Article
Medicine, General & Internal
Hyun-Joong Kim, Wonjae Choi, JiHye Jung, SunGeon Park, YoungLan Joo, Sangbong Lee, Seungwon Lee
Summary: Radial extracorporeal shock wave therapy (rESWT) is effective in improving shoulder function and muscle properties in patients who underwent arthroscopic rotator cuff repair and started active movement in rehabilitation.
Article
Surgery
Hung Leng Kaan, Vincent Khor, Wei Chee Liew, Tian Fu Loh, Sze Wai Leong, Shuo Ling Teo, Christopher Hang Liang Keh
Summary: The study compared the clinical outcomes of patients undergoing colonoscopy with and without sedation. Results showed that patients undergoing colonoscopy without sedation had significantly shorter recovery time than those with sedation. There were no significant differences between the two groups in terms of other outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, Research & Experimental
Cecilia Villegas, Rebeca Perez, Olov Sterner, Ivan Gonzalez-Chavarria, Cristian Paz
Summary: Colorectal cancer is the second leading cause of cancer death worldwide, mainly affecting men, with about 20% of cases due to hereditary syndromes. Curcumin, the main polyphenol pigment in turmeric, has antioxidant properties and synergistic effects with both anticancer and anti-inflammatory drugs in inhibiting the progression of CRC through multiple signaling pathways.
Article
Medicine, General & Internal
Guoqiang Ping, Yichen Tian, Ziqiang Zhou
Summary: Regulatory T cells are significantly enriched in the tumor microenvironment of colorectal cancer patients and are closely associated with patient prognosis. In this study, a Treg-associated signature was constructed based on genetic and single-cell RNA sequencing data to predict the prognosis of colorectal cancer patients. Further analysis revealed that high-risk patients had higher levels of tumor-suppressing immune cells and immune checkpoint genes in tumor tissues.
Article
Oncology
Kathryn R. Tringale, Elizabeth R. Berger, Varadan Sevilimedu, Hannah Y. Wen, Erin F. Gillespie, Boris A. Mueller, Beryl McCormick, Amy J. Xu, John J. Cuaron, Oren Cahlon, Atif J. Khan, Simon N. Powell, Monica Morrow, Alexandra S. Heerdt, Lior Z. Braunstein
Summary: In this study, it was found that for older women with early-stage ER+/HER2- breast cancer, adjuvant RT and HT monotherapy both reduce the risk of locoregional recurrence, with a slightly better outcome for the combination therapy. Distant recurrence and breast cancer-specific survival rates did not significantly differ between the treatment groups. Further research is needed to determine the optimal treatment approach for these patients.
Article
Biochemistry & Molecular Biology
Daisuke Kotani, Eiji Oki, Yoshiaki Nakamura, Hiroki Yukami, Saori Mishima, Hideaki Bando, Hiromichi Shirasu, Kentaro Yamazaki, Jun Watanabe, Masahito Kotaka, Keiji Hirata, Naoya Akazawa, Kozo Kataoka, Shruti Sharma, Vasily N. Aushev, Alexey Aleshin, Toshihiro Misumi, Hiroya Taniguchi, Ichiro Takemasa, Takeshi Kato, Masaki Mori, Takayuki Yoshino
Summary: Circulating tumor DNA (ctDNA) analysis can help with risk stratification and treatment decisions for patients with resectable colorectal cancer (CRC). The study found that postsurgical ctDNA positivity was associated with higher recurrence risk and was the most significant prognostic factor for patients with stage II or III CRC. Furthermore, ctDNA positivity identified patients who derived benefit from adjuvant chemotherapy.
Article
Oncology
Jose F. Carrillo, Jesus Manuel Flores, Gilberto Espinoza, Rafael Vazquez-Romo, Margarita C. Ramirez-Ortega, Liliana C. Carrillo, Beatriz Y. Cortes-Garcia, Francisco J. Ochoa-Carrillo, Luis F. Onate-Ocana
Summary: In patients with unresectable DTC, upfront EBRT followed by salvage surgery improves PFS and OS prognosis. High-risk histopathology and EBRT dose are independent factors affecting patient PFS and OS outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Tenna Vesterman Henriksen, Noelia Tarazona, Amanda Frydendahl, Thomas Reinert, Francisco Gimeno-Valiente, Juan Antonio Carbonell-Asins, Shruti Sharma, Derrick Renner, Dina Hafez, Desamparados Roda, Marisol Huerta, Susana Rosello, Anders Husted Madsen, Uffe S. Love, Per Vadgaard Andersen, Ole Thorlacius-Ussing, Lene Hjerrild Iversen, Kare Andersson Gotschalck, Himanshu Sethi, Alexey Aleshin, Andres Cervantes, Claus Lindbjerg Andersen
Summary: The study demonstrates the strong prognostic value of serial postoperative ctDNA analysis in predicting recurrence and assessing tumor growth rate. The novel combination of ctDNA detection and growth rate assessment provides unique opportunities for guiding treatment decisions.
CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Thea C. Heil, Rene J. F. Melis, Huub A. A. M. Maas, Barbara C. van Munster, Marcel G. M. Olde Rikkert, Johannes H. W. de Wilt, Eddy M. M. Adang
Summary: This study found significant technical efficiency variation in preoperative colorectal cancer care for older patients provided by Dutch hospitals. Offering a care pathway that includes prehabilitation was positively related to technical efficiency, especially in high-volume hospitals and general hospitals.
Review
Oncology
M. Chadha, J. White, S. M. Swain, E. Rakovitch, R. Jagsi, T. Whelan, J. A. Sparano
Summary: Older women are underrepresented in breast cancer clinical trials, and treatment guidelines are primarily based on studies in younger women. Omission of breast radiation therapy is associated with increased local relapse, but the risk of distant relapse in women aged 70 and above is very low. The incremental benefit of endocrine therapy in decreasing distant relapse rate and improving disease-free survival in older patients with low-risk breast cancer is unclear. Integration of molecular genomic assays in diagnosis and treatment may optimize risk-tailored adjuvant therapies, allowing for treatment de-escalation in older women with early-stage breast cancer. The lack of risk-specific adjuvant therapy guidelines highlights the need for prospective trials to inform optimal treatment selection, including the possibility of omitting adjuvant endocrine therapy in older women with low-risk breast cancer.
Article
Medicine, General & Internal
Thanapon Chobpenthai, Thanate Poosiripinyo, Pakjai Tuntarattanapong, Pichaya Thanindratarn, Warayos Trathitephun
Summary: 2-octyl cyanoacrylate (2OCA) is safe and effective for skin closure in musculoskeletal surgery, with low incidence of postoperative adverse events and high patient satisfaction.
Review
Oncology
Marie-France Savard, Mark Clemons, Brian Hutton, Meshari Jemaan Alzahrani, Jean-Michel Caudrelier, Lisa Vandermeer, Michelle Liu, Deanna Saunders, Marta Sienkiewicz, Carol Stober, Katherine Cole, Risa Shorr, Angel Arnaout, Lynn Chang
Summary: A systematic review found that radiation therapy can be omitted in older patients with lower-risk breast cancer after BCS, but more trials on the omission of endocrine therapy are needed.
CANCER TREATMENT REVIEWS
(2021)
Review
Oncology
Philip B. Paty, Julio Garcia-Aguilar
Summary: Although surgery has been the mainstay for treating colorectal cancer, advances in technology and clinical trials over the past 50 years have significantly expanded and improved the detection, staging, treatment, and understanding of this disease. This review highlights the contributions of surgeons, oncologists, gastroenterologists, engineers, and scientists in enhancing postsurgical survival, reducing treatment time and toxicity, and improving patients' quality of life over the past half-century.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Immunology
Xing He, Huanrong Lan, Ketao Jin, Fanlong Liu
Summary: Colorectal cancer, as a major threat to human life, affects many people each year and has significant negative impacts on quality of life and financial and social well-being. The current treatments, such as chemotherapy, are not able to completely cure the disease and can cause liver damage. Therefore, combining chemotherapy with immunotherapy has been proposed as an approach to enhance efficacy and reduce side effects. This review discusses different chemotherapy and immunotherapy methods for colorectal cancer and explores studies on combined treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Hsiu-Jung Tung, Huei-Jean Huang, Chyong-Huey Lai
Summary: Endometrial cancer is usually diagnosed as a localized or regional disease, with treatment options including surgery and adjuvant therapy. Risk group classification plays an important role in guiding the selection of adjuvant therapy.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Article
Biology
Carter Allen, Yuzhou Chang, Brian Neelon, Won Chang, Hang J. Kim, Zihai Li, Qin Ma, Dongjun Chung
Summary: High throughput spatial transcriptomics (HST) is a rapidly emerging experimental technology that allows for analyzing gene expression in tissue samples at or near single-cell resolution. We developed SPRUCE, a Bayesian spatial multivariate finite mixture model, to identify distinct cellular sub-populations in HST data.
Article
Chemistry, Applied
Jun Liu, Ziying Hu, Dunhua Liu, Anran Zheng, Qin Ma
Summary: This study investigated the mechanisms by which cold storage affects the water-holding capacity (WHC) of beef through analysis of exudates using an untargeted metabolomics strategy. The findings revealed the presence of ferroptosis during beef storage, which negatively impacted the WHC.
Article
Computer Science, Software Engineering
Qin Ma, Monika Kaczmarek-Hess, Sybren de Kinderen
Summary: This paper focuses on the systematic embedding of verification and validation techniques into the engineering of (enterprise) domain-specific modeling methods, aiming to improve the quality and effectiveness of enterprise models. By synthesizing and enriching existing approaches, the authors provide a roadmap for further advances in verification and validation in domain-specific modeling method engineering.
SOFTWARE AND SYSTEMS MODELING
(2023)
Article
Chemistry, Physical
Zhaoqing Lu, Bo Geng, Qin Ma, Doudou Ning, Ruixia Zhao, Fangong Kong, Songfeng E
Summary: Four types of polymers were selected as additives to improve the mechanical properties of aramid nanofiber (ANF) film. The results showed that all of these polymers enhanced the strength, elongation, and toughness of the ANF film. The TPU and PAM with amide structures formed ordered hydrogen bond networks and significantly improved the strength, while PAA and PVP showed strong enhancing capacities on toughness. This study also revealed the weak enhancing ability of nonpolar polymer PS on the mechanical properties of ANF film due to poor interfacial compatibility and phase separation.
APPLIED SURFACE SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Shiqiao Ye, Cankun Wang, Zhaohui Xu, Hui Lin, Xiaoping Wan, Yang Yu, Subhodip Adhicary, Joe Z. Zhang, Yang Zhou, Chun Liu, Matthew Alonzo, Jianli Bi, Angelina Ramirez-Navarro, Isabelle Deschenes, Qin Ma, Vidu Garg, Joseph C. Wu, Ming-Tao Zhao
Summary: This study demonstrates that NOTCH1 is crucial for the differentiation and proliferation of human cardiac cells. The absence of NOTCH1 leads to defective ventricular-like cardiomyocyte differentiation and impaired cell proliferation. These findings shed light on the mechanisms underlying hypoplastic left heart syndrome.
CIRCULATION RESEARCH
(2023)
Article
Computer Science, Information Systems
Ying Li, Hang Sun, Wensi Fang, Qin Ma, Siyu Han, Rui Wang-Sattler, Wei Du, Qiong Yu
Summary: For classification tasks in the bioinformatics field with limited negative samples, the researchers propose a novel deep reinforcement learning-based model called SURE, which can screen reliable negative samples from unlabeled samples. SURE consists of a sample selector and a sample inspector, which are trained together to optimize the screening strategies. Experimental results show that SURE has a robust negative sample screening capability and outperforms other methods in the task of NPI prediction. Additionally, 5 NPI datasets refined by SURE are provided through a web server.
INFORMATION SCIENCES
(2023)
Correction
Neurosciences
Mor Kenigsbuch, Pierre Bost, Shahar Halevi, Yuzhou Chang, Shuo Chen, Qin Ma, Renana Hajbi, Benno Schwikowski, Bernd Bodenmiller, Hongjun Fu, Michal Schwartz, Ido Amit
NATURE NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Ying Chen, Zengqiu Yang, Sibu Wang, Qin Ma, Lingyan Li, Xingjie Wu, Qianqian Guo, Ling Tao, Xiangchun Shen
Summary: Due to the unique characteristics of lysosomes, inducing lysosomal membrane permeabilization (LMP) through ROS generation has gained attention for cancer therapy. A lysosome-targeted ROS inducer, VC@(N3AM)cLAVs, has been developed to efficiently produce ROS in lysosomes and cause lysosomal membrane rupture, leading to tumor cell death.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Multidisciplinary Sciences
Anjun Ma, Xiaoying Wang, Jingxian Li, Cankun Wang, Tong Xiao, Yuntao Liu, Hao Cheng, Juexin Wang, Yang Li, Yuzhou Chang, Jinpu Li, Duolin Wang, Yuexu Jiang, Li Su, Gang Xin, Shaopeng Gu, Zihai Li, Bingqiang Liu, Dong Xu, Qin Ma
Summary: Single-cell multi-omics and deep learning have the potential to infer biological networks in specific cell types. DeepMAPS, a deep learning and graph-based approach, is developed for cell-type specific network inference from single-cell multi-omics data. Benchmarking results show that DeepMAPS outperforms existing tools in cell clustering and biological network construction.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yi Jiang, Ruheng Wang, Jiuxin Feng, Junru Jin, Sirui Liang, Zhongshen Li, Yingying Yu, Anjun Ma, Ran Su, Quan Zou, Qin Ma, Leyi Wei
Summary: In this study, a deep hypergraph learning framework called PHAT is proposed for predicting peptide secondary structures and exploring downstream tasks. The framework includes a novel interpretable deep hypergraph multi-head attention network that uses residue-based reasoning for structure prediction. The algorithm can incorporate sequential semantic information from a large-scale biological corpus and structural semantic information from multi-scale structural segmentation, leading to better accuracy and interpretability even with extremely short peptides. The importance of secondary structures in peptide tertiary structure reconstruction and downstream functional analysis is further demonstrated, highlighting the versatility of the models.
Article
Biology
Zhaoqian Liu, Qi Wang, Anjun Ma, Shaohong Feng, Dongjun Chung, Jing Zhao, Qin Ma, Bingqiang Liu
Summary: This paper introduces a novel computational method called IDAM for inferring disease-associated gene modules from microbial data, and demonstrates its superior performance compared to existing popular tools.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Qi Wang, Zhaoqian Liu, Anjun Ma, Zihai Li, Bingqiang Liu, Qin Ma
Summary: The human microbiome is closely related to cancer biology and plays a crucial role in cancer treatments, including immunotherapy. This review focuses on the intratumoral microbiome in the context of immuno-oncology-microbiome (IOM) and discusses the available data and computational methods for analyzing microbial profiling. The challenges in data analysis and integration are addressed, and the microorganisms associated with cancer and cancer treatment in IOM are summarized from the literature. Future directions in IOM research are also provided.
TRENDS IN MICROBIOLOGY
(2023)
Article
Biochemical Research Methods
Juan Xie, Hyeongseon Jeon, Gang Xin, Qin Ma, Dongjun Chung
Summary: We developed a computational framework called LRT for the integrative analysis of scRNA-seq and scTCR-seq data to explore clonal differentiation trajectory heterogeneity. LRT uses transcriptomics and TCR sequence information to identify clonotype clusters with distinct differentiation biasedness. This framework provides a comprehensive analysis workflow for cell trajectory inference, clonotype clustering, trajectory biasedness evaluation, and clonotype cluster characterization.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Oncology
Yihui Han, Wenming Yang, Qin Ma, Zhaolun Cai, Yun Yang, Junhe Gou, Tao Yuan, Mingming Zhang, Bo Zhang
Summary: Breast and vulvar metastases from rectal signet ring cell carcinoma (SRCC) are rare and associated with poor survival. This report describes a case of a 26-year-old woman who developed breast and vulvar metastases after neoadjuvant chemotherapy and surgical resection. The disease progressed rapidly and the patient died. The importance of identifying and treating metastatic lesions in the breast and vulva is emphasized in this report.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xinxin Zhang, Kui Dong, Zhiming Kang, Xuan Ji, Xiaoling Ning, Qin Ma, Bin Sun
Summary: This study compared the microbial communities of the eye, anterior nares (ANs), and oropharynx (OP) in healthy adults and found that the bacterial compositions and functions of the eye and ANs were similar but differed from those of the OP. The OP microbiota showed characteristics similar to that of the digestive tract flora. Additionally, Cutibacterium and Micrococcus were found to possibly migrate from the eye to the nose.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
