Article
Pharmacology & Pharmacy
Hyun Joo Bae, Sun Kyoung Kang, Woo Sun Kwon, Inhye Jeong, Sejung Park, Tae Soo Kim, Kyoo Hyun Kim, Hyunki Kim, Hei-Cheul Jeong, Hyun Cheol Chung, Sun Young Rha
Summary: The study found that in gastric cancer cells, EBV and MSI-H type cells with p16 methylation were sensitive to abemaciclib, while genomically stable and chromosomal instability type cells with p16 methylation and intact Rb showed responsiveness to the drug. Additionally, patients with p16 methylation in GC often had a poor prognosis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hui Li, Jing Lv, Jing Guo, Shasha Wang, Shihai Liu, Yingji Ma, Zhiwei Liang, Yunyun Wang, Weiwei Qi, Wensheng Qiu
Summary: The combination of 5-FU and TRAIL showed stronger inhibitory effects on the proliferation of gastric cancer cells, with 5-FU enhancing TRAIL-induced gastric cancer cell apoptosis by inactivating the MAPK pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Weijie Pan, Kaijing Wang, Jiayong Li, Hanhua Li, Yuchan Cai, Min Zhang, Aili Wang, Yazhou Wu, Wei Gao, Wenhao Weng
Summary: HOXD10 is frequently methylated and silenced in colorectal cancer, and its hypermethylation is associated with advanced disease and lymph node metastasis. Functionally, HOXD10 acts as a tumor suppressor gene, suppressing cell proliferation, colony formation, and migration and invasion. Mechanistically, DNMT1, DNMT3B, and MeCP2 are recruited in the HOXD10 promoter, and demethylation can induce HOXD10 expression. Restoring HOXD10 expression enhances chemosensitivity to 5-fluorouracil by upregulating miR-7 and IGFBP3, suggesting potential therapeutic relevance in colorectal cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Luigi Wolkmer Spagnol, Jossimara Polettini, Daniela Augustin Silveira, Gustavo Roberto Minetto Wegner, Daniel Felipe Fernandes Paiva
Summary: This study investigated the association of p16 gene promoter methylation with gastric carcinogenesis and progression through a systematic review and meta-analysis. The results demonstrated a significant association between p16 methylation and gastric oncogenesis, as well as several clinical indicators. Additionally, Epstein-Barr virus was found to play a crucial role in triggering p16 methylation.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Mawalizadeh, Ghorban Mohammadzadeh, Azam Khedri, Mojtaba Rashidi
Summary: This study found that the combination of Quercetin can enhance the apoptotic effect of 5-FU on breast cancer cells, reducing tumor cell colony formation. This combination therapy may be a potential approach for the treatment of breast cancer.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Oncology
Qiaoqi Sui, Jianhong Peng, Kai Han, Junzhong Lin, Rongxin Zhang, Qingjian Ou, Jiayi Qin, Yuxiang Deng, Wenhao Zhou, Lingheng Kong, Jinghua Tang, Binyi Xiao, Yuan Li, Long Yu, Yujing Fang, Pei-Rong Ding, Zhizhong Pan
Summary: Na(v)1.5, encoded by SCN5A, plays a significant role in metastasis of colorectal cancer (CRC). Upregulation of Na(v)1.5 is associated with poor prognosis in CRCs, while it stabilizes the KRas-calmodulin complex to modulate Ras signaling and promote Ca2+ influx, leading to enhanced 5-FU-stimulated apoptosis in CRCs. CRC patients with elevated SCN5A expression may benefit more from 5-FU-based chemotherapy.
Article
Medicine, General & Internal
Weiwei Zhang, Wenji Yan, Niansong Qian, Quanli Han, Weitao Zhang, Guanghai Dai
Summary: The PAX5 gene is downregulated by methylation in esophageal squamous cell carcinoma (ESCC) and has been found to inhibit cell proliferation, promote apoptosis, and activate the p53 signaling pathway. Restoring PAX5 expression can suppress tumor growth and increase chemosensitivity. PAX5 may serve as a potential marker for the chemosensitivity of ESCC.
CHINESE MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Jingjing Liu, Qi Zhang, Jiyu Wang, Changli Wang, Tian Lan, Tianyi Wang, Bing Wang
Summary: Knockdown of BAP31 in colorectal cancer cells enhances chemosensitivity to 5-FU and reduces stemness, potentially through the inhibition of the Wnt/beta-catenin signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ju Ma, Yongchen Ma, Shanwen Chen, Shihao Guo, Jianwen Hu, Taohua Yue, Junling Zhang, Jing Zhu, Pengyuan Wang, Guowei Chen, Yucun Liu
Summary: SPARC protein enhances the chemosensitivity of gastric cancer cell lines to 5-FU by regulating cell survival and apoptosis, as well as interfering with the process of epithelial-mesenchymal transition.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Qi Gao, Yunhua Wu, Chaoxiang Lu, Wang Kai, Weike Xie, Qi Wang, Lei Wang, Shiqi Liu, Yongkang Pan
Summary: RREB1 is highly expressed in gastric cancer and promotes cell proliferation. Knockdown of RREB1 inhibits cell proliferation and enhances p16 expression, providing insight into the mechanism of RREB1 in gastric cancer progression.
Article
Biochemistry & Molecular Biology
Jung Ho Han, MinJeong Kim, Hyeon Jin Kim, Se Bok Jang, Sung-Jin Bae, In-Kyu Lee, Dongryeol Ryu, Ki-Tae Ha
Summary: Resistance to anticancer therapeutics is a major challenge in cancer treatment, with altered cancer metabolism, such as the Warburg effect, playing a pivotal role. The use of antiglycolytic agents, such as catechin, may help overcome resistance to 5FU in gastric cancer cells by limiting LDHA expression and lactate production, providing a potential novel adjuvant drug option.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yannan Qin, Xiaoping Ma, Chen Guo, Shuang Cai, Hailin Ma, Lingyu Zhao
Summary: This study demonstrates that MeCP2 confers 5-FU resistance in gastric cancer cells by upregulating the NOX4/PKM2 pathway. Knockdown of MeCP2 enhances the sensitivity of cells to 5-FU, and silencing NOX4 can rescue the inductive effect of MeCP2 overexpression on 5-FU sensitivity. In vivo experiments also show that MeCP2 knockdown enhances 5-FU sensitivity in tumors.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Jingwen Yuan, Shahid Ullah Khan, Junfeng Yan, Jiatong Lu, Chen Yang, Qiang Tong
Summary: Baicalin inhibits gastric cancer and enhances the efficacy of 5-Fu by promoting ROS-related ferroptosis in gastric cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Yu Qin, Jing Zhou, Zhiyuan Fan, Jianhua Gu, Xinqing Li, Dongmei Lin, Dajun Deng, Wenqiang Wei
Summary: This study investigated the intratumoral heterogeneity (ITH) of esophageal cancer (EC) using a systematic sampling method. It found that there is inadequate concordance between tumor biopsy and tissue in pathological diagnosis and P16 methylation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Parisa Vasefifar, Souzan Najafi, Rouhollah Motafakkerazad, Mohammad Amini, Sahar Safaei, Basira Najafzadeh, Hajar Alemohammad, Mahdi Jafarlou, Behzad Baradaran
Summary: Regardless of advances in cancer treatment, gastric cancer incidence is increasing globally. Nanog, as a transcription factor involved in stemness, plays a crucial role in tumorigenesis, metastasis, and chemosensitivity. This study evaluated the effects of Nanog suppression on cisplatin chemosensitivity and tumorigenesis in gastric cancer cells. The findings showed that Nanog overexpression correlated with poor survival in gastric cancer patients, while Nanog silencing increased cell sensitivity to cisplatin through apoptosis induction, inhibited cell migration, and reduced CD44 and SOX-2 expression. Overall, Nanog may be a promising target for improving gastric cancer outcomes with cisplatin-based therapies.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Oncology
Wei Tian, Yantao Du, Yuwan Ma, Baozhen Zhang, Liankun Gu, Jing Zhou, Dajun Deng
Article
Multidisciplinary Sciences
Paiyun Li, Xuehong Zhang, Liankun Gu, Jing Zhou, Dajun Deng
Article
Biochemistry & Molecular Biology
Paiyun Li, Ying Gan, Sisi Qin, Xiao Han, Chenghua Cui, Zhaojun Liu, Jing Zhou, Liankun Gu, Zhe-Ming Lu, Baozhen Zhang, Dajun Deng
Article
Biochemistry & Molecular Biology
Wanru Ma, Juanli Qiao, Jing Zhou, Liankun Gu, Dajun Deng
Article
Gastroenterology & Hepatology
Wan-Ru Ma, Peng Xu, Zhao-Jun Liu, Jing Zhou, Lian-Kun Gu, Jun Zhang, Da-Jun Deng
WORLD JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Oncology
Yu Shi, Yang Zhang, Lian Zhang, Jun-Ling Ma, Tong Zhou, Zhe-Xuan Li, Wei-Dong Liu, Wen-Qing Li, Da-Jun Deng, Wei-Cheng You, Kai-Feng Pan
FRONTIERS IN ONCOLOGY
(2019)
Article
Genetics & Heredity
Meiyi Xiang, Wensu Liu, Wei Tian, Abin You, Dajun Deng
Article
Oncology
Yu Qin, Jing Zhou, Zhiyuan Fan, Jianhua Gu, Xinqing Li, Dongmei Lin, Dajun Deng, Wenqiang Wei
Summary: This study investigated the intratumoral heterogeneity (ITH) of esophageal cancer (EC) using a systematic sampling method. It found that there is inadequate concordance between tumor biopsy and tissue in pathological diagnosis and P16 methylation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Juanli Qiao, Yuan Tian, Xiaojing Cheng, Zhaojun Liu, Jing Zhou, Liankun Gu, Baozhen Zhang, Lianhai Zhang, Jiafu Ji, Rui Xing, Dajun Deng
Summary: The study suggests that somatic copy number deletion of the CDKN2A gene may drive gastric cancer metastasis and could serve as a predictor for hematogenous metastasis of gastric cancers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zhiyuan Fan, Yu Qin, Jing Zhou, Ru Chen, Jianhua Gu, Minjuan Li, Jiachen Zhou, Xinqing Li, Dongmei Lin, Jinwu Wang, Dajun Deng, Wenqiang Wei
Summary: P16 methylation was found to be associated with the development of esophageal squamous cell dysplasia (ESCdys) and esophageal squamous cell carcinoma (ESCC). P16 methylation in cytology specimens was positively associated with the risk of ESCC and ESCdys, while P16 methylation in biopsy specimens was only associated with a higher risk of developing ESCC. Adding P16 methylation in cytology specimens to the prediction model significantly improved its predictive capacity for ESCC and high-grade ESCdys.
Article
Oncology
Wei Tian, Hongfan Yuan, Sisi Qin, Wensu Liu, Baozhen Zhang, Liankun Gu, Jing Zhou, Dajun Deng
Summary: The study found that AKT1 can phosphorylate the Kaiso protein, causing its accumulation in the cytoplasm and de-repressing the Kaiso target gene CDH1 through binding to 14-3-3 proteins/P120ctn. Decreased phosphorylation of Kaiso may contribute to the development of gastrointestinal cancer.
MOLECULAR ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abin You, Wei Tian, Hongfan Yuan, Liankun Gu, Jing Zhou, Dajun Deng
Summary: TTC22 interacts with RPL4 to promote the binding of WTAP mRNA to RPL4, enhancing the stability and translation efficiency of WTAP mRNA and increasing the level of WTAP protein. TTC22 also triggers a positive feedback loop between WTAP expression and WTAP mRNA m6A modification, leading to an increased m6A level in total RNA. Additionally, TTC22 upregulates SNAI1 expression by increasing m6A level, promoting colon cancer metastasis.
Article
Cell Biology
Zhuoqi Li, Juanli Qiao, Wanru Ma, Jing Zhou, Liankun Gu, Dajun Deng, Baozhen Zhang
Summary: This study reveals that CBX7 is essential for P14AS to upregulate the expression of P16 (INK4A), P14 (ARF), P15 (INK4B), and ANRIL genes. P14AS may upregulate these genes' expression through competitively blocking CBX7-binding to ANRIL lncRNA and target gene promoters.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Hongfan Yuan, Qianwen Ren, Yantao Du, Yuwan Ma, Liankun Gu, Jing Zhou, Wei Tian, Dajun Deng
Summary: In this study, it was found that miR663AHG is mainly distributed in the nucleus of colon cancer cells and is positively correlated with miR663a. The expression level of miR663AHG is downregulated in colon cancer tissues and is associated with advanced disease stage, lymph metastasis, and shorter overall survival. Furthermore, miR663AHG can inhibit colon cancer cell proliferation, migration, and invasion, and its function is mediated through its binding to miR663a/pre-miR663a.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Zhaojun Liu, Hongmei Lin, Ying Gan, Chenghua Cui, Baozhen Zhang, Liankun Gu, Jing Zhou, Guangying Zhu, Dajun Deng
