Article
Biochemistry & Molecular Biology
Oscar Osorio-Conles, Arturo Vega-Beyhart, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Ana de Hollanda
Summary: The metabolic syndrome is a cluster of dangerous heart attack risk factors. This study compares the dysfunction of obesity-associated white adipose tissue (WAT) between women with severe obesity with or without metabolic syndrome. The results show that women with metabolic syndrome exhibit greater adipocyte hypertrophy, increased fibrosis, and higher expression of macrophage and hypoxia markers in subcutaneous adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alexander J. Knights, Shanshan Liu, Yingxu Ma, Victoria S. Nudell, Eric Perkey, Matthew J. Sorensen, Robert T. Kennedy, Ivan Maillard, Li Ye, Heejin Jun, Jun Wu
Summary: This study demonstrates that macrophages play a crucial role in regulating thermogenesis by secreting acetylcholine in adipose tissue. The abundance of ChAMs increases in response to acute cold exposure, and their regulation is mediated through adrenergic signaling. Deletion of the enzyme ChAT impairs cold-induced thermogenesis in mice.
Article
Endocrinology & Metabolism
Pavel Hruska, Jan Kucera, Matej Pekar, Pavol Holeczy, Miloslav Mazur, Marek Buzga, Daniela Kuruczova, Peter Lenart, Jana Fialova Kucerova, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku
Summary: The study compared the proteomic profiles of mature adipocytes from different adipose tissue depots, with findings showing that subcutaneous adipocytes are more active in vesicular transport, secretion, and lipid metabolism, while visceral adipocytes have higher protein expression related to mitochondrial energy metabolism and translational or biosynthetic activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Darcy Kahn, Emily Macias, Simona Zarini, Amanda Garfield, Karin Zemski Berry, Paul MacLean, Robert E. Gerszten, Andrew Libby, Claudia Solt, Jonathan Schoen, Bryan C. Bergman
Summary: Research has found that the secretions of adipose tissue vary based on anatomical location and affect insulin responsiveness through paracrine and endocrine signaling. Visceral adipose tissue secretes more cytokines and adipokines than subcutaneous adipose tissue, leading to a negative impact on insulin action in the liver and muscles.
Article
Biochemistry & Molecular Biology
Sarah Abdul Majeed, Helene Dunzendorfer, Juliane Weiner, John T. T. Heiker, Wieland Kiess, Antje Korner, Kathrin Landgraf
Summary: Obesity in children is associated with adipose tissue dysfunction and metabolic disease, increasing the risk of premature death. The brown adipose tissue (BAT), known for its energy-dissipating function, has been suggested to protect against obesity and metabolic dysfunction. Through genome-wide expression profiling, we identified several genes, including COBL, MKX, and MYOC, which have not been previously characterized in BAT biology and examined their functional role in BAT development. Our findings also reveal an association between the expression of these genes and early metabolic dysfunction in children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Elisa Felix-Soriano, Neira Sainz, Marta Fernandez-Galilea, Eva Gil-Iturbe, Jon Celay, Jose A. Martinez-Climent, Maria J. Moreno-Aliaga
Summary: This study aimed to investigate the potential beneficial effects of chronic docosahexaenoic acid (DHA) supplementation on restoring subcutaneous white adipose tissue (scWAT) plasticity in obese aged female mice. The results showed that the DHA-enriched diet reduced adipocyte size and reversed the upregulation of lipogenic genes induced by the high fat diet (HFD). DHA supplementation restored the increase of proinflammatory genes, switched scWAT macrophages profile to a healthier phenotype, and induced beige adipocyte markers in obese aged mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Menghua Zhu, Hongyu Li, Yue Yin, Min Ding, Cyriac Abby Philips, Fernando Gomes Romeiro, Xingshun Qi
Summary: Both excessive deficiency and accumulation of subcutaneous adipose tissues negatively influence the outcomes of cirrhotic patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Hinojosa-Moscoso, Anna Motger-Alberti, Elena De la Calle-Vargas, Marian Marti-Navas, Carles Biarnes, Maria Arnoriaga-Rodriguez, Gerard Blasco, Josep Puig, Diego Luque-Cordoba, Feliciano Priego-Capote, Jose Maria Moreno-Navarrete, Jose Manuel Fernandez-Real
Summary: Excess iron is associated with dysfunction in adipose tissue and insulin resistance. In this study, it was found that markers of iron status were linked to changes in abdominal adipose tissue over one year. These associations were mainly observed in women and non-obese subjects, and were independent of insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tamara Camino, Nerea Lago-Baameiro, Aurelio Sueiro, Susana Belen Bravo, Ivan Couto, Francisco Fernando Santos, Javier Baltar, Felipe F. Casanueva, Maria Pardo
Summary: Brown adipose tissue extracellular vesicles (EVs) play an important role in promoting energy expenditure and could potentially serve as biomarkers of thermogenesis activity. This study isolated EVs from lean and obese rats and found that the protein cargo of BAT EVs is affected by metabolic status and contains potential obesity biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Patricia Leticia Trindade, Fabiane Ferreira Martins, Elaine dos Ramos Soares, Elisa Monteiro Bernardes, Francisco Vardiero, Angela de Castro Resende, Vanessa Souza-Mello, Julio Beltrame Daleprane
Summary: This study found that supplementation with polyphenol-rich jaboticaba peel and seed powder can prevent obesity and fat accumulation induced by high-fat diet, improve insulin sensitivity, and promote browning in subcutaneous adipose tissue.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Endocrinology & Metabolism
Theresa Drabsch, Daniela Junker, Sandra Bayer, Mingming Wu, Cora Held, Dimitrios C. C. Karampinos, Hans Hauner, Christina Holzapfel
Summary: In this study, it was found that supraclavicular PDFF is not a determinant of resting metabolic rate (RMR), while a negative association was observed between the difference in PDFF between gluteal and supraclavicular regions and RMR. The FTO gene variant rs1421085 was not associated with RMR or PDFF in this study, highlighting the need for further research on the effect of brown adipose tissue on RMR.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Oscar Osorio-Conles, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Emilio Ortega, Ana de Hollanda
Summary: Hypertriglyceridemia is associated with increased risk of pancreatitis and cardiovascular disease. Fibrosis of subcutaneous adipose tissue is related to changes in triglyceride levels. FABP4 gene may be a potential drug target for the treatment of hypertriglyceridemia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chang Sun, Franz Forster, Beate Gutsmann, Yusef Moulla, Christine Stroh, Arne Dietrich, Michael R. Schoen, Daniel Gaertner, Tobias Lohmann, Miriam Dressler, Michael Stumvoll, Matthias Blueher, Peter Kovacs, Jana Breitfeld, Esther Guiu-Jurado
Summary: The GRB14/COBLL1 locus is associated with body fat distribution and metabolic diseases, particularly involving lipid metabolism and glucose homeostasis, likely mediated by AT GRB14 transcript levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Miriam Mengoni, Andreas Dominik Braun, Mattes Simon Hinnerichs, Thomas Tuting, Alexey Surov
Summary: This study aims to evaluate radiologic measurements of body composition as biomarkers predicting treatment response and adverse events (AEs) in melanoma patients receiving immune checkpoint inhibitors (ICI). The study found that low subcutaneous adipose tissue gauge index (SATGI) was associated with prolonged progression-free survival (PFS) and enhanced objective response rate. In addition, a significant enrichment of cases with vitiligo was observed in the SATGI-low cohort.
ACADEMIC RADIOLOGY
(2023)
Review
Physiology
Simon T. Bond, Anna C. Calkin, Brian G. Drew
Summary: Adipose tissue, through the secretion of extracellular vesicles, plays a crucial role in endocrine regulation and disease occurrence.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Regis Bordet, Jean-Christophe Dantonel, Eric Vacaresse, Claire Le Jeunne, Nora Benhabiles, Alain Beretz, Christian Boitard, Stephanie Debette, Gilles Duluc, Philippe Froguel, Benedicte Garbil, Stanislas Lyonnet, Abderrahim Mahfoudi, Pierre Marquet, Franck Mouthon, Olivier Rascol, Vincent Richard, Emmanuelle Simon, Nathalie Varoqueaux, Herve Watiert, Marie Zinsu
Summary: This article explores the impact of the Investments for the Future programme on health research and innovation, identifying five key factors for future development in healthcare innovation.
Article
Cell Biology
Florine Bornaque, Clement Philippe Delannoy, Emilie Courty, Nabil Rabhi, Charlene Carney, Laure Rolland, Maeva Moreno, Xavier Gromada, Cyril Bourouh, Pauline Petit, Emmanuelle Durand, Francois Pattou, Julie Kerr-Conte, Philippe Froguel, Amelie Bonnefond, Frederik Oger, Jean-Sebastien Annicotte
Summary: This study found that environmental variations, such as glucose concentration, can control m(6)A methylation in pancreatic beta cells, modulating gene expression and pancreatic beta-cell functions. These findings provide new insights into the causes and mechanisms of type 2 diabetes.
Article
Biochemistry & Molecular Biology
Natalia Pervjakova, Gunn-Helen Moen, Maria-Carolina Borges, Teresa Ferreira, James P. Cook, Catherine Allard, Robin N. Beaumont, Mickael Canouil, Gad Hatem, Anni Heiskala, Anni Joensuu, Ville Karhunen, Soo Heon Kwak, Frederick T. J. Lin, Jun Liu, Sheryl Rifas-Shiman, Claudia H. Tam, Wing Hung Tam, Gudmar Thorleifsson, Toby Andrew, Juha Auvinen, Bishwajit Bhowmik, Amelie Bonnefond, Fabien Delahaye, Ayse Demirkan, Philippe Froguel, Kadri Haller-Kikkatalo, Hildur Hardardottir, Sandra Hummel, Akhtar Hussain, Eero Kajantie, Elina Keikkala, Amna Khamis, Jari Lahti, Tove Lekva, Sanna Mustaniemi, Christine Sommer, Aili Tagoma, Evangelia Tzala, Raivo Uibo, Marja Vaarasmaki, Pia M. Villa, Kare Birkeland, Luigi Bouchard, Cornelia M. Duijn, Sarah Finer, Leif Groop, Esa Hamalainen, Geoffrey M. Hayes, Graham A. Hitman, Hak C. Jang, Marjo-Riitta Jarvelin, Anne Karen Jenum, Hannele Laivuori, Ronald C. Ma, Olle Melander, Emily Oken, Kyong Soo Park, Patrice Perron, Rashmi B. Prasad, Elisabeth Qvigstad, Sylvain Sebert, Kari Stefansson, Valgerdur Steinthorsdottir, Tiinamaija Tuomi, Marie-France Hivert, Paul W. Franks, Mark McCarthy, Cecilia M. Lindgren, Rachel M. Freathy, Deborah A. Lawlor, Andrew P. Morris, Reedik Magi
Summary: The study found that gestational diabetes mellitus (GDM) and type 2 diabetes (T2D) share the same underlying pathology, but there are also genetic determinants specific to glucose regulation in pregnancy.
HUMAN MOLECULAR GENETICS
(2022)
Article
Orthopedics
L. S. Lohmander, M. Peltonen, J. C. Andersson-Assarsson, C. Maglio, K. Sjoholm, M. Taube, P. Jacobson, P-A. Svensson, L. M. S. Carlsson, S. Ahlin
Summary: This study investigated the long-term effect of obesity and bariatric surgery on the incidences of osteoarthritis and arthroplasty of hip and knee. The results showed that the bariatric surgery group had a lower incidence of hip osteoarthritis but a higher incidence of knee arthroplasty compared to the control group.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Medicine, General & Internal
Amelie Bonnefond, Ranjit Unnikrishnan, Alessandro Doria, Martine Vaxillaire, Rohit N. Kulkarni, Viswanathan Mohan, Vincenzo Trischitta, Philippe Froguel
Summary: Monogenic diabetes encompasses several clinical conditions characterized by early-onset diabetes, including neonatal diabetes, maturity-onset diabetes of the young (MODY) and diabetes-associated syndromes. It can be misdiagnosed as type 2 diabetes, and different genetic variations can lead to different forms of diabetes. Precision medicine approaches and next-generation sequencing have improved diagnosis and treatment options.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Cell Biology
Clement Philippe Delannoy, Egon Heuson, Adrien Herledan, Frederik Oger, Bryan Thiroux, Mickael Chevalier, Xavier Gromada, Laure Rolland, Philippe Froguel, Benoit Deprez, Sebastien Paul, Jean-Sebastien Annicotte
Summary: Type 2 diabetes is a metabolic disorder affecting over 537 million people worldwide, characterized by loss of pancreatic beta-cell function and insulin resistance. Long-term control of glycemia is challenging, highlighting the need for new drugs and targets to improve beta-cell function and insulin secretion. In this study, a high-throughput screening method using automated cellular assays and mass spectrometry was developed, identifying potential regulators of insulin secretion and synthesis among siRNA and chemical compounds.
Article
Cell Biology
Yasmina Kahoul, Xi Yao, Frederik Oger, Maeva Moreno, Souhila Amanzougarene, Mehdi Derhourhi, Emmanuelle Durand, Raphael Boutry, Amelie Bonnefond, Philippe Froguel, Christian Dani, Jean-Sebastien Annicotte, Christophe Breton
Summary: Human induced pluripotent stem cells (hiPSCs) have the potential to differentiate into any cell type, making them relevant for therapeutic applications. In particular, they hold promise for obesity treatment by providing an unlimited source of brown/beige adipose progenitors (hiPSC-BAPs). However, the limited differentiation potential of brown/beige adipocytes in 2D cultures poses a challenge for clinical use.
Article
Endocrinology & Metabolism
Lena M. S. Carlsson, Bjorn Carlsson, Peter Jacobson, Cecilia Karlsson, Johanna C. Andersson-Assarsson, Felipe M. Kristensson, Sofie Ahlin, Per-Arne Svensson, Magdalena Taube, Ingmar Naeslund, Kristjan Karason, Markku Peltonen, Kajsa Sjoholm
Summary: A study in Sweden found that bariatric surgery is associated with increased life expectancy and reduced overall mortality, regardless of whether patients had baseline type 2 diabetes (T2D) or not.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Per-Arne Svensson, Markku Peltonen, Johanna C. Andersson-Assarsson, Sofie Ahlin, Petra Brembeck, My Engstrom, Peter Jacobson, Magdalena Taube, Kajsa Sjoholm, Lena M. S. Carlsson
Summary: This study aimed to investigate the association between bariatric surgery and substance use disorder (SUD) with substances other than alcohol. The results showed that gastric bypass surgery was associated with an increased risk of non-alcohol SUD. This finding should be taken into consideration in long-term postoperative care.
Article
Cardiac & Cardiovascular Systems
Grethe Albrektsen, Tom Wilsgaard, Ivar Heuch, Maja-Lisa Lochen, Dag Steinar Thelle, Inger Njolstad, Sameline Grimsgaard, Kaare Harald Bonaa
Summary: Adverse lipid levels can be seen 20 to 35 years before the occurrence of myocardial infarction, especially in relation to high-density lipoprotein cholesterol and triglyceride levels. This trend is more pronounced in women. However, the difference in mean lipid levels between myocardial infarction patients and the general population is not significant for both genders.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Lise Folon, Morgane Baron, Benedicte Toussaint, Emmanuel Vaillant, Mathilde Boissel, Victoria Scherrer, Helene Loiselle, Audrey Leloire, Alaa Badreddine, Beverley Balkau, Guillaume Charpentier, Sylvia Franc, Michel Marre, Soulaimane Aboulouard, Michel Salzet, Mickael Canouil, Mehdi Derhourhi, Philippe Froguel, Amelie Bonnefond
Summary: Rare biallelic pathogenic mutations in PCSK1 cause early-onset obesity and other endocrinopathies. Functional genomic study shows that rare heterozygous variants of PCSK1 can also impact obesity risk.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
A. Dance, M. Derhourhi, M. Canouil, M. Marre, G. Charpentier, A. Bonnefond, P. Froguel
Meeting Abstract
Endocrinology & Metabolism
L. Folon, M. Baron, M. Derhourhi, B. Balkau, G. Charpentier, S. Franc, R. Roussel, M. Canouil, P. Froguel, A. Bonnefond
Meeting Abstract
Endocrinology & Metabolism
M. Hu, I. Kim, M. Canouil, S. Bonas-Guarch, A. A. Khamis, J. Ferrer, P. Froguel, G. R. Rutter
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
