Article
Oncology
Lan Huang, Guisi Chen, Ying Chen, Wanwen Wu, Changli Tao, Hongwei Shao, Shulin Huang, Han Shen
Summary: Tumor immunotherapy targeting tumor-associated antigens and the impact of GM-CSF and CCL17 on tumor immunity have been widely studied. Combining survivin-specific CTL with CCL17 and GM-CSF genes can inhibit tumor growth more effectively through stable cell lines expressing these genes.
Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Medicine, Research & Experimental
Tomoyuki Hioki, Haruhiko Tokuda, Gen Kuroyanagi, Woo Kim, Junko Tachi, Rie Matsushima-Nishiwaki, Hiroki Iida, Osamu Kozawa
Summary: The study revealed that olive oil polyphenols, hydroxytyrosol and oleuropein, attenuated the synthesis of M-CSF and IL-6 in osteoblasts by inhibiting TNF-α signaling through Akt and p44/p42 MAP kinase pathways. These polyphenols did not significantly affect cell viability.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Gustavo de Souza Vieira, Talita de Carvalho Kimura, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Mayara Trevizol Goncalves, Ingrid Iara Damas, Tayna Figueiredo-Maciel, Raisa Sales de Sa, Iara Goncalves Aquino, Joao Paulo Goncalves de Paiva, Patricia Maria Fernandes, Moises Willian Aparecido Goncalves, Luiz Paulo Kowalski, Albina Altemani, Gary Chris Fillmore, Fernanda Viviane Mariano, Erika Said Abu Egal
Summary: This article provides an in-depth review of the role of hematopoietic cytokines in the tumor microenvironment of head and neck cancers, and summarizes the current clinical trials and findings on the therapeutic application of these cytokines.
Article
Fisheries
Muhammad Riadul Haque Hossainey, Amulya Yaparla, Zarafsha Uzzaman, Tyler Moore, Leon Grayfer
Summary: Comparisons between tadpole and frog immune cells reveal cytological and transcriptional differences, suggesting distinct roles in host defense and pathogen infection for different developmental stages.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Virology
Sarah Stonedahl, J. Smith Leser, Penny Clarke, Huntington Potter, Timothy D. D. Boyd, Kenneth L. L. Tyler
Summary: West Nile virus (WNV) is the main cause of epidemic arboviral encephalitis in the United States. Depleting microglia in WNV-infected mice enhances viral replication and tissue injury, while augmenting microglial activation through GM-CSF administration reduces viral titers and apoptotic activity and increases survival. Stimulation of microglial activation may be a viable therapeutic approach for WNV neuroinvasive disease.
JOURNAL OF VIROLOGY
(2023)
Article
Cell Biology
Lina Wu, Lu Wang, Xin Chai
Summary: This study aims to understand the role of granulocyte-macrophage-colony-stimulating factor (GM-CSF)-producing T helper (ThGM) cells in the pathophysiology of mouse experimental autoimmune uveitis (EAU). The study found that ThGM cells were present in the spleen and the eye after EAU induction, and they had an impact on the severity of EAU.
CELLULAR IMMUNOLOGY
(2023)
Article
Immunology
An-ran Xi, Yi-jun Luo, Jin-Tao Guan, Wei-Jie Wang, Zheng-Hao Xu
Summary: This study analyzed the efficacy and safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in COVID-19 patients. The results showed that GM-CSF antibody treatment can reduce the incidence of invasive mechanical ventilation and have slight but not significant effects on mortality and ventilation improvement. Sensitivity analysis revealed statistically significant results for mortality and ventilation improvement rate when one study was excluded. Furthermore, GM-CSF antibodies did not increase the risks of secondary infection and adverse events.
INFLAMMOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Slawomir Lewicki, Monika Lesniak, Agnieszka Sobolewska-Ruta, Aneta Lewicka, Marta Grodzik, Eugeniusz K. Machaj, Marek Saracyn, Jacek Z. Kubiak, Zygmunt Pojda
Summary: Encapsulation of cytokines in liposomes is an efficient method to deliver cytokines to cells at working concentrations without affecting cell morphology or proliferation. This method has great potential and important applications in tissue regeneration and other fields.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Gabriela Lopes Santos, Kellen Cristine Tjioe, Marco Antonio de Oliveira Magalhaes, Denise Tostes Oliveira
Summary: This study reviewed the molecular mechanisms and biological roles of granulocyte-macrophage colony-stimulating factor (GM-CSF) in head and neck squamous cell carcinoma, highlighting its potential clinical applications. The specific roles of GM-CSF in head and neck cancer are limited, with conflicting findings observed when studied alone. GM-CSF has been shown to induce angiogenesis and local tumor invasion, but it is also implicated in immune evasion. The potential of GM-CSF as adjuvant therapy in head and neck cancer needs further investigation.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Infectious Diseases
Jiaying Zhang, Jingxia Wang, Yiwen Gong, Yudan Gu, Qiangqiang Xiang, Ling-Ling Tang
Summary: This study found that IL-6 and G-CSF levels were strongly correlated with poor prognosis and severity of influenza-associated pneumonia. These cytokines can serve as important predictors for evaluating the prognosis and severity of pneumonia in influenza patients.
BMC INFECTIOUS DISEASES
(2022)
Article
Pharmacology & Pharmacy
Jin-Tao Guan, Wei-Jie Wang, Du Jin, Xiao-Yue Mou, Shan-Shan Lei, Zheng-Hao Xu
Summary: This meta-analysis showed that GM-CSF antibody treatment in COVID-19 patients could reduce the risk of death and increase ventilation, without significantly increasing the risk of secondary infection or ICU admission. Older age and length of stay may have an impact on these outcomes.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Fengqin Lin, Hongbo Yu, Li Zhang, Jing Zhou, Yuan Cao, Songli Wu, Junjie Wang
Summary: ThGM cells play a role in the pathogenesis of endometriosis, and IL-35 may alleviate the inflammation of endometriosis by suppressing the function of ThGM cells.
MOLECULAR IMMUNOLOGY
(2023)
Article
Immunology
Peilin Chen, Chunyu Huang, Qing Sun, Huixian Zhong, Feng Xiong, Su Liu, Zhihong Yao, Zhiqiang Liu, Caiyun Wan, Yong Zeng, Lianghui Diao
Summary: This study investigated the concentration of GM-CSF in human single-blastocyst conditioned medium (SBCM) and its association with embryo quality and pregnancy outcome. GM-CSF was found to be a potential biomarker for predicting pregnancy outcome and selecting embryos with high developmental potential for transfer in assisted reproductive technology (ART).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Kei Tamura, Kumiko Ishigaki, Keigo Iizuka, Takahiro Nagumo, Orie Yoshida, Kazushi Asano
Summary: This study describes the clinical features and cytokine profiles of canine lung adenocarcinoma with neutrophilic leucocytosis. Elevated levels of G-CSF and IL6 in pulmonary adenocarcinoma in dogs may indicate a guarded prognosis. Further investigations are needed to clarify the prognosis of canine cytokine-producing lung adenocarcinoma.
VETERINARY MEDICINE AND SCIENCE
(2022)