Article
Clinical Neurology
Elena Toffol, Nea Kalleinen, Sari-Leena Himanen, Timo Partonen, Jari Haukka, Paivi Polo-Kantola
Summary: The study found that melatonin concentrations varied across different sleep stages, and there were differences in the relationship between melatonin and sleep architecture in perimenopausal and postmenopausal women. High melatonin concentrations were associated with better sleep in perimenopausal women, while in postmenopausal women, high melatonin concentrations were associated with worse sleep.
Article
Public, Environmental & Occupational Health
Rose A. Maxwell, Keith M. Reisinger-Kindle, Traci M. Rackett, Jerome L. Yaklic, Stefan A. Czerwinski, Miryoung Lee
Summary: This study compares sleep quality among naturally and surgically post-menopausal women and identifies lifestyle factors that predict sleep quality in pre, peri, and postmenopausal women. The results indicate that there were no significant differences in overall sleep quality among the three reproductive stages, but depression, bodily pain, vitality, and surgical menopause were predictors of sleep quality.
HEALTH SCIENCE REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Janet S. Carpenter, James E. Tisdale, Chen X. Chen, Richard Kovacs, Joseph C. Larson, Katherine A. Guthrie, Kristine E. Ensrud, Katherine M. Newton, Andrea Z. LaCroix
Summary: This study aimed to describe the degree of menopausal palpitation distress and its correlates with demographic, clinical, symptom, and quality-of-life factors. The results showed that menopausal palpitation distress is common among women and is associated with factors such as smoking history, BMI, insomnia, depressive symptoms, perceived stress, and menopausal quality of life. These findings can be used for screening in clinical practice and to justify further research on this understudied symptom.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Geriatrics & Gerontology
Anees Ahmed Syed, Mohammad Irshad Reza, Pragati Singh, Athar Husain, Shailesh Dadge, Jiaur R. Gayen
Summary: This study discovered that the extract of Cissus quadrangularis (EECQ) has adiponectin mimetic activity, which can improve insulin resistance, hyperlipidemia, and obesity in peri-/post-menopausal rats. EECQ also upregulates the expression of adiponectin receptor 1 (AdipoR1) and restores normal insulin sensitivity markers. These findings highlight the importance of EECQ in mitigating insulin resistance in menopausal conditions.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Nutrition & Dietetics
Alexander P. Kanon, Caroline Giezenaar, Nicole C. Roy, Warren C. McNabb, Sharon J. Henare
Summary: This study investigated the acute effects of fresh and dried green kiwifruit on sleep quality, mood, and urinary serotonin and melatonin metabolite concentrations. The results showed that consumption of dried kiwifruit improved morning sleepiness, alertness, and vigor. Both fresh and dried kiwifruit treatments also tended to improve esteem and total mood disturbance. The improvements in sleep quality and mood may be mediated through changes in serotonin metabolism.
FRONTIERS IN NUTRITION
(2023)
Review
Multidisciplinary Sciences
Karan Srisurapanont, Yanisa Samakarn, Boonyasit Kamklong, Phichayakan Siratrairat, Arina Bumiputra, Montita Jaikwang, Manit Srisurapanont
Summary: This study evaluated the efficacy of blue-wavelength light therapy for post-TBI symptoms, finding that it may be useful in reducing depression and fatigue in these patients.
Article
Physiology
Savannah V. Wooten, Uwe Mittag, Jose Ramon Alvero Cruz, Sten Stray-Gundersen, Fabian Hoffmann, Sarah Michely, Stefan Moestl, Wolfram Sies, Edwin Mulder, Philipp Rauschendorfer, Philip D. Chilibeck, Jorn Rittweger, Hirofumi Tanaka
Summary: This study found that the lifestyles of masters athletes contribute to improved general life satisfaction and reduced sleep impairment, but not improved positive affect. These beneficial effects were observed regardless of age, gender, and type of sport.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Clinical Neurology
Xing-Yue Liu, Shu-Zhi Peng, Meng-Yun Pei, Peng Zhang
Summary: This study found that physical activity partially mediated the relationship between depression and quality of life in Chinese perimenopausal women. Suitable prevention methods and interventions for physical activity may improve the quality of life for perimenopausal women.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Laura M. Huiberts, Karin C. H. J. Smolders
Summary: Recent insights into the role of vitamin D in serotonin and melatonin regulation suggest potential benefits for mood and sleep improvement, but studies on healthy individuals have yielded mixed results. Future research should focus on factors such as timing and dosage to better understand the impact of vitamin D on mood and sleep indicators.
SLEEP MEDICINE REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Young-Sang Kim, Yon Chul Park, Ja-Eun Choi, Jae-Min Park, Kunhee Han, Kwangyoon Kim, Bom-Taeck Kim, Kyung-Won Hong
Summary: This study is the first attempt to analyze the genetic risk factors for various metabolic disorders in Korean adults according to sex and age groups. The study identified 101 significant loci associated with 8 metabolic phenotypes, with 15 loci being reported for the first time. The findings suggest that menopausal transition may potentiate the influence of genetic risks on metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
P. Garcia-Alfaro, S. Garcia, I. Rodriguez, C. Verges
Summary: Dry eye disease symptoms are common in perimenopausal and postmenopausal women, particularly more severe in postmenopausal women, affecting quality of life.
Article
Endocrinology & Metabolism
Lingyan Zhang, Xiangyan Ruan, Yamei Cui, Muqing Gu, Alfred O. Mueck
Summary: The study found that urogenital symptoms are common complaints among middle-aged Chinese women, often combined with sexual dysfunction. Postmenopausal women experience more prevalent and severe menopausal symptoms. Contrary to Western countries, vasomotor symptoms are rare among the Chinese population in this study.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Review
Multidisciplinary Sciences
Nicole Philippens, Ester Janssen, Stef Kremers, Rik Crutzen
Summary: This umbrella review provides a comprehensive overview of determinants of natural adult sleep, including biological, behavioral, environmental, and personal/socio-economic factors. Each determinant has a different impact on sleep and is influenced by both generic and specific moderators.
Article
Dermatology
Miaolan Guo, Jing Su, Shaoyan Zheng, Baixin Chen
Summary: This study analyzed 7 studies and found that objective sleep quality is worse in patients with atopic dermatitis (AD), characterized by decreased total sleep time, decreased sleep efficiency, prolonged wake time after sleep onset, and delayed rapid eye movement sleep. Furthermore, sleep problems are more severe in patients with severe AD, males, and adults.
Article
Obstetrics & Gynecology
Janet S. Carpenter, Rileigh Fagan, Mofareh A. Alzahrani, Heather A. Jaynes, James E. Tisdale, Richard J. Kovacs, Chen X. Chen, Claire B. Draucker
Summary: This study advances the understanding of how women describe their palpitations and related healthcare experiences. The findings could have important implications for developing research and clinical tools to guide assessment, communication, and education for patients and providers about palpitations, as well as for developing and testing behavioral interventions to address this poorly understood symptom in peri- and postmenopausal women.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Psychiatry
Raimo Palmu, Seppo Koskinen, Timo Partonen
Summary: Higher scores on the GHQ-12 are associated with an increased likelihood of suicidal ideation and suicide attempts. Specifically, item 6 and item 11 are associated with both suicidal ideation and suicide attempts, while item 7 is only associated with suicide attempts.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Anna Haukka, Minna Kaila, Jari Haukka, Anna M. Heikkinen
Summary: This study investigated whether adults attend oral health examinations based on their individual recall intervals (IRI) and found that many adults do not undergo follow-up examinations on time or delay them. Having an emergency appointment and a longer IRI were associated with a higher likelihood of not participating in the examinations. The results highlight the need to increase awareness among adults about the benefits and availability of follow-up oral health examinations based on their IRI.
CLINICAL AND EXPERIMENTAL DENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Konsta Teppo, K. E. Juhani Airaksinen, Olli Halminen, Miika Linna, Jussi Jaakkola, Jari Haukka, Jukka Putaala, Pirjo Mustonen, Ville L. Langen, Janne Kinnunen, Juha Hartikainen, Mika Lehto
Summary: Oral anticoagulants, especially direct oral anticoagulants (DOACs), are associated with a significantly lower risk of admission to long-term care in patients with atrial fibrillation. Increasing the coverage of guideline-based oral anticoagulant therapy can help prevent the need for long-term care, extend time spent at home, and potentially reduce healthcare costs.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Valtteri Muroke, Mikko Jalanko, Jari Haukka, Tommi Patila, Juha Hartikainen, Anna Tahvanainen, Heikki Ukkonen, Kari Ylitalo, Vesa Anttila, Jaana Pihkala, Juha Sinisalo
Summary: This study aimed to determine whether simple atrial septal defect (ASD) is an independent risk factor for infective endocarditis (IE). The results showed that patients with ASD have a higher risk of developing IE compared to the control group, and the mortality rate associated with IE is also higher in ASD patients.
SCANDINAVIAN CARDIOVASCULAR JOURNAL
(2023)
Editorial Material
Clinical Neurology
Timo Partonen
Article
Cardiac & Cardiovascular Systems
Konsta Teppo, K. E. Juhani Airaksinen, Fausto Biancari, Jussi Jaakkola, Olli Halminen, Miika Linna, Jari Haukka, Jukka Putaala, Pirjo Mustonen, Janne Kinnunen, Alex Luojus, Juha Hartikainen, Aapo L. Aro, Mika Lehto
Summary: This study aimed to assess the impact of aortic stenosis (AS) on outcomes in patients with atrial fibrillation (AF) and estimate the effects of direct oral anticoagulants (DOACs) versus warfarin in these patients. The results showed that patients with AS had a higher incidence rate compared to those without AS, and AS was associated with an increased risk of bleeding and death, but not with intracranial bleeding or ischemic stroke. Among patients with AS, DOACs were found to be more effective in preventing ischemic stroke compared to warfarin.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Konsta Teppo, K. E. Juhani Airaksinen, Jussi Jaakkola, Olli Halminen, Birgitta Salmela, Ksenia Kalatsova, Elis Kouki, Jari Haukka, Jukka Putaala, Miika Linna, Aapo L. Aro, Pirjo Mustonen, Juha Hartikainen, Mika Lehto
Summary: This study investigated sex-specific temporal trends in the initiation of oral anticoagulant therapy among patients diagnosed with atrial fibrillation in Finland between 2007 and 2018. The study found that although female sex was initially associated with a lower initiation of OAC therapy, the gender disparities resolved over the course of the study period.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Psychiatry
Raimo Palmu, Timo Partonen
Summary: Suicide prevention requires measures and understanding the role of adverse childhood experiences can help elucidate the suicide process and identify suicide risk.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Timo Partonen, Elena Toffol, Antti Latvala, Oskari Heikinheimo, Jari Haukka
Summary: Limited evidence suggests that the use of hormonal contraception may be associated with insomnia. A nationwide study of women aged 15-49 found significant associations between hormonal contraception use and insomnia. Specific products, such as drospirenone and ethinylestradiol, were associated with decreased odds of insomnia, while levonorgestrel-releasing intrauterine devices and vaginal rings with etonogestrel and ethinylestradiol were associated with increased odds of insomnia.
Article
Medicine, General & Internal
Tuukka Antero Helin, Pekka Raatikainen, Mika Lehto, Jari Haukka, Riitta Lassila
Summary: This study investigated the association between laboratory testing results and bleeding and stroke/transient ischaemic attack (TIA) outcomes in patients with atrial fibrillation treated with warfarin. The study found that lower haemoglobin levels were associated with bleeding, while slightly lower INR levels were associated with stroke/TIA. Repeatedly low haemoglobin values indicated suboptimal management and increased complication risk in anticoagulated patients.
Article
Family Studies
Janina Bosas, Elena Toffol, Elina Pohjoranta, Maarit J. Mentula, Ritva Hurskainen, Satu Suhonen, Oskari Heikinheimo
Summary: Sexual well-being is closely associated with general well-being, with lower anxiety levels and higher quality of life contributing to stable and higher levels of sexual well-being in fertile-aged women. The method of contraception or relationship status did not have a significant impact on sexual well-being during long-term follow-up.
BMJ SEXUAL & REPRODUCTIVE HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Raimo Palmu, Timo Partonen
Summary: This study found that cynical hostility and sense of coherence are related to suicidal thoughts. Cynical hostility increases the occurrence of suicidal thoughts, while sense of coherence can protect individuals from such thoughts.
HEALTH SCIENCE REPORTS
(2023)
Article
Clinical Neurology
Paeivi Polo-Kantola, Elena Toffol
SLEEP MEDICINE CLINICS
(2023)
