Article
Medicine, General & Internal
Savino Sciascia, Massimo Radin, Irene Cecchi, Elena Rubini, Silvia Grazietta Foddai, Alice Barinotti, Antonella Vaccarino, Daniela Rossi, Dario Roccatello
Summary: This study prospectively investigated the incidence of first thromboembolic events in SLE patients positive for aPS/PT antibodies, finding that the cumulative incidence of TEs increased over time and patients with IgG aPS/PT positivity were at significantly higher risk for TEs.
FRONTIERS IN MEDICINE
(2021)
Article
Hematology
Arne Vandevelde, Walid Chayoua, Bas de Laat, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: The presence of antiphosphatidylserine/prothrombin antibodies (aPS/PT), especially with high antibody titer, is associated with the diagnosis of thrombotic antiphospholipid syndrome (TAPS).
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biochemistry & Molecular Biology
Tatiana Reshetnyak, Fariza Cheldieva, Maria Cherkasova, Alexander Lila, Evgeny Nasonov
Summary: This study investigates the role of IgA antibodies to cardiolipin (aCL) and IgA antibodies to beta-2 glycoprotein 1 (anti-beta(2)-GP1) in the development of vascular complications in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). The results show that the levels of IgA aCL and IgA anti-beta(2)-GP1 are significantly higher in APS patients compared to SLE patients and the control group. These antibodies are closely associated with thrombosis in APS, demonstrating high specificity but low sensitivity for the diagnosis of APS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medical Laboratory Technology
Yuncong Zhang, Yang Su, Han Guo, Lu Wang, Aiwei Li, Chanjuan Wang, Jie Zhang, Rui Qiao
Summary: This study aimed to investigate whether aPS/PT antibodies could prolong phospholipid (PL)-dependent clotting time and increase the risk of thrombosis or pregnancy complications based on LA positivity. The results showed that PT was longer in aPS/PT IgG-positive patients, and there was a significant association between aPS/PT antibodies and SCT-S or dRVVT-S. The incidence of thrombosis was also higher in the aPS/PT IgG-positive group. Thus, aPS/PT antibodies prolong PL-dependent clotting time and increase the risk of thrombosis in LA positivity.
CLINICAL BIOCHEMISTRY
(2023)
Article
Immunology
Natalia Egri, Chelsea Bentow, Laura Rubio, Gary L. Norman, Susana Lopez-Sanudo, Michael Mahler, Albert Perez-Isidro, Ricard Cervera, Odette Vinas, Gerard Espinosa, Estibaliz Ruiz-Ortiz
Summary: The study found that persistently positive results for aPS/PT IgG antibodies were significantly associated with APS classification, thrombosis, triple aPL positivity, LA positive result, and the Global APS Score (GAPSS) > than 9 points, but not with pregnancy morbidity and SLE.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Chiara Schiavi, Luca Marri, Simone Negrini
Summary: Patients with systemic lupus erythematosus (SLE) are at increased risk of cardiovascular disease and thrombotic events, especially if they have antiphospholipid antibodies. In this case report, a SLE patient with triple positivity for antiphospholipid antibodies developed popliteal artery thrombosis due to severe hyperhomocysteinemia after starting methotrexate (MTX) treatment. It is known that MTX can induce hyperhomocysteinemia by interfering with folate metabolism, which further increases the risk of vascular complications. The findings suggest the need for monitoring homocysteine levels in high cardiovascular risk SLE patients receiving drugs that can induce hyperhomocysteinemia, such as MTX.
THROMBOSIS JOURNAL
(2023)
Article
Hematology
Arne Vandevelde, Jean-Christophe Gris, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: Currently, the added value of antiphosphatidylserine/prothrombin antibodies testing in the diagnosis of obstetric antiphospholipid syndrome seems limited compared with other antibodies. However, it may be useful in specific subsets of patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Fischer, Hanna Przepiera-Bedzak, Iwona Brzosko, Marcin Sawicki, Anna Walecka, Marek Brzosko
Summary: This study found that levels of anti-phosphatidylethanolamine (aPE) and anti-phosphatidylserine (aPS) antibodies are significantly higher in patients with systemic lupus erythematosus (SLE) compared to controls, and they are associated with increased cardiovascular risk and organ involvement. The presence of aPE may be a marker of disease activity and risk of renal injury development in this patient group. Classical atherosclerotic markers, including lipid indices, play an important role in analyzing the cardiovascular risk in lupus patients.
Article
Rheumatology
Selcan Demir, Jessica Li, Laurence S. Magder, Michelle Petri
Summary: The study showed that LA remained the best predictor of thrombosis in SLE patients, and adding additional aPL did not increase the risk except for anti-beta(2)-glycoprotein I IgA.
Article
Biochemistry & Molecular Biology
Tatiana Reshetnyak, Kamila Nurbaeva, Ivan Ptashnik, Anna Kudriaeva, Alexey Belogurov Jr, Aleksandr Lila, Evgeny Nasonov
Summary: This study aimed to assess the role of neutrophil extracellular traps (NETs) markers, MPO-DNA complex and nucleosomes, in the diagnosis of systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). The study found that levels of MPO-DNA complex were higher in SLE patients and associated with SLE activity and lupus glomerulonephritis. Lower levels of nucleosomes were observed in SLE patients and associated with SLE activity and arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Dongmei Yin, Philip G. de Groot, Marisa Ninivaggi, Katrien M. J. Devreese, Bas de Laat
Summary: Isolated lupus anticoagulant (LAC) positivity was highly associated with vascular thrombosis, even better than triple-positive samples. The levels of anti-phosphatidylserine/prothrombin antibodies (anti-PS/PT) were significantly lower in samples with isolated LAC positivity, and isolated LAC showed weaker LAC activity compared with triple-positive patients.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Medical Laboratory Technology
Marta Tonello, Elisa Bison, Maria Grazia Cattini, Elena Pontara, Luca Iaccarino, Gentian Denas, Chunyan Cheng, Vittorio Pengo
Summary: The study found a high positivity rate of aPS/PT antibodies, especially of the IgM subtype, in patients with isolated LA. There is an association between LA diagnosis based on two positive coagulation tests and the presence of aPS/PT antibodies, suggesting the evaluation method of isolated LA may impact the measurement of aPS/PT antibodies.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Immunology
Chaojun Hu, Siting Li, Zhijuan Xie, Hanxiao You, Hui Jiang, Yu Shi, Wanting Qi, Jiuliang Zhao, Qian Wang, Xinping Tian, Mengtao Li, Yan Zhao, Xiaofeng Zeng
Summary: This study found that detecting aCL IgA, aβ2GPI IgA, aAnxV IgG/M, and aPS/PT IgG/M as biomarkers provides additive value in APS diagnosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Aleida Susana Castellanos Gutierrez, Francesc Figueras, Diana M. Morales-Prieto, Ekkehard Schleussner, Gerard Espinosa, Nuria Banos
Summary: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that mainly affects women of childbearing age. During pregnancy, SLE is associated with a higher risk of perinatal morbidity and mortality. Several studies have suggested that placental dysfunction may play a crucial role in this association.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Stanley Niznik, Micha J. Rapoport, Orly Avnery, Aharon Lubetsky, Ronen Shavit, Martin H. Ellis, Nancy Agmon-Levin
Summary: Thrombotic events following diagnosis are common among female patients with primary antiphospholipid syndrome regardless of disease presentation. Heart valve disease and ANA positivity may be risk factors for thrombosis during follow-up of patients presenting with pure obstetric antiphospholipid syndrome.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Jeremy Lagrange, Patrick Lacolley, Denis Wahl, Laurent Peyrin-Biroulet, Veronique Regnault
Summary: Patients with inflammatory bowel diseases (IBD) have an increased risk of thrombosis, with reasons including increased platelet reactivity and continuous coagulation activation. Additionally, fibrinogen levels are increased and fibrin clots are denser in these patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Allergy
Jean-Louis Gueant, Rosa-Maria Gueant-Rodriguez, Julien Fromonot, Abderrahim Oussalah, Huguette Louis, Celine Chery, Mickael Gette, Stanislas Gleye, Jonas Callet, Jeremie Raso, Francois Blanchecotte, Patrick Lacolley, Regis Guieu, Veronique Regnault
Summary: The study found that levels of neutrophil elastase and histone-DNA were significantly increased in COVID-19 patients, while DNase activity was notably decreased. These markers were associated with disease severity and multi-organ manifestations, suggesting they could potentially serve as biomarkers and therapeutic targets for severe systemic manifestations of COVID-19.
Article
Urology & Nephrology
Lucie Tran, Bruno Pannier, Patrick Lacolley, Tomas Serrato, Athanase Benetos, Gerard M. London, Yvonnick Bezie, Veronique Regnault
Summary: Endothelial dysfunction is a likely link between early vascular aging and thrombosis or bleeding in end-stage kidney disease. Patients with kidney failure showed higher markers of endothelial dysfunction and in vivo coagulation activation, along with reduced thrombin generation in platelet-rich plasma. This highlights the complex relationship between coagulation changes, arterial stiffness, and therapeutic challenges in managing patients with kidney failure.
KIDNEY INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Jeremy Lagrange, Morel E. Worou, Jean-Baptiste Michel, Alexandre Raoul, Melusine Didelot, Vincent Muczynski, Paulette Legendre, Francois Plenat, Guillaume Gauchotte, Marc-Damien Lourenco-Rodrigues, Olivier D. Christophe, Peter J. Lenting, Patrick Lacolley, Cecile Denis, Veronique Regnault
Summary: VWF induces VSMC proliferation through A2 domain binding to LRP4 receptor and integrin alpha(v)beta(3) signaling. These findings provide new insights into the mechanisms that drive physiological repair and pathological hyperplasia of the arterial vessel wall.
CARDIOVASCULAR RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Pablo A. Olivera, Stephane Zuily, Paulo G. Kotze, Veronique Regnault, Sameer Al Awadhi, Peter Bossuyt, Richard B. Gearry, Subrata Ghosh, Taku Kobayashi, Patrick Lacolley, Edouard Louis, Fernando Magro, Siew C. Ng, Alfredo Papa, Tim Raine, Fabio Teixeira, David T. Rubin, Silvio Danese, Laurent Peyrin-Biroulet
Summary: Patients with inflammatory bowel disease (IBD) have an increased risk of venous and arterial thrombotic events. This Evidence-Based Guideline provides 19 recommendations for clinical practice, including the use of thromboprophylaxis during hospitalization and aiming for deep remission to reduce risk. Therapies for IBD may modulate this risk, and antitumour necrosis factor agents could potentially reduce the risk of thrombotic events.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Hematology
Romy M. W. de Laat-Kremers, Denis Wahl, Stephane Zuily, Marisa Ninivaggi, Walid Chayoua, Veronique Regnault, Jacek Musial, Philip G. de Groot, Katrien M. J. Devreese, Bas de Laat
Summary: The diagnosis of antiphospholipid syndrome (APS) relies on specific indicators and conventional coagulation assessment methods for healthy individuals do not apply to APS patients. Researchers have developed a neural network capable of accurately diagnosing APS and validated it in various control groups.
THROMBOSIS RESEARCH
(2021)
Review
Rheumatology
Thomas Foret, Virginie Dufrost, Lucie Salomon du Mont, Patricia Costa, Benjamin Lefevre, Patrick Lacolley, Veronique Regnault, Stephane Zuily, Denis Wahl
Summary: COVID-19 patients with a procoagulant state have a high prevalence of aPL, including LA, aCL, and a beta(2)-GPI, which present a challenge for treatment and may have varying impacts on patient outcomes.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Simon Toupance, Stephanie Simonici, Carlos Labat, Chloe Dumoulin, Tsung-Po Lai, Cecile Lakomy, Veronique Regnault, Patrick Lacolley, Francoise Dignat George, Florence Sabatier, Abraham Aviv, Athanase Benetos
Summary: The study found that individuals with longer telomeres have more self-renewing endothelial colony-forming cells. White blood cell telomere length can serve as a surrogate marker for endothelial repair capacity in clinical and laboratory practice, with potential applications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Rheumatology
Jerome Avouac, Elodie Drumez, Eric Hachulla, Raphaele Seror, Sophie Georgin-Lavialle, Soumaya El Mahou, Edouard Pertuiset, Thao Pham, Hubert Marotte, Amelie Servettaz, Fanny Domont, Pascal Chazerain, Mathilde Devaux, Pascal Claudepierre, Vincent Langlois, Arsene Mekinian, Alexandre Thibault Jacques Maria, Beatrice Banneville, Bruno Fautrel, Jacques Pouchot, Thierry Thomas, Rene-Marc Flipo, Christophe Richez
Summary: Rituximab therapy is associated with more severe COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases, and should be prescribed with caution.
LANCET RHEUMATOLOGY
(2021)
Article
Dermatology
S. Georgin-Lavialle, B. Terrier, A. F. Guedon, M. Heiblig, T. Comont, E. Lazaro, V Lacombe, L. Terriou, S. Ardois, J-D Bouaziz, A. Mathian, G. Le Guenno, A. Aouba, R. Outh, A. Meyer, M. Roux-Sauvat, M. Ebbo, L. P. Zhao, A. Bigot, Y. Jamilloux, V Guillotin, E. Flamarion, P. Henneton, G. Vial, V Jachiet, J. Rossignol, S. Vinzio, T. Weitten, J. Vinit, C. Deligny, S. Humbert, M. Samson, N. Magy-Bertrand, T. Moulinet, R. Bourguiba, T. Hanslik, C. Bachmeyer, M. Sebert, M. Kostine, B. Bienvenu, P. Biscay, E. Liozon, L. Sailler, F. Chasset, A. Audemard-Verger, E. Duroyon, G. Sarrabay, F. Borlot, C. Dieval, T. Cluzeau, P. Marianetti, H. Lobbes, G. Boursier, M. Gerfaud-Valentin, J. Jeannel, A. Servettaz, S. Audia, M. Larue, B. Henriot, B. Faucher, J. Graveleau, B. Sainte Marie, J. Galland, L. Bouillet, C. Arnaud, L. Ades, F. Carrat, P. Hirsch, P. Fenaux, O. Fain, P. Sujobert, O. Kosmider, A. Mekinian
Summary: VEXAS syndrome is a newly described autoinflammatory syndrome associated with somatic mutations of UBA1. It presents a wide range of clinical features, with different prognostic profiles identified, and the UBA1 p.Met41Leu mutation is associated with a better prognosis.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Veronique Regnault, Alexandre Raoul, Celia Schellenberg, Patrick Lacolley
HEART LUNG AND CIRCULATION
(2021)
Article
Rheumatology
Augustin Latourte, Anne-Christine Rat, Abdou Omorou, Willy Ngueyon-Sime, Florent Eymard, Jeremie Sellam, Christian Roux, Hang-Korng Ea, Martine Cohen-Solal, Thomas Bardin, Johann Beaudreuil, Francis Guillemin, Pascal Richette
Summary: Recent study found that intraarticular glucocorticoid injections did not significantly increase the risk of disease progression in patients with knee osteoarthritis over a 5-year follow-up period.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Health Care Sciences & Services
Christine Rotonda, F. Guillemin, T. Conroy, C. Alleyrat, B. Lefevre, M. Soudant, C. Tarquinio
Summary: The Generic Adherence for Chronic Diseases Profile (GACID-P) is a French scale used to measure adherence in various disease areas. A study was conducted to examine the measurement invariance of the scale, optimize the instrument version, and validate its use. The results showed that the scale had satisfactory psychometric properties and was valid for researching adherence in a broad perspective.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2023)
Review
Cardiac & Cardiovascular Systems
Veronique Regnault, Pascal Challande, Florence Pinet, Zhenlin Li, Patrick Lacolley
Summary: This review provides an update on the mechanisms of vascular cell senescence, connecting selected proteins in biological networks through a computational approach. It discusses the potential of senolytic drugs in treating age-related vascular diseases, as well as the feedback controls between identified networks.
CARDIOVASCULAR RESEARCH
(2021)
Meeting Abstract
Oncology
Jerome Razanamahery, Andrea Pastissier, Thibaud Soumagne, Daguindau Etienne, Chirouze Catherine, Humbert Sebastien, N. Magy-Bertrand
PEDIATRIC BLOOD & CANCER
(2021)
