Review
Immunology
Ali Masjedi, Farnaz Hajizadeh, Farzaneh Beigi Dargani, Behzad Beyzai, Mohsen Aksoun, Mohammad Hojjat-Farsangi, Angelina Zekiy, Farhad Jadidi-Niaragh
Summary: Oncostatin M (OSM), a member of the Interleukin-6 family cytokines, plays a significant role in inflammation, autoimmunity, and cancers. It can act as both an anti-cancer agent and a promoter of cancer progression, with its downstream signaling molecule STAT3 influencing key aspects of cancer cell behavior.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Samir Andrade Mendonca, Fernanda Antunes, Otto L. D. Cerqueira, Paulo Roberto Del Valle, Aline Hunger, Percillia V. S. de Oliveira, Barbara Brito, Eugenia Costanzi-Strauss, Bryan E. Strauss
Summary: This study explores oncolysis induced by nonreplicating adenoviral vectors used for p14(ARF) and interferon-beta (hIFN beta) gene transfer in human melanoma cell lines, and reveals an unexpected role for p14(ARF) in promoting cellular responses predictive of immune stimulation.
DNA AND CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daenique H. A. Jengelley, Meijing Wang, Ashok Narasimhan, Joseph E. Rupert, Andrew R. Young, Xiaoling Zhong, Daniel J. Horan, Alexander G. Robling, Leonidas G. Koniaris, Teresa A. Zimmers
Summary: Musculoskeletal diseases can harm overall health and survival, with the Interleukin-6 family of cytokines, particularly IL-6, playing a role. Oncostatin M (OSM) has negative effects on muscle, bone, and the heart, causing muscle atrophy, bone loss, and cardiac dysfunction.
Review
Pharmacology & Pharmacy
Davor Nestic, Ksenija Bozinovic, Isabela Pehar, Rebecca Wallace, Alan L. Parker, Dragomira Majhen
Summary: Adenoviruses have versatile therapeutic applications, from gene therapy to cancer treatment. Understanding the factors involved in adenovirus cell binding, entry, and trafficking, and how these factors can be manipulated to enhance the efficacy of adenovirus-based vectors, is crucial for optimizing gene therapy and vaccine development.
Article
Oncology
Kenneth N. Barton, Farzan Siddiqui, Robert Pompa, Svend O. Freytag, Gazala Khan, Irina Dobrosotskaya, Munther Ajlouni, Yingshu Zhang, Jingfang Cheng, Benjamin Movsas, David Kwon
Summary: The study evaluated the safety and efficacy of oncolytic adenovirus-mediated suicide and IL-12 gene therapy for metastatic pancreatic cancer patients. The results indicated immune system activation in patients after treatment and a median survival of 18.1 months for patients in the third cohort.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Virology
Lili Deng, Xue Yang, Yuedi Ding, Jun Fan, Ying Peng, Dong Xu, Biao Huang, Zhigang Hu
Summary: In this study, a recombinant vaccinia virus, VG9-IL-24, was constructed, which selectively infected hepatocellular carcinoma cells and induced apoptosis, showing promising antitumor effects. Additionally, VG9-IL-24 blocked the cell cycle progression and suppressed tumor growth.
Review
Biochemistry & Molecular Biology
Otto Luiz Dutra Cerqueira, Fernanda Antunes, Nadine G. Assis, Elaine C. Cardoso, Maria A. Clavijo-Salomon, Ana C. Domingues, Nayara G. Tessarollo, Bryan E. Strauss
Summary: Melanoma, the deadliest type of skin cancer, has been on the rise worldwide. Its high mutation rate leads to the presence of tumor specific antigens and increased immune cell infiltration. Immune checkpoint inhibitors and viral oncolysis are promising approaches for melanoma treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Gastroenterology & Hepatology
Hongyu Xiang, Chang Liu, Zhuanglong Xiao, Li Du, Ning Wei, Fang Liu, Yuhu Song
Summary: This study retrospectively analyzed the prognosis of patients with PAs-induced HSOS who received anticoagulation therapy, and confirmed the efficacy of low molecular weight heparin (LMWH) in animal models. Additionally, the underlying mechanism of enoxaparin in improving liver injury was explored.
LIVER INTERNATIONAL
(2023)
Article
Chemistry, Physical
Yao Huang, Tingting Peng, Yangyan Chen, Fapeng Zhang, Wanshan Hu, XinYi Gao, Hongyu Chen, Ping Tang, Chuanbin Wu, Xin Pan
Summary: This study developed an oxygen reservoir-irrigated photodynamic therapy (PDT) that integrates oxygen supply, oxygen economizing, and oxygen infiltration. By modulating tumor oxygenation and permeability, it achieves complete eradication of primary melanoma and stimulates immunogenic cell death.
Article
Chemistry, Physical
Yao Huang, Tingting Peng, Yangyan Chen, Fapeng Zhang, Wanshan Hu, XinYi Gao, Hongyu Chen, Ping Tang, Chuanbin Wu, Xin Pan
Summary: An oxygen reservoir-irrigated photodynamic therapy has been developed to improve the efficacy of tumor treatment by considering oxygen supply, economizing, and infiltration. This therapy effectively reduces tumor hypoxia, promotes immunogenic cell death, and enhances the antitumor effects when combined with checkpoint-blockade inhibitors.
Review
Environmental Sciences
Salman Ahmed, Waqas Alam, Khalaf F. Alsharif, Michael Aschner, Fuad M. Alzahrani, Luciano Saso, Haroon Khan
Summary: Malignant melanoma, a dangerous type of skin cancer, is becoming more common and resistant to treatment. Natural substances, particularly marine peptides, are being researched as alternative and safe treatments for melanoma.
ENVIRONMENTAL RESEARCH
(2023)
Review
Chemistry, Medicinal
Dulce Mata-Espinosa, Jacqueline V. Lara-Espinosa, Jorge Barrios-Payan, Rogelio Hernandez-Pando
Summary: This study reviews the model strategies for gene therapy and new vaccines in the treatment of tuberculosis, suggesting that it is a potential alternative therapy for active TB, as well as for the prevention and treatment of latent TB reactivation and transmission of Mtb.
Article
Oncology
Fernanda Costa Svedman, Ishani Das, Rainer Tuominen, Eva Darai Ramqvist, Veronica Hoiom, Suzanne Egyhazi Brage
Summary: The introduction of targeted therapies and immunotherapies has greatly improved the clinical outcomes for patients with advanced cutaneous melanoma. However, only a subset of patients benefit from these treatments in the long term. This study aims to identify gene signatures that can predict the treatment outcomes in melanoma patients. The findings suggest that up-regulation of immune-related genes is associated with better outcomes in targeted therapy, while down-regulation of proliferation and up-regulation of allograft rejection genes favor patients treated with immune checkpoint inhibitors.
Review
Cell Biology
Chia-Hsin Hsu, Keng-Jung Lee, Yi-Han Chiu, Kuo-Ching Huang, Guo-Shou Wang, Lei-Po Chen, Kuang-Wen Liao, Chen-Si Lin
Summary: Lysosomes play a crucial role in the pathogenesis and progression of melanoma, and understanding their function is critical for improving treatment outcomes for melanoma patients.
Article
Biochemistry & Molecular Biology
T. Komel, M. Bosnjak, S. Kranjc Brezar, M. De Robertis, M. Mastrodonato, G. Scillitani, G. Pesole, E. Signori, G. Sersa, M. Cemazar
Summary: The study demonstrated the high antitumor efficacy of combined IL-2 and IL-12 gene electrotransfer protocols in low-immunogenicity murine B16.F10 melanoma, resulting in significant tumor growth delay and 71% complete tumor regression through the activation of immune cells and inflammatory signals.
BIOELECTROCHEMISTRY
(2021)