Article
Medicine, Research & Experimental
Aline Pedro de Melo Yamamoto, Fernando Yamamoto Chiba, Rafael Dias Astolphi, Max Sander de Oliveira da Mota, Mario Jefferson Quirino Louzada, Maria Sara de Lima Coutinho Mattera, Clea Adas Saliba Garbin, Edilson Ervolino, Thais Veronica Saori Tsosura, Bianca Elvira Belardi, Rodrigo Martins dos Santos, Maristela Mitiko Okamoto, Ubiratan Fabres Machado, Doris Hissako Matsushita
Summary: The study demonstrated that resistance training had positive effects on glycemia, GLUT4 content, bone mineral density, and microstructural and biomechanical properties of osteopenic and non-osteopenic diabetic rats. These effects were not observed in the control groups without resistance training.
Article
Biochemistry & Molecular Biology
Sang R. Lee, Su Hee Jeong, Moeka Mukae, Kang Joo Jeong, Hyo-Jung Kwun, Eui-Ju Hong
Summary: This study establishes a moderate-obese diabetes model by inducing GLUT4 degradation with a chemical called GFI. GFI treatment leads to reduced GLUT4 levels, resulting in features of high blood glucose, insulin resistance, and decreased intracellular lipid accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Multidisciplinary Sciences
Jukka E. Hintikka, Juha P. Ahtiainen, Perttu Permi, Sirpa Jalkanen, Marko Lehtonen, Satu Pekkala
Summary: Physical activity is crucial for weight management, overall health improvement, and reduction of obesity-related risks. Regular exercise not only affects systemic metabolism, but also enhances gut microbial diversity and the abundance of beneficial bacteria. In a study involving overweight individuals, metabolomic and gut microbiota analysis revealed significant correlations between exercise and serum/fecal metabolites and metabolic pathways, indicating increased lipid oxidation and oxidative stress. Moreover, exercise was associated with elevated levels of serum lyso-phosphatidylcholine and fecal glycerophosphocholine, as well as various microbial metagenome pathways and the presence of Akkermansia. This study demonstrates that aerobic exercise can induce metabolic shifts that benefit the gut microbiota in overweight individuals, even in the absence of changes in body composition.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Xinlei Yao, Lei Liu, Wenjun Shao, Miao Bai, Xiaohan Ding, Geng Wang, Shuyue Wang, Lihua Zheng, Ying Sun, Guannan Wang, Yanxin Huang, Chunlei Yu, Zhenbo Song, Yongli Bao, Shaonian Yang, Luguo Sun
Summary: This study demonstrates that the natural compound tectorigenin (TG) enhances GLUT4 expression, glucose uptake, and insulin responsiveness by activating AMPK/MEF2 signaling. TG-mediated enhancement of AMPK signaling and GLUT4 expression in skeletal muscle improves insulin resistance and type 2 diabetes. This study suggests that TG could be a potential drug candidate for the treatment of insulin resistance and its related diseases and provides new insights into PKA signaling in glucose metabolism in skeletal muscle.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Plant Sciences
Yibing Lv, Ping Zhao, Kejian Pang, Yuanren Ma, Huiqi Huang, Tongxi Zhou, Xinzhou Yang
Summary: The study found that the extract from Sophora alopecuroides L. can improve hyperglycemia, dyslipidemia, and insulin resistance by activating the PKC/GLUT4 pathway and regulating PPAR α and PPAR γ expression.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ana Paula Garcia Bochi, Guilherme da Silva Ferreira, Vanessa Del Bianco, Paula Ramos Pinto, Leticia Gomes Rodrigues, Mayara da Silva Trevisani, Luzia Naoko Shinohara Furukawa, Kely Cristina Soares Bispo, Alexandre Alves da Silva, Ana Paula Pereira Velosa, Edna Regina Nakandakare, Ubiratan Fabres Machado, Walcy Paganelli Rosolia Teodoro, Marisa Passarelli, Sergio Catanozi
Summary: This study found that aerobic exercise training can prevent dyslipidemia, insulin resistance, and atherogenesis induced by severe low-sodium diet. Aerobic exercise training can improve arterial lipid infiltration, reduce AT1 receptor levels, and improve peripheral insulin resistance caused by dietary restriction. Additionally, the effects of aerobic exercise training are independent of improvements in plasma lipid profile.
Article
Nutrition & Dietetics
Alfonso Moreno-Cabanas, Juan Fernando Ortega, Felix Morales-Palomo, Miguel Ramirez-Jimenez, Laura Alvarez-Jimenez, Ricardo Mora-Rodriguez
Summary: The study aimed to investigate the effects of substituting parts of aerobic training (AT) with resistance training (RT) on metabolic syndrome (MetS) factors. Results showed that replacing 20% of AT with RT can improve glucose control and muscle strength in MetS individuals, suggesting that resistance training should be included in exercise recommendations for regaining glycemic control in MetS patients.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Nutrition & Dietetics
Guilherme da Silva Ferreira, Ana Paula Garcia Bochi, Paula Ramos Pinto, Vanessa Del Bianco, Leticia Gomes Rodrigues, Mychel Raony Paiva Teixeira Morais, Edna Regina Nakandakare, Ubiratan Fabres Machado, Sergio Catanozi, Marisa Passarelli
Summary: The study revealed that aerobic exercise training can alleviate hepatic lipid accumulation caused by a low-sodium diet, while improving insulin sensitivity and oxidative capacity. The low-sodium diet increased the expression of genes related to insulin resistance and lipid metabolism, but AET could partially prevent these adverse effects.
Article
Biochemistry & Molecular Biology
Francisco Diaz-Saez, Carla Blanco-Sinfreu, Adria Archilla-Ortega, David Sebastian, Montserrat Romero, Maria Isabel Hernandez-Alvarez, Silvia Mora, Xavier Testar, Wifredo Ricart, Jose Manuel Fernandez-Real, Jose Maria Moreno-Navarrete, Julian Aragones, Marta Camps, Antonio Zorzano, Anna Guma
Summary: The downregulation of Nrg4 in adipocytes impairs insulin action, likely due to decreased insulin receptor and Glut4 proteins, while also increasing proinflammatory cytokine expression and upregulating proteins involved in autophagy. Restoring lysosomal activity can partially reverse these effects, indicating that Nrg4 plays a role in maintaining insulin responsiveness and regulating autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Pablo Panico, Myrian Velasco, Ana Maria Salazar, Patricia Ostrosky-Wegman, Marcia Hiriart
Summary: This study evaluated the effects of sucrose and arsenic exposure on the pathways involved in insulin-stimulated GLUT4 translocation in muscle. The results showed that sucrose and arsenic exposure induced systemic insulin resistance, with defects in GLUT4 retention and docking in the quadriceps muscle, and impacts on the Akt pathway and proteolytic pathway in the gastrocnemius muscle.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Amy Zheng, Haiyan Wang, Edward B. Arias, Gengfu Dong, Jiahui Zhao, Gregory D. Cartee
Summary: The effects of calorie restriction on female wildtype and Akt substrate of 160 kDa knockout rats were evaluated. The results showed that calorie restriction increased muscle glucose uptake and GLUT4 protein abundance, and AS160 expression was essential for these increases.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Medicine, Research & Experimental
Jing Zhou, Tongyu Wu, Chun Li, Zhuozhou Hu, Liang Han, Xiangxiang Li, Jingjing Liu, Wenyang Zhao, Jia Kang, Xinping Chen
Summary: This study aims to find a new potential method and mechanism for the treatment of DM. The findings suggest that alfuzosin can improve oxidative stress, glycative stress, and insulin resistance. In a HFD/STZ-induced diabetic mouse model, alfuzosin reduces fasting blood glucose and improves insulin sensitivity, and it achieves this by activating PGK1 to stimulate the AKT signaling pathway.
Article
Cell Biology
Yan Chen, Da Lin, Changxuan Shi, Liang Guo, Linhua Liu, Lin Chen, Ting Li, Ying Liu, Chengchao Zheng, Xintong Chi, Chun Meng, Yaoming Xue
Summary: The study aimed to elucidate the molecular mechanism of insulin resistance (IR). Using an IR cell model, it was found that miR-3138 significantly deteriorated the IR of HUVECs via the KSR2/AMPK/GLUT4 signaling pathway.
Article
Biochemistry & Molecular Biology
Jun-Won Heo, Mi-Hyun No, Jinkyung Cho, Youngju Choi, Eun-Jeong Cho, Dong-Ho Park, Tae-Woon Kim, Chang-Ju Kim, Dae Yun Seo, Jin Han, Young C. Jang, Su-Jeen Jung, Ju-Hee Kang, Hyo-Bum Kwak
Summary: Moderate aerobic exercise training can improve mitochondrial function and structure in skeletal muscle, reducing obesity and hyperglycemia induced by high-fat diet. Exercise attenuates mitochondrial dysfunction, imbalance of fusion and fission, and dysregulation of mitophagy caused by high-fat diet, ultimately mitigating obesity-induced insulin resistance.
Article
Biology
Fatemeh Ashkar, Khushwant S. S. Bhullar, Xu Jiang, Jianping Wu
Summary: Metabolic syndrome is a cluster of risk factors associated with cardiovascular diseases and diabetes. This study aims to investigate the regulatory role of peptide IRW on aortic ACE2 and its associated signaling pathways in HFD-induced insulin-resistant mice. The results showed that upregulation of aortic ACE2 by IRW peptide activated the pathways associated with vasodilation and improved insulin resistance and glucose metabolism.
Review
Behavioral Sciences
Matthew W. McDonald, Kathryn S. Hayward, Ingrid C. M. Rosbergen, Matthew S. Jeffers, Dale Corbett
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2018)
Article
Endocrinology & Metabolism
Matthew W. McDonald, Michelle S. Dotzert, Mao Jiang, Michael R. Murray, Earl G. Noble, C. W. James Melling
JOURNAL OF DIABETES RESEARCH
(2018)
Article
Endocrinology & Metabolism
Michelle S. Dotzert, Matthew W. McDonald, Michael R. Murray, J. Zachary Nickels, Earl G. Noble, C. W. James Melling
CANADIAN JOURNAL OF DIABETES
(2018)
Article
Endocrinology & Metabolism
Matthew W. McDonald, T. Dylan Olver, Michelle S. Dotzert, Thomas J. Jurrissen, Earl G. Noble, Jaume Padilla, C. W. James Melling
DIABETES & VASCULAR DISEASE RESEARCH
(2019)
Article
Biochemical Research Methods
Clarissa Pedrini Schuch, Gustavo Balbinot, Matthew S. Jeffers, Matthew W. McDonald, Angela Dykes, Lydia M. Kuhl, Dale Corbett
JOURNAL OF NEUROSCIENCE METHODS
(2019)
Article
Clinical Neurology
Matthew W. McDonald, Sandra E. Black, David A. Copland, Dale Corbett, Rick M. Dijkhuizen, Tracy D. Farr, Matthew S. Jeffers, Rajesh N. Kalaria, Frini Karayanidis, Alexander P. Leff, Jess Nithianantharajah, Sarah Pendlebury, Terence J. Quinn, Andrew N. Clarkson, Michael J. O'Sullivan
INTERNATIONAL JOURNAL OF STROKE
(2019)
Article
Neurosciences
Jessica M. Livingston, Matthew W. McDonald, Therese Gagnon, Matthew S. Jeffers, Mariana Gomez-Smith, Sabina Antonescu, Greg O. Cron, Carlie Boisvert, Baptiste Lacoste, Dale Corbett
NEUROBIOLOGY OF DISEASE
(2020)
Review
Clinical Neurology
Allyson J. Ripley, Matthew S. Jeffers, Matthew W. McDonald, Joshua Montroy, Angela Dykes, Dean A. Fergusson, Gergely Silasi, Manoj M. Lalu, Dale Corbett
Summary: Remote ischemic conditioning (RIC) shows promise in reducing infarct volume in ischemic stroke, especially in males and when delivered poststroke. However, there is a high risk of bias and poor methodological reporting in many studies, potentially exaggerating efficacy. Important but under-investigated topics include the efficacy of RIC in different stroke models, varied infarct sizes and locations, and potential sex differences.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Clinical Neurology
Kathryn S. Hayward, Leonid Churilov, Emily J. Dalton, Amy Brodtmann, Bruce C. V. Campbell, David Copland, Numa Dancause, Erin Godecke, Tammy C. Hoffmann, Natasha A. Lannin, Matthew W. McDonald, Dale Corbett, Julie Bernhardt
Summary: The challenges of articulating dose in nonpharmacological stroke recovery research include the absence of specific internationally agreed dose reporting guidelines, inadequate conceptualization of dose, and unclear and inconsistent terminology. To address these challenges, a consistent approach to dose articulation is needed to stimulate critical thinking during intervention development and improve the accuracy of reported intervention doses.
Article
Neurosciences
Matthew W. McDonald, Matthew S. Jeffers, Melissa Filadelfi, Andrea Vicencio, Gavin Heidenreich, Junzheng Wu, Gergely Silasi
Summary: Brain microinfarcts are prevalent in humans, and in mice, a novel and semi-automated workflow has been developed to accurately determine the anatomic location of microspheres within the brain using histologic processing and atlas registration. The distribution of microspheres was found to be brain-wide, with the highest density in the thalamus.
Article
Physiology
Cameron J. Morse, Erika M. Boerman, Matthew W. McDonald, Jaume Padilla, T. Dylan Olver
Summary: This study found size-dependent heterogeneity in myogenic reactivity in porcine cerebral arteries. Smaller branches of the middle cerebral artery exhibited increased myogenic reactivity, but attenuated NOS-dependent increases in myogenic tone compared with larger branches. Flow-dependent regulation does not exhibit the same variation; diameter-independent flow-induced vasoconstrictions occur across all branch orders and are not affected by NOS inhibition.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Michelle S. Dotzert, Matthew W. McDonald, T. Dylan Olver, Mitchell J. Sammut, C. W. James Melling
Summary: This study aimed to investigate the effects of exercise combined with intensive insulin therapy on insulin resistance and intramyocellular lipids in animals with Type 1 Diabetes (T1D). The results showed that the exercise group had a slower onset of insulin resistance and enhanced intramyocellular lipid metabolism, while intensive insulin therapy and sedentary behavior exacerbated insulin resistance and fat accumulation.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Clinical Neurology
Matthew W. McDonald, Angela Dykes, Matthew S. Jeffers, Anthony Carter, Ralph Nevins, Allyson Ripley, Gergely Silasi, Dale Corbett
Summary: Remote ischemic conditioning (RIC) shows neuroprotective effects in stroke patients by inducing ischemia at specific time points, but fails to enhance post-stroke behavioral recovery in the later acute phase.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Clinical Neurology
Matthew W. McDonald, Matthew S. Jeffers, Lama Issa, Anthony Carter, Allyson Ripley, Lydia M. Kuhl, Cameron Morse, Cesar H. Comin, Bernard J. Jasmin, Baptiste Lacoste, Dale Corbett
Summary: The evidence supports early rehabilitation after stroke to limit disability, with a combination of aerobic and resistance exercise along with resveratrol showing promising results in mitigating cardiovascular and skeletal muscle deconditioning. However, there were no additive effects observed in these experiments, despite the potential benefits of early treatment for poststroke behavioral impairments.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Clinical Neurology
Matthew W. McDonald, Sandra E. Black, David A. Copland, Dale Corbett, Rick M. Dijkhuizen, Tracy D. Farr, Matthew S. Jeffers, Rajesh N. Kaaria, Frini Karayanidis, Alexander P. Leff, Jess Nithianantharajah, Sarah Pendlebury, Terence J. Quinn, Andrew N. Clarkson, Michael J. O'Sullivan
NEUROREHABILITATION AND NEURAL REPAIR
(2019)
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)