FMS Kinase Inhibitors: Current Status and Future Prospects

Sunlight Triggers Cutaneous Lupus through a CSF-1-Dependent Mechanism in MRL-Faslpr Mice

(2014) J. Menke et al.   JOURNAL OF IMMUNOLOGY

Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms

(2014) S. K. Biswas et al.   JOURNAL OF IMMUNOLOGY

Increased Serum Enzyme Levels Associated with Kupffer Cell Reduction with No Signs of Hepatic or Skeletal Muscle Injury

(2011) Zaher A. Radi et al.   AMERICAN JOURNAL OF PATHOLOGY

Pleiotropic role for monocyte C-fms protein in response to vascular injury: Potential therapeutic target

(2011) Pat Metharom et al.   ATHEROSCLEROSIS

3-Amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor

(2011) David A. Scott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Macrophage colony-stimulating factor and its receptor signaling augment glycated albumin-induced retinal microglial inflammation in vitro

(2011) Wei Liu et al.   BMC CELL BIOLOGY

Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation

(2011) Jason C Lenzo et al.   IMMUNOLOGY AND CELL BIOLOGY

Receptor tyrosine kinase inhibition causes simultaneous bone loss and excess bone formation within growing bone in rats

(2011) Mirja Nurmio et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Reductions in LPS- and Alzheimer's disease neuropathology-induced CNS inflammation with selective colony stimulating factor-1 receptor kinase inhibitors

(2010) Kim N. Green et al.   Alzheimers & Dementia

Colony stimulating factor-1 receptor as a target for small molecule inhibitors

(2010) Baratali Mashkani et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors

(2010) Kenneth J. Wilson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of a new potent bisamide FMS kinase inhibitor

(2010) Mohammed I. El-Gamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode

(2010) Marvin J. Meyers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation

(2010) K. P. A. MacDonald et al.   BLOOD

Synthesis of 5-substituted benzyl-2,4-diamino pyrimidine derivatives as c-Fms kinase inhibitors

(2010) Li Bao Xu et al.   CHINESE CHEMICAL LETTERS

Serum level of macrophage colony-stimulating factor is increased in prostate cancer patients with bone metastasis

(2010) Hisamitsu IDE et al.   Human Cell

Rapid publication: Impairment of macrophage colony-stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op Mouse

(2010) R. Felix et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclasts in vivo

(2010) Kate Vandyke et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Posttranscriptional Suppression of Proto-Oncogene c-fms Expression by Vigilin in Breast Cancer

(2010) H.-H. Woo et al.   MOLECULAR AND CELLULAR BIOLOGY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis

(2010) Ricardo T Paniagua et al.   ARTHRITIS RESEARCH & THERAPY

Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice

(2009) A. K. H. Lim et al.   DIABETOLOGIA

CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages

(2009) Richa K. Dave et al.   EXPERIMENTAL CELL RESEARCH

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

(2009) Yoshiaki Kubota et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pyrido[2,3-d]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors†

(2009) Hui Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

(2009) C. L. Manthey et al.   MOLECULAR CANCER THERAPEUTICS

Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor α, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor

(2008) Inmaculada Rioja et al.   ARTHRITIS AND RHEUMATISM

Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors

(2008) Mark J. Wall et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-based optimization of a potent class of arylamide FMS inhibitors

(2008) Sanath K. Meegalla et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of novel FMS kinase inhibitors as anti-inflammatory agents

(2008) Carl R. Illig et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer

(2008) David A. Scott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors

(2008) Hui Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

(2008) Christopher J. Burns et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3-Amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile

(2008) David A. Scott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase

(2008) David A. Scott et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Special Linker between Macrophage and Hematopoietic Malignant Cells: Membrane Form of Macrophage Colony-Stimulating Factor

(2008) L. Wang et al.   CANCER RESEARCH

Imatinib Mesylate Enhances Therapeutic Effects of Gemcitabine in Human Malignant Mesothelioma Xenografts

(2008) P. Bertino et al.   CLINICAL CANCER RESEARCH

Axitinib for renal cell carcinoma

(2008) Guru Sonpavde et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A potential role for colony-stimulating factor 1 in the genesis of the early endometriotic lesion

(2008) Jani R. Jensen et al.   FERTILITY AND STERILITY

Role of microRNAs in drug-resistant ovarian cancer cells

(2008) Antonio Sorrentino et al.   GYNECOLOGIC ONCOLOGY

Imatinib mesylate suppresses bone metastases of breast cancer by inhibiting osteoclasts through the blockade of c-Fms signals

(2008) Toru Hiraga et al.   INTERNATIONAL JOURNAL OF CANCER

The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis

(2008) Yasunori Uemura et al.   JOURNAL OF NEUROIMMUNOLOGY

Effects of the cFMS Kinase Inhibitor 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in Normal and Arthritic Rats

(2008) J. G. Conway et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Therapeutic concentrations of dasatinib inhibit in vitro osteoclastogenesis

(2008) K Vandyke et al.   LEUKEMIA

Multiple myeloma cells directly stimulate bone resorption in vitro by down-regulating mature osteoclast apoptosis

(2008) Iman El Hajj Dib et al.   LEUKEMIA RESEARCH

Structure of macrophage colony stimulating factor bound to FMS: Diverse signaling assemblies of class III receptor tyrosine kinases

(2008) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

(2008) H. Lin et al.   SCIENCE

The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model

(2007) Hiroaki Ohno et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antitumor Effects of Sunitinib or Sorafenib in Patients With Metastatic Renal Cell Carcinoma Who Received Prior Antiangiogenic Therapy

(2007) Ila Tamaskar et al.   JOURNAL OF UROLOGY