Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+FoxP3+ Treg cell population and prevents signs of experimental autoimmune encephalomyelitis in mice

CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells

(2014) T. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

The IL-17 pathway as a major therapeutic target in autoimmune diseases

(2010) Yan Hu et al.   Annals of the New York Academy of Sciences

Intradermal α1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses hyperglycaemia in the NOD mouse model of the disease

(2010) H. Ma et al.   DIABETOLOGIA

T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells

(2010) Jian Ma et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Peroxisome proliferator-activated receptor δ agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis

(2010) Saravanan Kanakasabai et al.   IMMUNOLOGY

α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8

(2010) David A. Bergin et al.   JOURNAL OF CLINICAL INVESTIGATION

CCR6 Marks Regulatory T Cells as a Colon-Tropic, IL-10-Producing Phenotype

(2010) K. Kitamura et al.   JOURNAL OF IMMUNOLOGY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

(2010) D. Gris et al.   JOURNAL OF IMMUNOLOGY

Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis

(2010) M. Mehling et al.   NEUROLOGY

Functional and Pathogenic Differences of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

(2010) Helena S. Domingues et al.   PLoS One

Increased IL-17 production by peripheral T helper cells after tumour necrosis factor blockade in rheumatoid arthritis is accompanied by inhibition of migration-associated chemokine receptor expression

(2010) N. E. Aerts et al.   RHEUMATOLOGY

α 1-antitrypsin enhances insulin secretion and prevents cytokine-mediated apoptosis in pancreatic β-cells

(2010) Martins Kalis et al.   Islets

α1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies

(2009) Ugo I. Ekeowa et al.   CLINICAL SCIENCE

New Findings in PiZZ α1-Antitrypsin Deficiency-Related Panniculitis

(2009) B. Gross et al.   DERMATOLOGY

Serum trypsin inhibitory capacity in normal pregnancy and gestational diabetes mellitus

(2009) Minoo Yaghmaei et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

CCR6 regulates EAE pathogenesis by controlling regulatory CD4+T‐cell recruitment to target tissues

(2009) Ricardo Villares et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Combination of alpha-1 antitrypsin and doxycycline suppresses collagen-induced arthritis

(2009) Christian Grimstein et al.   JOURNAL OF GENE MEDICINE

α-1-Antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood

(2009) Gregory B. Pott et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Curative and   cell regenerative effects of  1-antitrypsin treatment in autoimmune diabetic NOD mice

(2008) M. Koulmanda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice

(2008) E. C. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA