Article
Gastroenterology & Hepatology
Takao Miwa, Tatsunori Hanai, Maeda Toshihide, Yui Ogiso, Kenji Imai, Atsushi Suetsugu, Koji Takai, Makoto Shiraki, Naoki Katsumura, Masahito Shimizu
Summary: Zinc deficiency may predict the development of OHE and mortality in LC patients with MHE.
HEPATOLOGY RESEARCH
(2021)
Review
Health Care Sciences & Services
Jakub Gazda, Peter Drotar, Sylvia Drazilova, Juraj Gazda, Matej Gazda, Martin Janicko, Peter Jarcuska
Summary: Hepatic encephalopathy is a brain dysfunction caused by liver insufficiency and/or portosystemic shunting, with a spectrum of manifestations including overt HE, covert HE, and minimal HE. Despite the lack of universally accepted gold standard for diagnosing MHE, significant progress has been made in the application of artificial intelligence in medicine.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Kessarin Thanapirom, Monton Wongwandee, Sirinporn Suksawatamnuay, Panarat Thaimai, Napaporn Siripon, Wanwisar Makhasen, Sombat Treeprasertsuk, Piyawat Komolmit
Summary: The study aimed to establish the normative data of PHES in healthy Thai individuals, assess the prevalence of MHE, and validate the use of S-ANT1 in detecting MHE in cirrhotic patients. The results showed that MHE was present in 26.6% of cirrhotic patients. S-ANT1 had a moderate positive correlation with PHES.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Simon Johannes Gairing, Chiara Mangini, Lisa Zarantonello, Stefania Gioia, Elise Jonasson Nielsen, Sven Danneberg, Anna S. Lok, Philippe Sultanik, Peter Robert Galle, Joachim Labenz, Dominique Thabut, Jens Uwe Marquardt, Patricia P. Bloom, Mette Munk Lauridsen, Sara Montagnese, Silvia Nardelli, Christian Labenz
Summary: This large multicenter study demonstrates that screening for minimal hepatic encephalopathy (MHE) is a useful tool for predicting the development of overt hepatic encephalopathy (OHE) and poorer survival.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Segundo Moran, Marlene Lopez-Sanchez, Maria del Pilar Milke-Garcia, Gustavo Rodriguez-Leal
Summary: MHE represents the earliest stage of HE and is characterized by imperceptible neurocognitive alterations detected during routine clinical examination. MHE may impact daily activities, reduce job performance and quality of life, and potentially progress to overt encephalopathy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Igor G. Bakulin, Kristina N. Ivanova, Elena Y. Eremina, Natalya V. Marchenko, NORMIND Study Team
Summary: This study aimed to evaluate the effect of different rifaximin-alpha regimens on patients with liver cirrhosis and minimal hepatic encephalopathy. The results showed that continuous rifaximin-alpha therapy had a more pronounced effect on improving patients' quality of life and symptoms compared to cyclic use.
Review
Biochemistry & Molecular Biology
So Yeong Cheon, Juhyun Song
Summary: Hepatic encephalopathy and diabetic encephalopathy are emerging types of neurological diseases characterized by cognitive and motor impairments. The relationship between metabolic organs and the brain plays an important role in the pathogenesis of neurological diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Ming Luo, Rui-Juan Xin, Fang-Rui Hu, Li Yao, Sheng-Juan Hu, Fei-Hu Bai
Summary: Minimal hepatic encephalopathy (MHE) is a common neurological and psychiatric complication of liver cirrhosis, with a complicated and yet to be fully elucidated pathogenesis. Gut microbiota dysbiosis plays a significant role in MHE pathogenesis by inducing systemic inflammation, hyperammonemia, endotoxemia, and subsequent neuroinflammation via the gut-liver-brain axis. Therapeutic strategies for MHE mainly focus on modulating gut microbiota dysbiosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Christian Labenz, Michael Nagel, Paula Kaemper, Sinah Engel, Stefan Bittner, Leonard Kaps, Peter R. Galle, Joern M. Schattenberg, Marcus-Alexander Woerns, Felix Luessi
Summary: This proof-of-concept study found that higher levels of serum neurofilament light chains (sNfL) were associated with minimal hepatic encephalopathy (MHE) in patients with liver cirrhosis. sNfL had a reliable discriminative power for the detection of MHE, with an area under the curve of 0.872.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Dominique Thabut, Charlotte Bouzbib, Lucy Meunier, Manon Haas, Nicolas Weiss, Alexandre Louvet, Francois Imbert-Bismut, Fanny Mochel, Yann Nadjar, Antoine Santiago, Thierry Thevenot, Veronique Duhalde, Frederic Oberti, Claire Francoz, Audrey Coilly, Marie-Noelle Hilleret, Pascal Lebray, Amelie Liou-Schischmanoff, Louise Barbier, Christophe Duvoux, Georges-Philippe Pageaux, Michael Bismuth, Damien Galanaud, Thomas De Broucker, Jean-Francois Cadranel, Vincent Leroy, Vincent Di Martino, Dominique Larrey, Christophe Camus, Olivier Scatton, Victor De Ledinghen, Ariane Mallat, Marika Rudler, Christophe Bureau
Summary: Hepatic encephalopathy (HE) is a frequent and severe complication of liver disease that often goes undiagnosed due to a lack of understanding and consensus on diagnosis. Non-specific symptoms and comorbidities in cirrhotic patients make differential diagnosis challenging. Guidelines are provided to assist clinicians in diagnosing and treating HE. Liver transplantation may be indicated for HE, but its reversibility post-transplantation and the consequences in patients with other neurological disorders remain controversial.
LIVER INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Dalia Rega, Mika Aiko, Nicolas Penaranda, Amparo Urios, Juan-Jose Gallego, Carla Gimenez-Garzo, Franc Casanova, Alessandra Fiorillo, Andrea Cabrera-Pastor, Teresa San-Miguel, Cristina Ipiens, Desamparados Escudero-Garcia, Joan Tosca, Cristina Monton, Maria-Pilar Ballester, Jose Ballester, Luis Aparicio, Maria-Pilar Rios, Lucia Durban, Amparo Mir, Elena Kosenko, Paula Cases, Vicente Felipo, Carmina Montoliu
Summary: Cirrhotic patients with minimal hepatic encephalopathy (MHE) may experience alterations in thermal, vibration, and/or heat pain sensitivity, which are related to cognitive and motor deficits. Studies have found that MHE patients generally exhibit lower sensory abilities and attention deficits compared to cirrhotic patients without MHE, with these alterations appearing early on in the disease process.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Juan Jose Gallego, Alessandra Fiorillo, Franc Casanova-Ferrer, Amparo Urios, Maria-Pilar Ballester, Lucia Durban, Javier Megias, Teresa Rubio, Andrea Cabrera-Pastor, Desamparados Escudero-Garcia, Vicente Felipo, Carmina Montoliu
Summary: Minimal hepatic encephalopathy (MHE) is associated with changes in the immune system, and this study found that plasma extracellular vesicles (EVs) from MHE patients have altered miRNA and protein contents, enriched in inflammatory factors. These EVs can modulate the expression of inflammatory factors in cultured CD4+ T lymphocytes, increasing the proportion and activation of specific cell subtypes. These findings suggest that plasma EVs could play an important role in the immune changes observed in MHE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Jie-Ru Guo, Jia-Yan Shi, Qiu-Yi Dong, Yun-Bin Cao, Dan Li, Hua-Jun Chen
Summary: This study found abnormal neural activity in patients with minimal hepatic encephalopathy (MHE) through the analysis of static amplitude and dynamic amplitude. Dynamic ALFF shows potential in distinguishing MHE patients from non-MHE patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Gastroenterology & Hepatology
Thananya Jinato, Masoumeh Sikaroodi, Andrew Fagan, Richard K. Sterling, Hannah Lee, Puneet Puri, Brian C. Davis, Michael Fuchs, Edith Gavis, Patrick M. Gillevet, Jasmohan S. Bajaj
Summary: This study found linkages between bacteriophages and cognitive function in patients with cirrhosis, indicating a potential influence on bacteria that produce neuroactive metabolites. These findings suggest that bacteriophages could be explored as treatment options for minimal hepatic encephalopathy (MHE) in cirrhosis.
Article
Anatomy & Morphology
Hua-Jun Chen, Xiao-Hong Zhang, Jia-Yan Shi, Shao-Fan Jiang, Yi-Fan Sun, Ling Zhang, Dan Li, Rong Chen
Summary: The study revealed disrupted thalamic structural connections in cirrhotic patients with MHE, which worsened from NHE to MHE and were correlated with neurocognitive performance. The moderate classification accuracy using CS and MD measurements suggests that thalamic connections could serve as potential biomarkers for diagnosing and monitoring MHE. Further research is recommended to explore structural alterations in other white matter pathways in MHE.
FRONTIERS IN NEUROANATOMY
(2021)