Journal
MEDICAL MYCOLOGY
Volume 46, Issue 4, Pages 361-365Publisher
INFORMA HEALTHCARE
DOI: 10.1080/13693780701883490
Keywords
Bipolaris spicifera; disseminated disease; lung; liver; lupus anticoagulant
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We report a case of disseminated infection due to Bipolaris spicifera in an immunocompetent male. Histopathological studies of lymph node, lung, and liver biopsy specimens showed a dark pigmented, granular fungal structure inside the granuloma. The disease was accompanied by the unusual feature of positive lupus anticoagulant in serum and low-density areas expanding along the portal vein in the liver. The disease responded to combination therapy with intravenous amphotericin B and voriconazole, but recurred during oral itraconazole. The fungal isolate from the lymph node was identified as Bipolaris spicifera on the basis of morphology and molecular biological data.
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