Journal
MEDICINAL RESEARCH REVIEWS
Volume 30, Issue 4, Pages 603-645Publisher
WILEY
DOI: 10.1002/med.20170
Keywords
tuberculosis; antimycobacterial; phytomolecules; Mycobacterium tuberculosis; antitubercular
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Mycobacterium tube, (Atlas's is the most lethal pathogen causing tuberculosis in human After the discovery of antitubercular drugs pyrazinamide, rifampicin, isoniazid streptomycin, and ethambutol (PRISE), the disease was controlled for a limited period However, over the course of their usage, the pathogen acquired resistance and evolved into multi-drug resistant. single-drug resistant, and extensive drug resistant forms A good number of plant secondary metabolites are reported to have antitubercular activity comparable to the existing antitubercular drugs or sometimes even better in potency A well-defined strategy is required to exploit these phytomolecules as antitubercular drugs This review gives concise up-to-date information regarding the chemistry and pharmacology of plant-based leads and some insight into their structure-activity relationship (c) 2009 Wiley Periodicals, Inc Med Res Rev. 30. No 4 603-645, 2010
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