Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 23, Issue 6, Pages 2916-2929Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-013-0884-x
Keywords
Benzoxazole; Benzothiazole; Benzimidazole; Pyrrole; Pyrazole; Antioxidant activity
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Funding
- University Grants Commission (UGC), New Delhi
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The amido-linked benzoxazolyl/benzothiazolyl/benzimidazolyl-pyrroles and benzoxazolyl/benzothiazolyl/benzimidazolyl-pyrazoles were prepared from the synthetic intermediates (E)-N-(benzoxazol-2-yl)cinnamamide/(E)-N-(benzothiazol-2-yl)cinnamamide/(E)-N-(1H-benzimidazol-2-yl)cinnamamides adopting simple and versatile synthetic methodologies. All the new compounds were tested for antioxidant activity. The compounds 5b, 8b and 14b displayed greater antioxidant activity when compared with the standard drug ascorbic acid. It was also observed that benzoxazolyl amido-linked derivatives displayed greater radical scavenging activity than the benzothiazolyl and benzimidazolyl amido-linked derivatives. The amido-linked benzoxazolyl/benzothiazolyl/benzimidazolyl-pyrroles and benzoxazolyl/benzothiazolyl/benzimidazolyl-pyrazoles were prepared from the synthetic intermediates (E)-N-(benzoxazol-2-yl)cinnamamide/(E)-N-(benzothiazol-2-yl)cinnamamide/(E)-N-(1H-benzimidazol-2-yl)cinnamamides adopting simple and versatile synthetic methodologies. All the new compounds were tested for antioxidant activity. The compounds 5b, 8b and 14b displayed greater antioxidant activity when compared with the standard drug Ascorbic acid. It was also observed that benzoxazolyl amido-linked derivatives displayed greater radical scavenging activity than the benzothiazolyl and benzimidazolyl amido-linked derivatives.
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