Review
Oncology
Claus Garbe, Teresa Amaral, Ketty Peris, Axel Hauschild, Petr Arenberger, Nicole Basset-Seguin, Lars Bastholt, Veronique Bataille, Veronique Del Marmol, Brigitte Dreno, Maria C. Fargnoli, Ana-Maria Forsea, Jean-Jacques Grob, Christoph Holler, Roland Kaufmann, Nicole Kelleners-Smeets, Aimilios Lallas, Celeste Lebbe, Bohdan Lytvynenko, Josep Malvehy, David Moreno-Ramirez, Paul Nathan, Giovanni Pellacani, Philippe Saiag, Alexander J. Stratigos, Alexander C. J. Van Akkooi, Ricardo Vieira, Iris Zalaudek, Paul Lorigan
Summary: A unique collaboration of multidisciplinary experts has provided recommendations on diagnosis and treatment of cutaneous melanoma. The recommendations cover excision of melanomas, sentinel lymph node dissection, and systemic treatments.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Oncology
Marie-Lea Gauci, Cynthia Aristei, Jurgen C. Becker, Astrid Blom, Veronique Bataille, Brigitte Dreno, Veronique Del Marmol, Ana M. Forsea, Maria C. Fargnoli, Jean-Jacques Grob, Fabio Gomes, Axel Hauschild, Christoph Hoeller, Catherine Harwood, Nicole Kelleners-Smeets, Roland Kaufmann, Aimilios Lallas, Josep Malvehy, David Moreno-Ramirez, Ketty Peris, Giovanni Pellacani, Philippe Saiag, Alexander J. Stratigos, Ricardo Vieira, Iris Zalaudek, Alexander C. J. van Akkooi, Paul Lorigan, Claus Garbe, Celeste Lebbe
Summary: Merkel cell carcinoma is a rare and aggressive skin cancer with distinct molecular subtypes. Risk factors include age, UV exposure, and immunosuppression. Diagnosis is confirmed through histopathology and immunohistochemistry. Treatment options include surgery, radiation therapy, and immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Immunology
Prasad T. Oommen, Timmy Strauss, Karen Baltruschat, Ivan Foeldvari, Christoph Deuter, Gerd Ganser, Johannes-Peter Haas, Claas Hinze, Dirk Holzinger, Anton Hospach, Hans-Iko Huppertz, Arnold Illhardt, Michael Jung, Tilmann Kallinich, Ariane Klein, Kirsten Minden, Kirsten Monkemoller, Sonja Mrusek, Ulrich Neudorf, Gregor Dueckers, Tim Niehues, Matthias Schneider, Philipp Schoof, Angelika Thon, Michael Wachowsky, Norbert Wagner, Susanne Bloedt, Michael Hofer, Klaus Tenbrock, Catharina Schuetz
Summary: This article summarizes the recent update of the interdisciplinary, consensus-based German guidelines on the management of juvenile idiopathic arthritis (JIA). Through multi-disciplinary and consensus participation, therapeutic principles and recommendations were proposed, providing physicians with evidence-based tailored treatment approaches.
CLINICAL IMMUNOLOGY
(2022)
Review
Oncology
Xiang-Lin Tan, Amy Le, Fred C. Lam, Emilie Scherrer, Robert G. Kerr, Anthony C. Lau, Jiali Han, Ruixuan Jiang, Scott J. Diede, Irene M. Shui
Summary: This study reviewed global consensus treatment guidelines and found that the combination of immunotherapy or targeted therapy with stereotactic radiosurgery can improve progression-free survival and overall survival in patients with melanoma brain metastases.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tobias Johannes Dietrich, Andoni Paul Toms, Luis Cerezal, Patrick Omoumi, Robert Downey Boutin, Jan Fritz, Rainer Schmitt, Maryam Shahabpour, Fabio Becce, Anne Cotten, Alain Blum, Marco Zanetti, Eva Llopis, Maciej Bien, Radhesh Krishna Lalam, P. Diana Afonso, Vasco V. Mascarenhas, Reto Sutter, James Teh, Grzegorz Pracon, Milko C. de Jonge, Jean-Luc Drape, Marc Mespreuve, Alberto Bazzocchi, Guillaume Bierry, Danoob Dalili, Marc Garcia-Elias, Andrea Atzei, Gregory Ian Bain, Christophe L. Mathoulin, Francisco del Pinal, Luc Van Overstraeten, Robert M. Szabo, Emmanuel J. Camus, Riccardo Luchetti, Adrian Julian Chojnowski, Jorg G. Grunert, Piotr Czarnecki, Fernando Corella, Ladislav Nagy, Michiro Yamamoto, Igor O. Golubev, Jorg van Schoonhoven, Florian Goehtz, Maciej Klich, Iwona Sudol-Szopinska
Summary: This study used the Delphi technique to reach expert consensus on imaging of scapholunate joint instability, suggesting standardized radiographs, radiographic stress views, dynamic fluoroscopy, MR arthrography, and CT arthrography as the most useful and accurate imaging techniques for the work-up of SLJ instability. The study found that dorsopalmar and lateral radiographs, radiographic stress views, dynamic fluoroscopy, MR arthrography, and CT arthrography are essential for the accurate diagnosis of SLJ instability.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Katharina C. C. Kaehler, S. Huening, D. Nashan, F. Meiss, D. A. Rafei-Shamsabadi, H. Rissmann, C. Colapietro, E. Livingstone, L. V. Maul, M. Heppt, J. C. Hassel, R. Gutzmer, C. Loquai, L. Heinzerling, M. M. Sachse, A. S. Bohne, L. Moysig, W. Peters, J. Rusch, C. Blome
Summary: This study investigated the attitudes and preferences of melanoma patients towards adjuvant treatment with immune checkpoint inhibitors and targeted therapy, and found that patients had a clear preference for targeted therapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Claus Garbe, Teresa Amaral, Ketty Peris, Axel Hauschild, Petr Arenberger, Nicole Basset-Seguin, Lars Bastholt, Veronique Bataille, Veronique Del Marmol, Brigitte Dreno, Maria C. Fargnoli, Ana-Maria Forsea, Jean-Jacques Grob, Christoph Holler, Roland Kaufmann, Nicole Kelleners-Smeets, Aimilios Lallas, Celeste Lebbe, Bohdan Lytvynenko, Josep Malvehy, David Moreno-Ramirez, Paul Nathan, Giovanni Pellacani, Philippe Saiag, Alexander J. Stratigos, Alexander C. J. Van Akkooi, Ricardo Vieira, Iris Zalaudek, Paul Lorigan
Summary: This study provides recommendations for the diagnosis and treatment of cutaneous melanoma (CM) based on systematic literature reviews and the experts' experience. The study emphasizes the importance of clinical and dermatoscopic examination for the diagnosis of melanoma, followed by histopathological confirmation. Imaging diagnostics such as sequential digital dermatoscopy and full body photography are suggested for high-risk patients to improve early melanoma detection. The study also provides guidelines for classification, staging, and follow-up schemes, as well as the use of imaging examinations in different stages.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Luis Cerezal, Francisco del Pinal, Andrea Atzei, Rainer Schmitt, Fabio Becce, Maciej Klich, Maciej Bien, Milko C. de Jonge, James Teh, Robert Downey Boutin, Andoni Paul Toms, Patrick Omoumi, Jan Fritz, Alberto Bazzocchi, Maryam Shahabpour, Marco Zanetti, Eva Llopis, Alain Blum, Radhesh Krishna Lalam, Sutter Reto, P. Diana Afonso, Vasco V. Mascarenhas, Anne Cotten, Jean-Luc Drape, Guillaume Bierry, Grzegorz Pracon, Danoob Dalili, Marc Mespreuve, Marc Garcia-Elias, Gregory Ian Bain, Christophe L. Mathoulin, Luc Van Overstraeten, Robert M. Szabo, Emmanuel J. Camus, Riccardo Luchetti, Adrian Julian Chojnowski, Joerg G. Gruenert, Piotr Czarnecki, Fernando Corella, Ladislav Nagy, Michiro Yamamoto, Igor O. Golubev, Joerg van Schoonhoven, Florian Goehtz, Iwona Sudol-Szopinska, Tobias Johannes Dietrich
Summary: The objective of this study was to establish evidence-based consensus statements on imaging of distal radioulnar joint (DRUJ) instability and triangular fibrocartilage complex (TFCC) injuries. Through three rounds of Delphi discussions, the researchers concluded that CT scan is the most useful and accurate imaging technique for the diagnosis of DRUJ instability; MRI is the most valuable technique for the diagnosis of TFCC injuries; MR arthrography and CT arthrography are mainly used for diagnosing Palmer 1B foveal lesions of the TFCC.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Ketty Peris, Maria Concetta Fargnoli, Roland Kaufmann, Petr Arenberger, Lars Bastholt, Nicole Basset Seguin, Veronique Bataille, Lieve Brochez, Veronique del Marmol, Reinhard Dummer, Ana-Marie Forsea, Caroline Gaudy-Marqueste, Catherine A. Harwood, Axel Hauschild, Christoph Hoeller, Lidija Kandolf, Nicole W. J. Kellerners-Smeets, Aimilios Lallas, Ulrike Leiter, Josep Malvehy, Branka Marinovic, Zeljko Mijuskovic, David Moreno-Ramirez, Eduardo Nagore, Paul Nathan, Alexander J. Stratigos, Eggert Stockfleth, Luca Tagliaferri, Myrto Trakatelli, Ricardo Vieira, Iris Zalaudek, Claus Garbe, EADO, EDF, ESTRO, UEMS, V EAD
Summary: Basal cell carcinoma is the most common malignant tumor in white populations. This article provides updated recommendations on the diagnosis and treatment of BCC, including classification, surgical treatment, topical therapies, and the use of hedgehog inhibitors and immunotherapy. Regular skin examinations and long-term follow-up are also recommended for high-risk patients.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Oncology
Yongkun Sun, Wen Zhang, Xinyu Bi, Zhengqiang Yang, Yu Tang, Liming Jiang, Feng Bi, Minshan Chen, Shuqun Cheng, Yihebali Chi, Yue Han, Jing Huang, Zhen Huang, Yuan Ji, Liqun Jia, Zhichao Jiang, Jing Jin, Zhengyu Jin, Xiao Li, Zhiyu Li, Jun Liang, Lianxin Liu, Yunpeng Liu, Yinying Lu, Shichun Lu, Qinghua Meng, Zuoxing Niu, Hongming Pan, Shukui Qin, Wang Qu, Guoliang Shao, Feng Shen, Tianqiang Song, Yan Song, Kaishan Tao, Aiping Tian, Jianhua Wang, Wenling Wang, Zhe Wang, Liqun Wu, Feng Xia, Baocai Xing, Jianming Xu, Huadan Xue, Dong Yan, Lin Yang, Jianming Ying, Jingping Yun, Zhaochong Zeng, Xuewen Zhang, Yanqiao Zhang, Yefan Zhang, Jianjun Zhao, Jianguo Zhou, Xu Zhu, Yinghua Zou, Jiahong Dong, Jia Fan, Wan Yee Lau, Yan Sun, Jinming Yu, Hong Zhao, Aiping Zhou, Jianqiang Cai
Summary: Hepatocellular carcinoma (HCC) is a common type of liver cancer that causes many cancer-related deaths worldwide. Though a molecular targeted drug has been available for the treatment of advanced HCC, no Chinese guidelines for novel molecular targeted therapies have been established. An interdisciplinary panel has reviewed the treatment of advanced HCC and provided an overview of molecular targeted therapies for healthcare professionals.
Article
Rheumatology
Yarden Yavne, Yonatan Edel, Julia Berman, Tali Eviatar, Daniel Shepshelovich
Summary: This study aimed to characterize the data supporting the updated recommendations for SLE management and highlighted areas that need more high-quality research. The results revealed a scarcity of sufficiently powered high-quality research referenced in the recently published SLE treatment guidelines, indicating the need for well-designed large-scale studies to inform healthcare professionals caring for patients with SLE.
Review
Dermatology
M. Deleuran, B. Dezfoulian, J. Elberling, I. Knutar, H. Lapeere, A. H. Lossius, M. L. A. Schuttelaar, A. Stockman, E. Wikstrom, M. Bradley, M. de Bruin-Weller, J. Gutermuth, J. M. Mandelin, M. C. Schmidt, J. P. Thyssen, C. Vestergaard
Summary: Treating atopic dermatitis (AD) in women and men of reproductive age is challenging due to limited evidence on systemic anti-inflammatory treatment. This study aimed to establish consensus among dermatologists, obstetricians, and patients in Northwestern Europe on managing AD with systemic treatment. Full consensus was reached on 32 statements, including the use of cyclosporine A as the first-choice treatment for women, and short-course prednisolone for flare management. No consensus was reached on second-choice treatments during pregnancy, but dupilumab and azathioprine were considered suitable for breastfeeding.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Oncology
Iyad Kobeissi, Ahmad A. Tarhini
Summary: The incidence of cutaneous melanoma continues to increase, posing a significant mortality risk. Surgical excision is often curative, but patients with resected stages IIB-IV are at high risk for relapse and death, requiring systemic adjuvant therapy. High-dose interferon-alpha, previously used, improved relapse-free survival and overall survival, but is no longer in use. Adjuvant therapy with ipilimumab at 10 mg/kg showed significant improvements in relapse-free survival and overall survival, but at a high cost in terms of toxicity. Nivolumab, pembrolizumab, and BRAF-MEK inhibitors have shown significant improvements in relapse-free survival compared to ipilimumab, leading to changes in adjuvant therapy for resected stages III-IV melanoma.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Oncology
Aakash P. Desai, Ronald S. Go, Thejaswi K. Poonacha
Summary: The guidelines provided by the National Comprehensive Cancer Network (NCCN) in 2019 mainly consist of Category 2A recommendations, which indicate lower levels of evidence but with uniform expert opinion, showing consistency with the previous study conducted in 2010.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Oliver Cassell, Catherine Harwood, Melanie Hovey, Miranda Payne
Summary: This study investigates the current management pathways for patients with resected stage III melanoma in the UK and explores the expected changes with the routine availability of systemic adjuvant melanoma treatments. The findings suggest that the introduction of adjuvant therapy will have significant implications for the commissioning, organization, and delivery of melanoma services.
EUROPEAN JOURNAL OF CANCER CARE
(2022)
Article
Oncology
Julia Eckardt, Christopher Schroeder, Peter Martus, Sorin Armeanu-Ebinger, Olga Kelemen, Axel Gschwind, Irina Bonzheim, Thomas Eigentler, Teresa Amaral, Stephan Ossowski, Olaf Riess, Lukas Flatz, Claus Garbe, Andrea Forschner
Summary: BRAF mutation status and tumor mutational burden (TMB) were found to be independent predictive factors for relapse-free survival (RFS) in melanoma patients receiving adjuvant anti-PD-1 therapy. Patients with BRAF V600E/K mutation and high TMB had the best outcomes. A classification based on BRAF mutation status and TMB is proposed to predict RFS in these patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Letter
Dermatology
Andrea Forschner, Heike Niessner, Tobias Sinnberg, Thomas Eigentler, Teresa Amaral, Ferdinand Seith, Claus Garbe, Saskia Biskup, Florian Battke
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2022)
Article
Oncology
Stephan Forchhammer, Amar Abu-Ghazaleh, Gisela Metzler, Claus Garbe, Thomas Eigentler
Summary: This study developed a risk score for overall survival based on image analysis through artificial intelligence and validated it in a test cohort. The use of Google's Teachable Machine software achieved a statistically significant prognosis estimate with an AUC of 0.694 based on image sections of approximately 250 x 250 mu m. The low-risk prognosis group showed a higher overall survival rate compared to the high-risk group.
Review
Oncology
Marie-Lea Gauci, Cynthia Aristei, Jurgen C. Becker, Astrid Blom, Veronique Bataille, Brigitte Dreno, Veronique Del Marmol, Ana M. Forsea, Maria C. Fargnoli, Jean-Jacques Grob, Fabio Gomes, Axel Hauschild, Christoph Hoeller, Catherine Harwood, Nicole Kelleners-Smeets, Roland Kaufmann, Aimilios Lallas, Josep Malvehy, David Moreno-Ramirez, Ketty Peris, Giovanni Pellacani, Philippe Saiag, Alexander J. Stratigos, Ricardo Vieira, Iris Zalaudek, Alexander C. J. van Akkooi, Paul Lorigan, Claus Garbe, Celeste Lebbe
Summary: Merkel cell carcinoma is a rare and aggressive skin cancer with distinct molecular subtypes. Risk factors include age, UV exposure, and immunosuppression. Diagnosis is confirmed through histopathology and immunohistochemistry. Treatment options include surgery, radiation therapy, and immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Claus Garbe, Ulrike Keim, Teresa Amaral, Carola Berking, Thomas K. Eigentler, Lukas Flatz, Anja Gesierich, Ulrike Leiter, Rudolf Stadler, Cord Sunderkotter, Thomas Tuting, Jochen Utikal, Uwe Wollina, Lisa Zimmer, Christos C. Zouboulis, Paolo A. Ascierto, Alexander M. M. Eggermont, Jean-Jacques Grob, Axel Hauschild, Lidija Kandolf Sekulovic, Georgina Long, Jason J. Luke, Olivier Michielin, Ketty Peris, Dirk Schadendorf, John M. Kirkwood, Paul C. Lorigan
Summary: This study evaluates the survival probabilities of patients with stage I and II melanoma and finds that the melanoma-specific survival rates in the two cohorts are less favorable compared to the published AJCCv8 data.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Dermatology
Saskia Maria Schnabl, Claus Garbe, Helmut Breuninger, Vincent Walter, Valentin Aebischer, Julia Eckardt, Franziska Carola Ghoreschi, Hans-Martin Haefner, Alexander Scheu
Summary: This study aimed to investigate the risk of systemic side effects in elderly patients undergoing skin tumour surgery with tumescent local anaesthesia. The results showed that skin tumour surgery using tumescent local anaesthesia is safe for elderly patients and avoids complications caused by general anaesthesia. The incidence of systemic complications is low and is usually caused by pre-existing diseases and perioperative excitement, which can be rapidly detected and treated through monitoring.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Oncology
Stefanie Meyer, Lorenz Buser, Sebastian Haferkamp, Mark Berneburg, Tim Maisch, Monika Klinkhammer-Schalke, Armin Pauer, Thomas Vogt, Claus Garbe
Summary: By studying 439 patients with early-stage cutaneous melanoma, a new 7-biomarker signature was found to independently predict disease-free survival, melanoma-specific survival, and overall survival, regardless of AJCC classification. This 7-biomarker signature provides valuable complementary information to clinicopathological and demographic factors, improving the accuracy of prognosis for melanoma patients.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Ulrike Keim, Alexander Katalinic, Bernd Holleczek, Marlies Wakkee, Claus Garbe, Ulrike Leiter
Summary: In this study, the aim was to analyze the incidence rates of cSCC over three decades and make predictions for 2040. The research findings showed that the incidence rates of cSCC were increasing in all investigated countries, particularly among individuals aged over 60. The extrapolation results indicated that the incidence rates of cSCC would continue to rise in all countries until 2044.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Medicine, Research & Experimental
Paolo A. A. Ascierto, Christian Blank, Alexander M. M. Eggermont, Claus Garbe, Jeffrey E. E. Gershenwald, Omid Hamid, Axel Hauschild, Jason J. J. Luke, Janice M. M. Mehnert, Jeffrey A. A. Sosman, Hussein A. A. Tawbi, Mario Mandala, Alessandro Testori, Corrado Caraco, Iman Osman, Igor Puzanov
Summary: The Great Debate session at the 2022 Melanoma Bridge congress featured leading experts arguing two sides of five prominent topics in melanoma management. The debates covered choices between LAG-3 therapy or ipilimumab combined with PD-1 therapy, the acceptability of PD-1 monotherapy as a comparator arm in clinical trials, the usefulness of adjuvant treatment, the role of adjuvant therapy in stage II melanoma, and the continued role of surgery in melanoma treatment. The speakers' opinions did not necessarily align with their personal views, and the audience voted before and after each debate.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Editorial Material
Biochemistry & Molecular Biology
Claus Garbe, Reinhard Dummer, Teresa Amaral, Rodabe N. Amaria, Paolo A. Ascierto, Elizabeth M. Burton, Brigitte Dreno, Alexander M. M. Eggermont, Axel Hauschild, Christoph Hoeller, Roland Kaufmann, Celeste Lebbe, Mario Mandala, Alexander M. Menzies, David Moreno, Olivier Michielin, Paul Nathan, Sapna P. Patel, Caroline Robert, Dirk Schadendorf, Paul C. Lorigan, Richard A. Scolyer, Hussein A. Tawbi, Bart A. van de Wiel, Christian Blank, Georgina V. Long
Summary: Individuals with cutaneous melanoma who receive neoadjuvant immunotherapy demonstrate significant improvement, which should be included in standard care.
Article
Oncology
Jason A. Chesney, Igor Puzanov, Frances A. Collichio, Parminder Singh, Mohammed M. Milhem, John Glaspy, Omid Hamid, Merrick Ross, Philip Friedlander, Claus Garbe, Theodore Logan, Axel Hauschild, Celeste Lebbe, Harshada Joshi, Wendy Snyder, Janice M. Mehnert
Summary: In a randomized phase II study, the combination of T-VEC and ipilimumab showed greater antitumor activity compared to ipilimumab alone in patients with advanced melanoma. The 5-year outcomes demonstrated long-lasting efficacy and safety for the combination therapy of an oncolytic virus and a checkpoint inhibitor.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Editorial Material
Dermatology
Claus Garbe, Holger Reimann
AKTUELLE DERMATOLOGIE
(2023)
Editorial Material
Dermatology
Claus Garbe, Holger Reimann
AKTUELLE DERMATOLOGIE
(2023)
Article
Dermatology
Julia Huynh, Ulrike Leiter, Claus Garbe, Galina Shiderova, Vincent Walter, Thomas Eigentler, Alexander Scheu, Hans-Martin Haefner, Saskia Maria Schnabl
Summary: This study investigated the use of sentinel lymph node biopsy in patients with lentigo maligna melanoma and tumor thickness ≥1 mm. The results showed that sentinel lymph nodes were positive in 12.7% of cases. There was no significant difference in distant metastasis-free survival and overall survival between patients with and without sentinel lymph node biopsy.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Oncology
Paolo A. Ascierto, Reinhard Dummer, Helen J. Gogas, Ana Arance, Mario Mandala, Gabriella Liszkay, Claus Garbe, Dirk Schadendorf, Ivana Krajsova, Ralf Gutzmer, Vanna Chiarion-Sileni, Caroline Dutriaux, Jan Willem B. de Groot, Naoya Yamazaki, Carmen Loquai, Caroline Robert, Keith T. Flaherty
Summary: The purpose of this study was to evaluate the efficacy and safety of encorafenib alone or in combination with binimetinib for the treatment of advanced BRAF(V600)-mutant melanoma. The results showed that the combination of encorafenib and binimetinib improved progression-free survival and overall response rate, and had better tolerability compared to encorafenib alone.
JOURNAL OF CLINICAL ONCOLOGY
(2023)