Article
Chemistry, Physical
Zhiwei Zeng, Yuji Liu, Wei Huang, Jean'ne M. Shreeve, Yongxing Tang
Summary: A facile and efficient nitrogen-centered-radical-mediated approach to cleave C-N bonds in a monocyclic pyrazole has been described. The reaction achieved high yields and led to an energetic compound with promising application prospects.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Review
Chemistry, Medicinal
Gaz Serban Andrei, Boda Francisc Andrei, Pop Rahela Roxana
Summary: The research focused on exploring the chemical structures and antibacterial activity of imidazole derivatives, revealing promising results against both Gram-positive and Gram-negative bacterial strains. Further analysis is needed in terms of toxicity, pharmacokinetics and pharmacodynamics.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Microbiology
Yanhui Hu, Yuyuan Xing, Peng Ye, Haikuan Yu, Xianglei Meng, Yuting Song, Gongying Wang, Yanyan Diao
Summary: Ionic liquids (ILs) have been gaining attention in the biomedical field due to their unique properties. However, there is still a lack of understanding of their potential applications and underlying principles. We evaluated the antibacterial activity and mechanism of imidazole chloride ILs on Staphylococcus aureus, finding that the length of the imidazolidinyl side chain positively correlated with ILs toxicity. C12MIMCl caused bacterial death by simultaneously affecting the internal and external parts of S. aureus, stimulating oxidative stress and destroying the cell membrane.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Jun-Da Qi, Yu-Qing Meng, Jingxin Sun, Wan-Xin Li, Hou-Xiang Zhai, Changhao Zhang, Jishan Quan, Cheng-Hua Jin
Summary: Four novel pyrazole derivatives were synthesized and their antibacterial and antifungal activities were evaluated. Some of these compounds exhibited strong antifungal activity and high selectivity without cytotoxicity against human cells.
ARCHIV DER PHARMAZIE
(2023)
Article
Biochemistry & Molecular Biology
Wen-Bo Xu, Yu-Qing Meng, Jingxin Sun, Yu-Xuan Yang, Wan-Xin Li, Man-Yu Wang, Ming-Guan Piao, Siqi Li, Jishan Quan, Cheng-Hua Jin
Summary: A series of novel 2-cyclopropyl-5-(5-(6-methylpyridin-2-yl)-2-substituted-1H-imidazol-4-yl)-6-phenylimidazo[2,1-b][1,3,4]thiadiazoles were synthesized and evaluated for their antibacterial activities. Most of the compounds exhibited moderate to strong antibacterial activities, with compounds 15t (MIC=1-2 mu g/mL) and 16d (MIC=0.5 mu g/mL) showing the highest potency. Interestingly, compound 16d showed no cytotoxicity in HepG2 cells and no hemolysis, suggesting its potential as a candidate antibacterial agent.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Materials Science, Ceramics
Lei Han, Ziyan Huang, Min Zhu, Yufang Zhu, Huang Li
Summary: In this study, pH-responsive ZIF-8@VAN@BG scaffolds were developed for potentially infected bone repair. The scaffolds exhibited a porous structure, enhanced cell proliferation, and promoted the expression of osteogenic genes. Moreover, the scaffolds showed significant inhibitory effects on Staphylococcus aureus, making them promising for infected bone repair applications.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Organic
Srinivas Vangara, Nagarjuna Kommu, Vikranth Thaltiri, M. Balaraju, Akhila K. Sahoo
Summary: A series of methoxy-substituted polynitro-aryl-pyrazole/imidazole compounds with readily oxidizable functional groups have been synthesized. The molecular structure of these compounds has been confirmed by single crystal X-ray diffraction analysis. The energetic properties of the synthesized compounds have been determined through theoretical and experimental studies. Most of the compounds exhibit good thermal stability and resistance to impact, with some molecules even showing better detonation velocity and pressure than TNT.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Chungsik Kim, Mintesinot Kassu, Kenneth P. Smith, James E. Kirby, Roman Manetsch
Summary: A total of 20 novel derivatives of compound KP-40 containing Pyrazole-thiazole core were designed and synthesized through traditional SAR analysis. Four of the compounds showed significant adjunctive potential with improved solubility, and key physicochemical properties for the development of active Gram-negative antibacterials were revealed through further analysis using PEMPO algorithm. Consideration of PEMPO scores prior to synthesis of analogs may be a simple yet effective strategy in conjunction with traditional SAR approaches for designing potent Gram-negative antibacterials.
Article
Chemistry, Medicinal
Fang Yan Guo, Chang Ji Zheng, Meiyuan Wang, Jiangping Ai, Lan Ying Han, Liu Yang, Ye Fang Lu, Yu Xuan Yang, Ming Guan Piao, Hu-Ri Piao, Chun-Mei Jin, Cheng Hua Jin
Summary: Three series of new imidazole-fused imidazo[2,1-b][1,3,4]thiadiazole analogues have been synthesized and evaluated for their antibacterial and antifungal activities. One of the compounds showed strong antifungal activity with high selectivity for Candida albicans. This compound exhibited significantly higher activity against C. albicans compared to the positive control compounds.
Article
Biochemistry & Molecular Biology
Oluwakemi Ebenezer, Ashona Singh-Pillay, Neil A. Koorbanally, Parvesh Singh
Summary: A library of pyrazole-thiazolidinone conjugates was synthesized using a Vilsmeier-Haack reaction, and tested for antimicrobial activity against various Gram-positive and Gram-negative bacteria. Compounds 3a and 4b emerged as the most potent antimicrobial compounds with minimum bactericidal concentrations of < 0.2 µM. Molecular docking studies suggested these compounds interacted with their targets through hydrogen bonding.
MOLECULAR DIVERSITY
(2021)
Review
Pharmacology & Pharmacy
Shu-Rui Li, Yi-Min Tan, Ling Zhang, Cheng-He Zhou
Summary: The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is widely present in biomolecules and medicinal drugs. Its unique structure allows it to easily bind with various ions and molecules to form supramolecular complexes with medicinal potential. This research provides insights into medicinal applications of imidazole-based supramolecular complexes, including their role in anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and anti-inflammatory activities, as well as ion receptors, imaging agents, and pathologic probes. The study also explores the future research trends in imidazole-based supramolecular medicinal chemistry. The hope is that this work will contribute to the rational design of imidazole-based drug molecules, supramolecular medicinal agents, diagnostic agents, and pathological probes.
Article
Biochemistry & Molecular Biology
Meng Zhang, Shan Ye, Jiao Wang, Kuo Yu, Jingguo Cao, Guangbi Li, Xiaoyuan Liao
Summary: Zeolite imidazole framework materials (ZIFs) compounded with chitosan (CS) by in-situ growth method showed enhanced antibacterial effect, with CS/ZIF-67(1:6) exhibiting the best antibacterial activity, achieving high inhibitory rates against both E. coli and S. aureus. The composite materials were able to effectively disrupt bacterial cell membranes and internal components, demonstrating excellent long-term antibacterial properties and bio-compatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Faryal Chaudhry, Wardah Shahid, Mariya Al-Rashida, Muhammad Ashraf, Munawar Ali Munawar, Misbahul Ain Khan
Summary: Developing improved enzyme inhibitors is an effective therapy for various diseases. A new series of bis-diazoles conjugated with an aryl linker were found to be effective against alpha-glucosidase and moderately active against LOX enzyme. The inhibitory potentials of these compounds were influenced by factors such as lipophilicity, bulkiness, and specific interactions with enzyme active pockets.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Ahmed Hassoon Mageed, Wesam Hassan Ali
Summary: In this study, a series of imidazole-2-selone ligands and their Cu(I) complexes were synthesized, characterized, and investigated for antimicrobial activity. The results showed that these ligands and complexes exhibited promising antimicrobial activity against E. coli and S. aureus.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Suman Punia, Vikas Verma, Devinder Kumar, Ashwani Kumar, Laxmi Deswal
Summary: A series of pyrazole-imidazole-triazole hybrids were synthesized and evaluated for antimicrobial activity, with one compound demonstrating excellent potency against A. niger. Molecular docking studies were used to determine the binding conformation of the most active compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Microbiology
Florin Aonofriesei, Simona Lupsor
CURRENT MICROBIOLOGY
(2013)
Article
Pharmacology & Pharmacy
Florin Aonofriesei, Ana Cristina Sampaio, Gabriela Stanciu, Simona Lupsor
Summary: The study shows that 2-methyl-1-hydroxymethylimidazole (HIM) exhibits moderate inhibitory and bactericidal activity, especially against Staphylococcus strains. The interaction between HIM and surfactants is limited.
Article
Multidisciplinary Sciences
Gabriela Stanciu, Simona Lupsor, Elena Oancea, Magdalena Mititelu
Summary: Essential sage oil was obtained from dry leaves through steam distillation. Chemical analysis revealed high polyphenolic content and strong antioxidant activity. The oil also exhibited significant antibacterial activity against both Gram-positive and Gram-negative bacterial strains.
JOURNAL OF SCIENCE AND ARTS
(2022)
Article
Pharmacology & Pharmacy
Florin Aonofriesei, Irinel-Gratiela Manescu, Gabriela Stanciu, Simona Lupsor, Manuela Ghica, Magdalena Mititelu
Summary: Benzimidazoles are compounds widely used in clinical and pharmacological applications. There is ongoing research on synthesizing new derivatives and exploring their properties, particularly as potential antimicrobial agents. The study found that benzimidazole derivatives with photoprotective properties had significant inhibitory activity against Gram-positive bacteria and Candida strains.
Article
Biochemistry & Molecular Biology
Gabriela Stanciu, Florin Aonofriesei, Simona Lupsor, Elena Oancea, Magdalena Mititelu
Summary: The aim of this study was to identify and exploit the local plant resources with biologically active properties from the Dobrogea area, Romania. Black poplar buds were collected and macerated to evaluate their qualities as antioxidant and antimicrobial agents. The results showed that the hydroalcoholic macerates of black poplar buds contained high concentrations of phenolic compounds and exhibited potent antioxidant and antimicrobial activities.
Article
Multidisciplinary Sciences
Simona Lupsor, Ramona Rotariu, Elena Oancea, Ioana-Adina Oancea
JOURNAL OF SCIENCE AND ARTS
(2019)
Article
Chemistry, Multidisciplinary
Gabriela Stanciu, Simona Lupsor, Florin Aonofriesei, Nicoleta Calota, Antoanela Popescu, Rodica Sirbu
Article
Chemistry, Multidisciplinary
Gabriela Stanciu, Florin Aonofriesei, Simona Lupsor, Antoanela Popescu, Rodica Sirbu
Article
Chemistry, Multidisciplinary
Gabriela Stanciu, Simona Lupsor, Aneta Tomescu, Rodica Sirbu
Article
Chemistry, Multidisciplinary
Gabriela Stanciu, Nicoleta Cristache, Simona Lupsor, Simona Dobrinas
Article
Chemistry, Multidisciplinary
Gabriela Stanciu, Florin Aonofriesei, Nicoleta Cristache, Simona Lupsor
Article
Multidisciplinary Sciences
Simona Dobrinas, Gabriela Stanciu, Simona Lupsor
JOURNAL OF SCIENCE AND ARTS
(2017)
Article
Multidisciplinary Sciences
Gabriela Stanciu, Simona Lupsor, Antoanela Popescu, Ioana Adina Oancea
JOURNAL OF SCIENCE AND ARTS
(2017)
Article
Multidisciplinary Sciences
Gabriela Stanciu, Simona Lupsor, Rodica Sirbu
JOURNAL OF SCIENCE AND ARTS
(2017)
