Article
Oncology
Robert J. Motzer, Toni K. Choueiri, David F. McDermott, Thomas Powles, Yann-Alexandre Vano, Saurabh Gupta, Jin Yao, Celine Han, Ron Ammar, Simon Papillon-Cavanagh, Shruti S. Saggi, M. Brent McHenry, Petra Ross-Macdonald, Megan Wind-Rotolo
Summary: The study found that biomarkers previously associated with immune checkpoint inhibitor-containing regimens were not predictive for survival in RCC patients treated with nivolumab plus ipilimumab. However, gene expression analysis revealed an association between an inflammatory response and progression-free survival in patients receiving this treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Min Gwan Kim, Bo Ram Yang, Chang Min Park, Soon Ho Yoon
Summary: This study retrospectively analyzed the data of 415 patients with stage I lung cancer who underwent preoperative PTNB, and found that no particular PTNB techniques reduced the risk of pleural recurrence in these patients.
EUROPEAN RADIOLOGY
(2022)
Article
Health Care Sciences & Services
Jong Eun Lee, Luu Ngoc Do, Won Gi Jeong, Hyo Jae Lee, Kum Ju Chae, Yun Hyeon Kim, Ilwoo Park
Summary: This study successfully differentiated primary lung cancer from solitary lung metastasis in colorectal cancer patients using a radiomics approach combined with a machine learning algorithm.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Tianyu Zeng, Hai Xu, Yincheng Liu, Chunxiao Sun, Fan Yang, Yan Liang, Xiang Huang, Ziyi Fu, Wei Li, Yongmei Yin
Summary: This study assessed the frequency of lung cancer following breast cancer diagnosis and the associations between the two types of cancer. The results showed that breast cancer patients, especially those with low-grade malignancy, have a higher risk of developing primary lung cancer. Close follow-up is recommended for patients with isolated ground-glass nodules and high-risk factors. Additionally, EGFR may play an important role in primary lung adenocarcinomas and breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Antonio Passaro, Christine Bestvina, Maria Velez Velez, Marina Chiara Garassino, Edward Garon, Solange Peters
Summary: Lung cancer patients face unique challenges during the COVID-19 pandemic, and providing them with rational and safe treatment has become a crucial question. Oncologists worldwide have taken action to understand the impact of COVID-19 on cancer patients and have developed guidelines and recommendations accordingly.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Alice Yunzi L. Yu, Samantha M. Thomas, Gayle D. DiLalla, Rachel A. Greenup, E. Shelley Hwang, Terry Hyslop, Carolyn S. Menendez, Jennifer K. Plichta, Lisa A. Tolnitch, Oluwadamilola M. Fayanju
Summary: Breast cancer characteristics and outcomes vary significantly among Asian women, with Southeast Asian women potentially facing the worst survival rates according to the study findings.
Article
Oncology
Andrew M. D. Wolf, Kevin C. Oeffinger, Tina Ya-Chen Shih, Louise C. Walter, Timothy R. Church, Elizabeth T. H. Fontham, Elena B. Elkin, Ruth D. Etzioni, Carmen E. Guerra, Rebecca B. Perkins, Karli K. Kondo, Tyler B. Kratzer, Deana Manassaram-Baptiste, William L. Dahut, Robert A. Smith
Summary: Lung cancer is the leading cause of cancer-related deaths and years of life lost in the US. Early detection through screening has been shown to reduce mortality. The American Cancer Society has updated its guidelines for lung cancer screening, recommending annual low-dose CT screening for individuals aged 50-80 who currently smoke or formerly smoked and have a significant smoking history.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Clinical Neurology
Van Tri Truong, Fidaa Al-Shakfa, Nicholas Newman, David Roberge, Giuseppina Laura Masucci, Thi Phuoc Yen Tran, Ghassan Boubez, Daniel Shedid, Sung-Joo Yuh, Zhi Wang
Summary: This study found that the survival of patients with spinal metastasis and MPM involving lung cancer is not significantly worse than that of patients with spinal metastasis and lung cancer alone.
WORLD NEUROSURGERY
(2022)
Article
Oncology
Boyoung Park
Summary: This study found an association between obesity, metabolic syndrome, and endometrial cancer in East Asian women, with this association being most significant in obese women.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francis T. Delaney, John G. Murray, Barry D. Hutchinson, Jim J. Egan, Michelle Murray, Sara Winward, Nicola Ronan, Carmel G. Cronin
Summary: The importance of lung cancer as a complication of lung transplantation is increasingly recognized. Radiology plays a key role in the assessment of lung cancer before and after transplantation. Chest CT can detect suspicious lung lesions and chronic lung structural diseases such as pulmonary fibrosis associated with an increased risk of malignancy after transplantation. However, the effectiveness of regular chest CT for lung cancer screening after transplantation needs further research.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Benjamin Y. Lu, Richa Gupta, Adam Aguirre-Ducler, Nicole Gianino, Hailey Wyatt, Matthew Ribeiro, Veronica L. Chiang, Joseph N. Contessa, Adebowale J. Adeniran, Lucia B. Jilaveanu, Harriet M. Kluger, Kurt A. Schalper, Sarah B. Goldberg
Summary: This study evaluated the composition and functional properties of tumor-infiltrating lymphocytes within brain metastases and primary lung tumors using multiplexed quantitative immunofluorescence. It found that brain metastases had lower T cell infiltration, markers of cytolytic function, and immune regulatory signals compared to primary lung tumors. However, high TIM-3 and LAG-3 expressions in CD3(+) T-cells were associated with longer survival, highlighting unique aspects of the tumor immune microenvironment within the brain.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Taeho Ha, Wooil Kim, Jaehyung Cha, Young Hen Lee, Hyung Suk Seo, So Young Park, Nan Hee Kim, Sung Ho Hwang, Hwan Seok Yong, Yu-Whan Oh, Eun-Young Kang, Cherry Kim
Summary: DECT parameters play an important role in distinguishing between metastatic and benign lung nodules in thyroid cancer. The study found that specific cutoff values for IC, NIC, lambda HU, NICPA, and Z(eff) can aid in diagnosing metastases.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Gang Xiao, Lifeng Li, Guilong Tanzhu, Zhiyuan Liu, Xuan Gao, Xin Wan, Desheng Xiao, Liu Chen, Xuefeng Xia, Rongrong Zhou
Summary: This study found that lung adenocarcinomas (LUAD) with EGFR-positive and ALK-positive had a suppressive tumor immune microenvironment (TIME) and were less responsive to immunotherapy. The TIME in patients with EGFR/ALK-positive LUAD brain metastases (BMs) was different from that in primary lung cancer. Evaluating the immune characteristics of LUAD BMs is important for clinical treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Wen-Yu Zhai, Ze-Rui Zhao, Si Chen, Hui Yu, Yao-Bin Lin, Yi-Zhi Wang, Hao Long
Summary: Neoadjuvant immunotherapy shows satisfactory response in metastatic lymph nodes in non-small cell lung cancer patients. Especially in patients treated with immunochemotherapy, there is a higher probability of node clearance.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Luiz Henrique Araujo, Bianca Mendes Souza, Laura Rabelo Leite, Sabrina A. F. Parma, Natalia P. Lopes, Frederico S. V. Malta, Maira C. M. Freire
Summary: KRAS G12C mutation frequency is higher than other driver mutations in colorectal and non-small cell lung cancer, suggesting KRAS testing should be considered for all patients regardless of clinical or demographic characteristics.