weekly training sessions and remote support from personal coaches. The study found that the web-based program has potential in obesity management, with heavier individuals experiencing greater weight loss and baseline characteristics not affecting weight loss success.
JMIR FORMATIVE RESEARCH
(2022)
Article
Genetics & Heredity
Daniel Epting, Lokuliyange D. S. Senaratne, Elisabeth Ott, Asbjorn Holmgren, Dulika Sumathipala, Selma M. Larsen, Julia Wallmeier, Diana Bracht, Kari-Anne M. Frikstad, Suzanne Crowley, Alma Sikiric, Tuva Baroy, Barbara Kasmann-Kellner, Eva Decker, Christian Decker, Nadine Bachmann, Sebastian Patzke, Ian G. Phelps, Nicholas Katsanis, Rachel Giles, Miriam Schmidts, Manuela Zucknick, Soeren S. Lienkamp, Heymut Omran, Erica E. Davis, Dan Doherty, Petter Stromme, Eirik Frengen, Carsten Bergmann, Doriana Misceo
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
