Article
Oncology
Qiuju Wang, Yan Chen, Yibo Chen, Jian Jiang, Xiaoyu Song, Li Zhang, Qiao He, Bo Ye, Lichun Wu, Rui Wu, Qin Lai, Dongsheng Wang, Yanzhen Zhao
Summary: T-cadherin methylation is frequently detected in sera of patients with OSCC, associated with poor outcomes risk factors, and may serve as a potential independent prognostic marker for patients with OSCC.
Article
Cell Biology
Tao Wei, Jin Li, Jian Zhang, Qi Zhang, Xiaoyu Liu, Qi Chen, Liang Wen, Ke Ma, Wen Chen, Jianhui Zhao, Cheng Zhang, Jinyan Huang, Yali Xie, Hao Qin, Danfeng Qian, Tingbo Liang
Summary: While Mettl3 has been shown to have oncogenic roles in hepatocellular carcinoma (HCC), its function in early HCC tumorigenesis is unclear. Mettl3 loss leads to hepatocyte homeostasis disruption and liver damage, accelerating liver tumorigenesis. Depletion of Mettl3 enhances liver tumor development, while overexpression of Mettl3 inhibits hepatocarcinogenesis. These findings suggest a stage-dependent tumor-suppressive role of Mettl3 in HCC initiation and progression.
Article
Oncology
Yuan Shao, Wenxia Li, Lin Zhang, Bo Xue, Yongquan Chen, Zikuan Zhang, Dongwen Wang, Bo Wu
Summary: CDH13 is upregulated in clear cell renal cell carcinoma (ccRCC) and strongly correlated with better survival, lower cancer stages, and lower tumor grades of ccRCC patients. It may play a crucial role in regulating the tumor microenvironment of ccRCC. The altered epigenetic status of CDH13 and its prognosis are associated with DNA methylation and m6A modification.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Cell Biology
Cheng Du, XinLi Liu, Mingwei Li, Yi Zhao, Jie Li, Zhikang Wen, Min Liu, Meina Yang, Boshi Fu, Minjie Wei
Summary: The study revealed a close connection between 5mC regulators and oncogenic pathways in colon cancer, with a specific gene signature identified for colorectal cancer diagnosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanjing Wang, Siyi Wang, Yuchen Niu, Buyong Ma, Jingjing Li
Summary: CXCL14 is a tumor suppressor gene in colorectal carcinoma that is initially activated and then silenced during tumor occurrence and deterioration. Its silencing is primarily caused by promoter hypermethylation. The methylation level of CXCL14 is associated with the anatomical site of tumor occurrence and is correlated with patient age and prognosis. Reversing the hypermethylation of CXCL14 may serve as an epigenetic therapy for colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Magdalena Piotrowska, Mateusz Gliwinski, Piotr Trzonkowski, Dorota Iwaszkiewicz-Grzes
Summary: Regulatory T cells (Tregs) play a critical role in the immune system by exerting suppressive functions, and disturbances in their function can lead to autoimmune dysregulation. Apart from Foxp3, other genes are involved in Tregs development and function. Epigenetic changes, specifically DNA methylation, are believed to be crucial in determining Tregs function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Chaobin Dai, Bin Zhang, Yunyang Liao, Qicai Liu, Feiguang Wu, Xiaoting Lv, Kai Zeng, Xiaofeng Zhu
Summary: The study investigated the relationship between polymorphisms of the calcitonin-related peptide gene II and serum CGRP levels in salivary adenoid cystic carcinoma. The results showed that the T/T genotype of CALCB rs2839222 is closely related to the occurrence of salivary adenoid cystic carcinoma, and the serum CGRP concentration in the cancer group is significantly higher compared to the normal control group.
Article
Cell Biology
Jinlai Zhao, Yigang Wang, Jianchao Gao, Yang Wang, Xuan Zhong, Xiaotang Wu, Hua Li
Summary: This study established a risk predication model based on 9 genes to effectively predict the prognosis of colon carcinoma patients. The high-risk group showed lower survival rates according to Kaplan-Meier curve, and significant differences in biological pathways were observed between high and low-risk groups through GSEA analysis. The model could efficiently predict prognosis in patients of different ages and stages, laying a foundation for further research on the molecular mechanisms of colon carcinoma development.
Article
Medicine, Research & Experimental
Kensuke Suzuki, Yasunori Masuike, Rei Mizuno, Uma M. Sachdeva, Priya Chatterji, Sarah F. Andres, Wenping Sun, Andres J. Klein-Szanto, Sepideh Besharati, Helen E. Remotti, Michael P. Verzi, Anil K. Rustgi
Summary: The study uncovered the critical role of the LIN28B/CDX2 signaling axis in mediating colorectal cancer differentiation, with potential implications. LIN28B overexpression enhanced CRC cell differentiation by binding to CDX2 mRNA, contributing to the formation and spread of metastatic tumors.
Article
Multidisciplinary Sciences
Liping Tang, Shasha Zhu, Weiyan Peng, Xuedong Yin, Cui Tan, Yaying Yang
Summary: The protein expression of MAPK10 is significantly downregulated in HCC patients compared to normal tissues, and its negative expression is correlated with advanced tumor stage, more microsatellite nodules, higher serum AFP, and shorter overall survival time in HCC patients. MAPK10 is frequently methylated in HCC, and its methylation is associated with silenced or downregulated expression.
Article
Biochemistry & Molecular Biology
Chalermsin Permtermsin, H. Lalchungnunga, Sirintra Nakjang, John Casement, Laura Frances Ogle, Helen L. L. Reeves, Gordon Strathdee, Ruchi Shukla
Summary: Hepatocellular carcinoma (HCC) is a common and deadly form of liver cancer. Current treatments are not effective and have significant side effects. A new method using bioinformatics has been developed to identify genes that are necessary for the survival of specific molecular subgroups of HCC but not normal cells. By targeting these genes, it may be possible to induce synthetic lethality in cancer cells. One gene, TIAM1, has been identified as a potential therapeutic target in a specific subgroup of HCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Cell & Tissue Engineering
Coral K. Wille, Rupa Sridharan
Summary: Inhibiting the histone 3 lysine 79 (H3K79) methyltransferase, disruptor of telomeric silencing 1-like (DOT1L), increases the efficiency of reprogramming somatic cells to induced pluripotent stem cells (iPSCs). Contrary to the prevalent view, DOT1L inhibition does not immediately cause the shutdown of somatic transcriptional profile to enable transition to pluripotency. DOT1L inhibition is most potent at the midpoint of reprogramming, partly by repressing Nfix that persists at late stages of reprogramming.
Article
Cell Biology
Nupur Nigam, Benjamin Bernard, Samantha Sevilla, Sohyoung Kim, Mohd Saleem Dar, Daniel Tsai, Yvette Robbins, Kyunghee Burkitt, Cem Sievers, Clint T. Allen, Richard L. Bennett, Theophilus T. Tettey, Benjamin Carter, Lorenzo Rinaldi, Mark W. Lingen, Houssein Sater, Elijah F. Edmondson, Arfa Moshiri, Abbas Saeed, Hui Cheng, Xiaolin Luo, Kevin Brennan, Vishal Koparde, Chen Chen, Sudipto Das, Thorkell Andresson, Abdalla Abdelmaksoud, Madhavi Murali, Seiji Sakata, Kengo Takeuchi, Raj Chari, Yusuke Nakamura, Ravindra Uppaluri, John B. Sunwoo, Carter Van Waes, Jonathan D. Licht, Gordon L. Hager, Vassiliki Saloura
Summary: We identified SMYD3 as a mediator of immune escape in HPV-negative HNSCC. SMYD3 depletion upregulates type I IFN response and antigen presentation genes in HNSCC cells. Mechanistically, SMYD3 regulates the transcription of UHRF1, which binds to H3K9me3-enriched promoters of immune-related genes and silences their expression.
Article
Biochemistry & Molecular Biology
Abin You, Wei Tian, Hongfan Yuan, Liankun Gu, Jing Zhou, Dajun Deng
Summary: TTC22 interacts with RPL4 to promote the binding of WTAP mRNA to RPL4, enhancing the stability and translation efficiency of WTAP mRNA and increasing the level of WTAP protein. TTC22 also triggers a positive feedback loop between WTAP expression and WTAP mRNA m6A modification, leading to an increased m6A level in total RNA. Additionally, TTC22 upregulates SNAI1 expression by increasing m6A level, promoting colon cancer metastasis.