Article
Radiology, Nuclear Medicine & Medical Imaging
Donghyeon Lee, Xiaohui Zhan, W. Yang Tai, Wojciech Zbijewski, Katsuyuki Taguchi
Summary: The study improved a photon counting detector (PCD) model by using count-rate-dependent model parameters to address issues and evaluate agreement against physical PCDs. The proposed model showed high accuracy in estimating the outputs of physical PCDs from low to high count-rates, making it suitable for applications where pixel-by-pixel accuracy is important.
Article
Radiology, Nuclear Medicine & Medical Imaging
Katsuyuki Taguchi, Christoph Polster, W. Paul Segars, Nafi Aygun, Karl Stierstorfer
Summary: The purpose of this study is to develop a model-based algorithm that compensates for the effects of pulse pileup and charge sharing and evaluate its performance through computer simulations. The results show that the algorithm has little or no biases when the expected counts are sufficiently large, but still exhibits some biases when the expected counts are small.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mridul Bhattarai, Steve Bache, Ehsan Abadi, Ehsan Samei
Summary: This study evaluated the performance of clinical photon-counting CT systems and found that increasing tube currents did not affect spatial resolution but slightly affected CT numbers and noise measurements. However, these effects were only significant on a small phantom that is not commonly used in clinical practice.
Article
Radiology, Nuclear Medicine & Medical Imaging
Katsuyuki Taguchi, Jan S. Iwanczyk
Summary: This study assessed the performance of PCDs with MEICC in the presence of both CS and PP using computer simulations. Results showed that MEICC consistently provided better nCRLBs than the conventional PCD did for most tasks, indicating its superiority in spectral distortion correction.
Review
Medicine, General & Internal
Filippo Cademartiri, Antonella Meloni, Laura Pistoia, Giulia Degiorgi, Alberto Clemente, Carmelo De Gori, Vincenzo Positano, Simona Celi, Sergio Berti, Michele Emdin, Daniele Panetta, Luca Menichetti, Bruna Punzo, Carlo Cavaliere, Eduardo Bossone, Luca Saba, Riccardo Cau, Ludovico La Grutta, Erica Maffei
Summary: The photon-counting detector (PCD) is a new technology that provides significant benefits for cardiac and coronary artery imaging. Compared with conventional CT, PCCT has improved capabilities such as multi-energy capability, increased spatial resolution, reduced radiation exposure, and optimized use of contrast agents. It also overcomes limitations of traditional CCT/CCTA, such as reducing artifacts and enabling more precise assessment of stenosis and plaque characteristics. PCCT also has potential applications in characterizing myocardial tissue using a double-contrast agent.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefan J. van der Sar, Stefan E. Brunner, Dennis R. Schaart
Summary: The study explores the feasibility of using SiPM-based scintillation detectors in photon-counting computed tomography (PCCT) scanners as an alternative to CdTe and CZT detectors. By introducing a model and conducting validation experiments, the research shows promising results in terms of energy resolution and pulse shape. The study suggests that with further development, SiPM-based detectors have the potential to compete with traditional detectors in terms of performance.
Review
Medicine, General & Internal
Filippo Cademartiri, Antonella Meloni, Laura Pistoia, Giulia Degiorgi, Alberto Clemente, Carmelo De Gori, Vincenzo Positano, Simona Celi, Sergio Berti, Michele Emdin, Daniele Panetta, Luca Menichetti, Bruna Punzo, Carlo Cavaliere, Eduardo Bossone, Luca Saba, Riccardo Cau, Ludovico La Grutta, Erica Maffei
Summary: Photon-counting detector (PCD) is a novel computed tomography detector technology that has many advantages in the neurovascular field, such as increased spatial resolution, reduced radiation exposure, and optimization of contrast agents and material decomposition. This overview of literature on PCCT describes the principles, advantages, and disadvantages of conventional detectors and PCDs, and focuses specifically on its implementation in the neurovascular field.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Veit Sandfort, Mats Persson, Amir Pourmorteza, Peter B. Noel, Dominik Fleischmann, Martin J. Willemink
Summary: Photon-counting computed tomography (PCCT) is an emerging technology that shows promise in significantly improving cardiovascular imaging, with advantages such as reduced electronic noise and increased spatial resolution. Recent advancements in engineering and manufacturing by multiple vendors are expected to soon bring this new technology into clinical reality, with varying timescales for implementation and impact on different clinical scopes.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2021)
Article
Computer Science, Interdisciplinary Applications
Scott S. Hsieh, Kris Iniewski
Summary: This study discusses three paralysis compensation mechanisms for photon counting detectors, including pileup trigger, retrigger architecture, and retrigger architecture with dedicated secondary counters. Simulation results show that the proposed retrigger architecture with dedicated secondary counters can reduce noise and improve image quality at both moderate and high flux levels.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Review
Biochemistry & Molecular Biology
Stefan Sawall, Carlo Amato, Laura Klein, Eckhard Wehrse, Joscha Maier, Marc Kachelriess
Summary: Molecular imaging plays a crucial role in drug discovery, disease screening, and therapy assessment. Despite challenges in utilizing CT for molecular imaging due to low sensitivity and contrast, recent advancements such as spectral photon-counting detectors show promise in overcoming these limitations. The review highlights potential future directions for advancements in CT molecular imaging.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Josua A. Decker, Stefanie Bette, Nora Lubina, Katharina Rippel, Franziska Braun, Franka Risch, Claudia Wollny, Christian Scheurig-Muenkler, Thomas J. Kroencke, Florian Schwarz
Summary: This study compared the quantitative and qualitative image quality of a novel PCD-CT and a traditional EID-CT in low-dose CT scans of the abdomen. The results showed that the PCD-CT had lower image noise, higher SNR, improved subjective image quality, and better conspicuity of abdominal fine structures compared to the EID-CT.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Review
Medicine, General & Internal
Antonella Meloni, Filippo Cademartiri, Laura Pistoia, Giulia Degiorgi, Alberto Clemente, Carmelo De Gori, Vincenzo Positano, Simona Celi, Sergio Berti, Michele Emdin, Daniele Panetta, Luca Menichetti, Bruna Punzo, Carlo Cavaliere, Eduardo Bossone, Luca Saba, Riccardo Cau, Ludovico La Grutta, Erica Maffei
Summary: Photon-counting computed tomography (PCCT) is an emerging technology that is expected to revolutionize clinical CT imaging. PCCT offers various advantages over conventional CT, which can be utilized to enhance and broaden the diagnostic capabilities of CT angiography. This article discusses the potential opportunities and promising future applications of PCCT in vascular imaging.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Judith van der Bie, Marcel van Straten, Ronald Booij, Daniel Bos, Marcel L. Dijkshoorn, Alexander Hirsch, Simran P. Sharma, Edwin H. G. Oei, Ricardo P. J. Budde
Summary: Photon-counting computed tomography (PCCT) is a new technology that offers higher spatial resolution, energy resolved imaging, and spectral post-processing compared to conventional CT techniques. This results in improved contrast-to-noise ratio, reduction in artifacts and potential dose, as well as elimination of electronic noise. The shift from pre-clinical studies to clinical research has been observed since the introduction of clinical PCCT in 2021. This review article focuses on the initial clinical results of PCCT, including the current PCCT systems, applications, and challenges.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Review
Medicine, General & Internal
Salim Aymeric Si-Mohamed, Jade Miailhes, Pierre-Antoine Rodesch, Sara Boccalini, Hugo Lacombe, Valerie Leitman, Vincent Cottin, Loic Boussel, Philippe Douek
Summary: In recent years, the introduction of new X-ray detectors, such as photon-counting detectors (PCD) in diagnostic imaging equipment, has shown advantages in small pixel size, high dose efficiency, and energy-resolving capabilities. Studies have been conducted to explore the potential of PCD as an alternative to conventional CT for chest imaging.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Emese Zsarnoczay, Akos Varga-Szemes, Tilman Emrich, Balint Szilveszter, Niels R. van der Werf, Domenico Mastrodicasa, Pal Maurovich-Horvat, Martin J. Willemink
Summary: Noninvasive cardiac imaging has advanced rapidly in the past decade, with the introduction of the first clinical photon-counting detector CT (PCD-CT) system being a notable improvement. PCD-CT offers several benefits, including improved spatial resolution, reduced electronic noise, and decreased radiation exposure, which have the potential to enhance diagnostics and impact management pathways. This review focuses on the major applications of PCD-CT in cardiovascular imaging, specifically coronary calcium quantification, myocardial characterization, radiomics features, and qualitative assessment of coronary plaques and stents.
INVESTIGATIVE RADIOLOGY
(2023)