Article
Oncology
Shoukai Zhang, Hulai Wei, Xiaoqin Ha, Yueyu Zhang, Yufen Guo
Summary: The overexpression of NK4 gene inhibits cell proliferation and migration, promotes cell apoptosis, and induces cell cycle arrest in S phase in laryngeal carcinoma AMC-HN-8 cells. NK4 overexpression also inhibits the tumorigenic ability of AMC-HN-8 cells, possibly through the regulation of the DKK1/Wnt1/beta-Catenin signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Tianyi Wu, Yanan Sun, Zhanwei Sun, Shichao Li, Weiwei Wang, Boyu Yu, Guangke Wang
Summary: The study revealed that the hsa_circ_0042823/miR-877-5p/FOXM1 axis is involved in the progression of LSCC. Hsa_circ_0042823 accelerates cancer progression by regulating the miR-877-5p/FOXM1 axis in LSCC. Inhibition of hsa_circ_0042823 impedes the growth of LSCC tumors through the miR-877-5p/FOXM1 axis.
ANNALS OF MEDICINE
(2021)
Article
Medicine, General & Internal
Honghe Luo, Weize Lv, Huayong Zhang, Chunxia Lin, Fei Li, Fangfang Zheng, Beilong Zhong
Summary: This study revealed that miR-204-5p regulates cell proliferation and apoptosis in ESCC through targeting Nestin, providing potential therapeutic targets for ESCC.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Joanna Janiszewska, Magdalena Bodnar, Julia Paczkowska, Adam Ustaszewski, Maciej J. Smialek, Lukasz Szylberg, Andrzej Marszalek, Katarzyna Kiwerska, Reidar Grenman, Krzysztof Szyfter, Malgorzata Wierzbicka, Maciej Giefing, Malgorzata Jarmuz-Szymczak
Summary: The study demonstrates that miR-1290 suppresses MAF expression in LSCC, revealing the underlying interaction between the two. Immunohistochemistry staining showed loss of nuclear MAF expression in 58% of LSCC samples. Through data analysis, it was determined that loss-of-function mutations, promoter region DNA methylation or CNV are not responsible for MAF loss in LSCC.
Article
Oncology
Fan Yang, Zhanwen Sun, Dengyun Wang, Tian Du
Summary: The study reveals that miR-106b-5p enhances proliferation, colony formation, adhesion, migration, and invasion, and induces cell cycle progression, while repressing apoptosis in esophageal squamous cell carcinoma (ESCC) by targeting HPGD. This finding suggests that the miR-106b-5p/HPGD axis may serve as a promising target for the diagnosis and treatment of ESCC.
Article
Biotechnology & Applied Microbiology
Lixin Guo, Gang Luo, Yingjie Liu, Jing Xu
Summary: This study found that circ-CLK1 is significantly upregulated in oral squamous cell carcinoma and inhibiting circ-CLK1 can reduce cell viability and proliferation while promoting apoptosis. Furthermore, circ-CLK1 inhibits apoptosis through the miR-18b-5p/YBX2 axis.
Article
Biochemistry & Molecular Biology
Xiu Peng, Xintian Chen, Shuai Peng, Yingming Chen, Yong Li, Yang Tian
Summary: The study found that circPRRC2C plays an important role in the carcinogenesis of laryngeal squamous cell carcinoma (LSCC). CircPRRC2C is highly expressed in LSCC tissues and cells, and its deficiency impairs LSCC cell proliferation, migration, and invasion while inducing cell apoptosis and inhibiting tumor growth. CircPRRC2C acts as an oncogene by regulating the miR-136-5p/HOXD11 axis to promote the oncogenic phenotypes of LSCC cells. Additionally, circPRRC2C can be stably packaged into exosomes and may have potential diagnostic value for LSCC.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Oncology
Fu Chen, Zheng Lao, Hai-Yan Zhang, Jie Wang, Sheng-Zi Wang
Summary: This study found that miR-125b-5p suppresses proliferation and glycolysis and promotes apoptosis in LSCC cells by targeting MAP3K9. miR-125b-5p may be a promising candidate for LSCC treatment.
Article
Multidisciplinary Sciences
Nan Wang, Xuanyu Huang, Jinsheng Cheng
Summary: The study found that BIRC5 was strongly correlated with higher tumor grade and differentiation in Laryngeal squamous cell carcinoma (LSCC), and increased expression of BIRC5 was associated with overall survival in LSCC patients. Suppression of BIRC5 induced cell apoptosis and cell cycle arrest, inhibiting proliferation of LSCC cells. Higher level of BIRC5 expression predicted poor prognosis of LSCC patients, suggesting BIRC5 as a promising prognostic biomarker for LSCC.
Article
Medicine, Research & Experimental
Peng Zhang, Yanfei Zhang, Liang Wang, Weihua Lou
Summary: The study revealed an increase in type 2 macrophages and PDL-1 expression in laryngeal squamous cell carcinoma (LSCC), correlating with poor prognosis. Tumor cells induced macrophages into type 2 differentiation through TGF-beta/Smad3 signaling, leading to immunosuppression. Inhibition of JAK/STAT signaling enhanced tumor cell sensitivity to immune cell killing by regulating PDL-1 expression. Targeting TGF-beta or IL-10 could synergistically enhance sensitivity to chemotherapy in tumors.
Article
Immunology
Sen Zhang, Huangfu Hui, Qinli Zhao, Yujun Li, Lina Wu
Summary: This study revealed that the long noncoding RNA HCP5 is highly expressed in laryngeal squamous cell carcinoma (LSCC) and plays a role in promoting cancer cell growth, migration, and invasion. HCP5 interacts with miR-216a-5p, and its knockdown inhibits the malignant biological function of LSCC cells. Moreover, miR-216a-5p downregulates the expression of ZEB1, a target gene involved in LSCC progression. These findings suggest that targeting HCP5 may be a potential therapeutic strategy for LSCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiaobo Shi, Xiaoxiao Liu, Shan Huang, Yu Hao, Shupei Pan, Yue Ke, Wei Guo, Yuchen Wang, Hongbing Ma
Summary: In this study, miR-4443 was found to promote radiotherapy resistance in ESCC cells by regulating PTPRJ expression, providing a new perspective and clue to alleviate radioresistance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Ying Lou, Liuyang Ren, Lu Wang
Summary: In this study, the role of a novel circRNA, circ_0049396, and its underlying mechanism in oral squamous cell carcinoma (OSCC) were investigated. The findings showed that circ_0049396 overexpression inhibited the malignant behavior of OSCC cells by regulating the miR-663b/ENDOU axis. Based on these results, circ_0049396 could be a potential therapeutic agent for OSCC.
Article
Oncology
Jue Wang, Nanning Sheng, Ying Li, Yawei Fan, Xinrong Nan, Rong Fu
Summary: Overexpression of Ly6D contributes to chemoresistance in laryngeal squamous cell carcinoma (LSCC) cells, while silencing Ly6D abolishes this phenotype. Activation of the Wnt/beta-catenin pathway is involved in Ly6D-mediated chemoresistance. Ly6D overexpression attenuates the expression of miR-509-5p, which unleashes CTNNB1 to activate Wnt/beta-catenin pathway and promote chemoresistance.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Oncology
Yi He, Rong Hua, Yang Yang, Bin Li, Xufeng Guo, Zhigang Li
Summary: This study found that LncRNA JPX is highly expressed in esophageal squamous cell carcinoma (ESCC) and promotes ESCC cell proliferation, migration, and invasion through the miR-516b-5p/VEGFA pathway. This highlights the potential of JPX as a biomarker and therapeutic target for ESCC.