Article
Microbiology
Connie F. Canete-Gibas, James Mele, Hoja P. Patterson, Carmita J. Sanders, Dora Ferrer, Victor Garcia, Hongxin Fan, Marjorie David, Nathan P. Wiederhold
Summary: Dermatophytes are common pathogens causing skin, hair, and nail infections in humans. A study evaluated the antifungal susceptibility profiles and species identification of dermatophytes received from North America, revealing relatively common terbinafine resistance and the presence of Trichophyton indotineae in multiple areas. Continued surveillance is necessary.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Fritz Ka-Ho Ho, Albert Bolhuis, M. Begona Delgado-Charro
Summary: The study tested the use of polymeric films sprayed on the skin for the prevention and treatment of dermatophytosis, showing that the films can both prevent and treat fungal infections, and are generally acceptable for use by healthy volunteers.
Article
Immunology
Zhen Su, Weiwei Deng, Shuting Zhan, Meirong Li, Songchao Yin, Jian Chen
Summary: In this study, a mouse-human fusion TLR2 was constructed and compared to human TLR2. It was found that the fusion TLR2 activated different downstream signal pathways in response to T. rubrum and M. canis infections, leading to different inflammatory responses. This suggests that the interspecific difference of TLR2 ectodomain may contribute to the differential inflammatory manifestations between humans and mice infected by these two dermatophytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Anita Ciesielska, Anna Kawa, Katarzyna Kanarek, Adrian Sobon, Rafal Szewczyk
Summary: This study compared the intracellular metabolite content in T. rubrum and M. canis during keratin degradation, revealing key compounds associated with interactions of these fungi with the host tissue. The metabolomic results were supported by qPCR gene expression analysis, suggesting that metabolomic analysis could aid in understanding the pathogenesis of dermatophytes.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Muhammad Abdullah Akram, Barkat Ali Khan, Muhammad Khalid Khan, Ali Alqahtani, Sultan M. Alshahrani, Khaled M. Hosny
Summary: The study successfully developed a polymeric emulgel of eugenol and linalool for the treatment of Trichophyton rubrum infections. The emulgel showed good physical properties and demonstrated significant effects in treating the infections both in vitro and in vivo, making it a promising topical treatment option.
Article
Biochemical Research Methods
Jessica Houang, Catriona Halliday, Sharon Chen, Chun-Hoong Ho, Alina Bekmukhametova, Antonio Lauto
Summary: The study demonstrated that photodynamic therapy using Rose Bengal can act against a broader spectrum of fungal pathogens, potentially expanding its clinical antifungal applications.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Microbiology
Diletta Mazzantini, Francesco Celandroni, Marco Calvigioni, Antonella Lupetti, Emilia Ghelardi
Summary: The emergence/evolution of resistance against tavaborole in Trichophyton rubrum was analyzed in vitro, showing different frequency and levels of resistance under varying concentrations and exposure durations. Mutants isolated had similar increases in drug resistance, but no cross-resistance to other antifungals was observed.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Infectious Diseases
Huilin Su, Weiwei Jiang, Paul E. Verweij, Li Li, Junhao Zhu, Jiande Han, Min Zhu, Shuwen Deng
Summary: The emergence of resistance in Trichophyton rubrum to azoles and terbinafine has led to the need for the development of new antifungal drugs. In this study, the in vitro antifungal activity of 3 echinocandins against clinical isolates of T. rubrum was evaluated. The results showed that micafungin and anidulafungin exhibited greater potency than caspofungin, suggesting that echinocandins could be potential treatment options for managing recalcitrant dermatophytoses resulting from resistance.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Wenting Hu, Xiujiao Xia, Yangyang Ma, Ai-E Xu
Summary: This is a case report on a rare fungal infection of the scalp, which is often overlooked in clinic due to its atypical clinical symptoms or being accompanied with scalp ringworm. After fungal culture and identification, the patient was diagnosed with annular erythema with scales around the ear canal orifice and was cured after 3 weeks of topical use of clotrimazole cream.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Mycology
Zixiang Si, Juan Bai, Linwei Wei, Honglei Zhao, Songting Wang, Bin Liu, Jingjing Xu, Hong Fang, Zongxin Ling, Jianjun Qiao
Summary: This study analyzed the clinical features, pathogenic agents, and skin microbiome changes of tinea scrotum. The results showed that tinea scrotum is often accompanied by superficial fungal infections of other skin sites, with tinea cruris being the most common condition. The most frequently identified pathogen for tinea scrotum was Trichophyton rubrum, and the skin microbiome exhibited changes with increased Trichophyton and decreased Malassezia abundance.
Article
Microbiology
Karen Marie Thyssen Astvad, Rasmus Kroger Hare, Karin Meinike Jorgensen, Ditte Marie Lindhardt Saunte, Philip Kjettinge Thomsen, Maiken Cavling Arendrup
Summary: Terbinafine resistance in Trichophyton species is increasing in Denmark, with a high prevalence of non-wildtype isolates and known/novel SQLE mutations. T. rubrum is the most common species, but T. mentagrophytes/interdigitale SC isolates also contribute to resistance. Population-based studies and susceptibility testing are important for understanding and addressing this emerging problem.
Article
Microbiology
Leonardo Martins-Santana, Monise Fazolin Petrucelli, Pablo R. Sanches, Nilce M. Martinez-Rossi, Antonio Rossi
Summary: The study reveals the importance of alternative splicing in generating isoforms of virulence factors in Trichophyton rubrum, a common causative agent of dermatophytosis. The transcription factor StuA plays a crucial role in coordinating the expression of peptidase genes through alternative splicing in the presence of keratin. These findings shed light on the physiological adaptations of fungal cells and the regulation of virulence traits in dermatophyte infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Basem M. M. Abdallah, Peramaiyan Rajendran, Enas M. M. Ali
Summary: In this study, green synthesized silver nanoparticles (AS-AgNPs) using Achillea santolina extract were found to have anti-dermatophytic potential against Trichophyton rubrum. AS-AgNPs inhibited the growth of T. rubrum, suppressed conidial germination and hyphal growth, and caused structural and membrane damage. Moreover, AS-AgNPs reduced cell wall integrity and inflammatory response. Overall, AS-AgNPs represent a novel green topical therapy for T. rubrum dermatophytosis.
Article
Dermatology
Junichiro Hiruma, Hiromitsu Noguchi, Midori Hase, Yumie Tokuhisa, Tatsuya Shimizu, Takasuke Ogawa, Masataro Hiruma, Kazutoshi Harada, Rui Kano
Summary: Research investigated TRF-resistant Trichophyton interdigitale and T. rubrum strains isolated from Japanese patients, identifying some TRF-resistant strains and revealing genetic mutations in these strains.
JOURNAL OF DERMATOLOGY
(2021)
Article
Infectious Diseases
Anne Landreau, Loic Simon, Pascal Delaunay, Christelle Pomares, Lilia Hasseine
Summary: We conducted an epidemiological assessment of superficial fungal infections in the Laboratory of Parasitology-Mycology of the Hospital of Nice over a 2-year period. Dermatophytes, particularly Trichophyton rubrum, remain the predominant fungal species. Our study also revealed an increasing number of non-dermatophytic mould infections. This research provides important insights into the epidemiological profile of superficial fungal infections in our patient population.
