Article
Biochemistry & Molecular Biology
Yutang Wang, Owen Sargisson, Dinh Tam Nguyen, Ketura Parker, Stephan J. R. Pyke, Ahmed Alramahi, Liam Thihlum, Yan Fang, Morgan E. Wallace, Stuart P. Berzins, Ernesto Oqueli, Dianna J. Magliano, Jonathan Golledge
Summary: The study found that hydralazine inhibits the formation and rupture of AAA by suppressing inflammatory gene expression and apoptosis, providing new insights for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Haruhito A. Uchida, Tetsuharu Takatsuka, Yoshiko Hada, Ryoko Umebayashi, Hidemi Takeuchi, Kenichi Shikata, Venkateswaran Subramanian, Alan Daugherty, Jun Wada
Summary: The study found that edaravone can attenuate angiotensin II-induced abdominal aortic aneurysms and atherosclerosis through its antioxidant and anti-inflammatory effects.
Article
Biochemistry & Molecular Biology
Anja Hofmann, Bianca Hamann, Anna Klimova, Margarete Mueglich, Steffen Wolk, Albert Busch, Frieda Frank, Pamela Sabarstinski, Marvin Kapalla, Josef Albin Nees, Coy Brunssen, David M. Poitz, Henning Morawietz, Christian Reeps
Summary: Diuretics show the strongest association with HO-1 expression. The combination of ACE inhibitors, ARBs, and beta-blockers with diuretics is also associated with an increase in HO-1 mRNA expression. Statin therapy is negatively correlated with HO-1 expression.
Article
Cardiac & Cardiovascular Systems
Ville Rantasalo, Jarmo Gunn, Tuomas Kiviniemi, Jussi Hirvonen, Ilkka Saarenpaa, Juri Kivelev, Melissa Rahi, Elli Lassila, Jaakko Rinne, Dan Laukka
Summary: The study revealed that abdominal aortic calcification is more prominent in patients with ruptured and unruptured intracranial aneurysms compared to matched controls, and increases the risk for ruptured aneurysms.
Article
Surgery
Eugene S. Lee, Kevin C. Chun, Ankur Gupta, Richard C. Anderson, Zachary T. Irwin, Elise A. Newton, Natalia Jaime-Hughes, Sandipan Datta
Summary: This study evaluates the cost of implementing and sustaining an AAA screening program, and concludes that despite limitations, it is feasible, cost-effective, and a worthwhile endeavor.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Preetha Shridas, Avery C. Patrick, Lisa R. Tannock
Summary: Epidemiological data show a positive correlation between serum amyloid A (SAA) levels and cardiovascular disease severity and mortality. Animal studies suggest a causal role for SAA in atherosclerosis development. In mice, suppressing SAA has been shown to reduce abdominal aortic aneurysm formation. Researchers aim to understand the pathway of SAA involvement in order to consider it as a therapeutic target for cardiovascular diseases.
Article
Medicine, General & Internal
Andrea Sparks, Scott Oplinger, Elizabeth Maynes, Keiko Meshida, Maria Ximena Leighton, Gary Wind, Guinevere Granite
Summary: Screening for abdominal aortic aneurysms has been the standard of care for many years, but is still underutilized. Despite improvements in mortality rates, ruptured abdominal aortic aneurysms remain a significant issue, highlighting the need for further research into the effectiveness of current screening procedures.
Article
Hematology
Amy K. Searle, Yung-Chih Chen, Maria Wallert, James D. McFadyen, Ana C. Maluenda, Jonathan Noonan, Peter Kanellakis, Maria T. K. Zaldivia, Angela Huang, Hadi Lioe, Mark Biondo, Marc W. Nolte, Paolo Rossato, Alex Bobik, Con Panousis, Xiaowei Wang, Hamid Hosseini, Karlheinz Peter
Summary: This study demonstrates that inhibition of FXIIa can attenuate the severity of thromboinflammation-driven cardiovascular diseases. The monoclonal antibody 3F7 can reduce AAA severity, inhibit the development of atherosclerosis, and stabilize vulnerable plaques.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biochemistry & Molecular Biology
Lei Ji, Siliang Chen, Guangchao Gu, Wei Wang, Jinrui Ren, Fang Xu, Fangda Li, Jianqiang Wu, Dan Yang, Yuehong Zheng
Summary: This study investigated the differences between abdominal aortic aneurysm (AAA) and atherosclerosis (AS) at the metabolomics level, identifying 18 significantly different metabolites and proposing a combination of 7 metabolites as potential biomarkers to distinguish AAA and AS. The integration analysis with transcriptomics revealed that 2'-deoxy-d-ribose and 6 other metabolites were significantly correlated with differentially expressed genes, providing insights into the pathogenetic mechanisms in atherosclerotic AAA.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Review
Medicine, General & Internal
Wenqian Wu, Mingxing Xie, Hongyu Qiu
Summary: The article summarizes the advances in using advanced ultrasonographic techniques for evaluating aortic stiffness, mainly based on changes in aortic structure, hemodynamics, and tissue motion. It also discusses the differences in applications between humans and rodents and explores potential optimized strategies for experimental research.
Review
Medicine, General & Internal
Petroula Nana, Konstantinos Dakis, Alexandros Brodis, Konstantinos Spanos, George Kouvelos
Summary: A systematic review examined the correlation of abdominal aortic aneurysm expansion rates with serum circulating biomarkers, identifying specific biomarkers potentially useful for individualized surveillance of patients with increased AAA growth rates. Various biomarkers, including D-dimers, LDL-C, HDL-C, and genetic factors, were found to be significantly associated with AAA growth rates, suggesting a potential role for serum biomarkers in patient monitoring.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
John Anagnostakos, Brajesh K. Lal
Summary: Abdominal aortic aneurysms (AAA) are common in older adults and can lead to serious morbidity and mortality if not treated promptly. The causes include trauma, infection, and inflammatory disorders, with risk factors such as smoking, advanced age, dyslipidemia, hypertension, and coronary artery disease. The pathophysiology involves arterial insult leading to inflammation and weakening of the arterial wall, requiring monitoring of size and growth rate to prevent rupture. Management options include controlling risk factors, surgical intervention based on risk assessment, and post-operative monitoring for complications. Advancements in technology have improved the diagnosis and treatment of AAA in recent years.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Victoria N. Tedjawirja, Max Nieuwdorp, Kak Khee Yeung, Ron Balm, Vivian de Waard
Summary: Abdominal aortic aneurysm (AAA) is less common in women, but those affected tend to have faster aneurysm growth and higher rupture risk. High FSH levels during menopause may play a key role in aggravating AAA development and progression in postmenopausal women.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Surgery
Sydney L. Olson, Annalise M. Panthofer, William Blackwelder, Michael L. Terrin, John A. Curci, B. Timothy Baxter, Fred A. Weaver, Jon S. Matsumura
Summary: This study examines the predictors of abdominal aortic aneurysm (AAA) volume growth and finds that baseline volume, tortuosity, maximum transverse diameter (MTD), current tobacco use, angiotensin II receptor blocker use, and history of diabetes mellitus are predictive of volume growth over time.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Alexandra M. M. Filipkowski, Suman Kundu, Svetlana K. K. Eden, Charles W. W. Alcorn, Amy C. C. Justice, Kaku A. A. So-Armah, Hilary A. A. Tindle, Quinn S. S. Wells, Joshua A. A. Beckman, Matthew S. S. Freiberg, Aaron W. W. Aday
Summary: Compared with individuals without HIV infection, people with HIV do not have an increased risk of abdominal aortic aneurysm (AAA), but the risk of AAA is increased among HIV-infected individuals with low CD4+ T-cell counts or high HIV viral load.
Article
Medicine, General & Internal
Sergi Vilanova-Rotllan, Belchin Kostov, M. Jose Giner Martos, Jaume Benavent-Areu, Antoni Siso-Almirall
Summary: This study demonstrates the feasibility of performing abdominal ultrasound in the homes of frail patients, which reduces care delay and diagnostic uncertainty. Ultrasound performed in homecare significantly decreases the delay and provides important clinical benefits for patients.
Article
Primary Health Care
Antoni Siso-Almirall, Belchin Kostov, Encarna Sanchez, Jaume Benavent-Areu, Luis Gonzalez-de Paz
Summary: The COVID-19 pandemic has significantly impacted the incidence rates of common primary care diseases in Spain, mainly due to the prioritization of healthcare resources leading to a decrease in detection and management of chronic diseases.
ANNALS OF FAMILY MEDICINE
(2022)
Article
Geriatrics & Gerontology
Laia Gene Huguet, Belchin Kostov, Marta Navarro Gonzalez, Amparo Hervas Docon, Cristina Colungo Francia, Josep Maria Vilaseca Llobet, Jaume Benavent Areu, Lluis Gonzalez de Paz, Antoni Siso-Almirall
Summary: Multifactorial primary healthcare interventions can effectively prevent frailty and reduce the cost of healthcare resources in elderly populations.
Article
Peripheral Vascular Disease
Antoni Siso-Almirall, Belchin Kostov, Esther Blat, Noemi Garcia, Berta de Andres, Silvia Roura, Cristina Sierra-Benito, Maria C. Alvira-Balada, Cristina Colungo, Jaume Benavent-Areu, Luis Gonzalez-de Paz
Summary: The study aimed to validate the use of 1-hour automated office blood pressure measurement for diagnosing hypertension. The results showed that the 1-hour method had higher sensitivity, specificity and diagnostic accuracy compared to conventional office and home measurements. Additionally, it could effectively detect white-coat hypertension and masked hypertension.
JOURNAL OF HYPERTENSION
(2022)
Article
Environmental Sciences
Aina Perello-Bratescu, Christian Dursteler, Maria Asuncion Alvarez-Carrera, Laura Granes, Belchin Kostov, Antoni Siso-Almirall
Summary: The prescription of strong opioids for chronic non-cancer pain is steadily increasing, posing a high risk of adverse effects. A descriptive, longitudinal, retrospective population-based study was conducted to examine the concomitant risk prescription of strong opioids with other drugs. The study revealed that a significant percentage of patients prescribed strong opioids for chronic non-cancer pain received concomitant prescriptions with known risks and unauthorized indications of immediate-release fentanyl.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Miguel J. Martinez, Luca Basile, Antoni Siso-Almirall, Victor Cristino, Genoveva Cuesta, Juan Carlos Hurtado, Mariana Fernandez-Pittol, Maria Mar Mosquera, Alex Soriano, Ana Martinez, Ma Angeles Marcos, Jordi Vila, Climent Casals-Pascual
Summary: Despite some studies showing an association between low Ct values in hospitalized patients and poor prognosis, no significant association was found between Ct values and adverse outcomes in COVID-19 community cases. Age, rather than Ct values, was identified as an independent prognostic factor in this study.
INFECTIOUS DISEASES AND THERAPY
(2022)
Article
Environmental Sciences
Lourdes E. Baron-Miras, Antoni Siso-Almirall, Belchin Kostov, Encarna Sanchez, Silvia Roura, Jaume Benavent-Areu, Luis Gonzalez-de Paz
Summary: Primary healthcare services have shifted to tele-consults during COVID-19 period. Face-to-face consults decreased for general practitioners, while tele-consults increased for different age groups. The trend of tele-consults was inversely related to the trend of diagnostic registry and face-to-face consults.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Primary Health Care
Enric Aragones, Maribel Fernandez-San-Martin, Maria Rodriguez-Barragan, Francisco Martin-Lujan, Monica Solanes, Anna Berenguera, Antoni Siso, Josep Basora
Summary: This study aimed to explore gender differences and stress level differences in coping strategies among GPs during the Covid-19 pandemic. The study found that women were more likely to resort to emotional support, while men used acceptance and humor more commonly. Additionally, high stress levels were associated with an increase in non-adaptive coping strategies.
EUROPEAN JOURNAL OF GENERAL PRACTICE
(2023)
Article
Environmental Sciences
Monica Solanes-Cabus, Eugeni Paredes, Esther Limon, Josep Basora, Iris Alarcon, Irene Veganzones, Laura Conangla, Nuria Casado, Yolanda Ortega, Jordi Mestres, Jordi Acezat, Joan Deniel, Joan Josep Cabre, Daniel Sanchez Ruiz, Marcos Sanchez, Aroa Illa, Ignasi Vinas, Juan Jose Montero, Francesc Xavier Cantero, Anna Rodriguez, Francisco Martin, Montserrat Bare, Rosa Ripolles, Montse Castellet, Joan Lozano, Antoni Siso-Almirall
Summary: This survey aimed to understand the future work model of general practitioners and the changes in primary healthcare centers due to the COVID-19 pandemic. The results showed that a majority of family doctors felt they spent too much time on administrative tasks, opposed call center systems, believed in their responsibility for home care, supported continuity of care as a fundamental value, and advocated for primary healthcare to provide complementary tests and first hospital visits. The survey responses provide important insights for the future development of primary healthcare.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Respiratory System
Luis Gonzalez-de Paz, Laura Valdesoiro-Navarrete, Josep Roma, Esther Blat-Guimera, Jaume Benavent-Areu, Joan Bartra, Antoni Siso-Almirall
Summary: This study investigated the prevalence of asthma and allergies in children under 14 years old in Spain and their impact on health-related quality of life, activities, healthcare utilization, and environmental and household exposure risk factors. The results showed that asthma and allergies have a significant impact on children's daily life and healthcare utilization.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Health Care Sciences & Services
Ruben Gonzalez-Colom, Carmen Herranz, Emili Vela, David Monterde, Joan Carles Contel, Antoni Siso-Almirall, Jordi Piera-Jimenez, Josep Roca, Isaac Cano
Summary: This study aimed to improve the management of multimorbidity by developing predictive models and patient profiling. The predictive models showed good performance in predicting mortality and readmission risks at 90 days after discharge. Four distinct patient profiles were identified, providing personalized recommendations for service selection.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Health Care Sciences & Services
Carmen Herranz, Laura Martin -Moreno Banegas, Fernando Dana Muzzio, Antoni Siso-Almirall, Josep Roca, Isaac Cano
Summary: The study presents Health Circuit, an adaptive case management approach that empowers health care professionals and patients to implement personalized evidence-based interventions. The results show that Health Circuit has the potential to reduce emergency room visits, enhance patient empowerment, and demonstrate good acceptability and usability scores.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)