Journal
METABOLIC BRAIN DISEASE
Volume 23, Issue 1, Pages 95-104Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11011-007-9074-1
Keywords
apoptosis; necrotic cell death; inhibitor-1; inhibitor-2; okadaic acid; tautomycin
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Funding
- NINDS NIH HHS [R01 NS056315] Funding Source: Medline
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Protein phosphatase-2A (PP-2A) interacts with several regulators of cell death pathways and is therefore a potential component of signaling pathways linking global cerebral ischemia to cell death. Using a novel procedure to quantify PP-2A activity, we find that cardiac arrest with resuscitation and reperfusion leads to activation of PP-2A by 1.6-fold in pig brain extract and by 3.4-fold after partial purification of PP-2A. This is the first demonstration of PP-2A activation in a clinically relevant model of transient global cerebral ischemia. These results suggest that inhibition of PP-2A activity may be neuroprotective in global cerebral ischemia.
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