Article
Orthopedics
Ying Li, Jiao Song, Yangyang Jiang, Xue Yang, Li Cao, Chun Xiao, Suli Li, Birong Dong, Xiaoli Huang
Summary: The ACE2/Ang-(1-7) axis plays a protective role in skeletal muscle function and administering exogenous Ang-(1-7) can delay age-related decline in skeletal muscle function. Aged mice showed reduced skeletal muscle function and Ang-(1-7) expression levels compared to younger mice. ACE2KO mice had significantly lower skeletal muscle function and MEF2A protein expression than age-matched wild-type mice. After one month of Ang-(1-7) treatment, skeletal muscle function in aged ACE2KO mice improved, with similar MEF2A protein expression to the untreated group. Ang-(1-7) was shown to promote Glut4 expression in C2C12 cells.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Nutrition & Dietetics
Hikari Takeshita, Koichi Yamamoto
Summary: The severity of COVID-19 is characterized by systemic damage to organs, including skeletal muscle, due to excessive secretion of inflammatory cytokines. Clinical studies have found that tryptophan metabolism is selectively enhanced in patients with severe COVID-19.
FRONTIERS IN NUTRITION
(2022)
Article
Physiology
Naoya Kakutani, Shingo Takada, Hideo Nambu, Satoshi Maekawa, Hikaru Hagiwara, Katsuma Yamanashi, Yoshikuni Obata, Ippei Nakano, Yoshizuki Fumoto, Soichiro Hata, Takaaki Furihata, Arata Fukushima, Takashi Yokota, Shintaro Kinugawa
Summary: Skeletal muscle fibrosis is significantly increased in STZ-induced diabetic mice, but can be prevented by administration of an ACE inhibitor, which also helps to alleviate the reduction in muscle function. These findings suggest a potential new therapeutic target for skeletal muscle abnormalities in diabetes.
EXPERIMENTAL PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Geriatrics & Gerontology
Robert MacLachlan, Patrick Gavin Kehoe, J. Scott Miners
Summary: The activity of angiotensin-converting enzyme-1 (ACE-1) is induced in the early stages of Alzheimer's disease (AD), independently from the normal physiological changes in ACE-1 protein during aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Atila Duque Rossi, Joao Locke Ferreira de Araujo, Tailah Bernardo de Almeida, Marcelo Ribeiro-Alves, Camila de Almeida Velozo, Jessica Maciel de Almeida, Isabela de Carvalho Leitao, Samila Natiane Ferreira, Jessica da Silva Oliveira, Hugo Jose Alves, Helena Toledo Scheid, Debora Souza Faffe, Rafael Mello Galliez, Renata Eliane de Avila, Gustavo Gomes Resende, Mauro Martins Teixeira, Orlando da Costa Ferreira Junior, Terezinha Marta P. P. Castineiras, Renan Pedra Souza, Amilcar Tanuri, Renato Santana de Aguiar, Shana Priscila Coutinho Barroso, Cynthia Chester Cardoso
Summary: ACE2 and TMPRSS2 levels are positively correlated with age, which is strongly associated with respiratory distress. Increased ACE2 levels have a protective effect against this outcome, while the TMPRSS2/ACE2 ratio is associated with risk. In modeling COVID-19 severity, the TMPRSS2/ACE2 ratio outperforms ACE2.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Shidong Yang, Wentao Lin, Mengmeng Jia, Haichun Chen
Summary: This study aimed to assess athletic performance indicators of Chinese youth male football players with different ACE and ACTN3 gene profiles. The results indicate that ACE I/D and ACTN3 R577x polymorphisms are not associated with muscle power in Chinese elite and sub-elite players, while the XX genotype of ACTN3 is associated with the aerobic endurance of elite players.
Article
Biochemistry & Molecular Biology
Ingrid Fricke-Galindo, Ivette Buendia-Roldan, Daniel I. I. Ponce-Aguilar, Gloria Perez-Rubio, Leslie Chavez-Galan, Jesus Alanis-Ponce, Karina Perez-Torres, Daniela Valencia-Perez Rea, Fernanda Tellez-Quijada, Karol J. J. Nava-Quiroz, Rafael de Jesus Hernandez-Zenteno, Angelica Gutierrez-Nava, Ramces Falfan-Valencia
Summary: This paper examines the relationship between the ACE insertion/deletion variant and serum ACE activity with the severity of COVID-19 and its impact on post-COVID-19 patients, comparing it with non-COVID-19 respiratory disorder patients. The DD genotype is associated with an increased risk of invasive mechanical ventilation requirement in COVID-19 patients, and it is more prevalent in COVID-19 and post-COVID-19 groups compared to non-COVID-19 subjects. Serum ACE activity is lower in COVID-19 patients and may be related to disease severity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jing-Yuan Xu, Wei Chang, Qin Sun, Fei Peng, Yi Yang
Summary: The study found that plasma midkine levels were significantly elevated in sepsis patients and closely related to the ACE system. In a mouse model, increased midkine levels were associated with more severe lung injury. Regional interference of midkine expression in lung tissue was shown to alleviate acute lung injury.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biology
Hristo L. Svilenov, Florent Delhommel, Till Siebenmorgen, Florian Ruehrnoessl, Grzegorz M. Popowicz, Alwin Reiter, Michael Sattler, Carsten Brockmeyer, Johannes Buchner
Summary: The solution structure, stability, and dynamics of a broadly-acting antiviral ACE2-IgG-Fc fusion protein are determined. Small chemical compounds binding to ACE2 can be used to drastically increase the thermal stability of the ACE2 domain. Our findings reveal a general concept for stabilizing the labile receptor segments of therapeutic antiviral fusion proteins by chemical compounds.
COMMUNICATIONS BIOLOGY
(2023)
Article
Genetics & Heredity
Carina M. Mathey, Carlo Maj, Annika B. Scheer, Julia Fazaal, Bettina Wedi, Dorothea Wieczorek, Philipp M. Amann, Harald Loffler, Lukas Koch, Clemens Schoffl, Heinrich Dickel, Nomun Ganjuur, Thorsten Hornung, Susann Forkel, Jens Greve, Gerda Wurpts, Par Hallberg, Anette Bygum, Christian Von Buchwald, Malgorzata Karawajczyk, Michael Steffens, Julia Stingl, Per Hoffmann, Stefanie Heilmann-Heimbach, Elisabeth Mangold, Kerstin U. Ludwig, Eva R. Rasmussen, Mia Wadelius, Bernhardt Sachs, Markus M. Nothen, Andreas J. Forstner
Summary: This study investigated the possible association between ACEi/ARB-induced angioedema and HAE genes through molecular genetic screening. The results suggest that HAE-associated mutations are, at best, a rare cause of ACEi/ARB-induced angioedema, and there was no significant association found between ACEi/ARB-induced angioedema and other variants in the investigated genes.
FRONTIERS IN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Steven D. Brooks, Rachel L. Smith, Aline S. Moreira, Hans C. Ackerman
Summary: Lisinopril increases ACE2 expression in tissues relevant to COVID-19, while adding losartan prevents the lisinopril-induced increase. A sex difference was observed with higher ACE2 levels in the kidneys of male mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Physiology
Everett C. Minchew, Nicholas C. Williamson, Andrew T. Readyoff, Joseph M. McClung, Espen E. Spangenburg
Summary: Assessing contractile function of skeletal muscle in murine models is commonly employed in laboratory research. This study aimed to characterize the functional properties of hindlimb muscles in different mouse strains. The data reveals both unique differences and similarities between the muscles in different genetic backgrounds. Additionally, the strain of the mouse could potentially influence the measured biological outcome and interact with any genetic manipulation or therapeutic intervention. Therefore, careful consideration of the genetic background and documentation of the strain of mouse is critical in experimental design and publication.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Critical Care Medicine
Genevieve L. Y. Rocheleau, Terry Lee, Yassene Mohammed, David Goodlett, Kevin Burns, Matthew P. Cheng, Karen Tran, David Sweet, John Marshall, Arthur S. Slutsky, Srinivas Murthy, Joel Singer, David M. Patrick, Bin Du, Zhiyong Peng, Todd C. Lee, John H. Boyd, Keith R. Walley, Francois Lamontagne, Robert Fowler, Brent W. Winston, Greg Haljan, Donald C. Vinh, Alison McGeer, David Maslove, Santiago Perez Patrigeon, Puneet Mann, Kathryn Donohoe, Geraldine Hernandez, James A. Russell
Summary: This study examined the effects of angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme (ACE) inhibitors in hospitalized COVID-19 patients, focusing on gender differences. The results showed that ARBs were associated with reduced use of ventilation and vasopressors in male patients, but not in female patients. Additionally, sex-based differences in the renin-angiotensin system (RAS) components may contribute to variations in outcomes and responses to ARBs in COVID-19.
CRITICAL CARE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Thomas L. Williams, Gregory Strachan, Robyn G. C. Macrae, Rhoda E. Kuc, Duuamene Nyimanu, Anna L. Paterson, Sanjay Sinha, Janet J. Maguire, Anthony P. Davenport
Summary: ACE2 is a membrane protein that regulates the cardiovascular system and acts as a receptor for human coronaviruses, including SARS-CoV-2. A newly discovered short ACE2 isoform, deltaACE2, may affect individual susceptibility to viral infection and likelihood of developing Long COVID. Research shows that deltaACE2 is more expressed in the lung and liver compared to full-length ACE2.
SCIENTIFIC REPORTS
(2021)
Review
Physiology
Erik D. Hanson, Lauren C. Bates, David B. Bartlett, John P. Campbell
Summary: Unconventional T cells play a key role in linking innate and adaptive immunity, responding to infections and tumor suppression. Aging and chronic diseases negatively impact the numbers and function of these cells, with physical activity potentially offering a way to boost unconventional T cells. Acute exercise mobilizes immune cells and exercise training can lead to anti-inflammatory effects and improved fitness.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Oncology
Chad W. Wagoner, Jordan T. Lee, Erik D. Hanson, Zachary Y. Kerr, Kirsten A. Nyrop, Hyman B. Muss, Claudio L. Battaglini
Summary: The baseline fatigue levels in early-breast cancer survivors were not significantly different from the inactive controls. Fatigue was associated with physical and mental health, exercise expectations, self-efficacy, depression, anxiety, and balance.
SUPPORTIVE CARE IN CANCER
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Patricia Pagan Lassalle, Lauren C. Bates, Peter F. Halpin, Zachary Y. Kerr, Erik D. Hanson, Michelle L. Meyer, Lee Stoner
Article
Oncology
Erik D. Hanson, Mohamdod Alzer, Jackson Carver, Cameron K. Stopforth, Alexander R. Lucas, Young E. Whang, Matthew Milowsky, David B. Bartlett, Michael R. Harrison, Rhonda L. Bitting, Allison M. Deal, Lee Stoner, A. C. Hackney, Claudio L. Battaglini
Summary: The feasibility of a home-based exercise intervention in men with metastatic castration-resistant prostate cancer (mCRPC) was evaluated. The study found that home-based exercise is feasible during ARSI treatment for mCRPC and can improve endurance capacity and localized hypertrophy.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Sport Sciences
Erik D. Hanson, Matthew B. Cooke, Mitchell J. Anderson, Tracey Gerber, Jessica A. Danaher, Christos G. Stathis
Summary: This study compared the effects of heat acclimation and heat acclimation with hypoxia exposure on endurance performance. The results showed that both heat acclimation protocols improved short-duration exercise performance significantly, regardless of hypoxic exposure.
Review
Cardiac & Cardiovascular Systems
Lauren C. Bates, Margaret Damare, Erik D. Hanson, Justin B. Moore, Victoria Bae-Jump, Michelle L. Meyer, Lee Stoner
Summary: Endometrial cancer survivors have a high risk of cardiovascular disease, which is attributed to cancer treatment and sub-optimal lifestyle behaviors. There is a strong association between sedentary behavior and cardiovascular disease, but guidelines for reducing sedentary behavior are lacking. Endometrial cancer survivors face unique barriers such as fatigue and limited self-efficacy. Reducing sedentary behavior and achieving recommended levels of physical activity are critical for their health.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Chad W. Wagoner, Jordan T. Lee, Erik D. Hanson, Zachary Y. Kerr, Kirsten A. Nyrop, Hyman B. Muss, Claudio L. Battaglini
Summary: This study found that community-based exercise is beneficial for alleviating fatigue in early breast cancer survivors (EBCS). The improvements in fatigue may be driven by parallel improvements in psychosocial outcomes and objectively measured functional outcomes.
Article
Oncology
Andrea Sitlinger, Michael A. Deal, Erwin Garcia, Margery Connelly, Dana Thompson, Tiffany Stewart, Grace Macdonald, Erik D. Hanson, Megan Neely, Ben Neely, Ashley Artese, J. Brice Weinberg, Danielle Brander, David B. Bartlett
Summary: Many patients with CLL experience physical dysfunction and low overall fitness. Factors such as time since diagnosis, treatment, and specific metabolic parameters are associated with a higher likelihood of dysfunctional aerobic fitness and physical performance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ashley L. Artese, Andrea Sitlinger, Grace MacDonald, Michael A. Deal, Erik D. Hanson, Carl F. Pieper, J. Brice Weinberg, Danielle M. Brander, David B. Bartlett
Summary: The study aimed to investigate the effects of a 12-week high-intensity interval training and resistance training intervention on health-related quality of life (HRQOL) in adults with treatment naive chronic lymphocytic leukemia (CLL). The results showed significant improvements in physical, emotional, social, and overall well-being in the group that participated in the intervention, compared to the control group who only had improvements in lymphoma-specific symptoms.
JOURNAL OF GERIATRIC ONCOLOGY
(2023)
Article
Social Issues
Erik D. Hanson, Max K. Cossette, David C. Roberts
Summary: This paper examines the adoption of precision agriculture technologies by farm operators in North Dakota and finds that larger operations are more likely to adopt these technologies. Some technologies have complementary effects on the adoption of other technologies, especially variable rate technologies. Cropping patterns are related to technology adoption, with corn production positively associated with the adoption of multiple technologies while wheat production negatively associated with the adoption of variable rate technologies.
TECHNOLOGY IN SOCIETY
(2022)
Article
Medicine, Research & Experimental
Simon Higgins, Emma S. Cowley, Craig Paterson, Erik D. Hanson, Gaurav J. Dave, Michelle L. Meyer, Feng-Chang Lin, Bethany Barone Gibbs, Maihan Vu, Lee Stoner
Summary: This paper outlines the protocol for part I of the SWITCH study, which aims to investigate the effects of different sedentary behavior interruption strategies on cardiovascular disease risk. Healthy men and women will be recruited for a randomized crossover trial, and the primary outcome will evaluate the change in aortic arterial stiffness for each substitution strategy. The findings will inform the design of a subsequent randomized controlled trial and contribute to the development of public health policies addressing sedentary behavior.
CONTEMPORARY CLINICAL TRIALS
(2023)
Article
Multidisciplinary Sciences
Lauren C. Bates-Fraser, Sasha Riley, Cameron Stopforth, Kaileigh Moertl, Kyle Edgar, Lee Stoner, Erik D. Hanson
Summary: BCa and PCa are common and survivable cancers. Treatment may affect the quality of life. Supervised exercise improves QoL but is not accessible for all survivors. Home-based exercise is a feasible alternative, especially for those in rural communities. Home-based exercise improves QoL, PA, and CRF.
Article
Cell Biology
Hannah Lalunio, Lewan Parker, Erik D. Hanson, Paul Gregorevic, Itamar Levinger, Alan Hayes, Craig A. Goodman
Summary: Vitamin D and its receptor (VDR) play important roles in muscle development and function. This study investigated the differences in VDR protein abundance in muscle between different mouse strains and between mice and humans, using different sample preparation methods and antibodies. The findings showed differences in VDR protein levels among mouse strains and between mice and humans, and the detection of potential VDR isoforms in human muscle.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Meeting Abstract
Sport Sciences
Erik D. Hanson, Lauren C. Bates, Gabriel Zieff, Lee Stoner
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Meeting Abstract
Sport Sciences
Ashley L. Artese, Andrea Sitlinger, Grace MacDonald, Michael A. Deal, Erik D. Hanson, Carl F. Pieper, J. Brice Weinberg, Danielle M. Brander, David B. Bartlett
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)