Article
Endocrinology & Metabolism
Shang-Rong Zhong, Han-Hsuan Yang, Cheng-Hsi Liao, Deng-Ho Yang, Shih-Kai Tu, Chia-Lien Hung, Chun-Cheng Liao
Summary: The study revealed a strong association between serum testosterone and metabolic syndrome in Taiwanese men, with the predictive value increasing with age.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Public, Environmental & Occupational Health
Wei-Chen Shen, Zih-Jie Sun, Chieh-Ying Chou, Yu-Tsung Chou, Feng-Hwa Lu, Yi-Ching Yang, Chih-Jen Chang, Jin-Shang Wu
Summary: This study found that there is a higher risk of metabolic syndrome in individuals with simple renal cysts, particularly in those with larger (sizes ≥2cm) or plural (numbers ≥2) renal cysts.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Iwona Magdalena Gawron, Rafal Baran, Kamil Derbisz, Robert Jach
Summary: The study found that subclinical hypothyroidism (SCH) affects metabolic parameters in polycystic ovary syndrome (PCOS) but not hormonal parameters; the presence of SCH does not exclude the diagnosis of PCOS; and the metabolic disorders in PCOS patients with SCH do not significantly differ regardless of the presence of anti-thyroid antibodies (ATA).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Ki-Chun Yoo, Jae-Hyeok Kang, Mi-Young Choi, Yongjoon Suh, Yi Zhao, Min-Jung Kim, Jong Hee Chang, Jin-Kyoung Shim, Seon-Jin Yoon, Seok-Gu Kang, Su-Jae Lee
Summary: This study reveals that radiation-treated GBM cells produce sICAM-1, stimulating macrophage infiltration and enriching the tumor microenvironment with inflammatory macrophages. This process induces a mesenchymal shift in GBM cells, with potential for radiotherapy combined with sICAM-1 targeted inhibition to improve clinical outcomes for GBM patients.
Review
Biochemistry & Molecular Biology
Gracia Fahed, Laurence Aoun, Morgan Bou Zerdan, Sabine Allam, Maroun Bou Zerdan, Youssef Bouferraa, Hazem I. Assi
Summary: Metabolic syndrome is a cluster of metabolic dysregulations associated with insulin resistance and chronic low-grade inflammation. If left untreated, it significantly increases the risk of developing diabetes and cardiovascular diseases. However, many aspects of Metabolic syndrome are still not completely understood, and many questions remain unanswered. This review provides a comprehensive overview of the historical background, epidemiology, histopathology, pathophysiology, management, and prevention of Metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Itay Aizenbud, Asaf Wilensky, Galit Almoznino
Summary: Periodontal disease is a chronic inflammatory condition that leads to bone and tooth loss. It has been linked to various systemic diseases, including diabetes and obesity. These diseases are part of the metabolic syndrome cluster, which significantly increases the risk of cardiovascular diseases, diabetes, and stroke. This review aims to investigate the correlation between periodontal disease and the components and outcomes of the metabolic syndrome cluster, providing insights into the fundamental mechanisms that link each condition with the metabolic syndrome. Understanding this interplay can lead to more effective treatments considering the broader impact of managing periodontal disease on systemic disease treatment, and vice versa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jonathan D. Drake, Alison B. Chambers, Brian R. Ott, Lori A. Daiello
Summary: The study found that plasma-based vascular biomarkers, particularly VCAM-1 and ICAM-1, were associated with Alzheimer's disease (AD) and clinical impairment. VCAM-1 was linked with clinical dementia rating sum-of-boxes (CDR-SB) scores, with the APOE epsilon 4 genotype modifying this relationship. Additionally, combining VCAM-1 and cerebrospinal fluid (CSF) biomarkers showed independent associations with AD-related clinical impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Oncology
Xiang Shu, Qin Zhou, Xiaohui Sun, Michelle Flesaker, Xingyi Guo, Jirong Long, Mark E. Robson, Xiao-Ou Shu, Wei Zheng, Jonine L. Bernstein
Summary: This study identified 98 proteins that may have potential causal associations with the risk of breast cancer subtypes. The associations of ICAM1, PLA2R1, and TXNDC12 varied significantly across the subtypes. These findings contribute to understanding the heterogeneity in the etiology of different subtypes of breast cancer and may aid in personalized risk assessment of the disease.
BRITISH JOURNAL OF CANCER
(2022)
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biotechnology & Applied Microbiology
Weiwei Cao, Yu Chen, Wei Han, Juzheng Yuan, Weimin Xie, Kun Liu, Yan Qiu, Xudan Wang, Xiao Li
Summary: This study found that patients with normal or normalized AFP and sICAM-1 levels in liver cancer had lower tumor recurrence rates and better survival rates, while those with elevated levels of both markers had poorer outcomes. AFP and ICAM-1 play crucial roles in the diagnosis, prognostic prediction, and immunotherapy of HCC, and their combined application can improve predictive accuracy.
Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yung-Wen Cheng, Chun-Chi Hung, Wen-Hui Fang, Wei-Liang Chen
Summary: Klotho protein is associated with metabolic syndrome, with its concentration negatively correlated with central obesity and high TG levels.
Article
Pediatrics
Ketan Kumar, Rakesh Lodha, Kana Ram Jat, Vandana Jain, Sushil K. K. Kabra
Summary: This study investigated the prevalence of insulin resistance (IR), dyslipidemia, and metabolic syndrome (MS) in children with asthma aged 10 to 15 years. The results revealed that the prevalence of IR in children with asthma was 42.3%. Elevated serum insulin, triglycerides, and the presence of IR were associated with poorer asthma control, independent of BMI.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Yan Li, Zhenbin Xu
Summary: This meta-analysis aimed to evaluate the association between circulating irisin and metabolic parameters in nonobese, nondiabetic adults, and found a possible correlation between them.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Medicine, General & Internal
Elizabeth Perez-Cruz, Daniela Castro-Martinez, Otto Pavel Gonzalez-Guzman
Summary: The study found a significant association between sarcopenic obesity and insulin resistance in young adults, but no significant association with metabolic syndrome.
Editorial Material
Surgery
Kuan-Liang Liu, I-Shiang Tzeng, I-Chih Chen, Shih-Jung Jang, Hsin-Hua Chou, Hsuan-Li Huang
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Kuan-Hung Yeh, Lung-An Hsu, Jyh-Ming Jimmy Juang, Fu-Tien Chiang, Ming-Sheng Teng, I-Shiang Tzeng, Semon Wu, Jeng-Feng Lin, Yu-Lin Ko
Summary: SAA1 genetic variants are significantly associated with SAA levels, but can only predict the levels in the general population and CAD patients, not long-term prognosis.
TZU CHI MEDICAL JOURNAL
(2022)
Article
Surgery
Ting-Yun Lin, Hsin-Hua Chou, Tsung-Han Hsieh, Hsuan-Li Huang, Szu-Chun Hung
Summary: This study assessed the nutritional status of dialysis patients undergoing endovascular therapy and found that malnutrition is strongly associated with increased death and major adverse limb events.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Hsin-Hua Chou, Lung-An Hsu, Jyh-Ming Jimmy Juang, Fu-Tien Chiang, Ming-Sheng Teng, Semon Wu, Yu-Lin Ko
Summary: Resistin and sST2 are important predictors in patients with CAD, and their serum levels are significantly influenced by genetic variants in RETN and IL1RL1 loci. High levels of Resistin and sST2 predict poor long-term outcomes, and certain combinations of genetic variants have a synergistic effect on prognosis. Future studies with larger and more diverse populations are needed to validate these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Semon Wu, Lung-An Hsu, Ming-Sheng Teng, Hsin-Hua Chou, Yu-Lin Ko
Summary: This study investigated the effects of KLF14 gene variants and DNA methylation status on body shape indices and metabolic traits, and found that these effects were mediated by age, sex, and obesity. KLF14 variants and hypermethylation status were associated with metabolically healthy and unhealthy phenotypes in obese individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Kuan-Hung Yeh, Hsiang-Lin Wan, Ming-Sheng Teng, Hsin-Hua Chou, Lung-An Hsu, Yu-Lin Ko
Summary: This study investigated the genetic determinants of cardiometabolic traits and metabolic syndrome at the APOE locus in a Taiwanese population. The findings revealed several single-nucleotide variations (SNVs) at the APOE locus that were associated with cholesterol levels, metabolic syndrome, and serum albumin levels. Additionally, the study identified CLPTM1 as a new candidate locus for LDL and HDL cholesterol levels, and highlighted the independent associations of APOE and APOC1 variants with metabolic syndrome and serum albumin levels. These results underscore the importance of genetic variants at the APOE locus in predicting cardiometabolic traits and metabolic syndrome.
Article
Biochemistry & Molecular Biology
Lung-An Hsu, Ming-Sheng Teng, Semon Wu, Hsin-Hua Chou, Yu-Lin Ko
Summary: The study found that PCSK9 is linked to LDL-C levels and the risk of diabetes, with common and rare variants of PCSK9 showing significant associations with LDL-C levels and diabetes risk. Mendelian randomization analysis revealed an inverse association between LDL-C levels and diabetes mellitus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shih-Jung Jang, Wei-Lun Tuan, Lung-An Hsu, Leay-Kiaw Er, Ming-Sheng Teng, Semon Wu, Yu-Lin Ko
Summary: This study found that APOB locus variants are independently associated with lipid levels and metabolic syndrome in Taiwanese individuals. Mendelian randomization analyses supported the association of APOB variants with the risk of diabetes mellitus through their associations with LDL cholesterol levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Chi-Jen Chang, Ying-Ju Lai, Ying-Chang Tung, Lung-Sheng Wu, Lung-An Hsu, Chi-Nan Tseng, Gwo-Jyh Chang, Kai-Chien Yang, Yung-Hsin Yeh
Summary: Our study suggests that disturbed flow in dysfunctional arteriovenous fistulae (AVF) contributes to the development of neointimal hyperplasia (NH) through the induction of endothelial mesenchymal transition (EndMT) via the osteopontin/CD44 axis. We provided evidence from both animal and cell culture experiments to support this hypothesis. We also found that the osteopontin/CD44 axis is involved in AVF dysfunction in patients with uremia. These findings highlight the potential of targeting the osteopontin/CD44 axis as a therapeutic strategy for preventing AVF dysfunction.
KIDNEY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Chien-Te Ho, Fu-Chih Hsiao, Ying-Chang Tung, Sharon T. Cordero, Dominador V. V. del Castillo III, Hsin-Fu Lee, Shing-Hsien Chou, Chia-Pin Lin, Kun-Chi Yen, Lung-An Hsu, Chi-Jen Chang
Summary: This study aimed to evaluate the efficacy of a modified stenting strategy for diffuse coronary artery disease (CAD) with an extremely small distal residual lumen. The results showed that PCI using second-generation drug-eluting stents (DES) was effective and safe for patients with extremely small distal vessels. There were no significant differences in the target vessel revascularization rate between the two groups during follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Genetics & Heredity
Ming-Sheng Teng, Kuan-Hung Yeh, Lung-An Hsu, Hsin-Hua Chou, Leay-Kiaw Er, Semon Wu, Yu-Lin Ko
Summary: This study aimed to investigate the association between ABCG5/G8 gene region variants and lipid profile, cardiometabolic traits, and gallstone disease history in Taiwanese populations. The results revealed independent associations of four Asian-specific ABCG5 variants with cholesterol levels, as well as genome-wide significant associations of four other variants with gallstone disease history. Additionally, variants in the PLEKHH2 gene region showed significant associations with blood pressure status.
Article
Biology
Lung-An Hsu, Semon Wu, Ming-Sheng Teng, Yu-Lin Ko
Summary: This study investigated the genetic variants associated with erythrocyte indices, cardiometabolic traits, and diabetes risk in Taiwanese individuals. The findings suggest that certain genetic variants around the alpha-globin genes can serve as surrogate markers for common alpha-thalassemia mutations in Taiwan. The study also revealed causal links between alpha-thalassemia-related erythrocyte indices, cardiometabolic traits, and heightened diabetes risk.
LIFE SCIENCE ALLIANCE
(2023)
Article
Cardiac & Cardiovascular Systems
Ying-Chang Tung, Lung-Sheng Wu, Fu-Chih Hsiao, Lung-An Hsu, Yung-Hsin Yeh, Chih-Hsiang Chang, Yung-Chang Chen, Chi-Jen Chang
Summary: During the development of heart failure caused by volume overload, NGAL is upregulated in the heart but not in the kidney. The upregulation of NGAL enhances MMP-9 activity. The expression of myocardial NGAL is regulated by Egr-1.
ACTA CARDIOLOGICA SINICA
(2022)
Article
Dermatology
Ya-Ching Chang, Lung-An Hsu, Yu-Huei Huang
Summary: This study found no causal relationship between alcohol consumption and psoriasis. In the Taiwanese population, ALDH2 rs671 may not affect susceptibility to psoriasis.
DERMATOLOGICA SINICA
(2022)
Article
Cardiac & Cardiovascular Systems
Fu-Chih Hsiao, Cheng-Ting Tsai, Lung-An Hsu, Ying-Chang Tung, Fa-Chang Yu, Chia-Pin Lin, Shing-Hsien Chou, Hsin-Fu Lee, Yen-Chen Lin, Chi-Jen Chang
Summary: The use of 48 mm drug-eluting stents for the treatment of long coronary lesions is safe and effective. It reduces the number of stents required and avoids stent overlapping.
JOURNAL OF INVASIVE CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)