Article
Agriculture, Dairy & Animal Science
Martina Karasova, Csilla Tothova, Simona Grelova, Maria Fialkovicova
Summary: Babesia gibsoni is a parasite that causes red blood cell rupture in dogs, and its incidence has been increasing in European countries. Fighting dog breeds are more susceptible to the disease and may serve as potential sources of infection. The disease is often asymptomatic and easily introduced into Europe through importation or travel of dogs from endemic areas. This highlights the need for attention and study of B. gibsoni infection and its treatment, which can be challenging.
Article
Agriculture, Dairy & Animal Science
Oliwier Teodorowski, Marcin Kalinowski, Dagmara Winiarczyk, Banu Dokuzeylul, Stanislaw Winiarczyk, Lukasz Adaszek
Summary: Canine babesiosis is a tick-borne, hemoparasitic disease caused by protozoal infection by parasites of the genus Babesia. Babesia gibsoni is a small protozoan species with a prevalence of around 1% in infected dogs in Europe. It is more severe than Babesia canis infections and accurate detection and identification are important for proper treatment and disease prediction. It is expected that B. gibsoni infections may appear in other non-endemic regions in Europe in the future, posing challenges for veterinary practitioners.
Article
Parasitology
Rafael Chiummo, Eva Zschiesche, Balazs Capari, Robert Farkas, Mathieu Chiquet, Dhimiter Rapti, Rezart Postoli, Alain Audry, Michael Leschnik
Summary: This study demonstrated that the use of fluralaner chewable tablets effectively prevents the transmission of Babesia canis in dogs under natural conditions, with a 100% efficacy rate.
PARASITES & VECTORS
(2023)
Review
Microbiology
Wojciech Zygner, Olga Gojska-Zygner, Luke J. J. Norbury
Summary: Canine babesiosis is a tick-borne parasitic disease that leads to anemia in infected dogs. The anemia is not caused directly by the pathogen, but rather by the immune response to the infection. Pro-inflammatory cytokines and chemokines play a role in the mechanisms leading to anemia in canine babesiosis, including antibody production, erythrophagocytosis, oxidative damage, and splenic sequestration of red blood cells.
Review
Immunology
Vitomir Djokic, Sandra C. Rocha, Nikhat Parveen
Summary: Malaria is transmitted by Anopheles mosquitoes, while babesiosis is caused by ticks. Both diseases have similarities and differences, with inflammatory immune responses playing a role in disease severity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Parasitology
Hana Turna, Bronislava Vichova, Martina Miterpakova, Andrea Szarkova, Gad Baneth, Miroslav Svoboda
Summary: This study focuses on the clinical and hematologic changes in dogs with Babesia canis infection in eastern Slovakia. The most common clinical signs observed are lethargy, fever, anorexia, and icterus. Thrombocytopenia is the most frequent hematologic change, followed by lymphopenia and anemia. No co-infections were found.
ACTA PARASITOLOGICA
(2022)
Article
Biochemistry & Molecular Biology
Danyang Chen, Xiaolan Guo, Kaiying Wang, Weigang Zhao, Zhongjuan Chang, Quankai Wang, Chao Xu
Summary: This study investigated the changes in gene and protein expression in raccoon dogs infected with Eperythrozoon using transcriptome and proteome sequencing. The results showed significant alterations in genes related to immunity and metabolism, suggesting that Eperythrozoon infection can affect raccoon dog growth and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Parasitology
Erin Stayton, Megan Lineberry, Jennifer Thomas, Tina Bass, Kelly Allen, Ramaswamy Chandrashekar, Gene Yost, Mason Reichard, Craig Miller
Summary: This study reveals the presence of Babesia conradae in Oklahoma, emphasizing its consideration as a differential diagnosis when clinical signs are present. The effectiveness of atovaquone and azithromycin treatment in cases of B. conradae infection is supported, with complete clinical recovery demonstrated in all treated dogs. The study also highlights the role of chronic subclinical carrier dogs as potential reservoirs of B. conradae infection for naive dogs.
PARASITES & VECTORS
(2021)
Article
Veterinary Sciences
Ozcan Ozkan, Banucicek Yucesan, Yusuf Yilmaz, Zekeriya Ocal
Summary: This study conducted in a animal care center in Turkey detected the presence of Babesia bigemina, an important vector disease, in dogs. The positive cases were identified through sequence analysis and registered in the NCBI database. This is the first detection report of B. bigemina in dogs in Turkey.
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
(2024)
Article
Immunology
Lan He, Reginaldo G. Bastos, Long Yu, Jacob M. Laughery, Carlos E. Suarez
Summary: Babesia bigemina infection, responsible for bovine babesiosis, can be targeted by inhibiting lactate dehydrogenase (LDH) in the parasite's metabolic pathway. Gossypol, a known LDH inhibitor, shows significant inhibitory effects on B. bigemina growth. However, gossypol also affects the viability of cattle cells and the parasite displays higher LDH expression and resistance to gossypol in a low oxygen environment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Reginaldo G. Bastos, Heba F. Alzan, Vignesh A. Rathinasamy, Brian M. Cooke, Odir A. Dellagostin, Raul G. Barletta, Carlos E. Suarez
Summary: This article discusses the potential use of BCG TI as a strategy to control babesiosis infection more efficiently, supported by experimental evidence and the possibility of vaccine development.
Review
Immunology
Luis A. Marcos, Gary P. Wormser
Summary: Human babesiosis cases are increasing in incidence and geographic range worldwide, especially in immunosuppressed patients. The recommended treatment duration is at least 6 weeks, but relapses still occur even after this period. Genetic mutations have been identified as a potential cause of antimicrobial resistance in certain relapsing cases.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Veterinary Sciences
Caoimhe Sherlock, Celia V. Holland, Jason D. Keegan
Summary: Dogs are popular pets, but living closely with them carries risks of disease transmission. However, research shows that many dog owners do not adhere to parasite control practices and improperly dispose of their dogs' faeces. This highlights the need for better education on risk reduction.
VETERINARY SCIENCES
(2023)
Review
Parasitology
Abhinav Kumar, Aditya Kabra, Ikuo Igarashi, Peter J. Krause
Summary: Animal models of human babesiosis have contributed to our understanding of immunological mechanisms and pathological processes. Babesia infection can range from asymptomatic to severe disease with organ dysfunction and death. Many similarities exist between animal and human responses to Babesia infection, and in this review, we discuss the knowledge gained from animal studies and propose using animal models or alternative approaches to enhance our understanding of human babesiosis.
TRENDS IN PARASITOLOGY
(2023)
Letter
Immunology
David Stead, Desiree du Plessis, Lisa Ming Sun, John Frean
Summary: A study revealed that an HIV-positive man from Zimbabwe living in South Africa was infected with an African rodent piroplasm, Anthemosoma garnhami, expanding the known geographic and host range of this parasite.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Parasitology
Domenico Otranto, Filipe Dantas-Torres, Josephus J. Fourie, Vincenzo Lorusso, Marie Varloud, Luigi Gradoni, Jason Drake, Thomas Geurden, Ronald Kaminsky, Anja R. Heckeroth, Bettina Schunack, Matthias Pollmeier, Frederic Beugnet, Peter Holdsworth
Summary: These guidelines aim to provide a thorough review of the efficacy of parasiticides in reducing transmission of vector-borne pathogens to dogs and cats, offering detailed recommendations for planning and implementation of related studies. Currently, prevention of VBP transmission in companion animals is achieved through products that repel or kill arthropods, with guidelines emphasizing the need for further basic research on VBP transmission times.
VETERINARY PARASITOLOGY
(2021)
Article
Parasitology
Angela Di Cesare, Simone Morelli, Giulia Morganti, Giulia Simonato, Fabrizia Veronesi, Mariasole Colombo, Michele Berlanda, Wilfried Lebon, Matilde Gallo, Frederic Beugnet, Donato Traversa
Summary: The study demonstrated that NEXGARD SPECTRA(R) was safe and highly effective in reducing Capillaria aerophila and Capillaria boehmi eggs in dogs after one treatment, with complete reduction of egg output and recovery from respiratory signs after the second administration.
PARASITES & VECTORS
(2021)
Article
Infectious Diseases
Rossella Panarese, Roberta Iatta, Frederic Beugnet, Domenico Otranto
Summary: This study evaluated the incidence of Dirofilaria immitis and Leishmania infantum infections in two dog shelters in southern Italy. The results showed that one of the dog shelters had higher infection rates, potentially posing a threat to animal and human health.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Parasitology
Stefania Zanet, Simone Morelli, Angela Di Cesare, Stefano Bo, Donato Traversa, Wilfried Lebon, Frederic Beugnet, Giulia Simonato, Ezio Ferroglio
Summary: The study demonstrated that Broadline (R) provides 100% efficacy against feline thelaziosis and significantly reduces ocular inflammation symptoms after treatment.
PARASITES & VECTORS
(2021)
Article
Parasitology
Rossella Panarese, Roberta Iatta, Jairo Alfonso Mendoza-Roldan, Andrea Zatelli, Frederic Beugnet, Domenico Otranto
Summary: The study results showed that afoxolaner is effective in reducing the transmission of D. immitis and L. infantum, with a significant difference in seasonal incidence only observed for D. immitis infection. Preventive measures are recommended throughout the year in endemic areas to reduce the risk of pathogen transmission.
PARASITES & VECTORS
(2021)
Article
Parasitology
Wilfried Lebon, Leon Meyer, Fatima Ezzahra Akki, Maxime Madder, Frederic Beugnet
Summary: The study demonstrated high efficacy of afoxolaner and fipronil/permethrin against adult H. marginatum ticks in dogs, with at least 97% efficacy at 48 hours and at least 99% efficacy at 72 hours, lasting for at least five weeks.
VETERINARY PARASITOLOGY- REGIONAL STUDIES AND REPORTS
(2021)
Article
Ecology
Phrutsamon Wongnak, Severine Bord, Sophie Donnet, Thierry Hoch, Frederic Beugnet, Karine Chalvet-Monfray
Summary: This study proposed a framework integrating expert opinions into a Bayesian Parametric Survival Model (B-PSM) to study the effects of continuous explanatory variables on the survival time of Ixodes ricinus ticks. The results showed variation in expert opinions, with most experts agreeing on the effects of abiotic variables but lacking confidence in the interaction effect. Pooling and averaging methods were used to handle the variation in opinions, each with its advantages and limitations in capturing expert consensus.
ECOLOGICAL MODELLING
(2022)
Article
Parasitology
Rossella Panarese, Roberta Iatta, Riccardo Paolo Lia, Wilfried Lebon, Frederic Beugnet, Domenico Otranto
Summary: The study evaluated the efficacy of oral administrations of afoxolaner against ear mites in naturally infested dogs, finding that two doses were able to completely cure the infestation in field conditions. No adverse events related to the treatment were recorded in the study group.
VETERINARY PARASITOLOGY
(2021)
Article
Health Care Sciences & Services
Isabelle Lebert, Severine Bord, Christine Saint-Andrieux, Eva Cassar, Patrick Gasqui, Frederic Beugnet, Karine Chalvet-Monfray, Sophie O. Vanwambeke, Gwenael Vourc'h, Magalie Rene-Martellet
Summary: Using a knowledge-based method, this study mapped the habitat suitability for I. ricinus ticks in France and Corsica, taking into account climate, land cover, altitude, and density of wild ungulates. The results showed that most areas of France and Corsica are suitable for I. ricinus, with particularly suitable habitats in central, north-eastern and south-western France. The study also demonstrated the value of multi-criteria decision analysis in estimating tick abundance and highlighting priority areas for preventive measures.
Article
Multidisciplinary Sciences
Phrutsamon Wongnak, Severine Bord, Maude Jacquot, Albert Agoulon, Frederic Beugnet, Laure Bournez, Nicolas Cebe, Adelie Chevalier, Jean-Francois Cosson, Naima Dambrine, Thierry Hoch, Frederic Huard, Nathalie Korboulewsky, Isabelle Lebert, Aurelien Madouasse, Anders Marell, Sara Moutailler, Olivier Plantard, Thomas Pollet, Valerie Poux, Magalie Rene-Martellet, Muriel Vayssier-Taussat, Helene Verheyden, Gwenael Vourc'h, Karine Chalvet-Monfray
Summary: This study investigated the host-seeking activity of Ixodes ricinus nymphs in different climatic types in France and found that this activity is influenced by climate factors and habitat characteristics. The findings can potentially contribute to predicting the risk of Lyme borreliosis.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Stephane Picot, Frederic Beugnet, Gilles Leboucher, Anne-Lise Bienvenu
Summary: Antimicrobials, including antibiotics, antiparasitic, and antifungals, are facing resistance, calling for a comprehensive approach to counteract the issue, especially in the context of the COVID-19 pandemic that may exacerbate antimicrobial resistance.
Article
Parasitology
Ilaria Bernardini, Cristiana Poggi, Sara Manzi, Marcos Antonio Bezerra-Santos, Frederic Beugnet, Josephus Fourie, Domenico Otranto, Marco Pombi
Summary: This study presents an effective breeding protocol for Phortica variegata and Phortica oldenbergi under insectary conditions, allowing the production of three generations and paving the way for future research on these vectors. The use of enriched chestnut-based feeding medium showed promising results in terms of adult production and survival probability.
PARASITES & VECTORS
(2022)
Article
Infectious Diseases
Marcos Antonio Bezerra-Santos, Lucia Oliveira de Macedo, Viet-Linh Nguyen, Ranju R. S. Manoj, Younes Laidoudi, Maria Stefania Latrofa, Frederic Beugnet, Domenico Otranto
Summary: This study investigated the occurrence of Cercopithifilaria species in ticks collected from dogs and cats in Asian countries. Cercopithifilaria bainae was found to be the most prevalent species. Molecular detection of C. bainae in ticks collected from cats and R. haemaphysaloides ticks was reported for the first time. This suggests that the biological cycle of C. bainae may involve other tick species and domestic cats. Further studies on the role of these hosts are needed.
TICKS AND TICK-BORNE DISEASES
(2022)
Article
Parasitology
Andre A. Cutolo, Nadege Perier, Ingrid Menz, Patricia Thyssen, Fabiano O. Silva, Frederic Beugnet
Summary: This study treated 14 healthy client-owned dogs naturally infested by Cochliomyia hominivorax larvae with afoxolaner, demonstrating 100% larvicidal efficacy against the larvae within 24 hours post-treatment.
VETERINARY PARASITOLOGY- REGIONAL STUDIES AND REPORTS
(2021)
Article
Parasitology
Frederic Beugnet, Carin Rautenbach, Luther van der Mescht, Wilfried Lebon, Nesrine Aouiche, Julian Liebenberg
Summary: The study evaluated the insecticidal efficacy of afoxolaner against bedbugs on dogs, revealing a significant reduction in live bedbugs in the treated group. Monthly treatment of dogs with afoxolaner may help prevent bedbugs from establishing a population in a household.