4.2 Article

Ionic liquids-assisted synthesis of 3,4-dihydroisoquinolines by the Bishler-Napieralski reaction

Journal

MENDELEEV COMMUNICATIONS
Volume 22, Issue 5, Pages 267-269

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.mencom.2012.09.014

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Funding

  1. Merck KGaA
  2. Russian Academy of Sciences

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The Bishler-Napieralski cyclodehydration of N-acyl-2-arylethylamines into the corresponding 3,4-dihydroisoquinolines with POCl3 as a dehydration reagent proceeds in ionic liquids under milder conditions and in higher yields.

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