Article
Biotechnology & Applied Microbiology
Jian Xiao, Chuming Zhu, Peidong Ni, Wangwang Chen, Zengliang Li, Hao Fan, Xiang Ma, Zekuan Xu, Li Yang
Summary: The study found that the polymorphism rs61396151 in the SNHG5 gene is associated with a decreased risk of gastric cancer, but not with clinicopathological features. However, it was associated with overall survival rate, which was reversed after adjustments.
Article
Multidisciplinary Sciences
Shangshang Hu, Huaifeng Liu, Jinyan Zhang, Shujing Li, Huadong Zhou, Yu Gao
Summary: In this study, the down-regulated expression of miR-30c-5p in gastric cancer tissues and the up-regulation of target genes ADAM12, EDNRA, and CPNE8 were identified. These genes were found to be related to various clinicopathological factors in gastric cancer patients and may play a role in the progression of gastric cancer through cancer-related pathways. They could serve as potential prognostic markers for poor survival in gastric cancer patients.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Xiang Ma, Younan Wang, Hao Fan, Chuming Zhu, Wangwang Chen, Zengliang Li, Jian Xiao, Peidong Ni, Zekuan Xu, Li Yang
Summary: This study investigated the correlation of CTSB-related polymorphisms with gastric cancer (GC) risk and prognosis, finding that certain variants were associated with decreased risks of GC, earlier T stage, and better overall prognosis. The results suggest the importance of CTSB-related polymorphisms in predicting GC risk and prognosis.
Article
Pathology
Peidong Ni, Gang Wang, Yuanhang Wang, Kanghui Liu, Wangwang Chen, Jian Xiao, Hao Fan, Xiang Ma, Zengliang Li, Kuan Shen, Zekuan Xu, Li Yang
Summary: This study investigates the associations of five polymorphisms in the lncRNA MIF-AS1 with the risk and prognosis of gastric cancer (GC). The results show that rs17004044 variant of MIF-AS1 is associated with increased predisposition and poor prognosis in GC.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Xuedong Wang, Kui Deng, Jing Tao, Juan Zou, Yiting Du, Li Dai
Summary: This study found that RIPK1 gene polymorphisms are associated with susceptibility to epithelial ovarian cancer (EOC) and clinical outcomes. Specifically, certain SNPs and genotypes variants are associated with early-onset EOC and better survival outcomes. Furthermore, the study also observed increased plasma levels of RIPK1 and reduced RIPK1 mRNA expression in EOC patients.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Hui-Ning Fan, Zhao-Yu Chen, Xiao-Yu Chen, Ming Chen, You-Cai Yi, Jin-Shui Zhu, Jing Zhang
Summary: Our study reveals that METTL14-mediated m(6)A modification of circORC5 suppresses the progression of gastric cancer by regulating the miR-30c-2-3p/AKT1S1 axis.
Article
Oncology
Reiko Mitsueda, Hiroko Toda, Yoshiaki Shinden, Kosuke Fukuda, Ryutaro Yasudome, Mayuko Kato, Naoko Kikkawa, Takao Ohtsuka, Akihiro Nakajo, Naohiko Seki
Summary: Accumulating evidence indicates that the miR-30 family plays a critical role in various human cancers, acting as either tumor suppressors or oncogenes. The downregulation of miR-30c-1-3p and miR-30c-2-3p in cancer tissues is associated with worse prognosis in breast cancer (BrCa) patients, and overexpression of these miRNAs inhibits cancer cell aggressiveness, suggesting their tumor-suppressor function in BrCa cells. Furthermore, TRIP13 is identified as a direct target of these two miRNAs and its inactivation attenuates BrCa cell aggressiveness and prevents malignant transformation. Understanding the molecular networks controlled by miRNAs, including passenger strands, may lead to the identification of diagnostic markers and therapeutic targets for BrCa.
Article
Oncology
Limei Luo, Qin Li, Zhenzhen Su, Lixin Li, Bei Cai, Yufu Peng, Yangjuan Bai, Fei Liu
Summary: This study investigated the relationship between CD35 polymorphisms and hepatocellular carcinoma (HCC) in the Chinese Han population. The results suggest that CD35 rs7525160 polymorphism may contribute to the susceptibility and prognosis of HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yihan Cui, Wenjin Wang, Peipei Luo, Yun Feng, Chen Mi, Ai Jia
Summary: This study found that SP4 gene polymorphisms are associated with gastric cancer risk, and specific genotypes may reduce the risk of gastric cancer.
Article
Biochemistry & Molecular Biology
Danyang Wang, Qingmin Liu, Yanjun Ren, Yan Zhang, Xin Wang, Bing Liu
Summary: The study reveals abnormal expression of miR-143/145 and KRAS in colorectal cancer and suggests that genetic polymorphisms related to miRNA may have an impact on CRC development and progression. Certain genetic variations are associated with susceptibility to CRC and patient survival.
BIOSCIENCE REPORTS
(2021)
Article
Oncology
Giulia Peduzzi, Manuel Gentiluomo, Francesca Tavano, Paolo Giorgio Arcidiacono, Stefano Ermini, Pavel Vodicka, Ugo Boggi, Giulia Martina Cavestro, Gabriele Capurso, Luca Morelli, Anna Caterina Milanetto, Raffaele Pezzilli, Rita T. Lawlor, Silvia Carrara, Martin Lovecek, Pavel Souc, Feng Guo, Thilo Hackert, Faik G. Uzunoglu, Maria Gazouli, Andrea Parniczky, Juozas Kupcinskas, Maarten F. Bijlsma, Bas Bueno-de-Mesquita, Roel Vermeulen, Casper H. J. van Eijck, Krzysztof Jamroziak, Renata Talar-Wojnarowska, William Greenhalf, Domenica Gioffreda, Maria C. Petrone, Stefano Landi, Livia Archibugi, Marta Puzzono, Niccola Funel, Cosimo Sperti, Maria L. Piredda, Beatrice Mohelnikova-Duchonova, Ye Lu, Viktor Hlavac, Xin Gao, Martin Schneider, Jakob R. Izbicki, George Theodoropoulos, Stefania Bunduc, Edita Kreivenaite, Olivier R. Busch, Ewa Malecka-Panas, Eithne Costello, Francesco Perri, Sabrina Gloria Giulia Testoni, Giuseppe Vanella, Claudio Pasquali, Martin Oliverius, Hermann Brenner, Martin Loos, Mara Gotz, Konstantinos Georgiou, Alint Eross, Evaristo Maiello, Andrea Szentesi, Francesca Bazzocchi, Daniela Basso, John P. Neoptolemos, P. Eter Hegyi, Vytautas Kiudelis, Federico Canzian, Daniele Campa
Summary: Mitochondrial metabolism has been linked to PDAC risk, with genetic variability potentially playing a role. However, this study did not find significant associations between mtSNPs or n-mtSNPs and PDAC risk. Gene-level analysis highlighted three genes (TERT, SUGCT, and SURF1) that showed some association with PDAC, but not at a statistically significant level.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Minyan Yuan, Xueqing Zheng, Jiaojiao Jing, Yang Li, Nianke Liu, Yaling Song
Summary: This study evaluated the association between SYN2, PPARG, RAF1, TIMP4, and IQSEC1 polymorphisms in 3p25 and oral squamous cell carcinoma (OSCC) in the Chinese Han population. IQSEC1-rs2686742 was found to be correlated with the onset of OSCC, and several SNPs in IQSEC1 and PPARG genes were significantly associated with clinical characteristics of OSCC. IQSEC1-rs2600322 was shown to have an important role in the survival of OSCC patients, and various SNPs influenced survival outcomes. Functional annotation revealed changes in transcript levels of IQSEC1 and PPARG genes in OSCC tissues.
Article
Biochemistry & Molecular Biology
Alisha N. Jones, Andreas Walbrun, Fabio Falleroni, Matthias Rief, Michael Sattler
Summary: MicroRNAs (miRNAs) are small noncoding RNAs that play a role in post-transcriptional downregulation of specific target genes. This study investigates the structural effects of a cancer-linked G/A mutation in the terminal loop of pri-miR-30c RNA and its influence on binding by SRSF3 and hnRNP A1 RBPs involved in its processing. The results reveal that both wildtype and G/A variant pri-miR-30c RNAs adopt similar structures and bind SRSF3. However, the G to A mutation partially destabilizes the dimer in the variant transcript, promoting recognition and binding by hnRNP A1. These findings provide insights into the conformational effects of a G/A mutation in pri-miR-30c RNA and its potential impact on cancer.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Li-Wen Hsu, Kuo-Hung Huang, Ming-Huang Chen, Wen-Liang Fang, Yee Chao, Su-Shun Lo, Anna Fen-Yau Li, Chew-Wun Wu, Yi-Ming Shyr
Summary: Gender differences exist in tumor recurrence and PD-L1 expression among gastric cancer patients, especially in stage III GC.
Article
Toxicology
Xiaowei Wang, Dan Guan, Dafei Wang, Hanting Liu, Yanling Wu, Weida Gong, Mulong Du, Haiyan Chu, Jing Qian, Zhengdong Zhang
Summary: The study revealed the crucial regulatory role of m(6)A modification genes in gastric cancer (GC) development, with the SNP rs9906944 C > T in IGF2BP1 significantly associated with a decreased risk of GC. Higher expression of IGF2BP1 was linked to poorer overall survival in GC patients.
ARCHIVES OF TOXICOLOGY
(2021)