Article
Medicine, General & Internal
Ana Bontic, Selena Gajic, Danka Bjelic, Jelena Pavlovic, Verica Stankovic-Popovic, Milan Radovic, Aleksandra Kezic
Summary: This study investigated the relationship between baseline peritoneal albumin and protein loss and transport status, comorbidities including DM, and survival in PD patients. The results showed no significant differences in protein and albumin loss between diabetics and non-diabetics. In non-diabetics, high transporters had higher protein and albumin loss compared to slow transporters, but this association was not observed in diabetics. Peritoneal protein and albumin loss were not associated with DM and did not predict survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Aayushi Balda, Irshad Wani, Tamsheel Fatima Roohi, Suman, K. L. Krishna, Seema Mehdi, Abhishek P. R. Nadiga, Manasa Makkapati, Awaise Iqbal Baig
Summary: Psoriasis, a chronic auto-immune-mediated disease, is associated with a significant risk of malignancies, especially skin tumors. This review examines the relationship between psoriasis and cancer risk, discusses the significance of inflammation in cancer, and explores the various classes of drugs used to treat psoriasis and how they increase the risk of cancer. The review also discusses possible mechanisms associated with inflammation and psoriasis, as well as the risk of cancer in other cutaneous auto-inflammatory diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Enric Sanchez, Marta Sanchez, Carolina Lopez-Cano, Marcelino Bermudez-Lopez, Jose Manuel Valdivielso, Cristina Farras-Salles, Reinald Pamplona, Gerard Torres, Didac Mauricio, Eva Castro, Elvira Fernandez, Albert Lecube
Summary: This study assessed the impact of obesity on the accumulation of advanced glycation end-products (AGEs) and found that AGE levels were associated with abdominal adiposity but not total body fat. Furthermore, elevated AGE levels were related to cardiovascular risk factors.
Review
Medicine, General & Internal
Alessandro Ferretti, Mattia Gatto, Margherita Velardi, Giovanni Di Nardo, Thomas Foiadelli, Gianluca Terrin, Manuela Cecili, Umberto Raucci, Massimiliano Valeriani, Pasquale Parisi
Summary: The relationship between migraines and allergies is still not well understood, although there is an epidemiological link between them. Genetic and biological factors contribute to both migraines and allergic disorders. The histaminergic system, particularly the H3 and H4 receptors, may play a role in the pathophysiology of both conditions. Antihistamine drugs could potentially be helpful in treating migraines and allergic disorders. Further research is needed to fully understand the mechanistic link between these two common and debilitating conditions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Daisy Vedder, Martijn Gerritsen, Joost C. M. Meijers, Michael T. Nurmohamed
Summary: This study aimed to investigate the coagulation system in gout patients and its association with disease activity. The results showed that patients with active gout had higher levels of thrombin generation markers, indicating a link between disease activity and coagulation. However, changes in disease activity after 1 year were not associated with significant changes in coagulation markers.
CLINICAL RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Raymond E. E. Garrett, Carlos H. H. Palacio, David Bar-Or
Summary: Metabolic causes and renal tubular injury are potential factors contributing to Long COVID symptoms. In this study, we propose three mechanisms including creatine phosphate metabolism, un-reclaimed glomerular filtrate, and injury to COVID-specific proximal tubule cells, which may play a major role in Long COVID. This research aims to improve diagnostics and therapy for long-haul sufferers.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Emilia Sawicka-Smiarowska, Anna Moniuszko-Malinowska, Karol Adam Kaminski
Summary: Cardiovascular diseases are the leading causes of hospitalization, death, and disability in Europe, resulting in significant social and economic costs. Recent studies have suggested a potential link between the human microbiota, particularly those in the digestive system, and the development of cardiovascular diseases through their impact on metabolic homeostasis and immune processes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Giuseppe Murdaca, Alessandra Gerosa, Francesca Paladin, Lorena Petrocchi, Sara Banchero, Sebastiano Gangemi
Summary: The importance of both the microbiome and vitamin D in health and disease is increasingly recognized. Microbiome studies have shown unique patterns in autoimmune diseases and dysbiosis is associated with allergies. Vitamin D deficiency affects the microbiome and immune system, highlighting the need for further research in allergic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Melissa E. Chambers, Madushka Y. De Zoysa, Afshan B. Hameed
Summary: Maternal mortality in the United States has been increasing due to cardiovascular disease (CVD) and the lack of recognition and delayed diagnosis. Risk factors such as race, age, hypertension, diabetes, and obesity play a significant role in CVD-related deaths. Universal CVD screening is proposed to identify at-risk women and provide education.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Endocrinology & Metabolism
C. Indolfi, A. Klain, G. Di Nardo, C. Cuppari, A. Ceravolo, D. Concolino, R. De Sarro, A. Salpietro, F. Decimo, M. Miraglia del Giudice
Summary: This article discusses the strong link between asthma and infections, as well as the potential mechanisms for translating these infections into asthma.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Environmental Sciences
Yueqiu Yu, Xiang Lin, Feiyang Feng, Yuanyun Wei, Shuang Wei, Yaqi Gong, Caimao Guo, Qingyu Wang, Peimeng Shuai, Tiantian Wang, Hui Qin, Guoqing Li, Lan Yi
Summary: Observational findings show that ionizing radiation (IR) can disrupt the gut microbiota, leading to changes in its structure, function, and species, as well as its metabolites. These changes can worsen IR-induced damage and aggravate inflammatory responses. On the other hand, commensal bacteria and beneficial metabolites can restore the disrupted gut microbial structure, promote a balance between anti-inflammatory and proinflammatory mechanisms, and reduce IR toxicity. Given the increasing threats of radiation toxicity from recent radiological disasters and medical exposures, it is crucial to discover effective and safe remedies for preventing and treating radiation-induced injuries. This review examines the relationship between the gut microbiota and IR-induced harm, highlights protective measures through gut microbe interventions, and proposes prospects for future research in preventing and treating IR-induced damage.
ENVIRONMENTAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Borden A. Emily, Furey Matthew, Gattone J. Nicholas, Hambardikar D. Vedangi, Liang Xiao Hua, Scoma R. Ernest, Abou Samra Antonella, D-Gary R. Lakeshia, Dennis J. Dayshaun, Fricker Daniel, Garcia Cindy, Jiang ZeCheng, Khan A. Shariq, Kumarasamy Dheenadhayalan, Kuppala Hasmitha, Ringrose Savannah, Rosenheim J. Evan, Van Exel Kimberly, Vudhayagiri Hemanth Sai, Zhang Jiarui, Zhang Zhaowen, Guitart-Mampel Mariona, Urquiza Pedro, Solesio E. Maria
Summary: Mitochondrial dysfunction is a common feature in neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease, with inorganic polyphosphate (polyP) potentially being a promising pharmacological target against these conditions. Further research is needed to fully understand the role of polyP in neurodegeneration and its effects on cellular and mitochondrial physiology.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Clinical Neurology
Rabia Bouali-Benazzouz, Abdelhamid Benazzouz
Summary: SARS-CoV-2 has the potential to worsen symptoms of Parkinson's disease and increase mortality rates in patients, as it can enter the brain and trigger cellular processes involved in neurodegeneration.
MOVEMENT DISORDERS
(2021)
Review
Nutrition & Dietetics
Shengjie Zhu, Prasanth Surampudi, Nancy T. Field, Maria Chondronikola
Summary: Hyperglycemia during pregnancy and gestational diabetes mellitus pose health risks for both mothers and offspring. Studies suggest that meal timing and nutrient distribution can impact glycemic control during pregnancy, with early food consumption and short-term fasting showing potential benefits. However, further research is needed to fully understand the effects and mechanisms involved in this relationship.
Article
Public, Environmental & Occupational Health
Iman Dadgar, Thor Norstrom
Summary: The study found that an increase in unemployment is significantly associated with a decrease in all-cause mortality, while GDP growth is associated with reduced long-term mortality rates.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2022)
