Review
Cell Biology
Ulises Ahumada-Castro, Galdo Bustos, Eduardo Silva-Pavez, Andrea Puebla-Huerta, Alenka Lovy, Cesar Cardenas
Summary: Recent studies have shown that cross-organelle communication plays a significant role in metabolism, with calcium ions playing a crucial role in this process, especially in cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Dong-Xu Huang, Xin Yu, Wen-Jun Yu, Xin-Min Zhang, Chang Liu, Hong-Ping Liu, Yue Sun, Zi-Ping Jiang
Summary: The precise regulation of calcium ion by neurons is essential for cellular signaling and survival, with calcium homeostasis maintained by both endoplasmic reticulum and mitochondria. Dysregulation of calcium signaling is associated with Alzheimer's disease, highlighting the importance of understanding the cellular and molecular mechanisms underlying calcium regulation in neurodegenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Zehui Li, Yu Cao, Hui Pei, Lina Ma, Yang Yang, Hao Li
Summary: Alzheimer's disease is the most common neurodegenerative disease without effective treatments. Mitochondria-associated endoplasmic reticulum membranes (MAMs) are associated with AD pathogenesis, but there is a lack of literature summarizing recent advances. This article reviews the roles of MAM structure and tethering proteins in the pathogenesis of AD and potential treatment strategies targeting MAMs.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cell Biology
Benjamin Cartes-Saavedra, Josefa Macuada, Daniel Lagos, Duxan Arancibia, Maria E. Andres, Patrick Yu-Wai-Man, Gyoergy Hajnoczky, Veronica Eisner
Summary: Autosomal Dominant Optic Atrophy (ADOA), caused by OPA1 mutations, affects Ca2+ homeostasis by modulating ER-mitochondria coupling, potentially contributing to the progression of ADOA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Na Song, Ming Yang, Hao Zhang, Shi-kun Yang
Summary: Kidney disease is a serious health concern, and understanding the pathogenesis is crucial for precise therapies. Disruption of calcium homeostasis plays a fundamental role in kidney disease development and is a promising therapeutic strategy. The endoplasmic reticulum and mitochondria are key organelles, with pharmacologic modulation of cellular calcium homeostasis as a novel treatment approach.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Leandro Henrique de Paula Assis, Gabriel de Gabriel Dorighello, Helena Coutinho Franco De Oliveira
Summary: In this study, the relationship between macrophage immune phenotype and mitochondrial bioenergetics, cell redox state, and endoplasmic reticulum (ER)-mitochondria interaction was investigated. The results reveal that different inflammatory stimuli lead to changes in macrophage metabolism and redox state, which are associated with the interaction between mitochondria and ER.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Patrick A. Fletcher, Ben Thompson, Chante Liu, Richard Bertram, Leslie S. Satin, Arthur S. Sherman
Summary: The standard model for Ca2+ oscillations in insulin-secreting pancreatic 13 cells relies on voltage-activated Ca2+ channels for Ca2+ entry. These channels work together with ATP-dependent K+ channels to regulate the secretion of insulin in response to the metabolic state of the cells. However, an alternative model proposes that calcium-induced calcium release from the endoplasmic reticulum is the key driver of islet oscillations. This study shows that the alternative model is incompatible with established experimental data and that the standard model provides a better explanation for the new observations.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Barbara Zablocka, Dariusz C. Gorecki, Krzysztof Zablocki
Summary: Duchenne muscular dystrophy is caused by mutations in the DMD gene, leading to the loss of full-length dystrophin and resulting in muscle degeneration, neuropsychological impairment, and bone deformities. Abnormalities in calcium homeostasis are a common feature of this disease, playing a fundamental role in the various abnormalities associated with DMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Cell Biology
Karim Rahhali, Fabio Di Lisa, Nina Kaludercic
Summary: The close contacts between the endoplasmic reticulum and mitochondria are crucial for various cell functions. A recent article in Nature Communications demonstrated that motile IP(3)Rs can quickly transfer Ca2+ at ERMCs, thereby stimulating mitochondrial oxidative metabolism.
Article
Cell Biology
Yuan Che, Wanfen Xu, Chujie Ding, Tianyu He, Xiaowei Xu, Yubing Shuai, Hai Huang, Jiawei Wu, Yun Wang, Chen Wang, Guangji Wang, Lijuan Cao, Haiping Hao
Summary: Bile acids serve as endogenous ligands of mitofusin 2 (MFN2) and regulate innate immune response to bacterial infection under cholestatic and physiological conditions. At high concentrations, bile acids promote the activation of NLRP3 inflammasome and pyroptosis, while at physiologically relevant low concentrations, they enhance mitochondrial fusion and strengthen macrophage-mediated phagocytotic clearance. These findings highlight the important role of bile acids as activators of MFN2 in shaping innate immune responses against infections, connecting systemic metabolism with mitochondrial dynamics.
Article
Clinical Neurology
Tania Rizo, Lisa Gebhardt, Julia Riedlberger, Esther Eberhardt, Lars Fester, Dalia Alansary, Jurgen Winkler, Soeren Turan, Philipp Arnold, Barbara A. Niemeyer, Michael J. M. Fischer, Beate Winner
Summary: The study demonstrates that pathogenic variants in the SPAST gene lead to dysregulation of spastin, affecting the dynamics of the endoplasmic reticulum and resulting in aberrant calcium regulation.
Article
Water Resources
Nadia Perez-Fuentes, Rebeca Alvarino, Amparo Alfonso, Jesus Gonzalez-Jartin, Mercedes R. Vieytes, Luis M. Botana
Summary: This study investigates the effects of enniatins A and B on Ca2+ fluxes and mitochondrial function in human neuroblastoma cells. The results reveal that these toxins have distinct effects on Ca2+ fluxes and different mechanisms of action.
EXPOSURE AND HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Anna Signorile, Anna Ferretta, Consiglia Pacelli, Nazzareno Capitanio, Paola Tanzarella, Maria Laura Matrella, Alessio Valletti, Domenico De Rasmo, Tiziana Cocco
Summary: Parkin plays a crucial role in mitochondrial function and calcium balance. Treatment with resveratrol in Parkin-mutant fibroblasts can lead to increased Ca2+ level, modulation of cAMP homeostasis, and restoration of protein expression involved in ER-mitochondria contact points.
Review
Cell Biology
Yu Wang, Xinrong Zhang, Ya Wen, Sixuan Li, Xiaohui Lu, Ran Xu, Chao Li
Summary: Cardiovascular remodeling is a critical pathological basis for heart failure caused by various cardiac diseases, affecting morbidity and mortality. The ER and mitochondria are connected by ERMCs, playing a key role in cellular processes and potentially contributing to cardiovascular remodeling-associated diseases. Ongoing research suggests that targeting ERMCs may offer new therapeutic strategies against diseases induced by cardiovascular remodeling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wen Zhang, Fanghua Ye, Nan Pang, Miriam Kessi, Juan Xiong, Shimeng Chen, Jing Peng, Li Yang, Fei Yin
Summary: This study elucidates the role and mechanism of SERCA2b gene mutants in glutamate-induced excitotoxicity, showing that they worsen cell damage by accelerating Ca2+ depletion and causing ER stress and mitochondrial Ca2+ overload. Enhancing SERCA2b pumping capacity or inhibiting Ca2+ leakage can alleviate this toxicity response.
FRONTIERS IN PHARMACOLOGY
(2022)