Review
Medicine, Research & Experimental
Anirban Goutam Mukherjee, Kaviyarasi Renu, Abilash Valsala Gopalakrishnan, Rama Jayaraj, Abhijit Dey, Balachandar Vellingiri, Raja Ganesan
Summary: Epicardial adipose tissue (EAT) is a visceral fat deposit that is morphologically and physiologically connected to the myocardium and coronary arteries. It has cardioprotective characteristics, but under clinical processes, it can impact the heart and coronary arteries by secreting proinflammatory cytokines. The factors affecting this equilibrium are still not fully understood. This review focuses on the physiological and pathophysiological dimensions of EAT and its various clinical utilities.
Article
Biochemistry & Molecular Biology
Jesus Fernandez-Felipe, Adrian Plaza, Gema Dominguez, Javier Perez-Castells, Victoria Cano, Francesco Cioni, Nuria Del Olmo, Mariano Ruiz-Gayo, Beatriz Merino
Summary: High-fat diets enriched with lauric acid do not increase leptin production and reduce the effect of leptin on kinase phosphorylation. Both high-fat diets affect adipocyte-size distribution and gene expression related to adipogenesis and inflammation. The composition of white adipose tissue is different between the two diets, which may impact the biophysical properties and signaling of leptin receptor.
Article
Medicine, Research & Experimental
Trine Baur Opstad, Bianca Papotti, Sissel Akra, Charlotte Holst Hansen, Bjorn Braathen, Theis Tonnessen, Svein Solheim, Ingebjorg Seljeflot
Summary: The study found that the levels of SIRT1 and NAMPT were similar in patients with CHD and controls. In CHD patients, SIRT1 and NAMPT were inter-correlated in all adipose tissue compartments and differently expressed between compartments, with the highest expression in SAT. Circulating SIRT1 and NAMPT levels were inversely associated. SIRT1 expression was inversely associated with IL-18 in EAT and SAT, while NAMPT expression was positively associated with NLRP3 inflammasome-related markers in all compartments.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Pavel Hruska, Jan Kucera, Matej Pekar, Pavol Holeczy, Miloslav Mazur, Marek Buzga, Daniela Kuruczova, Peter Lenart, Jana Fialova Kucerova, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku
Summary: The study compared the proteomic profiles of mature adipocytes from different adipose tissue depots, with findings showing that subcutaneous adipocytes are more active in vesicular transport, secretion, and lipid metabolism, while visceral adipocytes have higher protein expression related to mitochondrial energy metabolism and translational or biosynthetic activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Tiziana Zotti, Antonia Giacco, Arianna Cuomo, Luigi Cerulo, Giuseppe Petito, Stefania Iervolino, Rosalba Senese, Federica Cioffi, Pasquale Vito, Gaetano Cardinale, Elena Silvestri, Assunta Lombardi, Maria Moreno, Antonia Lanni, Pieter de Lange
Summary: Combining exercise with fasting can increase the release of fatty acids from adipose tissues, providing fuel for surrounding organs. This study compared the effect of fasting and exercise on fatty acid composition in different adipose tissue depots, and found that exercise combined with fasting led to increased fatty acid mobilization from visceral adipose tissue.
Article
Multidisciplinary Sciences
Iokfai Cheang, Xu Zhu, Xin Yue, Yuan Tang, Yujie Gao, Xinyi Lu, Shi Shi, Shengen Liao, Wenming Yao, Yanli Zhou, Haifeng Zhang, Yinsu Zhu, Yi Xu, Xinli Li
Summary: The purpose of this study was to investigate the prognostic values of ventricle epicardial fat volume (EFV) in patients with chronic heart failure (CHF) using cardiac magnetic resonance. A total of 516 CHF patients were recruited, and 136 (26.4%) of them experienced major adverse cardiovascular events (MACE) within a median follow-up of 24 months. The study found that EFV was significantly associated with MACE and showed promising predictive ability for MACE at different time points.
Review
Biochemistry & Molecular Biology
Sara Leo, Elena Tremoli, Letizia Ferroni, Barbara Zavan
Summary: Obesity and insulin resistance are risk factors for cardiovascular diseases, associated with inflamed and defective adipose tissue. Extracellular vesicles, involved in insulin resistance, diabetes, and CVDs, play a role in the onset and development of these pathologies. Inflammation triggers the transition of adipose tissue secretome, leading to an increase in pro-inflammatory mediators.
Article
Medicine, General & Internal
Caterina Beatrice Monti, Davide Capra, Alexis Malavazos, Giorgia Florini, Carlo Parietti, Simone Schiaffino, Francesco Sardanelli, Francesco Secchi
Summary: This study aimed to evaluate the density of epicardial adipose tissue on CT scans and its correlation with coronary artery disease (CAD). Results showed that the density of epicardial adipose tissue measured on contrast-enhanced scans was higher than on unenhanced scans, but there were no significant differences in adipose tissue density between CAD patients and non-CAD patients. CAD patients may have varying phenomena affecting epicardial adipose tissue density, making it challenging to detect consistent patterns.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Genetics & Heredity
Linghui Wang, Hao Gu, Tianci Liao, Yuhang Lei, Yanhao Qiu, Qiuyang Chen, Lei Chen, Shunhua Zhang, Jinyong Wang, Xiaoxia Hao, Dongmei Jiang, Ye Zhao, Lili Niu, Xuewei Li, Linyuan Shen, Mailin Gan, Li Zhu
Summary: By sequencing, identifying, and analyzing tsRNAs using pigs as animal models, this research reports the characteristics of tsRNAs in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). A total of 474 tsRNAs, with differential expression in endocrine and immune systems, as well as lipid metabolism, were found in white adipose tissue (WAT). The study also discovered a connection between the activity of the host tRNA engaged in translation and the production of tsRNAs. Furthermore, tsRNAs and miRNAs were found to be involved in the regulation of fatty acid metabolism in adipose tissue.
Article
Endocrinology & Metabolism
Chao Cao, Han-Chow E. Koh, Stephan Van Vliet, Bruce W. Patterson, Dominic N. Reeds, Richard Laforest, Robert J. Gropler, Bettina Mittendorfer
Summary: This study found that enhanced FFA clearance in people with obesity is negatively correlated with muscle insulin sensitivity, and the stimulatory effect of insulin on FFA clearance is more significant in obese individuals.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Cardiac & Cardiovascular Systems
Takashi Kataoka, Ken Harada, Akihito Tanaka, Tomohiro Onishi, Shun Matsunaga, Hiroshi Funakubo, Kazuhiro Harada, Tomoyuki Nagao, Norihiro Shinoda, Nobuyuki Marui, Kiyoshi Niwa, Hiroshi Tashiro, Yusuke Hitora, Kenji Furusawa, Hideki Ishii, Tetsuya Amano, Toyoaki Murohara
Summary: The study found that Epicardial adipose tissue (EAT) volume is significantly associated with coronary artery spasm, while total abdominal adipose tissue (AAT) may not have a significant impact.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Chemistry, Medicinal
Long Cheng, Lu Shi, Changhao He, Chen Wang, Yinglan Lv, Huimin Li, Yongcheng An, Hongyu Dai, Yuhui Duan, Huilin Zhang, Yan Huang, Wanxin Fu, Yanyan Meng, Baosheng Zhao
Summary: The study found that rutin can activate thermogenesis in brown and white adipose tissue by increasing the concentration of short-chain fatty acids, thereby improving obesity and diabetes.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Debora Maria Soares de Souza, Maria Claudia Silva, Silvia Elvira Barros Farias, Ana Paula de J. Menezes, Cristiane Maria Milanezi, Karine de P. Lucio, Nivia Carolina N. Paiva, Paula Melo de Abreu, Daniela Caldeira Costa, Kelerson Mauro de Castro Pinto, Guilherme de Paula Costa, Joao Santana Silva, Andre Talvani
Summary: The study showed that tissue from mice subjected to a lard diet was more favorable for the growth of T. cruzi parasites, supporting the hypothesis of a relationship between the source of dietary lipids and parasite-induced immunopathology.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
N. Ma, Y. Liang, D. N. Coleman, Y. Li, H. Ding, F. Liu, F. F. Cardoso, C. Parys, F. C. Cardoso, X. Shen, J. J. Loor
Summary: Enhanced post-ruminal supply of methionine affects protein abundance of insulin, amino acids, and antioxidant signaling pathways in subcutaneous adipose tissue. It is unclear if SAT directly responds to methionine supply and induces molecular alterations. The study showed that increased methionine supply during an oxidative stress challenge can alter protein abundance related to insulin, amino acids, inflammation, and antioxidant signaling pathways.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Piotr Domaradzki, Bozena Nowakowicz-Debek, Lukasz Wlazlo, Mateusz Ossowski, Malgorzata Dmoch, Mariusz Florek
Summary: This study investigated the effect of adding natural sorbents to pig feed on the fatty acid content of pig meat and fat. The results showed that the sorbents had limited effects on muscle tissue but had significant effects on kidney fat. The impact of different sorbents varied, but overall, they did not have a negative effect on the nutritional and pro-health quality of pig adipose tissue during fattening.
Article
Environmental Sciences
Mohammad Heydari, Hamed Benisi Ghadim, Mahmood Rashidi, Mohammad Noori
POLISH JOURNAL OF ENVIRONMENTAL STUDIES
(2020)
Article
Immunology
Tayebeh Mehdipour, Mohammad R. Tohidkia, Amir Ata Saei, Amir Kazemi, Shirin Khajeh, Ali A. Rahim Rahimi, Sepideh Nikfarjam, Mehrdad Farhadi, Monireh Halimi, Ramin Soleimani, Roman A. Zubarev, Mohammad Nouri
Article
Cardiac & Cardiovascular Systems
Yousef Faridvand, Parinaz Haddadi, Vahid Vahedian, Samira Nozari, Hamid Reza Nejabati, Masoud Pezeshkian, Abbas Afrasiabi, Nasser Safaie, Ahmadreza Jodati, Mohammad Nouri
CARDIOVASCULAR TOXICOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Sanya Haiaty, Mohammad-Reza Rashidi, Maryam Akbarzadeh, Nazila F. Maroufi, Bahman Yousefi, Mohammad Nouri
Review
Cell Biology
Abolfazl Barzegari, Virginie Gueguen, Yadollah Omidi, Alireza Ostadrahimi, Mohammad Nouri, Graciela Pavon-Djavid
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Review
Immunology
Mehdi Hassanpour, Fateme Hajihassani, Amirataollah Hiradfar, Nasser Aghamohammadzadeh, Reza Rahbarghazi, Nasser Safaie, Mohammad Nouri, Yunes Panahi
JOURNAL OF INFLAMMATION-LONDON
(2020)
Review
Medicine, Research & Experimental
Nazila Fathi Maroufi, Mohammad Reza Rashidi, Vahid Vahedian, Maryam Akbarzadeh, Amir Fattahi, Mohammad Nouri
Article
Pharmacology & Pharmacy
Nazila Fathi Maroufi, Maryam Amiri, Babak Faraji Dizaji, Vahid Vahedian, Maryam Akbarzadeh, Neda Roshanravan, Sanya Haiaty, Mohammad Nouri, Mohammad-Reza Rashidi
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Immunology
Saeideh Akseh, Maryam Nemati, Elham Zamani-Gharehchamani, Arezoo Rezaie Nezhad Zamani, Ahmadreza Jodati, Masoud Pezeshkian, Mohammad Nouri, Davoud Gholizadeh, Nasser Safaie, Yousef Faridvand
Summary: In this study, amnion membrane proteins (AMPs) were found to alleviate LPS-induced cardiomyocytes cells injury by up-regulating miR-21 and miR-146 expression, and suppressing TLR4/NF-kappa B pathway. Additionally, AMPs effectively mitigated pro-inflammatory cytokine expression and inhibited miR-155 expression.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Saeideh Akseh, Mohammad-Ali Karimi, Nasser Safaie, Amir Valizadeh, Dara Rahmanpour, Masoud Pezeshkian, Mohammad Nouri, Yousef Faridvand, Ahmadreza Jodati
Summary: In this study, it was observed that testosterone levels were significantly lower in CAD patients compared to the control group, while levels of ET-1 were higher in CAD patients. Additionally, levels of NO and eNOS were significantly lower in CAD patients. Correlation analysis indicated a negative correlation between testosterone and NO levels.
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2022)
Article
Oncology
Nazila Fathi Maroufi, Mohsen Rashidi, Vahid Vahedian, Raheleh Jahanbazi, Sahar Mostafaei, Maryam Akbarzadeh, Hamid Kazemzadeh, Hamid-Reza Nejabati, Alireza Isazadeh, Mohammad-Reza Rashidi, Mohammad Nouri
Summary: Melatonin and Apatinib can reduce the survival rate of CSCs and inhibit proliferation, invasion, and formation of VM in breast cancer cells. The combination of Apatinib/melatonin shows promising potential in managing patients with breast cancer. Further studies are needed to understand the anti-cancer mechanisms of melatonin and Apatinib for better patient management.
Article
Pharmacology & Pharmacy
Yousef Faridvand, Hamid Kazemzadeh, Vahid Vahedian, Pourya Mirzajanzadeh, Hamid Reza Nejabati, Nasser Safaie, Nazila Fathi Maroufi, Masoud Pezeshkian, Mohammad Nouri, Ahmadreza Jodati
Summary: This study demonstrates that DAPA has protective effects on endothelial cells under hyperglycaemic conditions. It increases cell viability, reduces oxidative stress and inflammation, prevents apoptosis, and activates the SIRT1 and AMPK pathways to promote cell protection.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Faride Ranjbari, Mohammad R. Rashidi, Salar Hemmati, Ebrahim Safari, Habib Tajalli
Summary: New tetracationic meso substituted chlorins were designed, synthesized, and characterized. The synthesized compounds showed low toxicity in the absence of light but demonstrated good toxic effect on cancer cells under laser light.
CURRENT RADIOPHARMACEUTICALS
(2023)
Article
Chemistry, Multidisciplinary
Faride Ranjbari, Salar Hemmati, Mohammad Reza Rashidi
Summary: This study describes the successful synthesis of a new bis-dipyrromethane with desirable spectroscopic properties for potential application as part of bis-porphyrins or for other purposes in future research. The synthesis method involved a Lewis acid catalyzed reaction at room temperature.
TURKISH JOURNAL OF CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Hossein Haghaei, Somaieh Soltani, Seyedrafie Arefhosseini, Mohammad-Reza Rashidi, Saeed Karima
Summary: The main active ingredients of Boswellia extract, Boswellic acids, show promising therapeutic potential in the treatment of Alzheimer's disease with multi-targeting effects. The efficacy of Boswellic acids in different AD-related pathways has been confirmed through in vitro and in vivo studies.
PHARMACEUTICAL SCIENCES
(2021)