Article
Biochemistry & Molecular Biology
Oxana Kazakova, Codruta Soica, Marat Babaev, Anastasiya Petrova, Elmira Khusnutdinova, Alexander Poptsov, Ioana Macasoi, George Draghici, Stefana Avram, Lavinia Vlaia, Alexandra Mioc, Marius Mioc, Cristina Dehelean, Adrian Voicu
Summary: In this study, modified lupane and ursane derivatives showed high activity in inhibiting cancer cell proliferation by inducing apoptotic cell death. The compounds 6 and 7 exhibited high inhibitory activity against the antiapoptotic protein Bcl-XL, suggesting a potential mechanism for inducing apoptotic cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Organic
Nermine A. Osman, Nermine S. EL Sayed, Hanan A. Abdel A. Fattah, Ahmad J. Almalki, Ahmed K. Kammoun, Tarek S. Ibrahim, Abdulrahman S. Alharbi, Amany M. A. L. Mahmoudy
Summary: Novel pyrimidine-pyrazole derivatives were synthesized and evaluated for their anticancer activity. Some of the compounds exhibited potential anticancer activity against multiple cancer cell lines.
CURRENT ORGANIC SYNTHESIS
(2023)
Article
Chemistry, Multidisciplinary
Carlos Andres Coy-Barrera, Inti Camilo Monge, Diego Quiroga
Summary: In this study, a series of chalcone analogs were synthesized and tested as corrosion inhibitors for carbon steel in HCl solutions. Three chalcone compounds (CH11, CH15, and CH16) showed significant anticorrosive activity with increasing mass. Theoretical calculations using DFT were performed to explain the mechanism of corrosion inhibition by these compounds.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Bathelemy Ngameni, Kamdoum Cedric, Armelle T. Mbaveng, Musa Erdogan, Ingrid Simo, Victor Kuete, Arif Dastan
Summary: A new series of O-substituted chalcone derivatives with different substituents were designed, synthesized, and characterized, showing promising cytotoxic effects against leukemia and colon adenocarcinoma cells in preliminary cytotoxicity tests.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Inorganic & Nuclear
Harshal Dabhane, Suresh Ghotekar, Manohar Zate, Sagar Kute, Ghanshyam Jadhav, Vijay Medhane
Summary: Nanotechnology offers a method for synthesizing nanoparticles, while green plant extract synthesis methods have been successfully applied to overcome environmental issues. The study demonstrates a simple, efficient, inexpensive, and environmentally friendly approach to produce magnesium oxide nanoparticles.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Chuan-Huizi Chen, Yuan Jiang, Runfang Wu, Yanling Tang, Chunping Wan, Hui Gao, Zewei Mao
Summary: In this study, a series of novel heterocyclic substituted dihydropyrazole derivatives were synthesized, among which piperazine substituted compounds showed superior anticancer activity. Particularly, compound 4o was found to induce G2/M arrest in HCC1806 cells and significantly accumulate p21 protein, demonstrating potent antitumor activity.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
M. Fatih Polat, Derya Aktas Anil, Gizem Ozkemahli, Burcin Turkmenoglu, Ceylan Hepokur, Serdar Burmaoglu, Oztekin Algul
Summary: A novel series of trimethoxy chalcones with CF3 or F substituents at different positions of ring B were designed and synthesized. These compounds were characterized using IR, NMR spectral data, and elemental analyses. Their cytotoxicity against A549, HEPG2, MCF7, and L929 cells was evaluated, and compound 13 showed the highest activity and induced cell cycle arrest at the G0/G1 phase in MCF7 cells. The apoptotic mechanisms of compound 13 involving Bax, Bcl-2, and p53 were also investigated, along with their effects on human EGFR and VEGFR-2 receptors.
Article
Chemistry, Organic
Kangsheng Xue, Guoxiang Sun, Yanzhi Zhang, Xubing Chen, Yang Zhou, Jinjun Hou, Huali Long, Zijia Zhang, Min Lei, Wanying Wu
Summary: The method developed for the synthesis of chalcone derivatives by a Claisen-Schmidt reaction in non-strongly alkaline conditions significantly expands the range of applicable substrates, especially for groups that are unstable under alkaline conditions. It is a straightforward and general method that shows promise for the synthesis of a variety of chalcone derivatives.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Zhe Xiang, Xi Zhao, Guoxiang Wang, Chenze Qi, Sujing Zhou, Jinjing Li, Yong Gao
Summary: In this study, an efficient and recyclable platform for interfacial catalytic reaction was constructed using pH-responsive n-decane-in-water Pickering emulsions. The prepared emulsions showed high stability and rapid demulsification at low pH. The catalytic platform exhibited a far higher reaction efficiency compared to ordinary n-decane-water systems. This study demonstrates the potential application of Pickering emulsions in heterogeneous reactions.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Nicolas Giacoletto, Frederic Dumur
Summary: Over the past several decades, photopolymerization research has been actively developing, with bis-chalcones found to be promising photosensitizers for different polymerization reactions. This review provides an overview of the various bis-chalcones reported to date and their applications in different fields.
Article
Biochemistry & Molecular Biology
Emilia P. T. Leitao, Osvaldo S. Ascenso, Tania Santos de Almeida, Ignacio Gonzalez, Inmaculada Hernandez, Jose Quintana, Francisco Estevez, Patricia Rijo
Summary: A series of hydroxylated chalcone derivatives with different substitution patterns were prepared, and it was found that the naphthylchalcone containing a methoxy group in position 6 ' of the A ring exhibited the highest cytotoxicity against human leukaemia cells.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Suraj R. Attar, Aboli C. Sapkal, Chaitali S. Bagade, Sarfraj H. Mujawar, Santosh B. Kamble
Summary: A new strategy for improving the catalytic activity of nanoparticles in organic transformations has been reported. Gel-entrapped zinc oxide nanorods (GE-ZnO NRs) were prepared and characterized by various techniques. The catalytic activity of GE-ZnO NRs was investigated in the CSC reaction of aldehydes and acetophenone in an aqueous medium at room temperature. The catalyst was easily separated from the reaction mixture using a centrifugation-free filtration process and could be reused multiple times without significant loss in activity. The use of low-cost biodegradable materials, centrifugation-free separation, and isolation of the product without column chromatography are noteworthy features of this sustainable approach.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Applied
Min Huang, Manman Sun, Lanxin Zhang, Xuebo Yang, Yuntao Shi, Kun Xing, Hongguang Deng, Zhenwei Zhang, Dan Liu, Linxiang Zhao
Summary: This article presents an efficient new synthesis method for a peroxisome proliferator-activated receptor delta agonist fonadelpar. The method utilizes Claisen-Schmidt condensation and an optimized process to prepare the drug candidate with fewer steps and higher yield.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Article
Chemistry, Medicinal
Dorota Olender, Malgorzata Jozkowiak, Hanna Piotrowska-Kempisty, Katarzyna Sowa-Kasprzak, Lucjusz Zaprutko, Izabela Muszalska-Kolos, Ewa Baranowska-Wojcik, Dominik Szwajgier
Summary: The study aimed to design and synthesize a series of curcuminoid chalcone-NSAID hybrid derivatives and evaluate their biological activity and stability. The results showed that some curcuminoid chalcone derivatives exhibited promising neuroprotective activity and could be used effectively for sonodynamic therapy. Additionally, these hybrid compounds were found to be unstable in acidic and neutral environments, with extreme instability in acidic conditions.
Review
Chemistry, Medicinal
Rui Pereira, Artur M. S. Silva, Daniela Ribeiro, Vera L. M. Silva, Eduarda Fernandes
Summary: This review article provides an overview of the chemical structure, chemical properties, and synthesis methods of bis-chalcones. It also emphasizes the anti-inflammatory activity of bis-chalcones and their mechanisms of action.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
