Article
Immunology
Keyvan Amirshahrokhi, Ali Niapour
Summary: Carvedilol exerts a protective effect against HE-induced brain injury through increasing antioxidant defense mechanisms and inhibiting inflammatory and apoptotic pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ghada M. Shafey, Engy R. Rashed, Hala F. Zaki, Amina S. Attia, Mona A. El-Ghazaly
Summary: This study investigates the potential beneficial effects of morin flavonoid compared to silymarin as a hepatic/neuronal-supportive agent with similar effects and higher bioavailability in a rat model of hepatic encephalopathy (HE). The results demonstrate that morin improves liver function, attenuates brain and liver tissue injuries, and reduces apoptotic and inflammatory insults in both organs.
Article
Chemistry, Medicinal
Liping Luo, Dehuai Li, Xiaojia Xu, Qi Jia, Zhiyin Li, Ruilong Xu, Zhenyu Chen, Yu Zhao
Summary: This study aimed to develop new derivatives of genipin with improved stability and activity for the treatment of stroke. Nineteen new derivatives were evaluated in HT22 cells and 3e showed significantly greater neuroprotection and improved stability compared to genipin. Further investigation revealed that 3e inhibited oxidative stress by down-regulating the phosphorylation levels of p38 MAPK and activating Nrf2 and HO-1 proteins. These results suggest that 3e has the potential to serve as a promising candidate for the treatment of stroke by protecting against glutamate-induced oxidative stress.
Article
Medicine, Research & Experimental
Nada F. Abo El-Magd, Dalia H. El-Kashef, Mohamed El-Sherbiny, Salma M. Eraky
Summary: Hesperidin exhibits hepatoprotective effects and ameliorates hepatic encephalopathy through modulation of NLRP3/Sirt1/FOXO signaling pathway. It reduces liver enzymes, bile and ammonia levels, restores oxidant/antioxidant balance, improves motor and cognitive abilities, and enhances tissue architecture. Hesperidin also decreases IL-113 and caspase-1 expression.
Article
Medicine, Research & Experimental
Smritee Pokharel, Nailya Gliyazova, Srinivasa Dandepally, Alfred Williams, Gordon Ibeanu
Summary: The present study investigated the neuroprotective properties of B355227, a BBB penetrant, and its role in a glutamate-induced oxidative injury model. The results demonstrated that B355227 crossed the BBB in vitro and protected neuronal cells from oxidative injury induced by glutamate exposure.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Kaihui Lu
Summary: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome caused by metabolic disorders in the liver. It is characterized by hyperammonemia, EEG abnormalities, and disturbances in sensory, motor, and cognitive functions. The main mechanisms of HE include ammonia poisoning, oxidative/nitrosative stress, manganese toxicity, autophagy inhibition, mitochondrial damage, inflammation, and senescence.
Review
Biochemistry & Molecular Biology
Silke Haeusler, Nicola J. Robertson, Klervi Golhen, John van den Anker, Katie Tucker, Thomas K. Felder
Summary: Despite improvements in survival after preterm birth, the long-term cognitive and behavioral consequences remain a significant challenge. Neuroprotective treatment options, such as melatonin, are urgently needed to improve neurodevelopmental outcomes in preterm infants. Melatonin can alleviate inflammatory and oxidative stress and may have a direct neurotrophic impact, making it a promising therapeutic option.
Article
Pharmacology & Pharmacy
Kakarla Ramakrishna, Sangeetha Sinku, Shreyasi Majumdar, Neha Singh, T. A. Gajendra, Asha Rani, Sairam Krishnamurthy
Summary: This study investigated the hepatic and neuroprotective roles of Indole-3-carbinol (I3C) in thioacetamide (TAA)-induced hepatic encephalopathy. The results showed that I3C could significantly decrease the levels of ammonia in the blood, liver, and brain, improve liver function, inhibit CYP2E1 enzyme activity in the liver and brain, alleviate mitochondrial dysfunction, oxidative stress, inflammation, and apoptosis, and improve the histological abnormalities in the brain.
Article
Neurosciences
Somayeh Hajipour, Yaghoob Farbood, Mahin Dianat, Mohammad Rashno, Laya Sadat Khorsandi, Alireza Sarkaki
Summary: The study evaluated the therapeutic effects of thymoquinone (TQ) on behavioral deficits in a thioacetamide (TAA)-induced hepatic encephalopathy (HE) model. Results showed that TQ treatment ameliorated anxiety and depression-like behaviors in HE rats by reducing oxidative stress levels in the hippocampus, suggesting notable effects against acute hepatic failure and HE complications through modulation of oxidative stress.
NEUROSCIENCE LETTERS
(2021)
Article
Endocrinology & Metabolism
James DS. Aridas, Tamara Yawno, Amy E. Sutherland, Ilias Nitsos, Flora Y. Wong, Rod W. Hunt, Michael Ditchfield, Michael C. Fahey, Atul Malhotra, Euan M. Wallace, Alistair J. Gunn, Graham Jenkin, Suzanne L. Miller
Summary: This study found that combined use of TH and MLT for neonatal encephalopathy in newborn lambs provides significantly greater neuroprotection than either treatment alone.
JOURNAL OF PINEAL RESEARCH
(2021)
Review
Nutrition & Dietetics
Xiaonan Zhang, Mengxue Xia, Yingjie Wu, Fang Zhang
Summary: Retinopathy is a major cause of irreversible blindness and vision loss worldwide. Imbalanced nutrients, especially Branched-Chain Amino Acids (BCAAs), play important roles in the development and progression of retinal diseases. This review summarizes the changes in BCAA levels in retinopathy, especially in diabetic retinopathy and aging-related macular disease, as well as the genetics, functions, and mechanisms of BCAAs in the retina and other metabolic tissues. The aim of this review is to provide fundamental knowledge of BCAAs for further research on retina health.
Article
Endocrinology & Metabolism
Ufuk Okkay, Irmak Ferah Okkay, Betul Cicek, Ismail Cagri Aydin, Mustafa Ozkaraca
Summary: This study demonstrated that taxifolin had hepatoprotective and neuroprotective effects by reducing liver damage markers, improving hyperammonemia, enhancing antioxidant capacity, modulating expression of inflammatory factors, inhibiting nitric oxide and DNA oxidative damage, and protecting liver and nerve. Additionally, taxifolin also alleviated thioacetamide-induced neurobehavioral impairments.
METABOLIC BRAIN DISEASE
(2022)
Article
Neurosciences
Somayeh Hajipour, Yaghoob Farbood, Mahin Dianat, Ali Nesari, Alireza Sarkaki
Summary: This study investigated the effect of berberine on spatial cognition in a rat model of liver cirrhosis induced by thioacetamide. The results showed that berberine improved spatial learning and memory by improving the blood-brain barrier function, oxidative stress, and neuroinflammation in TAA-induced liver cirrhosis rats. Berberine may be a promising therapeutic agent for cognitive improvement in patients with liver cirrhosis.
Article
Biochemistry & Molecular Biology
Yevgeniya I. I. Shurubor, Alexander E. E. Rogozhin, Elena P. P. Isakova, Yulia I. I. Deryabina, Boris F. F. Krasnikov
Summary: This study examines the delayed consequences of hepatic encephalopathy (HE) on animal metabolism. The development of acute HE under the influence of thioacetamide (TAA) toxin was found to cause liver pathology, imbalance in CoA and acetyl CoA, and changes in TCA cycle metabolites. Six days after exposure to TAA, alterations in amino acids, related metabolites, glutamine transaminase (GTK) and omega-amidase enzymes were observed in vital organs. Despite apparent physiological recovery, an imbalance in amino acids and enzymes persisted, providing insight into metabolic trends for prognostic and therapeutic purposes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Rosario Cazares-Camacho, J. Abraham Dominguez-Avila, Humberto Astiazaran-Garcia, Marcelino Montiel-Herrera, Gustavo A. Gonzalez-Aguilar
Summary: The study suggests that mango has potent neuroprotective properties against diabetes-induced oxidative stress, and can be an alternative to prevent and treat biochemical alterations caused by diabetes.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreia Rocha, Bruna Bellaver, Debora G. Souza, Guilherme Schu, Igor C. Fontana, Gianina T. Venturin, Samuel Greggio, Fernanda U. Fontella, Manoela L. Schiavenin, Luiza S. Machado, Diogo Miron, Jaderson C. da Costa, Pedro Rosa-Neto, Diogo O. Souza, Luc Pellerin, Eduardo R. Zimmer
Summary: This study used FDG-PET imaging to investigate the impact of the antipsychotic drug clozapine on brain glucose metabolism in rats, and found that downregulation of GLT-1 resulted in astrocyte-dependent cortical hypometabolism, resembling the hypometabolic signature observed in people developing dementia.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Neurosciences
Leticia Barbieri Caus, Mayara Vendramin Pasquetti, Bianca Seminotti, Michael Woontner, Moacir Wajner, Maria Elisa Calcagnotto
Summary: This study investigated the impact of quinolinic acid on the neurological features of GA-I, finding that Gcdh(-/-)-Lys mice showed increased susceptibility to quinolinic acid-induced seizures and enduring alterations in brain oscillation patterns.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Krislei Scienza-Martin, Fernanda Nogueira Lotz, Querusche Klippel Zanona, Fabiana Santana-Kragelund, Ana Paula Crestani, Flavia Zacouteguy Boos, Maria Elisa Calcagnotto, Jorge Alberto Quillfeldt
Summary: The endocannabinoid system plays a role in regulating synaptic plasticity in the hippocampus during memory formation. The mechanisms underlying this regulation are not well understood. In this study, the authors investigated the effects of AM404, an inhibitor of anandamide transport and metabolism, on aversive memory consolidation. They found that AM404 disrupted memory consolidation and retrieval, and abolished Long-Term Potentiation induction. The effects of AM404 were reversed by metyrapone, suggesting an interaction between glucocorticoids and endocannabinoids in memory consolidation. CB1 receptors mediated the amnestic effect caused by increased anandamide levels, while TRPV1 receptors did not. The results also suggest an interesting interaction between the endocannabinoid and cholinergic systems.
Article
Psychiatry
Luisa K. Pilz, Natividade S. Couto Pereira, Ana Paula Francisco, Alicia Carissimi, Debora B. Constantino, Leticia B. Caus, Ana Carolina O. Abreu, Guilherme R. Amando, Fernanda S. Bonatto, Paula V. V. Carvalho, Jose Cipolla-Neto, Ana Harb, Gabriela Lazzarotto, Joseane Righes Marafiga, Luciano Minuzzi, Francisco Montagner, Fernanda A. Nishino, Melissa A. B. Oliveira, Bruno G. T. dos Santos, Eduardo G. Steibel, Patrice S. Tavares, Andre C. Tonon, Nicoli B. Xavier, Querusche Klippel Zanona, Fernanda G. Amaral, Maria Elisa Calcagnotto, Benicio N. Frey, Maria Paz Hidalgo, Marco Idiart, Thais Russomano
Summary: This study assessed the adherence to evidence-based recommendations for supporting mental health during the COVID-19 pandemic and its association with depressive and anxiety symptoms. The results showed that adherence to the recommendations was significantly associated with reduced anxiety and depression symptoms. The recommendations developed in this study could be important for preventing negative mental health effects during and beyond the pandemic.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2022)
Review
Endocrinology & Metabolism
Paula Michele da Silva Schmidt, Aline Longoni, Ricardo Tavares Pinheiro, Adriano Martimbianco de Assis
Summary: This study conducted a systematic review on the prevalence of postpartum depression in women with thyroid abnormalities during pregnancy or in the postpartum period. The findings suggest a possible association between thyroid antibodies and depression during pregnancy and the postpartum period. The prevalence of postpartum depression in pregnant women with thyroid disorders ranged from 8.3% to 36.0%.
Article
Biochemistry & Molecular Biology
Leticia Rodrigues, Krista Mineia Wartchow, Michael Buchfelder, Diogo Onofre Souza, Carlos-Alberto Goncalves, Andrea Kleindienst
Summary: In this study, the researchers investigated the role of S100B, a neurotrophic protein, in brain injury and neuroregeneration. Using S100Btg mice with increased expression of the S100B gene, they found enhanced proliferation and migration of progenitor cells, as well as reduced levels of GFAP, ApoE, and BDNF in certain brain regions. The study highlights the importance of the S100Btg model in evaluating the role of S100B in neuroregenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Natividade de Sa Couto Pereira, Querusche Klippel Zanona, Marcelo Pastore Bernardi, Joelma Alves, Carla Dalmaz, Maria Elisa Calcagnotto
Summary: Maternal separation in male rats can lead to resistant memory labilization in adulthood. The desynchronization between the dorsal hippocampus and the basolateral amygdala during fear memory reactivation may be responsible for this impairment.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Neurosciences
Querusche Klippel Zanona, Gabriel Alves Marconi, Natividade de Sa Couto Pereira, Gabriela Lazzarotto, Ana Luiza Ferreira Donatti, Jose Antonio Cortes de Oliveira, Norberto Garcia-Cairasco, Maria Elisa Calcagnotto
Summary: Adding a second insult to the genetic background of mice can enhance epileptogenesis and spontaneous epileptic seizures. Experimental results showed that microgyria intensified SWD events while reducing anxiety-like behavior, suggesting that WAR-FL could be a reliable model for studying epileptogenesis.
Article
Neurosciences
Adriana L. Silva, Joana L. Oliveira, Ravena P. do Nascimento, Leticia O. Santos, Fillipe M. de Aranjo, Balbino L. dos Santos, Rejane C. Santana, Eduardo Luiz T. Moreira, Maria Jose M. Batatinha, Iura M. Alves, Eudes S. Velozo, Mauricio M. Victor, Adriano M. Assis, Roberto F. Almeida, Diogo O. G. de Souza, Victor Diogenes A. Silva, Silvia L. Costa
Summary: The ingestion of MCT induces cerebrovascular lesions and toxicity to neurons in rats, accompanied by astroglial cell response and neuroinflammation in the cortex and hippocampus.
Article
Neurosciences
Mellanie Fontes-Dutra, Joseane Righes Marafiga, Julio Santos-Terra, Iohanna Deckmann, Gustavo Brum Schwingel, Bruna Rabelo, Rafael Kazmierzak de Moraes, Marilia Rockenbach, Mayara Vendramin Pasquetti, Carmem Gottfried, Maria Elisa Calcagnotto
Summary: Prenatal exposure to valproic acid (VPA) leads to autism spectrum disorder (ASD), but resveratrol (RSV) can prevent these impairments. This study found that prenatal VPA exposure reduced synaptic inhibition in the somatosensory area, resulting in behavioral and electroencephalogram changes. However, RSV prevented these synaptic inhibition alterations and improved behavioral and electroencephalogram abnormalities.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Information Science & Library Science
Carolina Bittencourt Gomes, Luciana Calabro, Suzana Rachel de Oliveira, Leo Anderson Meira Martins, Diogo Onofre Souza, Ediane Maria Gheno
Summary: This article evaluated the characteristics of grantees in the Health Sciences area of the National Council for Scientific and Technological Development. Various indicators were used to assess 1,634 researchers with current grants in 2021. The study found differences in the distribution of articles among Committees and the influence of article numbers on the level of grants. It provides important insights for public policies in Science and Technology and contributes to the field by evaluating the Health Sciences area using diverse indicators.
Article
Psychiatry
Paula Michele da Silva Schmidt, Jessica Puchalski Trettim, Aline Longoni, Mateus Grings, Mariana Bonati de Matos, Luciana de Avila Quevedo, Ana Paula Ardais, Fernanda Nedel, Gabriele Ghisleni, Guilhian Leipnitz, Ricardo Tavares Pinheiro, Adriano Martimbianco de Assis
Summary: This study evaluates the serum levels of oxidative stress biomarkers in women at risk of suicide 18 months after postpartum. The findings suggest that low levels of glutathione may be a potential biomarker or etiologic factor in women at moderate to high risk of suicide.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Blessing A. Obafemi, Isaac A. Adedara, Ana L. A. Segatto, Diogo O. Souza, Joao B. T. da Rocha, Olawande C. Olagoke
Summary: In this study, the mechanism of inflammatory response to organometallic cation methylmercury, common cooking seasoning (NaCl and MSG), and their crosstalk with redox signaling were investigated using the lobster cockroach as a model. The activation of Nox/Duox NADPH oxidases, along with JNK and Rel signaling pathways, was found to play crucial roles during methylmercury and MSG exposure.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Pedro Ozorio Brum, Camila Tiefensee Ribeiro, Daniel Opperman Peixoto, Lucas dos Santos Silva, Flavio Kessler, Carolina Saibro Girardi, Natividade de Sa Couto Pereira, Querusche Klippel Zanona, Jose Claudio Moreira Fonseca, Juciano Gasparotto, Cleiton Lopes Aguiar, Maria Elisa Calcagnotto, Daniel Pens Gelains
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Neurosciences
Julia D. Moreira, Leticia Vicari Siqueira, Alexandre P. Muller, Lisiane O. Porciuncula, Lucia Vinade, Diogo O. Souza
Summary: Dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) can positively influence the glutamatergic system and prevent seizure-related memory deficits.
NUTRITIONAL NEUROSCIENCE
(2022)