Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 21, Issue 5, Pages 663-671Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-011-9576-6
Keywords
Quinoxaline; Thiosemicarbazone; Antidiabetic agent; Blood-glucose test; Oral glucose tolerance test
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Funding
- Karnatak University, Dharwad
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New transition metal complexes of quinoxaline-thiosemicarbazone ligands were prepared and characterised by spectroanalytical techniques. The ligands L H-1(2) and L H-2(2) were obtained by the reaction of quinoxaline-2.3(1,4H)-dione with methyl and phenyl thiosemicarbazide, respectively. All the complexes are found to be monomeric in nature and have tetrahedral geometry. The copper complexes have shown redox responses in the applied voltage range, whereas the ligands and other complexes are electrochemically innocent. The ligands, copper and zinc complexes are explored for antidiabetic activity in the diabetes-induced Wister rats. Evaluation of antidiabetic activity was done by blood-glucose test and oral glucose tolerance test; few compounds have exhibited significant antidiabetic activity and posses low toxicity with a high safety profile.
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