Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus

The thiazolidinediones rosiglitazone and pioglitazone and the risk of coronary heart disease: A retrospective cohort study using a US health insurance database

(2010) Najat Ziyadeh et al.   CLINICAL THERAPEUTICS

Self-organizing molecular field analysis of 2,4-thiazolidinediones: A 3D-QSAR model for the development of human PTP1B inhibitors

(2010) Suresh Thareja et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes

(2009) Carolyn F. Deacon et al.   ADVANCES IN THERAPY

Docking Simulations and in Vitro Assay Unveil Potent Inhibitory Action of Papaverine against Protein Tyrosine Phosphatase 1B

(2009) Yasser Bustanji et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors

(2009) Rosaria Ottanà et al.   BIOORGANIC & MEDICINAL CHEMISTRY

5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents

(2009) Fateh V. Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects

(2009) Bharat Raj Bhattarai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of protein tyrosine phosphatase 1B inhibitors: Model validation and docking studies

(2009) Anil K. Saxena et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activation of Src by Protein Tyrosine Phosphatase 1B Is Required for ErbB2 Transformation of Human Breast Epithelial Cells

(2009) L. E. Arias-Romero et al.   CANCER RESEARCH

Structure-Based Optimization of Benzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B and Low Molecular Weight Protein Tyrosine Phosphatase

(2009) Rosanna Maccari et al.   ChemMedChem

Recent advances in the discovery and development of PTP-1B inhibitors

(2009) S. Tam et al.   DRUGS OF THE FUTURE

Inhibition of Protein Tyrosine Phosphatase-1B with Antisense Oligonucleotides Improves Insulin Sensitivity and Increases Adiponectin Concentrations in Monkeys

(2009) Michael M. Swarbrick et al.   ENDOCRINOLOGY

The α-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic β-cells in OLETF rats

(2009) Nanae Fukaya et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Significance of protein tyrosine kinase/protein tyrosine phosphatase balance in the regulation of NF-κB signaling in the inflammatory process and aging

(2009) Kyung Jin Jung et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues

(2009) B. Xue et al.   MOLECULAR AND CELLULAR BIOLOGY

Cinnamic acid, from the bark of Cinnamomum cassia, regulates glucose transport via activation of GLUT4 on L6 myotubes in a phosphatidylinositol 3-kinase-independent manner

(2009) Baddireddi Subhadra LAKSHMI et al.   Journal of Diabetes

Flavanones from the stem bark of Erythrina abyssinica

(2008) Long Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of triazole-linked β-C-glycosyl dimers as inhibitors of PTP1B

(2008) Li Lin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides

(2008) Sanjib Bhattacharya et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PTP1B inhibitors: Synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold

(2008) Christopher P. Holmes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B) Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic Reticulum Stress

(2008) M. Delibegovic et al.   DIABETES

Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammationin Vivo

(2008) Janice M. Zabolotny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prodrugs of Phosphates and Phosphonates

(2008) Scott J. Hecker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines

(2007) Brent Douty et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hepatic dysfunction and insulin insensitivity in type 2 diabetes mellitus: a critical target for insulin-sensitizing agents

(2007) P. D. Home et al.   DIABETES OBESITY & METABOLISM

DPP-4 inhibitor therapy: new directions in the treatment of type 2 diabetes

(2007) Carolyn et al.   Frontiers in Bioscience-Landmark

Rosiglitazone ameliorates abnormal expression and activity of protein tyrosine phosphatase 1B in the skeletal muscle of fat-fed, streptozotocin-treated diabetic rats

(2005) Yong Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY