Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 22, Issue 12, Pages 5912-5919Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-013-0573-9
Keywords
Benzotriazole; Antibacterial; Antifungal; Oxidoreductase (1XDQ, 3QLS) proteins
Categories
Ask authors/readers for more resources
A new series of 2-((4-(2H-benzo[d][1,2,3]triazol-2-yl)piperidin-1-yl)methyl)-5-substituted-1-yl)-acetic acid hydrazide (3) with various substituted aromatic carboxylic acids phenyl-1,3,4-oxadiazoles (4a-j) were synthesized by cyclization of 4-benzotriazol-2-yl-piperidin in the presence of POCl3. The structures were characterized by spectral data. The representative examples were screened invitro antibacterial activity and antifungal activity. The compounds showed significant antibacterial activity and showed moderate antifungal activity as that of standards, respectively. The data were further compared with structure-based investigations using docking studies with the crystal structure of oxidoreductase (1XDQ) protein organism: Escherichia coli for antibacterial activity and oxidoreductase (3QLS) protein, organism: Candida albicans for antifungal activity. The score values estimated by genetic algorithm were found to have a good correlation with the experimental inhibitory potencies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available