Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 23, Issue 3, Pages 1278-1289Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-013-0721-2
Keywords
Sulfonamide; Pyrazole; HeLa cell lines; C6 cell lines; Antiproliferative activity
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Funding
- Scientific and Research Council of Turkey [TUBI-TAK 106T180]
- State Planning Organization, Turkey [DPT 2003K120510]
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In this study, a series of pyrazole-sulfonamide derivatives were designed and synthesized from 1-(4-aminophenyl)-4-benzoyl-5-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-3-carboxamide (1). The newly synthesized sulfonamides were characterized by FT-IR, H-1 NMR, C-13 NMR, and elemental analyses. The compounds were tested for their in vitro antiproliferative activities against HeLa and C6 cell lines. The tests were carried out as dose-dependent assay starting from 5 to 100 mu g/mL. All compounds showed especially cell selective effect against rat brain tumor cells (C6). Some of the tested compounds (3) and (7) showed promising broad spectrum antitumor activity comparable to the activities of the commonly used anticancer drugs, 5-fluorouracil and cisplatin.
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