Article
Endocrinology & Metabolism
Milina Tancic-Gajic, Miodrag Vukcevic, Miomira Ivovic, Ljiljana V. Marina, Zorana Arizanovic, Ivan Soldatovic, Milos Stojanovic, Aleksandar Dogo, Aleksandra Kendereski, Svetlana Vujovic
Summary: The study suggests that obstructive sleep apnea is associated with lower total and free testosterone levels in severely obese men. This finding indicates a potential impact of sleep disorders on sex hormone levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Andras Bikov, Stefan M. Frent, Martina Meszaros, Laszlo Kunos, Alexander G. Mathioudakis, Alina Gabriela Negru, Laura Gaita, Stefan Mihaicuta
Summary: OSA is associated with increased insulin resistance, and the triglyceride-glucose index (TyG) has been found to be significantly higher in OSA patients, related to disease severity. However, further evaluation in non-obese, non-diabetic subjects is needed to determine the clinical significance of TyG in OSA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Hyunjin Jo, Sujung Choi, Dongyeop Kim, Eunyeon Joo
Summary: Patients with epilepsy have milder characteristics of obstructive sleep apnea (OSA), but because of the high coexistence of OSA and epilepsy, continuous positive airway pressure (CPAP) therapy can reduce the frequency of seizures. Therefore, it is important to evaluate the presence of OSA in patients with epilepsy and provide concurrent treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jae Hyuk Choi, Eunkyu Lee, Sang Duk Hong, Seung Kyu Chung, Yong Gi Jung, Hyo Yeol Kim
Summary: A retrospective analysis of OSA patients undergoing CPAP therapy showed significant improvements in laryngopharyngeal reflux symptoms and examination findings, independent of body mass index or OSA severity.CPAP treatment has the potential to reduce laryngeal reflux symptoms and improve laryngeal examination results in OSA patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Yoko Fujino, Yasunori Oka, Tomoko Wakamura
Summary: This study found that seasonal differences can impact the CPAP adherence of patients with obstructive sleep apnea. Patients in the adherent group had lower CPAP use rate and shorter duration in summer, while the non-adherent group showed significant differences between winter and summer.
Article
Medicine, General & Internal
Laetitia S. Gaspar, Janina Hesse, Muge Yalcin, Barbara Santos, Catarina Carvalhas-Almeida, Mafalda Ferreira, Joaquim Moita, Angela Relogio, Claudia Cavadas, Ana Rita Alvaro
Summary: The study revealed that obstructive sleep apnea (OSA) affects the biological clock, and long-term continuous positive airway pressure (CPAP) treatment can partially restore normal clock function. However, the treatment does not fully reverse the impact on clock gene expression levels.
Article
Medicine, General & Internal
Baixin Chen, Miaolan Guo, Yueksel Peker, Neus Salord, Luciano F. Drager, Geraldo Lorenzi-Filho, Xiangdong Tang, Yun Li
Summary: CPAP treatment leads to a significant decrease in total cholesterol but has no effect on other lipid profiles in patients with obstructive sleep apnea. Factors such as age, gender, body mass index, daytime sleepiness, OSA severity, follow-up duration, CPAP compliance, and presence of cardiometabolic disease do not moderate the effects of CPAP treatment on lipid profiles.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Christopher M. Cielo, Brendan T. Keenan, Andrew Wiemken, Ignacio E. Tapia, Andrea Kelly, Richard J. Schwab
Summary: The study found that neck fat is associated with obesity and neck circumference in adolescents, with females having significantly greater neck fat than males. However, neck fat does not appear to correlate with the presence and severity of OSAS.
Article
Clinical Neurology
Christopher M. Cielo, Brendan T. Keenan, Andrew Wiemken, Ignacio E. Tapia, Andrea Kelly, Richard J. Schwab
Summary: Neck fat is associated with obesity and neck circumference in adolescents, with females having more neck fat than males. However, it does not appear to correlate with the presence and severity of obstructive sleep apnea syndrome (OSAS).
Article
Medicine, General & Internal
Maria Perticone, Raffaele Maio, Paola Elisa Scarpino, Luana Mancuso, Mara Volpentesta, Benedetto Caroleo, Edoardo Suraci, Angela Sciacqua, Giorgio Sesti, Francesco Perticone
Summary: Obese patients with OSAS have lower e-GFR values compared to non-OSAS patients, and CPAP therapy can significantly improve e-GFR values in these patients. Delta AHIa is the main independent predictor of Delta e-GFR after CPAP therapy.
FRONTIERS IN MEDICINE
(2021)
Article
Clinical Neurology
Angela J. Campbell, Shelley J. Mather, Dawn E. Elder
Summary: Children with a parent diagnosed with OSA are more likely to have risk factors for pediatric OSA, such as higher mallampati scores and BMI, compared to children of parents without OSA. However, there was no significant difference in symptom presentation between the two groups.
Article
Multidisciplinary Sciences
Zi-Jun Liu, Tiffany Do, Hanson Fong
Summary: Computational flow dynamics (CFD) was used to study the airflow dynamics in obese/obstructive sleep apnea (OSA) minipigs, finding that despite narrower pharyngeal airway and higher airflow velocity, turbulence was not produced in obese/OSA minipigs based on finite element model (FEM) simulation.
Article
Anesthesiology
Edwin Seet, Mahesh Nagappa, David T. Wong
Summary: Patients with obstructive sleep apnea (OSA) are at a higher risk of difficult intubation and mask ventilation during the perioperative period, requiring proactive management strategies to mitigate potential risks.
ANESTHESIA AND ANALGESIA
(2021)
Article
Clinical Neurology
Wan-Ju Cheng, Eysteinn Finnsson, Jon S. Agustsson, Scott A. Sands, Liang-Wen Hang
Summary: Determining endotypes of OSA can have potential implications for precision interventions. The study aimed to assess whether CPAP treatment outcomes differ across endotypic subgroups. Retrospective analysis of data obtained from 225 patients with OSA showed that certain endotypic subgroups had different outcomes in CPAP treatment, including optimal CPAP pressure, improvements in sleep architecture, and CPAP adherence.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Pediatrics
Indira Chandrasekar, Mary Anne Tablizo, Manisha Witmans, Jose Maria Cruz, Marcus Cummins, Wendy Estrellado-Cruz
Summary: Neonatal obstructive sleep apnea (OSA) is a common but under-recognized condition that can have significant impacts on growth, development, and even life-threatening cardiovascular morbidity. Diagnosis requires polysomnography and direct visualization of the airway, and treatment should be tailored to the severity of OSA and associated co-morbidities.
Article
Medicine, General & Internal
Hiddo J. L. Heerspink, Hans-Henrik Parving, Dennis L. Andress, George Bakris, Ricardo Correa-Rotter, Fan-Fan Hou, Dalane W. Kitzman, Donald Kohan, Hirofumi Makino, John J. V. McMurray, Joel Z. Melnick, Michael G. Miller, Pablo E. Pergola, Vlado Perkovic, Sheldon Tobe, Tingting Yi, Melissa Wigderson, Dick de Zeeuw
Article
Medicine, General & Internal
Helena Hachul, Daniel N. Polesel, Luciana Tock, Glaucia Carneiro, Andrea Z. Pereira, Maria Teresa Zanella, Sergio Tufik, Sonia M. Togeiro
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2019)
Article
Medicine, General & Internal
Hertzel C. Gerstein, Helen M. Colhoun, Gilles R. Dagenais, Rafael Diaz, Mark Lakshmanan, Prem Pais, Jeffrey Probstfield, Fady T. Botros, Matthew C. Riddle, Lars Ryden, Denis Xavier, Charles Messan Atisso, Leanne Dyal, Stephanie Hall, Purnima Rao-Melacini, Gloria Wong, Alvaro Avezum, Jan Basile, Namsik Chung, Ignacio Conget, William C. Cushman, Edward Franek, Nicolae Hancu, Markolf Hanefeld, Shaun Holt, Petr Jansky, Matyas Keltai, Fernando Lanas, Lawrence A. Leiter, Patricio Lopez-Jaramillo, Ernesto German Cardona Munoz, Valdis Pirags, Nana Pogosova, J. Raubenheimer, Jonathan E. Shaw, Wayne H-H Sheu, Theodora Temelkova-Kurktschiev
Article
Medicine, General & Internal
Hertzel C. Gerstein, Helen M. Colhoun, Gilles R. Dagenais, Rafael Diaz, Mark Lakshmanan, Prem Pais, Jeffrey Probstfield, Jeffrey S. Riesmeyer, Matthew C. Riddle, Lars Ryden, Denis Xavier, Charles Messan Atisso, Leanne Dyal, Stephanie Hall, Purnima Rao-Melacini, Gloria Wong, Alvaro Avezum, Jan Basile, Namsik Chung, Ignacio Conget, William C. Cushman, Edward Franek, Nicolae Hancu, Markolf Hanefeld, Shaun Holt, Petr Jansky, Matyas Keltai, Fernando Lanas, Lawrence A. Leiter, Patricio Lopez-Jaramillo, Ernesto German Cardona Munoz, Valdis Pirags, Nana Pogosova, Peter J. Raubenheimer, Jonathan E. Shaw, Wayne H-H Sheu, Theodora Temelkova-Kurktschiev
Letter
Clinical Neurology
S. Roizenblatt, S. M. G. P. Togeiro, A. C. Cabanas-Pedro, M. S. Figueredo
Article
Clinical Neurology
Luciana B. M. de Godoy, Ksdy M. M. Sousa, Luciana de Oliveira Palombini, Dalva Poyares, Cibele Dal-Fabbro, Thais M. Guimaraes, Sergio Tufik, Sonia M. Togeiro
JOURNAL OF CLINICAL SLEEP MEDICINE
(2020)
Article
Neurosciences
Jose Apolinario Silva Neves Junior, Ana Paula Andrade Fernandes, Maria Angela Tardelli, Americo Massafuni Yamashita, Sonia Maria Pereira Guimaraes Togeiro Moura, Sergio Tufik, Helga Cristina Almeida da Silva
ARQUIVOS DE NEURO-PSIQUIATRIA
(2020)
Article
Clinical Neurology
Luciana Oliveira e Silva, Thais Moura Guimaraes, Gabriela Pontes, Glaury Coelho, Luciana Badke, Cibele Dal Fabbro, Sergio Tufik, Lia Bittencourt, Sonia Togeiro
Summary: This study compared the effects of MAD and CPAP on the metabolic profile in patients with mild OSA. After 1 year of treatment, CPAP was found to be superior to MAD in reducing total cholesterol and low-density lipoprotein cholesterol levels.
SLEEP AND BREATHING
(2021)
Article
Pediatrics
Cristiane Fumo-dos-Santos, Anna K. Smith, Sonia M. G. P. Togeiro, Sergio Tu, Gustavo A. Moreira
Summary: The study aimed to analyze the prevalence of obstructive sleep apnea in asthmatic children and investigate the influence of gender and asthma severity on the prevalence. The results showed that obstructive sleep apnea was frequent among asthmatic children, but gender and asthma severity were not risk factors.
JORNAL DE PEDIATRIA
(2023)
Review
Endocrinology & Metabolism
Giovanna Braganholo Carpentieri, Sandra Elisa Adami Batista Goncalves, Walid Mohamed Mourad, Lara Guimaras Carelo Pinto, Maria Teresa Zanella
Summary: Postprandial hypoglycemia is a complex complication of bariatric surgery that can have severe symptoms or be asymptomatic. Treatment involves dietary changes and, in more severe cases, drug therapy. However, finding effective drugs with minimal side effects remains a challenge for physicians and patients.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Respiratory System
Maria Vera Cruz de Oliveira Castellano, Luiz Fernando Ferreira Pereira, Paulo Henrique Ramos Feitosa, Marli Maria Knorst, Carolina Salim, Mauri Monteiro Rodrigues, Eloara Vieira Machado Ferreira, Ricardo Luiz de Menezes Duarte, Sonia Maria Togeiro, Licia Zanol Lorencini Stanzani, Pedro Medeiros Junior, Karime Nadaf de Melo Schelini, Liana Sousa Coelho, Thiago Lins Fagundes de Sousa, Marina Buarque de Almeida, Alfonso Eduardo Alvarez
Summary: Some chronic respiratory diseases can lead to hypoxemia, and long-term home oxygen therapy is an effective treatment option to improve patient quality of life and life expectancy. In addition to improving survival, home oxygen therapy has other beneficial effects such as improved cognitive function, exercise capacity, and reduced hospitalizations. The usage of long-term home oxygen therapy has increased in Brazil.
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2022)
Article
Respiratory System
Adriana Fontes Hora, Lara Maris Napolis, Debora Strose Villaca, Renata dos Santos, Thales Delmondes Galvao, Sonia Maria Guimaraes Togeiro, Lia Rita Bittencourt, Luiz Eduardo Nery
Summary: This study aimed to assess the anthropometric measurements, clinical characteristics, and quality of life of obese patients, determine the occurrence and severity of Obstructive Sleep Apnea (OSA) using polysomnography, and identify the best anthropometric and clinical indicators to predict OSA in obese patients eligible for bariatric surgery. The results showed that waist-to-hip ratio (WHR) was the best clinical factor associated with the severity of OSA, with a cut-off value of 0.95.
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2022)
Article
Respiratory System
Ricardo Luiz de Menezes Duarte, Sonia Maria Guimaraes Pereira Togeiro, Luciana de Oliveira Palombini, Fabiola Paula Galhardo Rizzatti, Simone Chaves Fagondes, Flavio Jose Magalhaes-da-Silveira, Marilia Montenegro Cabral, Pedro Rodrigues Genta, Geraldo Lorenzi-Filho, Danielle Cristina Silva Climaco, Luciano Ferreira Drager, Vitor Martins Codeco, Carlos Alberto de Assis Viegas, Marcelo Fouad Rabahi
Summary: This article discusses the importance of sleep for individuals' proper functioning and the main causes of sleep-disordered breathing in adults and children. Obstructive sleep apnea, a common yet often overlooked disease, is accompanied by comorbidities that significantly impact quality of life and mortality rates. To establish consensus, the Sleep-Disordered Breathing Department of the Brazilian Thoracic Association gathered 14 experts with proven experience in the field.
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2022)
Article
Psychiatry
Cristina Cardoso Freire, Maria Teresa Zanella, Carlos Haruo Arasaki, Adriano Segal, Glaucia Carneiro
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2020)
Article
Nutrition & Dietetics
Camila Maria de Melo, Mariana Pantaleao del Re, Marcus Vinicius Lucio dos Santos Quaresma, Hanna Karen Moreira Antunes, Sonia Maria Togeiro, Sandra Maria Lima Ribeiro, Sergio Tufik, Marco Tulio de Mello
CLINICAL NUTRITION ESPEN
(2019)