Article
Physiology
Silvia Pogliaghi, Enrico Tam, Carlo Capelli
Summary: Pre-exercise [PCr], pre-exercise metabolic rate, and intramuscular energetic state may affect the kinetics of muscular oxidative metabolism and tau.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Sport Sciences
Eric Williamson, Hugo J. W. Fung, Carolyn Adams, Daniel W. D. West, Daniel R. Moore
Summary: This study aimed to determine the daily protein requirements of female and male endurance athletes in a home-based setting using noninvasive stable isotope methodology. The results indicated that consuming a daily protein intake of approximately 1.85 g/kg maximizes whole-body protein synthesis during postexercise recovery, regardless of sex.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Pharmacology & Pharmacy
William G. Warren, Eleni P. Papagianni, Ed Hale, Rebecca A. Brociek, Helen J. Cassaday, Carl W. Stevenson
Summary: Endocannabinoid transmission plays an important role in treating anxiety-related disorders through the regulation of fear extinction. The inhibition of FAAH can enhance extinction by increasing anandamide levels, while inhibiting MAGL can impair extinction by elevating 2-arachidonoylglycerol levels. However, the specific effects of endocannabinoids on fear relapse and extinction resistance are still uncertain.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Sport Sciences
Joshua F. Yarrow, Russell D. Wnek, Christine F. Conover, Michael C. Reynolds, Kinley H. Buckley, Jayachandra R. Kura, Tommy W. Sutor, Dana M. Otzel, Alex J. Mattingly, Stephen E. Borst, Summer M. Croft, J. Ignacio Aguirre, Darren T. Beck, Danielle J. Mccullough
Summary: Activity-based physical therapy (ABPT) can improve bone density and skeletal integrity in patients with severe spinal cord injury (SCI) by promoting blood flow in the bone system. Passive-isokinetic bicycle training can suppress bone loss and promote bone recovery. This study suggests that ABPT is of great significance for bone health recovery.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Nutrition & Dietetics
Cas J. Fuchs, Wesley J. H. Hermans, Joey S. J. Smeets, Joan M. Senden, Janneau van Kranenburg, Stefan H. M. Gorissen, Nicholas A. Burd, Lex B. Verdijk, Luc J. C. van Loon
Summary: There is no significant difference in muscle protein synthesis rates after ingesting raw eggs compared to boiled eggs in healthy young men. However, raw eggs can attenuate the postprandial rise in circulating amino acid concentrations.
JOURNAL OF NUTRITION
(2022)
Article
Mathematical & Computational Biology
Chuanliang Han, Tian Wang, Yujie Wu, Hui Li, Encong Wang, Xixi Zhao, Qingjiu Cao, Qiujin Qian, Yufeng Wang, Fei Dou, Jian K. K. Liu, Li Sun, Dajun Xing
Summary: Alpha rhythms in the human electroencephalogram (EEG) are believed to be related to attention and mental disorders, but the difference in alpha oscillation between ADHD and control groups has shown inconsistent results. This study suggests that ADHD recovery may involve compensatory mechanisms and abnormalities in EEG may be influenced by behavior rather than brain signal differences.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Agata Kaczmarek, Mieczyslawa Bogus
Summary: Insects, with over one million described species, play important ecological roles, such as pollinating plants and influencing agriculture. They also have significant impacts on human health as disease vectors and in medical treatments. In addition, insects are used in forensic science and research as model organisms.
Article
Sport Sciences
S. E. A. N. A. NEWSOM, H. A. R. R. I. S. O. N. D. STIERWALT, S. A. R. A. H. E. EHRLICHER, M. A. T. T. H. E. W. M. ROBINSON
Summary: In sedentary adults, a single bout of moderate-intensity cycling induces modest increases in intrinsic mitochondrial oxidative phosphorylation that are consistent across multiple substrates.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Sport Sciences
Anastasia Rosvoglou, Ioannis G. Fatouros, Athanasios Poulios, Themistoklis Tsatalas, Konstantinos Papanikolaou, Evaggeli Karampina, Christina A. Liakou, Panagiotis Tsimeas, Panagiota Karanika, Dimitrios Tsoukas, Ioannis Katrabasas, Athanasios Chatzinikolaou, Chariklia K. Deli, Giannis Giakas, Athanasios Z. Jamurtas, Dimitrios Draganidis
Summary: This study compared the effects of different intensities of eccentric contractions on muscle damage and recovery. The results showed that higher intensity eccentric contractions resulted in more severe muscle damage and slower recovery.
JOURNAL OF SPORTS SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
K. L. Uken, C. T. Schaeff, L. Vogel, M. Gnott, D. Dannenberger, S. Goers, A. Tuchscherer, A. Troescher, W. Liermann, H. M. Hammon
Summary: The study demonstrates that maternal EFA and CLA supplementation can be transferred to calves through colostrum and transition milk, affecting the fatty acid status of calves without influencing their growth performance.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Yingxue Li, Jingjie Zhou, Yong Zhang, Huibin Liang, Jinyuan Sun, Yuqi Liu, Gerardino D'Errico, Yongqiang Sun, Martino Di Serio
Summary: Various catalysts were used to catalyze the ethoxylation reaction of C12-14 primary alcohols with ethylene oxide, resulting in the synthesis of alcohol ethoxylates with a ratio of ethylene oxide/substrate near 3. The products obtained using the catalysts MCT-09 and NAE-03 had a narrower oligomer distribution and excellent wetting properties compared with those obtained using conventional ethoxylation catalysts.
Article
Biochemistry & Molecular Biology
Hanna Sarah Kutsche, Rolf Schreckenberg, Klaus-Dieter Schlueter
Summary: Uncoupling proteins UCP2 and UCP3 may have multiple functions in striated muscles, including protection against mitochondria-dependent oxidative stress, transportation of pyruvate, fatty acids, and protons, and metabolic sensing. UCP2 is mainly expressed in cardiac tissues, while UCP3 dominates in skeletal muscles.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Physiology
Remi Durand, Mayeul Galli, Marie Chenavard, David Bandiera, Hubert Freund, Laurent A. Messonnier
Summary: The study aimed to compare three models and methods to investigate lactate exchange and removal abilities during and/or after exercise. It was found that considering the entire recovery period led to better fitting of experimental data and improved assessment of lactate exchange and removal abilities.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Patrick O. Saboe, Lorenz P. Manker, Hanna R. Monroe, William E. Michener, Stefan Haugen, Eric C. D. Tan, Ryan L. Prestangen, Gregg T. Beckham, Eric M. Karp
Summary: Bio-based carboxylic acids are established as adaptable precursors to renewable biofuels and chemicals, but their separation poses significant energy and cost challenges. The use of weak-base adsorption processes shows promising results in reducing operating costs, energy consumption, and greenhouse gas emissions compared to conventional methods.
Article
Nutrition & Dietetics
Maria Dolores Mesa, Fernando Gil, Pablo Olmedo, Angel Gil
Summary: This study aims to estimate the amount of n-3 LC-PUFA provided by commonly consumed fishes, shrimps, and mollusks, to conduct a risk-benefit analysis of fish consumption. Consuming 2-3 servings of a variety of fishery products per week can help meet recommended n-3 LC-PUFA levels while maintaining a balance to avoid potential risks from contaminants.
Review
Physiology
Faidon Magkos, Dominic N. Reeds, Bettina Mittendorfer
Summary: This paper provides an overview of the evolution of hyperglycemia definition and the changes in glucose dynamics that lead to fasting and postprandial hyperglycemia. Extensive research has contributed to our understanding of different types of hyperglycemia, such as prediabetes and diabetes, and their subtypes, as well as their relationships with medical complications and strategies for prevention and treatment.
PHYSIOLOGICAL REVIEWS
(2023)
Review
Oncology
Dimitrios Tsilingiris, Narjes Nasiri-Ansari, Nikolaos Spyrou, Faidon Magkos, Maria Dalamaga
Summary: This article provides an overview of the association between obesity and hematological cancers and their role as risk factors for severe COVID-19. It also reviews the challenges faced by patients with hematologic malignancies during the pandemic, including the treatment of the underlying disease and the management of SARS-CoV-2 infection. Furthermore, the unresolved issues and future challenges for the management of hematologic malignancies in the era of COVID-19 are discussed.
Article
Endocrinology & Metabolism
Irene Karampela, Natalia Vallianou, Faidon Magkos, Caroline M. Apovian, Maria Dalamaga
Summary: This review emphasizes the epidemiological impact of obesity and hypovitaminosis D in the context of the ongoing COVID-19 pandemic. Obesity and hypovitaminosis D are independently associated with COVID-19 infection, severity of disease, and poor outcomes.
CURRENT OBESITY REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Mahsa Jalili, Maryam Nazari, Faidon Magkos
Summary: Fermented foods, rich in probiotics and prebiotics, are widely consumed in many countries and populations. They can improve digestion, enhance immunity, and aid in weight loss, making them a potential tool for combating obesity. This article provides a comprehensive overview of the health effects of fermented foods and their mechanisms of action in obesity and related metabolic abnormalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Christian Sumeghy Sondergaard, Paulina Nunez Esquivel, Maria Dalamaga, Faidon Magkos
Summary: Diabetes patients may have an altered risk of cancer when using antihyperglycemic medications. Certain medications are associated with a lower risk of cancer, while others may increase the risk.
CURRENT ONCOLOGY REPORTS
(2023)
Review
Food Science & Technology
Jaap Keijer, Xavier Escote, Sebastia Galmes, Andreu Palou-March, Francisca Serra, Mona Adnan Aldubayan, Kristina Pigsborg, Faidon J. Magkos, Ella C. Baker, Philip Calder, Joanna Goralska, Urszula Razny, Malgorzata Malczewska-Malec, David Sunol, Mar A. Galofre, Miguel Rodriguez, Nuria G. Canela, Radu Malcic, Montserrat Bosch, Claudia Favari, Pedro Mena, Daniele Del Rio, Antoni Caimari, Biotza M. Gutierrez, Josep del Bas
Summary: Personalized nutrition (PN) is a tool that empowers consumers to make dietary changes, improve health, and prevent diet-related diseases. However, the implementation of PN faces obstacles due to the complexity of individual metabolic characterization. This study proposes a conceptual framework that focuses on dysregulation of key processes and specific markers to assess metabolic health. Machine learning and data analysis algorithms can integrate omics and genetic markers, and digital tools can simplify their implementation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Sofie Hauerberg Henninger, Anna Yde Fibieger, Faidon Magkos, Christian Ritz
Summary: Current treatment options for overweight and obesity rely on strict diet and exercise regimes, making it difficult to sustain as a lifelong routine. This study explored the effects of mindful eating and YogaDance, individually and in combination, as alternative approaches to manage obesity. The findings suggest modest benefits of an 8-week combination of mindful eating and YogaDance, supporting previous research on the effectiveness of mindful eating, yoga, and dance.
Article
Pediatrics
Christina Sonne Mogensen, Helle Zingenberg, Jens Svare, Arne Astrup, Faidon Magkos, Nina Rica Wium Geiker
Summary: This study analyzed data from 208 mothers and examined the association of gestational weight gain (GWG) among women with pre-pregnancy overweight or obesity with infant weight and BMI z-score at birth. The results showed that limiting GWG by 1 kg was associated with lower birthweight, BMI z-score, weight z-score, and infant abdominal circumference. Additionally, GWG below the Institute of Medicine guideline of a maximum of 9 kg was associated with lower birthweight and fewer emergency cesarean deliveries.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, Research & Experimental
Bettina Mittendorfer, Brandon D. Kayser, Mihoko Yoshino, Jun Yoshino, Jeramie D. Watrous, Mohit Jain, J. Christopher Eagon, Bruce W. Patterson, Samuel Klein
Summary: This study evaluated the metabolic effects of weight loss in women with obesity and found that the heterogeneity in the effect of weight loss on muscle and hepatic insulin sensitivity is determined by baseline insulin action.
Article
Nutrition & Dietetics
Mona Adnan Aldubayan, Xiaotian Mao, Martin Frederik Laursen, Kristina Pigsborg, Lars H. Christensen, Henrik M. Roager, Dennis S. Nielsen, Mads Fiil Hjorth, Faidon Magkos
Summary: This study found that a high fiber plant-based diet can reduce body weight and improve cardiometabolic health in individuals with obesity. Additionally, the addition of inulin-type fructans (ITF) can alter gut microbiota composition and attenuate some of the realized cardiometabolic benefits.
FRONTIERS IN NUTRITION
(2023)
Review
Nutrition & Dietetics
Julie Marvel Mansfeldt, Faidon Magkos
Summary: This paper reviews studies on the changes in non-exercise physical activity (NEPA) in response to exercise-induced energy expenditure. The majority of studies show a compensatory decrease in NEPA upon starting a structured exercise training program, which may attenuate the energy deficit caused by exercise and prevent weight loss.
CURRENT NUTRITION REPORTS
(2023)
Editorial Material
Endocrinology & Metabolism
Faidon Magkos, Anahita Ataran, Ali Javaheri, Bettina Mittendorfer
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2023)
Article
Endocrinology & Metabolism
Michelle H. H. Lee, Eveline Febriana, Maybritte Lim, Sonia Baig, Jeffrey B. B. Halter, Faidon Magkos, Sue-Anne Toh
Summary: This study aimed to investigate the effect of sex on obesity-driven changes in the mechanisms regulating glucose metabolism. The results showed that the adverse effects of obesity on insulin action and secretion were more pronounced in males than females, and females had greater insulin sensitivity and lower insulin secretion compared to males among participants with obesity.
Article
Nutrition & Dietetics
Kristina Pigsborg, Valdemar Stentoft-Larsen, Samuel Demharter, Mona Adnan Aldubayan, Alessia Trimigno, Bekzod Khakimov, Soren Balling Engelsen, Arne Astrup, Mads Fiil Hjorth, Lars Ove Dragsted, Faidon Magkos
Summary: A predictive model was developed using machine learning to predict successful weight loss on a New Nordic Diet. The study found that individual responses to weight loss vary and the optimal diet for successful weight loss may differ for different individuals. This research is important for improving precision dietary treatment for obesity.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Sasha A. S. Kjeldsen, Mads N. Thomsen, Mads J. Skytte, Amirsalar Samkani, Michael M. Richter, Jan Frystyk, Faidon Magkos, Elizaveta Hansen, Henrik S. Thomsen, Jens J. Holst, Sten Madsbad, Steen B. Haugaard, Thure Krarup, Nicolai J. Wewer Albrechtsen
Summary: This study aimed to investigate the dependency of body weight loss following a reduction in hepatic steatosis on markers of glucagon resistance in type 2 diabetes. The results showed that weight loss may contribute to the improvement of glucagon resistance in individuals with type 2 diabetes.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)