Review
Biochemistry & Molecular Biology
Marta Waliszewska-Prosol, Marta Nowakowska-Kotas, Justyna Chojdak-Lukasiewicz, Slawomir Budrewicz
Summary: Migraine and sleep disorders are common chronic diseases with significant negative impacts on society and economy. The association between them is observed but not fully understood, with recent progress in understanding common anatomical structures and pathogenetic mechanisms. Better understanding of these mechanisms in the future will expand treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Melissa P. Knauert, Najib T. Ayas, Karen J. Bosma, Xavier Drouot, Mojdeh S. Heavner, Robert L. Owens, Paula L. Watson, M. Elizabeth Wilcox, Brian J. Anderson, Makayla L. Cordoza, John W. Devlin, Rosalind Elliott, Brian K. Gehlbach, Timothy D. Girard, Biren B. Kamdar, Kenneth Kiedrowski Amy S. Korwin, Elizabeth R. Lusczek, Sairam Parthasarathy, Claudia Spies, Jag Sunderram, Irene Telias, Gerald L. Weinhouse, Phyllis C. Zee
Summary: Sleep and circadian disruption (SCD) is common and severe in the ICU, and it has a profound negative impact on patient outcomes. Establishing research priorities to advance understanding of ICU SCD is urgent.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Jillian L. Gregory, Anna T. Brown, Sapna R. Kudchadkar
Summary: This pilot study aimed to investigate the association between sleep characteristics and delirium development in pediatric cardiac ICU patients. The data suggest that most children in the ICU experience severe sleep disruption and delirium is common.
PEDIATRIC CRITICAL CARE MEDICINE
(2021)
Article
Clinical Neurology
Lena Xiao, Kanokkarn Sunkonkit, Jackie Chiang, Indra Narang
Summary: This retrospective study describes the clinical manifestations, polysomnography data, interventions, and trajectory of idiopathic central sleep apnea (ICSA) in term infants. The results show a favorable clinical trajectory over time with significant reductions in central apnea-hypopnea index, oxygen desaturation index, average transcutaneous carbon dioxide, and improved nadir oxygen saturation. Treatment options included supplemental oxygen, caffeine, and noninvasive ventilation.
SLEEP AND BREATHING
(2023)
Review
Neurosciences
Zachary Zamore, Sigrid C. Veasey
Summary: Recent studies question the full recovery after chronic sleep disruption in both humans and animals. Human studies identify specific cognitive domains, such as sustained vigilance and episodic memory, that are particularly vulnerable to delayed or incomplete recovery. These findings guide animal model studies in examining the lasting impact of sleep loss on the brain. The article proposes common injury pathways in various forms of sleep disruption and discusses the implications of this injury in aging and neurodegenerative disorders.
TRENDS IN NEUROSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Agata Gabryelska, Szymon Turkiewicz, Filip Franciszek Karuga, Marcin Sochal, Dominik Strzelecki, Piotr Bialasiewicz
Summary: Obstructive sleep apnea (OSA) is a chronic condition characterized by recurrent pauses in breathing, leading to intermittent hypoxia and arousals during the night. It is associated with comorbidities in various systems, including cardiovascular, metabolic, psychiatric, and neurological complications. The disruption of the circadian clock may play a significant role in the development and progression of OSA-related complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anesthesiology
Michael R. Irwin, Richard Olmstead, Martin F. Bjurstrom, Patrick H. Finan, Michael T. Smith
Summary: Sleep loss increases pain sensitivity, and this study aimed to explore the mechanisms behind this association. By disrupting sleep and inducing inflammation and loss of slow wave, N3 sleep, the researchers found that sleep disruption led to decreased pain threshold. A causal mediation analysis revealed that the effect of sleep disruption on pain sensitivity was mediated by decreased N3 sleep and subsequent inflammation.
Article
Economics
Yi Fan, Diana M. Weinhold
Summary: This study investigates the causal relationship between self-reported sleep disruption and health using individual-specific exposure to neighbor noise as an instrument. The results provide evidence of significant causal effects of sleep disruption on cardiovascular problems, auto-immune diseases, and headache, highlighting the importance of noise-related public policies.
Review
Neurosciences
Yun Shen, Qian-kun Lv, Wei-ye Xie, Si-yi Gong, Sheng Zhuang, Jun-yi Liu, Cheng-jie Mao, Chun-feng Liu
Summary: Disruptions of circadian rhythms and sleep cycles are bidirectionally related to neurodegenerative diseases, aggravating neurodegeneration and increasing the risk of such diseases. Harnessing circadian biology findings can reduce the risk of neurodegeneration and improve symptoms and quality of life via precision medicine approaches. This review summarizes evidence from human and animal studies, highlighting the bidirectional links between sleep, circadian rhythms, and prevalent forms of neurodegeneration, providing valuable insights into the pathogenesis of these diseases and suggesting the potential of circadian-based interventions.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Medicine, General & Internal
Laura Croce, Spyridon Chytiris, Francesca Coperchini, Giovanni Ferraro, Linda Minelli, Antonella Navarra, Flavia Magri, Luca Chiovato, Pierpaolo Trimboli, Mario Rotondi
Summary: This study aimed to evaluate potential strategies for clinical and biochemical characterization of UH patients. The results showed that laboratory interferences are not more frequent in UH patients, suggesting that they should be managed in the same way as CAT patients until proven otherwise.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Laura Johnsen, Jessica C. Bird, Paul Salkovskis, Anthony C. James, Hannah J. Stratford, Bryony Sheaves
Summary: Sleep problems are common in adolescent psychiatric inpatients, and improving sleep treatment could aid in their mental health recovery. However, there is limited knowledge about the nature of sleep problems and how to optimize sleep treatment specifically for inpatient settings. This study aimed to better understand sleep disturbances in adolescent inpatients through a mixed-methods approach.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Neurosciences
Adrian Berisha, Kyle Shutkind, Jeremy C. Borniger
Summary: Sleep plays a crucial role in evolutionary fitness, and chronic disruption of sleep can lead to various physiological problems, including cancer. The interaction between sleep and cancer is bidirectional, with evidence suggesting that sleep disturbances may promote cancer development and vice versa.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Betul Rauf, Brian A. Sharpless, Dan Denis, Rotem Perach, Juan J. Madrid-Valero, Christopher C. French, Alice M. Gregory
Summary: Study objectives: This study aimed to investigate the clinical features, associated demographic characteristics, and prevention as well as disruption strategies of isolated sleep paralysis (ISP). The findings revealed that ISP is associated with shorter sleep duration, longer sleep onset latency, and greater insomnia symptoms. Various prevention and disruption techniques were identified, which can support existing treatment approaches and inform future treatment development.
Review
Biochemistry & Molecular Biology
Herlinda Bonilla-Jaime, Helena Zeleke, Asheebo Rojas, Claudia Espinosa-Garcia
Summary: Sleep disturbances, such as insomnia, obstructive sleep apnea, and daytime sleepiness, are common in people diagnosed with epilepsy. Poor sleep quality in epilepsy patients is associated with intensified seizure frequency and disease progression. Understanding the relationship between sleep and epilepsy is crucial, as neuroinflammation may play a role in worsening seizures in sleep-deprived individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Sport Sciences
Julien D. Periard, Mathew G. Wilson, Samuel T. Tebeck, James B. Gilmore, Jamie Stanley, Olivier Girard
Summary: This study aimed to characterize the thermal and cardiovascular strain of professional cyclists during the 2019 Tour Down Under and determine the associations between thermal indices and power output, and physiological strain. The results showed that the gastrointestinal temperature, heart rate, and power output of cyclists were associated with various thermal indices.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Clinical Neurology
Tyler Gumb, Akosua Twumasi, Shahnaz Alimokhtari, Alan Perez, Kathleen Black, David M. Rapoport, Jag Sunderram, Indu Ayappa
SLEEP AND BREATHING
(2018)
Article
Critical Care Medicine
Benjamin G. Wu, Imran Sulaiman, Jing Wang, Nan Shen, Jose C. Clemente, Yonghua Li, Robert J. Laumbach, Shou-En Lu, Iris Udasin, Oanh Le-Hoang, Alan Perez, Shahnaz Alimokhtari, Kathleen Black, Michael Plietz, Akosua Twumasi, Haley Sanders, Patrick Malecha, Bianca Kapoor, Benjamin D. Scaglione, Anbang Wang, Cameron Blazoski, Michael D. Weiden, David M. Rapoport, Denise Harrison, Nishay Chitkara, Eugenio Vicente, Jose M. Marin, Jag Sunderram, Indu Ayappa, Leopoldo N. Segal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Article
Critical Care Medicine
Jag Sunderram, Michael Weintraub, Kathleen Black, Shahnaz Alimokhtari, Akosua Twumasi, Haley Sanders, Iris Udasin, Denise Harrison, Nishay Chitkara, Rafael E. de la Hoz, Shou-En Lu, David M. Rapoport, Indu Ayappa
Article
Clinical Neurology
Ankit Parekh, Anna E. Mullins, Korey Kam, Andrew W. Varga, David M. Rapoport, Indu Ayappa
Article
Clinical Neurology
Omonigho M. Bubu, Elizabeth Pirraglia, Andreia G. Andrade, Ram A. Sharma, Sandra Gimenez-Badia, Ogie Q. Umasabor-Bubu, Megan M. Hogan, Amanda M. Shim, Fahad Mukhtar, Nidhi Sharma, Alfred K. Mbah, Azizi A. Seixas, Korey Kam, Ferdinand Zizi, Amy R. Borenstein, James A. Mortimer, Kevin E. Kip, David Morgan, Ivana Rosenzweig, Indu Ayappa, David M. Rapoport, Girardin Jean-Louis, Andrew W. Varga, Ricardo S. Osorio
Article
Clinical Neurology
Girardin Jean-Louis, Rebecca Robbins, Natasha J. Williams, John P. Allegrante, David M. Rapoport, Alwyn Cohall, Gbenga Ogedegbe
JOURNAL OF CLINICAL SLEEP MEDICINE
(2020)
Article
Clinical Neurology
Omonigho M. Bubu, Ogie Q. Umasabor-Bubu, Arlener D. Turner, Ankit Parekh, Anna E. Mullins, Korey Kam, Madeline K. Birckbichler, Fahad Mukhtar, Alfred K. Mbah, Natasha J. Williams, David M. Rapoport, Mony de Leon, Girardin Jean-Louis, Indu Ayappa, Andrew W. Varga, Ricardo S. Osorio
Summary: This study found that regardless of TN-status, participants with OSA+/Aβ+ were 2 to 4 times more likely to progress to MCI/AD and progress 6 to 18 months earlier compared to other participants. The study also demonstrated synergistic effects between OSA and Aβ, as well as between OSA and tau, leading to shorter progression time to MCI/AD in CN and MCI-OSA patients when Aβ and tau accumulation becomes increasingly abnormal.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Jay T. Guevarra, Robert Hiensch, Andrew W. Varga, David M. Rapoport
NATURE AND SCIENCE OF SLEEP
(2020)
Article
Clinical Neurology
Anna E. Mullins, Masrai K. Williams, Korey Kam, Ankit Parekh, Omonigho M. Bubu, Bresne Castillo, Zachary J. Roberts, David M. Rapoport, Indu Ayappa, Ricardo S. Osorio, Andrew W. Varga
Summary: The study found that untreated OSA affects the morning spatial navigation performance of older adults, independent of a deleterious effect on morning vigilance or evening navigation performance. Relative frontal slow wave activity is associated with overnight maze performance improvement in older participants with OSA.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2021)
Article
Clinical Neurology
Rebecca Robbins, Ralph J. DiClemente, Andrea B. Troxel, Girardin Jean-Louis, Mark Butler, David M. Rapoport, Charles A. Czeisler
Summary: The study found that 15% of older adults in the US routinely use sleep medication, and this use is associated with incident dementia. Future research may focus on behavioral approaches to improving sleep among older adults.
Article
Biochemical Research Methods
Korey Kam, David M. Rapoport, Ankit Parekh, Indu Ayappa, Andrew W. Varga
Summary: This study introduces WaveSleepNet, a deep neural network that utilizes wavelet transformed images to automatically score sleep and wake in mice. WSN shows promising performance compared to manual scoring, especially in mice with high levels of sleep fragmentation which leads to difficulties in differentiating REM from NREM sleep.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Clinical Neurology
Ankit Parekh, Korey Kam, Anna E. Mullins, Bresne Castillo, Asem Berkalieva, Madhu Mazumdar, Andrew W. Varga, Danny J. Eckert, David M. Rapoport, Indu Ayappa
Summary: The study found that sustained inspiratory airflow limitation may lead to changes in K-complex morphology, including an increased occurrence of K-complexes with bursts of alpha as arousal surrogates, which may contribute to decreased vigilance.
Article
Respiratory System
Jag Sunderram, Indu Ayappa, Shou-En Lu, Han Wang, Kathleen Black, Akosua Twumasi, Haley Sanders, Denise Harrison, Iris Udasin, Nishay Chitkara, Rafael E. de la Hoz, Jeffrey L. Carson, David M. Rapoport
Summary: Contrary to expectations, the study results showed no significant difference in adherence to CPAP (FLEX) between subjects with high or low nasal resistance. Overall, CPAP demonstrated slightly better adherence compared to CPAP (FLEX).
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Communication
Rebecca Robbins, Paul Krebs, David M. Rapoport, Girardin Jean-Louis, Dustin T. Duncan
HEALTH COMMUNICATION
(2019)
Article
Communication
Rebecca Robbins, Yalini Senathirajah, Natasha J. Williams, Carly Hutchinson, David M. Rapoport, John P. Allegrante, Alwyn Cohall, April Rogers, Olugbenga Ogedegbe, Girardin Jean-Louis
HEALTH COMMUNICATION
(2019)
