Article
Biochemistry & Molecular Biology
Pawel Jarmuzek, Piotr Defort, Marcin Kot, Edyta Wawrzyniak-Gramacka, Barbara Morawin, Agnieszka Zembron-Lacny
Summary: Cytokines play a critical role in tumor cell development and multiplication, but their involvement in glioblastoma (GBM) is still not well understood. This study evaluated the inflammatory profile and identified potential molecular signatures specific to GBM. The results showed elevated neutrophils and neutrophil-to-lymphocyte ratio (NLR) in GBM patients, with an inverse correlation between neutrophil count and survival time. Pro-inflammatory cytokines IL-1 beta, IL-6, and IL-8 were significantly higher in GBM, while TNF alpha and HMGB1 were lower. IL-6 and IL-8 had the highest diagnostic potential for clinical prognosis, with a three-fold higher probability of GBM development above certain threshold values.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yuanliu Nie, Guangyue Yao, Liang Li, Alei Feng, Wentao Zhang, Xiaoying Xu, Qiang Li, Zhe Yang
Summary: This study assessed the effects of immunotherapy plus radiotherapy on survival outcomes in patients with advanced esophageal cancer and established a prognostic nomogram based on independent prognostic factors. The results showed that immunotherapy plus radiotherapy resulted in significantly longer progression-free survival and overall survival compared to immunotherapy alone. The nomogram based on prognostic factors can guide personalized treatment and monitoring of prognosis.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Endocrinology & Metabolism
Xinran Li, Lin Zhou, Yuxin Chen, Na Li, Jian Meng
Summary: This study retrospectively analyzed 71 patients with ACC and found that preoperative neutrophil-to-lymphocyte ratio (NLR) is an effective biomarker for the prognosis of ACC patients. High NLR is associated with lymph node metastasis and tumor stage, and it is correlated with overall survival but not disease-free survival in ACC patients.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Immunology
James Broadley, Robb Wesselingh, Udaya Seneviratne, Chris Kyndt, Paul Beech, Katherine Buzzard, Cassie Nesbitt, Wendyl D'Souza, Amy Brodtmann, Tomas Kalincik, Helmut Butzkueven, Terence J. O'Brien, Mastura Monif
Summary: This study suggests that NLR on initial hospital admission blood tests may provide important prognostic information for cases of seropositive AE. High NLR was associated with higher odds of first line treatment failure, while increased MLR was not associated with any short or long-term outcome.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Ralph Bou Chebl, Mohamad Assaf, Nadim Kattouf, Saadeddine Haidar, Mohamed Khamis, Karim Abdeldaem, Maha Makki, Hani Tamim, Gilbert Abou Dagher
Summary: This study aimed to examine the prognostic ability of Neutrophil to lymphocyte ratio (NLR) in predicting in-hospital mortality among sepsis patients. The optimal cutoff for NLR was found to be 14.20, with patients above this cutoff having a lower chance of survival. However, after adjusting for confounders, there was no association between NLR and in-hospital mortality.
Article
Oncology
Chengcheng Qian, Renjie Cai, Wenying Zhang, Jiongyi Wang, Xiaohua Hu, Yanjie Zhang, Bin Jiang, Haihua Yuan, Feng Liu
Summary: High NLR (>3.21) and high CTCs level (>1) were associated with shorter DFS and OS, with patients having both higher NLR and higher CTCs counts showing the shortest DFS and OS. This suggests that combining NLR and CTCs counts may serve as a reliable predictor for poor prognosis in patients with gastrointestinal cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Ke Shi, Yunyi Huang, Qun Zhang, Chongping Ran, Jie Hou, Yi Zhang, Yufei Bi, Xianbo Wang
Summary: A dynamic nomogram has been developed to predict the risk of 30-day transplant-free mortality in patients with OHE and HBC. The MELD score and NLR are independently associated with the 30-day mortality. The nomogram shows good predictive accuracy and can guide clinical decision-making.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Alexandra Gomes dos Santos, Rodolfo Figueiredo de Carvalho, Artur Nobrega Lima Rodrigues de Morais, Tamires Martins Silva, Victor Matheus Ribeiro Baylao, Mayara Azevedo, Adilson J. M. de Oliveira
Summary: NLR is a low-cost method associated with tumor grading and overall survival in patients with gliomas.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Oncology
Jiali Leng, Fei Wu, Lihui Zhang
Summary: This meta-analysis found that pretreatment neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may serve as biomarkers for predicting poor prognosis in patients with endometrial cancer, while monocyte-lymphocyte ratio (MLR) is not associated with prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Shihai Yang, Shangdong Li
Summary: This study aimed to establish a predictive model using neutrophil-lymphocyte ratio (NLR) to predict the survival prognosis of patients with gastric signet ring cell carcinoma (GSRC). The results showed that patients with NLR < 2.8 had significantly better overall survival and tumor recurrence rates compared to those with NLR > 2.8. After adjusting for other risk factors, NLR < 2.8, tumor size, and tumor metastasis remained independent predictors of tumor recurrence rate and overall survival. The study confirmed the value of NLR in predicting the prognosis of GSRC patients.
Review
Surgery
Francesca Savioli, Elizabeth S. Morrow, Ross D. Dolan, Laszlo Romics, Alison Lannigan, Joanne Edwards, Donald C. McMillan
Summary: Through a systematic review and meta-analysis, it was found that preoperative circulating markers of the systemic inflammatory response, such as NLR, dNLR, LMR, PLR, and CRP, may serve as prognostic markers in primary operable breast cancer.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Multidisciplinary Sciences
Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa
Summary: Patients with multiple sclerosis showed elevated counts of total white blood cells, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Maurizio A. Leone, Jessica Mandrioli, Sergio Russo, Aliona Cucovici, Giulia Gianferrari, Vitalie Lisnic, Dafin Fior Muresanu, Francesco Giuliani, Massimiliano Copetti, Andrea Fontana
Summary: This study suggests that the neutrophil-to-lymphocyte ratio (NLR) could be a potential marker for disease progression and survival in ALS, possibly associated with low-grade inflammation. Further prospective studies are needed to validate these findings.
Article
Veterinary Sciences
Ryan C. Fries, Saki Kadotani, Jonathan P. Stack, Leah Kruckman, Gabrielle Wallace
Summary: This study assessed the predictive value of NLR for cardiac death in cats with hypertrophic cardiomyopathy. The results showed that cats with higher NLR had a higher risk of cardiac death, and NLR was significantly associated with echocardiographic measurements.
FRONTIERS IN VETERINARY SCIENCE
(2022)
