Emerging Sulfated Flavonoids and other Polyphenols as Drugs: Nature as an Inspiration

Sulfated Small Molecules Targeting EBV in Burkitt Lymphoma: FromIn SilicoScreening to the Evidence ofIn VitroEffect on Viral Episomal DNA

(2013) Raquel T. Lima et al.   Chemical Biology & Drug Design

Discovery of novel sulfonated small molecules that inhibit vascular tube formation

(2012) Karthik Raman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Designing Allosteric Regulators of Thrombin. Monosulfated Benzofuran Dimers Selectively Interact With Arg173 of Exosite 2 to Induce Inhibition

(2012) May H. Abdel Aziz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of PG545: A Highly Potent and Simultaneous Inhibitor of Angiogenesis, Tumor Growth, and Metastasis

(2012) Vito Ferro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Limitations of conventional anticoagulant therapy and the promises of non-heparin based conformational activators of antithrombin

(2012) Qudsia Rashid et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Anticancer Properties and Mechanisms of Fucoidan on Mouse Breast Cancer In Vitro and In Vivo

(2012) Meilan Xue et al.   PLoS One

On the Specificity of Heparin/Heparan Sulfate Binding to Proteins. Anion-Binding Sites on Antithrombin and Thrombin Are Fundamentally Different

(2012) Philip D. Mosier et al.   PLoS One

In vitro antioxidant and antitumor evaluation of new sulfated antithrombotic small molecules

(2012) M. Correia-da-Silva et al.   THROMBOSIS RESEARCH

Effect of O-glycosylation and tyrosinesulfation of leech-derived peptides on binding and inhibitory activity against thrombin

(2011) Yves S. Y. Hsieh et al.   CHEMICAL COMMUNICATIONS

Dual anticoagulant/antiplatelet persulfated small molecules

(2011) Marta Correia-da-Silva et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties

(2011) Silvina B. Lotito et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rational Design of Potent, Small, Synthetic Allosteric Inhibitors of Thrombin

(2011) Preetpal Singh Sidhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polysulfated Xanthones: Multipathway Development of a New Generation of Dual Anticoagulant/Antiplatelet Agents

(2011) Marta Correia-da-Silva et al.   JOURNAL OF MEDICINAL CHEMISTRY

Designing Nonsaccharide, Allosteric Activators of Antithrombin for Accelerated Inhibition of Factor Xa

(2011) Rami A. Al-Horani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae

(2011) Guangling Jiao et al.   Marine Drugs

Microbial metabolism of α-mangostin isolated from Garcinia mangostana L.

(2011) Panarat Arunrattiyakorn et al.   PHYTOCHEMISTRY

Fucans, but Not Fucomannoglucuronans, Determine the Biological Activities of Sulfated Polysaccharides from Laminaria saccharina Brown Seaweed

(2011) Diego O. Croci et al.   PLoS One

Identification of a Dendrimeric Heparan Sulfate-Binding Peptide That Inhibits Infectivity of Genital Types of Human Papillomaviruses

(2010) M. Donalisio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Baculiferins A–O, O-sulfated pyrrole alkaloids with anti-HIV-1 activity, from the Chinese marine sponge Iotrochota baculifera

(2010) Guotao Fan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Heparin/heparan sulphate-based drugs

(2010) Neha S. Gandhi et al.   DRUG DISCOVERY TODAY

Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites

(2010) Juma Hoshino et al.   JOURNAL OF MEDICINAL CHEMISTRY

Flavonoids with an Oligopolysulfated Moiety: A New Class of Anticoagulant Agents

(2010) Marta Correia-da-Silva et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Xanthones and Benzophenones as Inhibitors of Tumor Cell Growth

(2010) Elisangela Costa et al.   Letters in Drug Design & Discovery

Anti-HIV Activities of the Compounds Isolated fromPolygonum cuspidatumandPolygonum multiflorum

(2010) Hong-Wei Lin et al.   PLANTA MEDICA

Study of sulfated derivatives of polyhydroxy compounds as inhibitors of blood coagulation

(2010) V. B. Krylov et al.   RUSSIAN CHEMICAL BULLETIN

Chemical sulfation of small molecules—advances and challenges

(2010) Rami A. Al-Horani et al.   TETRAHEDRON

Coagulation update: What's new in hemostasis testing?

(2010) Emmanuel J. Favaloro et al.   THROMBOSIS RESEARCH

Tyrosine Sulfation of the Amino Terminus of PSGL-1 Is Critical for Enterovirus 71 Infection

(2010) Yorihiro Nishimura et al.   PLoS Pathogens

First steps in the direction of synthetic, allosteric, direct inhibitors of thrombin and factor Xa

(2009) Jenson Verghese et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expression of sulfotransferases and sulfatases in human breast cancer: Impact on resveratrol metabolism

(2009) Michaela Miksits et al.   CANCER LETTERS

An efficient approach to sulfate metabolites of polychlorinated biphenyls

(2009) Xueshu Li et al.   ENVIRONMENT INTERNATIONAL

In vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferases and sulfotransferases in humans

(2009) Chi Chun Wong et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Study of physico-chemical properties of novel highly sulfated, aromatic, mimetics of heparin and heparan sulfate

(2009) Aiye Liang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Tyrosine sulfation: an increasingly recognised post-translational modification of secreted proteins

(2009) Martin J. Stone et al.   New Biotechnology

Sulfated K5 Escherichia coli polysaccharide derivatives: A novel class of candidate antiviral microbicides

(2009) Marco Rusnati et al.   PHARMACOLOGY & THERAPEUTICS

Sulfated, low-molecular-weight lignins are potent inhibitors of plasmin, in addition to thrombin and factor Xa: Novel opportunity for controlling complex pathologies

(2009) Brian Henry et al.   THROMBOSIS AND HAEMOSTASIS

Sequential Tyrosine Sulfation of CXCR4 by Tyrosylprotein Sulfotransferases†

(2008) Christoph Seibert et al.   BIOCHEMISTRY

On designing non-saccharide, allosteric activators of antithrombin

(2008) Arjun Raghuraman et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Apigenin Inhibits Platelet Adhesion and Thrombus Formation and Synergizes with Aspirin in the Suppression of the Arachidonic Acid Pathway

(2008) L. Navarro-Núñez et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Efficient acid-promoted per-O-sulfation of organic polyols

(2008) Vadim B. Krylov et al.   TETRAHEDRON LETTERS