Article
Chemistry, Applied
Ruth Prieto-Montero, Alejandro Prieto-Castaneda, Alberto Katsumiti, Rebeca Sola-Llano, Antonia R. Agarrabeitia, Miren P. Cajaraville, Maria J. Ortiz, Virginia Martinez-Martinez
Summary: Three different molecular designs based on BODIPY dye have been proposed as photosensitizers for photodynamic therapy, showing a good balance between singlet oxygen generation and fluorescence for potential applications. In vitro experiments in HeLa cells were conducted to elucidate the best potential candidate for PDT.
Article
Chemistry, Applied
Bingjie Hou, Wenyuan Zhang, Cuili Li, Xueqin Sun, Xiaoxia Feng, Jiacheng Liu
Summary: This study reports the synthesis and evaluation of four cationic porphyrins as potential photodynamic therapeutic agents. The results show that ZnP2 exhibits high phototoxicity towards cancer cells and low toxicity towards normal cells, making it a promising candidate for photodynamic therapy.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
William Crisp, Stephon Amadis Fagan-Avery, Brandon M. Campbell, Daniel R. Morphet, Kristopher G. Reynolds, Bryan Kudisch, Miguel I. Gonzalez, Shao-Liang Zheng, Dilek K. Dogutan, Daniel G. Nocera
Summary: The crystal structures of Mn(III)Cl and Pd(II) meso-(4-fluoro-2,6-dimethyl-phenyl) porphyrins have been synthesized and characterized. These homologous series of porphyrins, along with their Zn(II) counterpart, exhibit the manifestation of d-d states and spin-orbit coupling in the excited state dynamics of metalloporphyrins.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Kseniya A. Zhdanova, Inga O. Savelyeva, Artem V. Ezhov, Andrey P. Zhdanov, Konstantin Yu. Zhizhin, Andrey F. Mironov, Natal'ya A. Bragina, Alla A. Babayants, Irina S. Frolova, Nadezhda I. Filippova, Nadezhda N. Scliankina, Olga N. Scheglovitova
Summary: This study focused on identifying new anti-HSV-1 drugs among synthetic tetrapyrroles under nonphotodynamic conditions. The synthesized compounds 3a, 3b, and TMePyP showed virucidal efficiency against HSV-1, with 3b exhibiting the highest antiviral activity. Incorporating the compounds into Pluronic F-127 polymeric micelles had a noticeable impact on antiviral activity at higher concentrations. The compounds have potential for development as utilitarian antiviral agents and medical antiviral drugs.
Article
Chemistry, Multidisciplinary
Pallas Chou, Lauren Kim, Sammer M. Marzouk, Rui Sun, Alaina C. Hartnett, Dilek K. Dogutan, Shao-Liang Zheng, Daniel G. Nocera
Summary: Zn(II), Cu(II), and Ni(II) 5,10,15,20-tetrakis(4-fluoro-2,6-dimethylphenyl)porphyrins (TFPs) were synthesized and characterized. The catalytic activity of Cu(II)TFP for the hydrogen evolution reaction (HER) was observed, and the mechanism of the reaction was determined by analyzing the voltammograms.
Article
Spectroscopy
Wenbin Hu, Mingyue Fan, Xian-Fu Zhang, Mengmeng Li, Guoying Li
Summary: meso-RNH substituted BODIPY compounds with different substituents (R = C3H7, C4H9, PhCH2, H, and Ph) were synthesized to investigate their photophysical properties and photosensitizing abilities. UV-vis absorption, fluorescence spectroscopy, laser flash photolysis, and chemical trapping methods were employed to measure various parameters. The results show that the presence of meso-RNH leads to blue shift of absorption and emission wavelength, decrease in fluorescence quantum yield and lifetime, and increase in singlet oxygen formation. The mechanisms include photoinduced charge transfer, S0 and S1 geometry, and ground state structural isomerization. These findings are valuable for designing new functional materials.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Applied
Pinar Sen, Rodah Soy, Sithi Mgidlana, John Mack, Tebello Nyokong
Summary: The emergence of antimicrobial resistance has made the development of photodynamic therapy (PDT) related applications essential, since microorganisms cannot develop resistance to this method. This study focuses on the synthesis, characterization, and evaluation of the utility of palladium porphyrins and their chitosan inclusion complexes as photosensitizer dye in photodynamic antimicrobial therapy (PACT). The photophysical-chemical studies showed that the immobilization of the porphyrins into the chitosan influenced their properties. Furthermore, the PACT activity of cationic porphyrin and its chitosan immobilization form were found to be effective in decreasing the number of viable cells up to 100% in vitro.
Article
Chemistry, Inorganic & Nuclear
Umit Demirbas, Dilek Ozturk, Hakki Turker Akcay, Mahmut Durmus, Emre Mentese, Halit Kantekin
Summary: In this study, the structures of magnesium phthalocyanine, lead phthalocyanine, and zinc phthalocyanine were confirmed using various spectroscopic techniques. It was found that zinc phthalocyanine exhibited the highest singlet oxygen quantum yield and photostability, while magnesium phthalocyanine had the highest fluorescence quantum yield. Zinc phthalocyanine, with its high singlet oxygen generation ability, photostability, and formation of non-aggregated species, showed excellent photosensitizer performance.
JOURNAL OF COORDINATION CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Guangyu Lin, Mei Hu, Rong Zhang, Yuanxing Zhu, Kedan Gu, Junping Bai, Jiyang Li, Xiaochun Dong, Weili Zhao
Summary: Antimicrobial photodynamic therapy (aPDT) is a promising approach for treating pathogenic microorganism infections, with a methyl meso-(meta-pyridinium) BODIPY photosensitizer demonstrating the highest phototoxicity and impressive antimicrobial efficacy.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Vijayalakshmi Pandey, Anu Janaagal, Ashmita Jain, Shigeki Mori, Iti Gupta
Summary: In this study, trans-A2B2 type porphyrins and their complexes were synthesized and studied using various techniques. The results showed efficient energy transfer and significant donor-acceptor interaction in these porphyrins. The Pd(II) porphyrin demonstrated good performance in photocatalytic applications, with efficient generation of singlet oxygen and oxidation of aromatic aldehydes.
Article
Biochemistry & Molecular Biology
Rodah Soy, Balaji Babu, John Mack, Tebello Nyokong
Summary: A series of tetraarylchlorins with different meso-aryl rings and their Sn(IV) complexes were synthesized and assessed for their potential as photosensitizer dyes for use in photodynamic therapy and photodynamic antimicrobial chemotherapy. The Sn(IV) complexes showed high singlet oxygen quantum yield values and exhibited significant activities against breast cancer cells, as well as planktonic bacteria.
Article
Chemistry, Multidisciplinary
Dili R. Subedi, Ryan Reid, Patrick F. D'Souza, Vladimir N. Nesterov, Francis D'Souza
Summary: A series of Pt and Pd porphyrins with different substituents were synthesized and characterized. The study revealed that aromatic substituents can minimize steric hindrance, resulting in higher electrochemical redox gaps. Additionally, Pt and Pd porphyrins exhibited higher quantum yields in generating singlet oxygen.
Article
Food Science & Technology
Victor Ryu, Silvette Ruiz-Ramirez, Piyanan Chuesiang, Lynne A. McLandsborough, David Julian McClements, Maria G. Corradini
Summary: This study evaluated the encapsulation of curcumin in surfactant micelles and its effects on water dispersibility, stability, and antimicrobial activity. The addition of surfactants enhanced the dispersibility, stability, and efficacy of curcumin as a photosensitizer, enhancing its antimicrobial activity. Gram-positive bacteria were more susceptible than Gram-negative bacteria to curcumin-loaded micelles.
Article
Biochemistry & Molecular Biology
Sofia N. N. Sarabando, Cristina J. J. Dias, Catia Vieira, Maria Bartolomeu, Maria G. P. M. S. Neves, Adelaide Almeida, Carlos J. P. Monteiro, Maria Amparo F. Faustino
Summary: Sulfonamides are effective antibiotics against infections but misuse leads to antibiotic resistance. Porphyrins and analogs have shown good photosensitizing properties as antimicrobial agents, including against MRSA. This study synthesized and evaluated a new sulfonamide-functionalized meso-arylporphyrin and its Zn(II) complex for antibacterial activity against MRSA, both with and without the co-adjuvant KI. Photodynamic studies demonstrated effective photoinactivation of MRSA by all the porphyrin derivatives, with significantly improved outcomes when combined with KI.
Article
Optics
Aram G. Gyulkhandanyan, Marina H. Paronyan, Anna G. Gyulkhandanyan, Karapet R. Ghazaryan, Marina Parkhats, Boris M. Dzhagarov, Maria Korchenova, Ekaterina N. Lazareva, Elena S. Tuchina, Grigor Gyulkhandanyan, Valery V. Tuchin
Summary: Photodynamic inactivation of microorganisms using cationic porphyrins/metalloporphyrins as photosensitizers shows high photoactivity and phototoxicity against both Gram-negative and Gram-positive bacteria. Zinc complexes of porphyrins exhibit higher phototoxicity than metal-free porphyrin analogs, and the antibacterial activity of cationic porphyrins/metalloporphyrins is correlated with singlet oxygen generation.
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
(2022)
Article
Parasitology
S. Maksoud, J. T. Ortega, M. Hidalgo, H. R. Rangel
Summary: This study aimed to partially describe the Leishmania/HIV co-infection events by measuring molecular and functional parameters associated with both pathogens in vitro. The results showed that co-infection enhanced the replication/infectivity of both the parasite and the virus, increased syncytia induction, and altered cell viability. In addition, an amplification in NF-xB activation, changes in CXCR4/CCR5 surface expression, and a Th1-Th2 shift in cytokine/chemokine secretion were observed.
Article
Microbiology
Joseph Thomas Ortega, Beata Jastrzebska, Hector Rafael Rangel
Summary: This study evaluated the changes in the viral spike of SARS-CoV-2 Omicron variant and found an increased interaction with the human ACE2 receptor. This contributes to a better understanding of the impact of Omicron variant on virus pathogenicity.
Article
Medicine, Research & Experimental
Rossanct C. Jaspe, Jose Luis Zambrano, Mariana Hidalgo, Yoneira Sulbaran, Carmen L. Loureiro, Zoila C. Moros, Domingo J. Garzaro, Ferdinando Liprandi, Hector R. Rangel, Flor H. Pujol
Summary: This study describes a rapid method for identifying cases infected with the Omicron variant and provides more information on the prevalence and rapid detection of this new variant.
INVESTIGACION CLINICA
(2022)
Editorial Material
Microbiology
Isabelle Chemin, Flor Helene Pujol
Article
Virology
Rossana C. Jaspe, Carmen L. Loureiro, Yoneira Sulbaran, Zoila C. Moros, Pierina D'Angelo, Mariana Hidalgo, Lieska Rodriguez, Victor Alarcon, Marwan Aguilar, Doneyla Sanchez, Jesus Ramirez, Domingo J. Garzaro, Jose Luis Zambrano, Ferdinando Liprandi, Hector R. Rangel, Flor H. Pujol
Summary: The aim of this study was to monitor the dissemination of VOIs and VOCs in Venezuela, and it found that Delta VOC became the predominant circulating variant, while Omicron VOC was able to displace Delta variant within a month.
Article
Public, Environmental & Occupational Health
Rossana C. Jaspe, Yoneira Sulbaran, Carmen L. Loureiro, Zoila C. Moros, Ernestina Marulanda, Francis Bracho, Nieves A. Ramirez, Yeilis Canonico, Pierina D'Angelo, Lieska Rodriguez, Julio Castro, Ferdinando Liprandi, Hectot R. Rangel, Flor H. Pujol
Summary: Genomic surveillance of samples from international travelers returning to Venezuela allowed for the rapid detection of the introduction of the Omicron variant in the country, and the detection of this variant coincided with an unprecedented increase in the frequency of passengers with positive nucleic acid testing.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Infectious Diseases
Franklin Claro, Douglas Silva, Jesus A. Perez Bogado, Hector Rafael Rangel, Jacobus H. de Waard
Summary: This study evaluated the long-term immunogenicity of the Sputnik V vaccine and found that it can provide long-lasting humoral immunity, especially for individuals who have been vaccinated and previously infected with SARS-CoV-2.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, Research & Experimental
Jose Luis Zambrano, Rossana C. Jaspe, Mariana Hidalgo, Carmen L. Loureiro, Yoneira Sulbaran, Zoila C. Moros, Domingo J. Garzaro, Esmeralda Vizzi, Hector R. Rangel, Ferdinando Liprandi, Flor H. Pujol
Summary: This study describes the characteristic mutations of the Omicron variant in the Spike protein and the behavior of the sub-lineages in different parts of the world. The mutations in the Spike protein may enable the virus to evade vaccine protection, reduce susceptibility to host proteases for fusion process, and may be associated with enhanced replication in nasal epithelial cells and decreased replication in pulmonary tissue, which may explain the apparent reduced severity of Omicron compared to other variants.
INVESTIGACION CLINICA
(2022)
Article
Infectious Diseases
Pierina D'Angelo, Carmen L. L. Loureiro, Rossana C. C. Jaspe, Yoneira F. F. Sulbaran, Lieska Rodriguez, Victor Alarcon, Jose Manuel Garcia, Jose Luis Zambrano, Ferdinando Liprandi, Hector R. Rangel, Flor H. H. Pujol
Summary: The ongoing epidemic of monkeypox virus (MPXV) infection has affected over 50,000 individuals worldwide until the end of August 2022. We present the first case detected in Venezuela, where the patient had traveled from Spain and had contact with friends who tested positive for MPXV. Phylogenetic analysis categorized the isolate within the major circulating clade II of MPXV globally. As of August 2022, no other cases of MPXV have been detected in Venezuela, though undiagnosed cases cannot be ruled out due to the fear of stigmatization.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Medicine, Research & Experimental
Zoila C. Moros, Carmen L. Loureiro, Rossana C. Jaspe, Yoneira Sulbaran, Mariangel Delgado, Olga Carolina Aristimuno, Christopher Franco, Domingo J. Garzaro, Mariajose Rodriguez, Hector R. Rangel, Ferdinando Liprandi, Flor H. Pujol, Jose Luis Zambrano
Summary: The resources and platforms available on the internet allow us to closely monitor the evolution of SARS-CoV-2 and assess the extent of the current global monkeypox outbreak.
INVESTIGACION CLINICA
(2023)
Article
Virology
Zoila C. Moros, Jose Luis Zambrano, Yoneira Sulbaran, Carmen L. Loureiro, Ernestina Marulanda, Francis Bracho, Pierina D'Angelo, Lieska Rodriguez, Ferdinando Liprandi, Hector R. Rangel, Rossana C. Jaspe, Flor H. Pujol
Summary: The Omicron Variant of Concern (VOC) has caused a surge in cases worldwide, leading to subsequent waves in many countries. Venezuela has monitored the circulation of the Omicron VOC and its major sub-lineages among community cases and international travelers. Sub-lineages generally circulated earlier in international travelers than in community cases, and the diversity of sub-lineages found in international travelers resembled those found in the USA.
Review
Microbiology
Rayana Maryse Toye, Carmen Luisa Loureiro, Rossana Celeste Jaspe, Fabien Zoulim, Flor Helene Pujol, Isabelle Chemin
Summary: HBV genotypes E to J are understudied and have specific distributions across different regions. Genotype F is the most divergent and has further subgenotypes. There is a lack of data from sub-Saharan Africa and Latin America due to under-representation in clinical and research cohorts.
