Synthesis and molecular structure of moxifloxacin drug with metal ions as a model drug against some kinds of bacteria and fungi

Metal complexes of antibiotic molecules can be used as antimicrobial mimetic drug models. The current study is devoted to the synthesis, physicochemical properties, computational, and antimicrobial activity of the products of chelation of moxifloxacin hydrochloride (mox-HCl) antibiotic drug and metal ions including Ca(II), Mg(II), Zn(II), and Fe(III). Structures of the complexes were elucidated on the basis of elemental analyses, electronic, IR, Raman, and H-1 NMR spectra. The data revealed that chelation of moxifloxacin could follow mono and bidentate pathways. Ca(II), Zn(II) and Fe(III) ions coordinated via N atoms of the piperidyl ring but Mg(II) coordinated via oxygen atoms of the carbonyl (quinolone) and carboxylic groups. According to molar conductance data the complexes had non-electrolyte nature. Formulas of the complexes can be presented as [Mg(mox-HCl)(2)(Cl)(2)]center dot 2H(2)O (1), [Ca(mox-HCl)(2)(Cl)(2)]center dot 2H(2)O (2), [Zn(mox-HCl)(2)(NO3)(2)] (3), and [Fe(mox-HCl)(3)(Cl)(3)] (4). All synthesized mox-HCl complexes demonstrated some antibacterial but no antifungal activities.