Article
Endocrinology & Metabolism
May Majimbi, Samuel McLenachan, Michael Nesbit, Fred K. Chen, Virginie Lam, John Mamo, Ryu Takechi
Summary: This study found that retinal thinning in a type 2 diabetes mouse model is associated with cognitive decline, indicating that changes in retinal thickness may serve as an indicator of diabetic cognitive dysfunction and neuroinflammation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jeanette A. M. Maier, Laura Locatelli, Giorgia Fedele, Alessandra Cazzaniga, Andre Mazur
Summary: Magnesium plays a crucial role in regulating metabolism and maintaining tissue homeostasis, including the brain. It is essential for nerve signal transmission and protecting the blood-brain barrier. Deficiency in magnesium can lead to systemic low-grade inflammation, which is common in various diseases, particularly neurodegenerative disorders. This review provides evidence linking magnesium imbalance to multiple sclerosis, Alzheimer's, and Parkinson's diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Yong Yang, Guoying Deng, Peng Wang, Guangzhao Lv, Rui Mao, Yuhao Sun, Baofeng Wang, Xijian Liu, Liuguan Bian, Dong Zhou
Summary: The porous Se@SiO2 nanocomposite exerts neuroprotective effects by suppressing oxidative stress, improving neurological function, reducing cell apoptosis, brain edema, and blood-brain barrier permeability in a collagenase-induced ICH mouse model. It may be a potential candidate for the clinical treatment of ICH and oxidative stress-related brain injuries.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Pharmacology & Pharmacy
Satyam Pati, Avtar Singh Gautam, Mangaldeep Dey, Aman Tiwari, Rakesh Kumar Singh
Summary: Inflammation and cell death processes controlled by RIPK1 play a crucial role in maintaining organ homeostasis. Inhibiting RIPK1 has shown promising effects in preventing neuronal cell death, leading to a potential reduction in neurodegeneration and neuroinflammation. Therefore, RIPK1 has emerged as an important therapeutic target for Alzheimer's disease.
DRUG DISCOVERY TODAY
(2023)
Article
Biochemistry & Molecular Biology
Jin Yu, Hong Zhu, Mark S. Kindy, Saeid Taheri
Summary: This study demonstrates that suppression of CYP2E1 can alleviate I/R injury and protect BBB integrity by reducing oxidative stress and inflammation. CYP2E1 KO mice showed lower lesion volume and neurological deficits after I/R, with decreased oxidative stress and inflammatory responses.
Article
Immunology
Atsuko Katsumoto, Olga N. Kokiko-Cochran, Shane M. Bemiller, Guixiang Xu, Richard M. Ransohoff, Bruce T. Lamb
Summary: This study found that traumatic brain injury promotes Alzheimer's disease-like pathological features and that deficiency of TREM2 accelerates inflammation and neurodegeneration, leading to brain damage and impaired neurological function.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ana Aragon-Gonzalez, Pamela J. Shaw, Laura Ferraiuolo
Summary: This review provides a detailed explanation of the importance of maintaining a healthy blood-brain barrier (BBB) for disease prevention and the main pathomechanisms affecting BBB function. Barrier disruption is a common feature in both neurodegenerative and neurodevelopmental diseases. Potential therapies based on the BBB properties, such as molecular Trojan horses, and innovative treatments like stem cell therapies are being reviewed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Haidy Abbas, Heba A. Gad, Mohamed A. Khattab, Mai Mansour
Summary: This study developed resveratrol-loaded bilosomes as a promising drug delivery system for Alzheimer's disease, showing superiority over traditional drug suspensions in enhancing therapeutic effects in an AD animal model.
Article
Neurosciences
P. M. Abdul-Muneer, Bibhuti Ballav Saikia, Saurav Bhowmick
Summary: After a mild traumatic brain injury (mTBI), victims often experience emotional/psychological stress such as heightened irritability, anxiety, apathy, and depression. The combination of TBI and alcohol exacerbates these symptoms and leads to psychological stress such as depression and anxiety. This study analyzed biomarkers and functional outcomes to understand the biochemical mechanisms and pathophysiology of neurological damage caused by the synergistic effect of TBI and alcohol. It found that oxidative stress, neuroinflammation, amyloidogenesis, tau pathology, and neurodegeneration markers were elevated, while glial activation and blood-brain barrier (BBB) damage were exacerbated. Decreases in certain neurotransmitters and increases in monoamine oxidase-a were also observed. These findings contribute to a comprehensive therapeutic approach for patients suffering from TBI and alcohol-mediated neurological damage and psychological stress.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Xingyong Chen, Yanguang Mao, Yueting Guo, Dongyun Xiao, Zejing Lin, Yiyi Huang, Ying Chun Liu, Xu Zhang, Yinzhou Wang
Summary: This study aims to explore the contribution of the immunoproteasome subunit LMP2 in neurobehavioral functions. The results showed that LMP2 gene deletion caused metabolic abnormalities, cognitive impairment, increased anxiety-like behavior, multiple myelin loss, increased blood-brain barrier leakage, and enhanced amyloid-beta protein deposition in rats. These factors led to chronic oxidative stress and neuroinflammation in the brain, contributing to cognitive impairment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Batoul Ghaddar, Laura Gence, Bryan Veeren, Matthieu Bringart, Jean-Loup Bascands, Olivier Meilhac, Nicolas Diotel
Summary: The aqueous extract of Psiloxylon mauritianum exhibits lipid-lowering effects and prevents weight gain, hyperglycemia, liver steatosis, and detrimental effects on the central nervous system in zebrafish models. It also increases feces production, possibly through its effects on intestinal lipid absorption or microbiota. These findings highlight the potential of Psiloxylon mauritianum as a therapeutic agent for obesity.
Article
Environmental Sciences
Hongjing Zhao, Yu Wang, Menghao Guo, Yachen Liu, Hongxian Yu, Mingwei Xing
Summary: The study found that exposure to cypermethrin and sulfamethoxazole, as well as their mixture in water environment, significantly affects the brain function, oxidative stress, and apoptosis of grass carp. The results showed that these two chemicals induce similar biological responses and may enhance each other's toxic effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Immunology
Xin Wang, Jia-ying Yu, Yan Sun, Heng Wang, Hu Shan, Shubai Wang
Summary: Baicalin, a bioactive extract from Scutellaria Baicalensis Georgi, has anti-inflammatory and anti-oxidative functions, and its preventive protection can improve cell apoptosis and Fluorescein sodium infiltration in the brain tissue. Baicalin can also inhibit pro-inflammatory cytokines production, up-regulate Claudin-5 and ZO-1 protein expression, reduce ROS and MDA production, promote SOD production, and activate Nrf2-mediated antioxidant stress pathway to protect blood-brain barrier damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Wenlong Zhang, Huaqing Chen, Liuyan Ding, Junwei Gong, Mengran Zhang, Wenyuan Guo, Pingyi Xu, Shiying Li, Yunlong Zhang
Summary: In this study, a Trojan horse system was used for targeted delivery of a blood brain barrier-penetrating peptide (RVG29) conjugated to nanoparticles loaded with the natural autophagy inducer 4,4 '-dimethoxychalcone (DMC) for the treatment of Parkinson's disease. The neuroprotective effects of DMC were demonstrated, showing improvement in motor deficits and nigral DA neuron death in PD mice without causing adverse effects. rvanism by using RVG-nDMC provides a potentially effective approach for intervention against Parkinson's disease.
Article
Biochemistry & Molecular Biology
Farzane Sivandzade, Faleh Alqahtani, Hemangini Dhaibar, Diana Cruz-Topete, Luca Cucullo
Summary: Traumatic Brain Injury (TBI) is a leading cause of cerebrovascular and neurological disorders worldwide. Smoking is believed to worsen post-TBI brain injury and hinder recovery by affecting the blood-brain barrier endothelium. Antidiabetic drugs such as metformin and rosiglitazone have been found to protect the blood-brain barrier and reduce brain damage caused by chronic smoking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)