Article
Ophthalmology
Hassan Boskabadi, Maryam Marefat, Gholamali Maamouri, Majid Abrishami, Mojtaba Abrishami, Nasser Shoeibi, Mostafa Soltan Sanjari, Majid Ghayour Mobarhan, Seyed Reza Habibzadeh Shojaei, Shima Tavallaei, Fathemeh Sanei, Mahsa Kakavandi, Ali Moradi, Maryam Zakerihamidi
Summary: This study aimed to evaluate the role of oxidative stress and peroxidant antioxidant balance (PAB) in the pathogenesis and prediction of Retinopathy of Prematurity (RoP). The results showed that PAB level could be helpful in predicting the incidence of RoP, with increasing PAB associated with increased severity of RoP.
Article
Medicine, General & Internal
Hassan Boskabadi, Majid Ghayour-Mobarhan, Amin Saeidinia
Summary: This study compared the levels of serum pro-oxidant/antioxidant balance (PAB) in preterm versus term neonates and found that the PAB level was significantly lower in preterm neonates. Additionally, there was a significant negative correlation between PAB levels and gestational age.
Review
Biochemistry & Molecular Biology
Agnieszka Wolnicka-Glubisz, Anna Wisniewska-Becker
Summary: Curcumin, a natural polyphenol with antioxidant properties, can have therapeutic effects on different disorders. However, it can also be toxic under certain conditions, such as exposure to blue light or excessive use.
Article
Biochemistry & Molecular Biology
Dannah R. Miller, Matthew A. Ingersoll, Yu -Wei Chou, Elizabeth A. Kosmacek, Rebecca E. Oberley-Deegan, Ming-Fong Lin
Summary: This study investigates the role of the reactive oxygen species (ROS) signaling pathway in the progression of castration-resistant prostate cancer (CR PCa). The elevated levels of HO-1 and p66Shc proteins in AI PCa cells suggest their involvement in the development of the CR phenotype. Knockdown or inhibition of HO-1 or p66Shc leads to reduced tumorigenicity and the corresponding protein levels. Knockdown of HO-1 alone increases ROS levels, nucleotide and protein oxidation, and induces cell death. These findings suggest that HO-1 and p66Shc can be potential targets for treating CR PCa.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Nutrition & Dietetics
Thu T. M. Pham, Tuyen Van Duong, Lien T. K. Nguyen, Manh-Tan Vu, Khue M. Pham, Minh H. Nguyen, Thuc C. Luong, Binh N. Do, Lan T. H. Le, Nga H. Dang, Thao T. P. Nguyen, Hoang P. Le, Cuong Q. Tran, Kien T. Nguyen, Chaur-Jong Hu, Chang-Chuan Chan, Hui-Chuan Hsu, Chyi-Huey Bai
Summary: This study examined the association between hypertension and stroke recurrence, as well as the modifying effect of the pro-oxidant-anti-oxidant balance. The results showed that hypertension was associated with an increased likelihood of stroke recurrence, while a higher pro-oxidant-anti-oxidant (PAB) score was associated with a lower likelihood of recurrence. The study highlights the importance of considering the interplay of health behaviors in stroke prevention strategies.
Article
Biochemistry & Molecular Biology
Izabela Kokot, Agnieszka Piwowar, Marcin Jedryka, Ewa Maria Kratz
Summary: The study found that serum concentrations of FRAP, telomerase and AOPP were significantly higher in patients with endometriosis and other gynecological disorders, indicating their potential as promising diagnostic markers for endometriosis.
Article
Biochemistry & Molecular Biology
Simona Mattioli, Elisa Angelucci, Alessandro Dal Bosco, Cinzia Signorini, Lakamy Sylla, Luigia Bosa, Giulia Collodel, Thierry Durand, Jean-Marie Galano, Camille Oger, Cesare Castellini
Summary: Dietary factors can affect sperm traits, and diets rich in pro-oxidant and pro-atherogenic substances may lead to a decline in sperm kinetics and viability.
Review
Biochemistry & Molecular Biology
Amanda Shen-Yee Kong, Sathiya Maran, Polly Soo-Xi Yap, Swee-Hua Erin Lim, Shun-Kai Yang, Wan-Hee Cheng, Yong-Hui Tan, Kok-Song Lai
Summary: The rapid evolution of antimicrobial resistance is a major public health issue, and natural products such as plant extracts and essential oils have the potential to combat this issue due to their complex chemistry. The pro-oxidant and antioxidant activities in essential oils represent a promising strategy to tackle antimicrobial resistance.
Article
Biochemical Research Methods
Mahsa Ahmadnezhad, Hamideh Ghazizadeh, Moniba Bijari, Mohammad Reza Oladi, Habibollah Esmaily, Seyed javad Hoseini, Elham Barati, Samaneh Silakhori, Maryam Mohammadi-Bajgiran, Hafezeh Davari, Mohammad Reza Parizadeh, Naghme Mokhber, Payam Sharifan, Seyed Rafie Aref-Hosseini, Gordon A. Ferns, Mohsen Moohebati, Majid Ghayour-Mobarhan
Summary: The study aimed to investigate the relationship between type 2 diabetes mellitus (T2DM) and serum pro-oxidant-antioxidant balance (PAB) in a large population-based study. Results showed that individuals with a serum PAB greater than 82.6 HK had a higher risk of T2DM, and this association remained significant after adjustment for confounding factors in multivariable analysis, suggesting that increased pro-oxidant levels may be a major complication of T2DM.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Article
Biochemistry & Molecular Biology
Anna Bizon, Justyna Chojdak-Lukasiewicz, Aleksandra Koltuniuk, Slawomir Budrewicz, Anna Pokryszko-Dragan, Agnieszka Piwowar
Summary: This study evaluated oxidative stress parameters in the serum of patients with relapsing-remitting multiple sclerosis (RRMS), and found associations between these parameters and clinical/laboratory markers. AOPP and FRAP concentrations were higher in male patients. There were correlations between AOPP and inflammation markers, and differences in AOPP among subgroups receiving different treatments.
Review
Cardiac & Cardiovascular Systems
Veronica Sanda Chedea, Liliana Lucia Tomoiaga, Stefan Octavian Macovei, Dan Claudiu Magureanu, Maria Lucia Iliescu, Ioana Corina Bocsan, Anca Dana Buzoianu, Crinuta Maria Vosloban, Raluca Maria Pop
Summary: Grape by-products are rich in polyphenols and can be used as a source of bioactive polyphenols for complementary therapy in ischemic heart diseases. These compounds have antioxidant properties that can counteract oxidative stress, but may also exhibit pro-oxidant activity to some extent.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Raffaella Marina Lecci, Isabella D'Antuono, Angela Cardinali, Antonella Garbetta, Vito Linsalata, Antonio F. Logrieco, Antonella Leone
Summary: This study aimed to evaluate the antioxidant, pro-oxidant, and photoprotective effects of ultra-filtered (UF) olive mill wastewater (OMWW) fractions, as well as their underlying action mechanisms, to substantiate their potential use as natural cosmeceutical ingredients.
Review
Engineering, Chemical
Celia Maria Curieses Andres, Jose Manuel Perez de la Lastra, Celia Andres Juan, Francisco J. Plou, Eduardo Perez-Lebena
Summary: This review focuses on the antioxidant and pro-oxidant capacity of polyphenols and the mechanism of catechol group oxidation to quinones. The redox balance generated between oxidase and reductase enzymes allows reversible oxidation of polyphenolic groups. This balance activates cellular antioxidant responses and cell proliferation. Understanding the ambivalent character of polyphenols can lead to the design of specific therapies for scientific and medical purposes.
Article
Medicine, General & Internal
Tuba Damar Cakirca, Mehmet Resat Ceylan, Ismail Koyuncu, Gokhan Cakirca
Summary: The study found that the thiol/disulphide homeostasis shifts towards the disulphide direction in HCV-infected patients, and higher HCV-RNA levels are associated with higher levels of disulphide.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Marko Baralic, Ivan Spasojevic, Goran Miljus, Milos Sunderic, Dragana Robajac, Zorana Dobrijevic, Nikola Gligorijevic, Olgica Nedic, Ana Penezic
Summary: This study aims to investigate the changes in the antioxidative capacity of HSA and Cu(II) binding affinity in peritoneal dialysis patients. The findings suggest that ESRD patients have modified HSA molecules with reduced antioxidant capacity and impaired Cu(II) binding capacity, which exacerbates oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Srikanth Karnati, Gulcan Guntas, Ranjithkumar Rajendran, Sergey Shityakov, Marcus Hoering, Gerhard Liebisch, Djuro Kosanovic, Sueleyman Erguen, Michiaki Nagai, Carola Y. Foerster
Summary: Takotsubo syndrome, also known as transient left ventricular apical ballooning syndrome, is a novel acute cardiac syndrome characterized by transient abnormal left ventricular function. The exact cause of this syndrome is unknown, but stress hormones and inflammation are believed to play a role. A recent study analyzed the lipid profiles of Takotsubo syndrome patients and found significant differences compared to a control group. Computational analysis linked these altered lipids to pro-inflammatory cytokines and identified potential mechanistic pathways involving TNF alpha and IL-6. The study provides valuable insights into the lipidome of Takotsubo syndrome patients and may aid in pre-diagnosis and prevention of the disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Aykut Oruc, Kadriye Yagmur Oruc, Karolin Yanar, Murat Mengi, Aysel Caglar, Bahar Ozturk Kurt, Mehmet Altan, Osman Fuat Sonmez, Ufuk Cakatay, Hafize Uzun, Gonul Simsek
Summary: Through studying rats with glutamate-induced neurotoxicity, it was found that metformin may exert neuroprotective effects and increase neuronal survival through zinc-dependent inhibition of GSK-3 beta.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Pediatrics
Yusuf Elgormus, Omer Okuyan, Hafize Uzun
Summary: This study aimed to evaluate the relationship between vitamin D status and systemic inflammatory markers NLR, LMR, and PLR in newborns. The results suggest that vitamin D deficiency in newborns may be associated with inflammation and changes in NLR, LMR, and PLR. NLR and other hematologic indices may serve as non-invasive, simple, easily measurable, and cost-effective markers of inflammation in newborns.
Article
Virology
Omer Okuyan, Yusuf Elgormus, Seyma Dumur, Ugurcan Sayili, Hafize Uzun
Summary: This study examined the relationship between SII, NLR, and PLR with clinical findings of RSV infection in children with LRTI. The results showed that CRP levels were higher in RSV positive cases, while NLR, PLR, and SII were lower in these cases. CRP performed better than other blood parameters as a marker. Determining the cause of the disease using these parameters can aid in disease management and avoid unnecessary antibiotic use.
Article
Immunology
Omer Okuyan, Yusuf Elgormus, Ugurcan Sayili, Seyma Dumur, Ozlem Erkan Isik, Hafize Uzun
Summary: This study evaluated the impact of the RV vaccine on the natural course of RV infections. The results showed that children who received the RV vaccine had lower rates of fever and hospitalization for acute gastroenteritis (AGE), and breastfeeding was also associated with a lower risk of infection. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic immune inflammatory index (SII) were significantly higher in the RV-unvaccinated group.
Article
Medicine, General & Internal
Pelin Uysal, Arzu Yuksel, Sinem Durmus, Caglar Cuhadaroglu, Remise Gelisgen, Hafize Uzun
Summary: In this study, the relationship between NF-kappa B, oxidative stress, and disease severity in new COVID-19 patients was investigated. LOX-1, NF-kappa B, and oxLDL levels were found to be higher in COVID-19 patients compared to healthy subjects. oxLDL showed the highest discrimination power in distinguishing COVID-19 patients.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Derya Ozturk, Adem Melekoglu, Ertugrul Altinbilek, Mustafa Calik, Arzu Kosem, Hakan Kilci, Naile Fevziye Misirlioglu, Hafize Uzun
Summary: This study aimed to investigate the associations between serum irisin levels and acute myocardial infarction (AMI). The findings showed that STEMI patients had significantly lower irisin levels compared to control subjects, and these levels were correlated with cTi levels and QTc interval.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nevin Fazlioglu, Pelin Uysal, Sinem Durmus, Sibel Yurt, Remise Gelisgen, Hafize Uzun
Summary: This study investigated the relationship between plasma irisin, RBP-4, and adiponectin levels and the severity of OSAS. The results showed that these biomarkers were associated with the disease and could be used for diagnosis in the absence of polysomnography. Patients with an AHI score greater than thirty should be closely monitored for metabolic abnormalities.
Article
Medicine, General & Internal
Gulseren Sagcan, Zeki Dogan, Hafize Uzun, Caglar Cuhadaroglu, Gulfer Okumus, Orhan Arseven
Summary: This study found that higher levels of NT-proBNP and GDF-15 were associated with the severity, prognosis, and mortality of acute pulmonary embolism.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Z. Dogan, S. Durmus, D. D. Ergun, R. Gelisgen, H. Uzun
Summary: This study evaluated the effectiveness of ranolazine on hypoxia-inducible factor-1 alpha (HIF-1 alpha) and oxidative stress in H9c2 cardiomyocyte cells. The results showed that ranolazine can protect cardiomyocytes from oxidative damage induced by methotrexate (MTX) by reducing oxidative stress and increasing antioxidant capacity markers. The antioxidant properties of ranolazine may contribute to these protective effects.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Zeki Dogan, Gokhan Bektasoglu, Seyma Dumur, Hafize Uzun, Ismail Erden, Mustafa Yurtdas
Summary: This study aimed to evaluate the monocyte count and high-density lipoprotein cholesterol levels and their ratio in patients with deep venous thrombosis and investigate whether this ratio can indicate thrombus burden in terms of thrombus location. The results showed a significantly higher monocyte/high-density lipoprotein ratio in deep venous thrombosis patients compared to the control group. This ratio was associated with thrombus location and the number of vein segments involved.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2023)
Meeting Abstract
Physiology
Emine Uygur, Hakki Oktay Seymen, Hafize Uzun, Matem Tuncdemir, Aysim Buge Oz, Elif Polat, Ahsen Yilmaz, Elif Yaman
Meeting Abstract
Physiology
Emine Uygur, Hakki Oktay Seymen, Hafize Uzun, Matem Tuncdemir, Aysim Buge Oz, Elif Polat, Ahsen Yilmaz, Elif Yaman
Article
Medicine, General & Internal
Yusuf Elgormus, Omer Okuyan, Seyma Dumur, Ugurcan Sayili, Hafize Uzun
Summary: This study aimed to investigate the vitamin B12 levels and risk factors in preschool children. The results showed that B12 deficiency was significantly higher in the 6-11-month group compared to other age groups. Children with insufficient B12 levels had higher homocysteine levels. There was no significant difference in weekly dairy and meat consumption levels among different age groups. The study concluded that low vitamin B12 levels and increased homocysteine levels could be important risk factors in preschool children, especially those starting to consume additional foods from the age of 6 months.
MEDICINA-LITHUANIA
(2023)
Article
Biochemistry & Molecular Biology
Mustafa Calik, Yildizhan Sengul, Zahide Mail Gurkan, Deniz Hintoglu, Naile Fevziye Misirlioglu, Hafize Uzun
Summary: This study investigated the relationship between serum irisin levels and the subtype classification of acute ischemic stroke, as well as the National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Score (mRS) in Turkish patients. The results showed that high serum irisin levels were associated with stroke attributed to small vessel disease and with ischemic stroke patients who did not exhibit neurological deficits with a localization value.
JOURNAL OF MEDICAL BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)