Article
Medicine, Research & Experimental
Chuangzhen Lin, Bingqing Yu, Xuelian Liu, Lixin Chen, Zhaohui Zhang, Weixiang Ye, Hui Zhong, Wenke Bai, Yuping Yang, Biao Nie
Summary: Objective: This study revealed a novel mechanism by which Obeticholic acid (OCA) improves nonalcoholic fatty liver disease (NAFLD) independent of farnesoid X receptor (FXR), suggesting a potential therapeutic effect of OCA through inhibiting hepatic long-chain fatty acids uptake mediated by FATP5.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Nutrition & Dietetics
Estefania Aparicio, Carla Martin-Grau, Cristina Bedmar, Nuria Serrat Orus, Josep Basora, Victoria Arija
Summary: This study found that factors such as high education levels, older age, consumption of fish and seafood, and non-smoking are significantly associated with serum fatty acid concentrations in pregnant women, leading to a better omega-3 fatty acid profile. Further research is needed to explore the health consequences of these findings.
Article
Nutrition & Dietetics
Inigo San-Millan, Genevieve C. Sparagna, Hailey L. Chapman, Valerie L. Warkins, Kathryn C. Chatfield, Sydney R. Shuff, Janel L. Martinez, George A. Brooks
Summary: Chronic lactate exposure decreases cardiac mitochondrial activity, which may have implications for metabolic health and flexibility.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Gui-Hua Jiang, Guang Wang, Cheng Luo, Yong-Feng Wang, Jian-Feng Qiu, Ru-Ji Peng, Yang-Hu Sima, Shi-Qing Xu
Summary: Hyperproteinemia negatively affects female reproduction by causing ovarian developmental delay, reduced egg numbers, and poor egg quality. This is due to disrupted ovarian sugar metabolism caused by elevated plasma protein concentrations, which increase blood sugar levels through activation of the gluconeogenic pathway and inhibition of the Insulin/Insulin-like growth factor signaling pathway, leading to disruption of the sugar metabolic homeostasis in the ovary.
Review
Nutrition & Dietetics
Daniela Alvarez, Yasna Munoz, Macarena Ortiz, Manuel Maliqueo, Raphael Chouinard-Watkins, Rodrigo Valenzuela
Summary: Maternal health is crucial for the supply of essential fatty acids to offspring, and maternal obesity can alter the fatty acid profile, leading to increased risks of obesity and other health issues in the offspring.
Article
Plant Sciences
Weiwei Tang, Fenghua Wang, Hao Chu, Mingtong You, Qiang Lv, Wenjun Ji, Xiangwen Deng, Bo Zhou, Dan Peng
Summary: WRKY transcription factors play crucial roles in plants' response to abiotic stress. Phosphate starvation is a major challenge for plants, and understanding the molecular mechanisms of phosphate absorption and transport from the soil is important for optimizing phosphate acquisition efficiency in plants. In this review, recent advances in the study of complex WRKY TF networks that regulate phosphate acquisition and maintain phosphate homeostasis in plants are summarized. The transcriptional regulation and functions of these WRKY TFs in plant growth and development processes, such as flowering, leaf senescence, and seed germination under phosphate limitation, are also analyzed. This review provides a basis for potential guidelines to develop plant cultivars with improved phosphate uptake and utilization for sustainable agricultural and forestry development.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Czajka, Krzysztof Sawicki, Magdalena Matysiak-Kucharek, Marcin Kruszewski, Jacek Kurzepa, Paulina Wojtyla-Buciora, Lucyna Kapka-Skrzypczak
Summary: Chlorpyrifos, a representative of organophosphorus pesticides, has effects on the viability, proliferation, differentiation, and fatty acid uptake in 3T3-L1 cells. Exposure to chlorpyrifos decreases cell viability but increases it at low concentrations. It inhibits proliferation and differentiation of preadipocytes, reduces lipid accumulation, and down-regulates key transcription factors. In fully differentiated adipocytes, chlorpyrifos increases basal free fatty acid uptake. These findings suggest that chlorpyrifos may play a role in the development of obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ganesan Muthusamy, Chin-Chi Liu, Andrea N. Johnston
Summary: Metabolic dysfunction-associated steatotic liver disease is a primary cause of hepatocellular carcinoma, and alterations in lipid metabolism play a significant role in hepatocellular carcinoma. The overexpression of PGAM5 in hepatocellular carcinoma cells may impact lipid metabolism and contribute to lipid droplet accumulation.
Article
Biology
Robert A. Griffin, Chris N. Glover, Jenelle D. McCuaig, Tamzin A. Blewett
Summary: Dissolved organic matter, including amino acids, is an important component in freshwater and marine environments. There are pathways for the direct uptake of amino acids from water in various marine phyla, and these absorbed amino acids play important roles in metabolism and adaptation of aquatic animals.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ane Landajuela, Martha Braun, Alejandro Martinez-Calvo, Christopher D. A. Rodrigues, Carolina Gomis Perez, Thierry Doan, David Z. Rudner, Ned S. Wingreen, Erdem Karatekin
Summary: In Bacillus subtilis, membrane fission during cell division and endospore formation involves forespore inflation, increased membrane tension, and the presence of FisB protein. Forespore inflation leads to higher tension in the engulfment membrane, causing membrane flow and supplying membrane for forespore growth. FisB oligomerization at the membrane neck slows tension equilibration, further increasing engulfment membrane tension and promoting fission.
Article
Biotechnology & Applied Microbiology
Djamila Onesime, Lea Vidal, Stephane Thomas, Celine Henry, Veronique Martin, Gwenaelle Andre, Piotr Kubiak, Philippe Minard, Ewelina Celinska, Jean-Marc Nicaud
Summary: Yarrowia lipolytica has been found to have a family of extracellular fatty acid binding proteins, proposed to be named eFbp1 to eFbp4. The exact mechanism of action of these proteins remains to be elucidated, but they are expected to have applications in lipid biotechnology, such as improving fatty acid production and bioconversion.
MICROBIAL CELL FACTORIES
(2022)
Article
Medicine, General & Internal
Ling-Jun Li, Jing Wu, Zhen Chen, Natalie L. Weir, Michael Y. Tsai, Paul Albert, Cuilin Zhang
Summary: This study found that higher levels of plasma DHA and ALA in early pregnancy were associated with increased fetal size and weight throughout subsequent pregnancy.
Article
Biochemistry & Molecular Biology
Kaili Cui, Lichao Zhang, Xiaoqin La, Haili Wu, Ruipeng Yang, Hanqing Li, Zhuoyu Li
Summary: This study investigated the mechanism underlying the impact of ferulic acid and p-coumaric acid on non-alcoholic fatty liver disease (NAFLD). The results suggested that these acids improve NAFLD by inhibiting free fatty acid uptake and may serve as potential dietary supplements and drugs for preventing NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Yang Zhang, Zhi Cao, Laidi Wang, Bingqiang Dong, Shangzong Qi, Xinlei Xu, Qiang Bao, Yu Zhang, Qi Xu, Guobin Chang, Guohong Chen
Summary: This study evaluated the effects of feeding time of a linseed oil diet on duck meat performance and gene expression. The results showed that linseed oil had no negative effect on duck performance or meat quality performance, but affected the composition of muscle fatty acids. Four weeks of feeding time may be a key factor in promoting the deposition of n-3 polyunsaturated fatty acids in duck meat.
Article
Medicine, Research & Experimental
Helen Carrasco Hope, Rebecca J. Brownlie, Christopher M. Fife, Lynette Steele, Mihaela Lorger, Robert J. Salmond
Summary: Activation of T cell receptor results in metabolic reprogramming and upregulation of cell surface transporters for increased nutrient uptake, facilitating T cell exiting quiescence. The role of intracellular pathways of amino acid biosynthesis, specifically the activity of asparagine synthetase (ASNS), in CD8(+) T cell activation is crucial. ASNS expression is initially low in activated CD8(+) T cells, impairing cell viability and function, but later mTOR-dependent signals allow for ASNS upregulation, enabling cells to function independently of extracellular asparagine.
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
