Article
Acoustics
JiaYi Li, WeiMing Guo, Fei Yu, Lu Liu, XiaoTing Wang, LvYuan Li, Bing Fang, Lunguo Xia
Summary: The study demonstrated that LIPUS could promote the proliferation and angiogenic differentiation of endothelial cells (ECs) via the activation of the AKT signaling pathway. Additionally, LIPUS could alter the DNA methylation of ECs through the AKT signaling pathway activation, which in turn affected biomolecular changes in the cells.
Article
Food Science & Technology
Ho-Jeong Bang, Eunju Yoon, Sun Wook Kim, Mok-Ryeon Ahn
Summary: Benzyl caffeate significantly inhibits angiogenesis by inducing apoptosis and anti-proliferative effects on endothelial cells, showing potential antiangiogenic effects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Ho-Jeong Bang, Mok-Ryeon Ahn
Summary: This study found that pinobanksin exhibits antiangiogenic effect by inducing endothelial cell apoptosis, and it can be developed as an antiangiogenic agent. The mechanism involves inactivation of the Raf/MEK/ERK pathway and activation of apoptotic signaling such as caspase cascades.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Kejia Kan, Yifei Mu, Marielle Bouschbacher, Carsten Sticht, Natalia Kuch, Martin Sigl, Nuh Rahbari, Norbert Gretz, Prama Pallavi, Michael Keese
Summary: The study revealed a novel biphasic response of human umbilical vein endothelial cells to blue light illumination. Low fluence blue light promoted cell activities, while high fluence illumination had the opposite effect by upregulating pro-apoptotic signaling pathways. These findings provide insights into photobiomodulation by blue light and potential treatment strategies for angiogenesis-dependent diseases.
Article
Pharmacology & Pharmacy
Wei Liu, Yanghui Ou, Yumeng Yang, Xuemei Zhang, Liqi Huang, Xiaohua Wang, Buling Wu, Mingcheng Huang
Summary: The study demonstrated that punicalagin has a protective effect on HUVECs activation through an endothelial-mediated mechanism, which may be used in the treatment of various disorders such as cancer, rheumatoid arthritis, and cardiovascular disease. This effect is achieved by reducing adhesion of monocyte cells to HUVECs, decreasing expression of ICAM-1 and VCAM-1, and inhibiting permeability, proliferation, migration, and tube formation in VEGF-induced HUVECs. Additionally, punicalagin suppresses IKK-mediated activation of NF-kappa B signaling and inhibits VEGFR2 activation and downstream p-PAK1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Amjad Husain, Arogya Khadka, Allen Ehrlicher, Magali Saint-Geniez, Ramaswamy Krishnan
Summary: The study reveals the underlying role of the PI3K/Akt/mTOR signaling pathway in regulating vascular endothelial growth factor-A (VEGF-A) mediated signaling and functions. The pathway is activated on stiffer substrates, amplified by VEGF-A stimulation, and correlated with enhanced endothelial cell (EC) proliferation, contraction, pro-angiogenic secretion, and capillary-like tube formation. These findings have important implications for understanding age-related macular degeneration and provide insight into potential therapeutic pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Liming Li, Jiafu Mu, Yu Zhang, Chenyang Zhang, Teng Ma, Lu Chen, Tianchen Huang, Jiahe Wu, Jian Cao, Shiqing Feng, Youzhi Cai, Min Han, Jianqing Gao
Summary: This study found that exosomes derived from hypoxic preconditioned human umbilical vein endothelial cells can stimulate angiogenic MSCs, showing great potential in the treatment of traumatic spinal cord injury.
Article
Immunology
Jin-Li Guo, Xiang Han, Xian-Yan Yan, Juan-Juan Wang, Ya-Qiong Chang, Bei-Lei Zhang, Xiu-Juan Guo
Summary: This study investigates the efficacy and mechanism of action of isoliquiritigenin (ISL) in treating phlebitis induced by amiodarone (AM). The results show that ISL pretreatment promotes cell proliferation and migration, inhibits cell apoptosis, increases angiogenesis, and downregulates p-NF-kappa Bp65 expression.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Materials Science, Biomaterials
Jae Sung Lee, Ping Guo, Katarina Klett, MacGregor Hall, Krishna Sinha, Sudheer Ravuri, Johnny Huard, William L. Murphy
Summary: Autologous platelet-rich plasma (PRP) is a popular treatment for musculoskeletal tissue injuries due to its favorable safety profile and cost-effectiveness. However, the therapeutic efficacy of PRP for osteoarthritis and damaged cartilage has been inconsistent. In this study, the researchers developed a method to enhance the efficacy of PRP treatment by attenuating a growth factor known to inhibit cartilage repair. The results showed that VEGF-attenuated PRP significantly improved healing of rat OA cartilage compared to conventional PRP treatment or control group. This study provides a new PRP customization method that can be applied to various tissue repair processes.
BIOMATERIALS SCIENCE
(2022)
Article
Veterinary Sciences
Ulrike Lessiak, Barbara Pratscher, Alexander Tichy, Barbara Nell
Summary: Angiogenesis plays a crucial role in physiological processes, but pathological vascularization can lead to tissue and organ dysfunctions. Vascular endothelial growth factor A (VEGF-A) and its receptors are important in angiogenesis. This study investigated the effect of bevacizumab on an equine cell line and found that it efficiently inhibited cellular processes associated with angiogenesis, suggesting it could be a promising therapeutic approach in vascular-driven diseases in horses.
VETERINARY SCIENCES
(2023)
Article
Food Science & Technology
Qing Li, Qiaoling Yuan, Tianjie Wang, Yang Zhan, Lingchen Yang, Ying Fan, Hongyu Lei, Jianming Su
Summary: The research suggests that FB1 inhibits cell proliferation and disrupts the barrier function of SUVECs by regulating cell cycle-related genes, leading to increased blood vessel permeability.
Article
Biotechnology & Applied Microbiology
Yan Huang, Bo Liang, Xiangjuan Chen
Summary: In this study, it was found that the expression of circ_0074673 was upregulated in GDM patients' exosomes and silencing circ_0074673 promoted proliferation, migration, and angiogenesis of HG-HUVECs via the miR-1200/MEOX2 axis affecting biological functions.
Article
Biochemistry & Molecular Biology
Yi-Fan Chou, Yu-Hsuan Lan, Jun-Han Hsiao, Chiao-Yun Chen, Pei-Yu Chou, Ming-Jyh Sheu
Summary: Curcumin and demethoxycurcumin demonstrated antiangiogenic activity via the inhibition of endoglin/Smad1 signaling. Combination treatment with curcuminoids and semaxanib is expected to reverse semaxanib resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Jialing Yuan, Ke Yi, Lingyun Yang
Summary: The study revealed that lncRNA NEAT1 up-regulates FGF9 by sponging miR-365, thus promoting ovarian cancer cell proliferation and angiogenesis of HUVECs. Additionally, it was found that NEAT1 competes with FGF9 for binding to miR-365 during this process.
Article
Biotechnology & Applied Microbiology
Jianli Wang, Minghua Wu
Summary: Studies have shown that gastrodin upregulates miR-21 expression in HUVECs, leading to increased cell proliferation, migration, and tube formation ability, as well as the activation of the PI3K/Akt signaling pathway. This ultimately promotes angiogenesis in HUVECs.
Article
Cell & Tissue Engineering
Shuichi Ogino, Michiharu Sakamoto, Sunghee Lee, Hiroki Yamanaka, Itaru Tsuge, Jun Arata, Yuki Sakamoto, Yusuke Kambe, Tetsuji Yamaoka, Naoki Morimoto
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2020)
Article
Biotechnology & Applied Microbiology
Toshihito Mitsui, Naoki Morimoto, Atsushi Mahara, Sharon Claudia Notodihardjo, Tien Minh Le, Maria Chiara Munisso, Natsuko Kakudo, Tetsuji Yamaoka, Kenji Kusumoto
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Multidisciplinary Sciences
Michiharu Sakamoto, Shuichi Ogino, Yoshihiro Shimizu, Masukazu Inoie, Sunghee Lee, Hiroki Yamanaka, Itaru Tsuge, Susumu Saito, Naoki Morimoto
Review
Pediatrics
Motoki Katsube, Shigehito Yamada, Natsuko Utsunomiya, Naoki Morimoto
Summary: The face is a small complex three-dimensional structure composed of various bones and essential organs. Geometric morphometrics (GM) uses shape configurations to retain geometric information and help visualize results, making it advantageous in morphometric studies of congenital facial anomalies.
CONGENITAL ANOMALIES
(2022)
Article
Cell & Tissue Engineering
A. Shoji-Pietraszkiewicz, M. Sakamoto, M. Katsube, S. Ogino, I Tsuge, H. Yamanaka, J. Arata, N. Morimoto
Summary: In this study, cultured epithelial autografts (CEA) were applied after curettage or abrasion of giant congenital melanocytic nevi (GCMN). The results showed successful growth of CEA on wounds and improvement in lesion color. Histopathological examination revealed regenerated dermis without nevus cells.
REGENERATIVE THERAPY
(2021)
Article
Cell & Tissue Engineering
Naoki Morimoto, Toshihito Mitsui, Yasuhiro Katayama, Natsuko Kakudo, Shuichi Ogino, Itaru Tsuge, Michiharu Sakamoto, Masakatsu Hihara, Kenji Kusumoto
Summary: CEA appears to accelerate epithelization after curettage or ablation of CMN, and can significantly improve the color of CMN when applied initially. The color of the target nevus improved significantly in both the Curettage group and non-Curettage group with initial treatment, with no significant differences in epithelization period or incidence of hypertrophic scars among the groups.
REGENERATIVE THERAPY
(2021)
Article
Cell & Tissue Engineering
Yuanjiaozi Li, Eiichi Sawaragi, Michiharu Sakamoto, Takashi Nakano, Hiroki Yamanaka, Itaru Tsuge, Kumiko Matsuno, Yasuhiko Tabata, Naoki Morimoto
Summary: The study concluded that Genocel (R) can serve as an equivalent skin substitute for wound healing, demonstrating comparable performance to conventional substitutes. Additionally, Genocel (R) exhibited the ability to accelerate capillary formation, making it a more suitable treatment option for chronic skin ulcers such as diabetic ulcers.
REGENERATIVE THERAPY
(2022)
Article
Cell & Tissue Engineering
Takashi Nakano, Michiharu Sakamoto, Yasuhiro Katayama, Yoshihiro Shimizu, Masukazu Inoie, Yuanjiaozi Li, Hiroki Yamanaka, Itaru Tsuge, Susumu Saito, Naoki Morimoto
Summary: Autologous cultured epidermis (CE) is an effective approach for treating extensive burns, but its production time is too long. Allogeneic CE can be prepared in advance and used as a wound dressing to promote wound healing. Dried CE, prepared by removing all water and viable cells, accelerates wound healing and may be a new therapeutic strategy. This study evaluated the safety and efficacy of dried CE in wound healing using a miniature swine model.
REGENERATIVE THERAPY
(2023)
Article
Surgery
Shinsuke Akita, Hiraku Kumamaru, Hisashi Motomura, Nobuyuki Mitsukawa, Naoki Morimoto, Minoru Sakuraba
Summary: This study analyzed data from 19,482 free-flap surgeries performed at 407 facilities in Japan and found that free-flap surgeries performed at institutions with a low average annual number of procedures had a higher risk of total necrosis. It is recommended to either aggregate cases into high-volume centers or improve management at low-volume centers.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Letter
Surgery
Itaru Tsuge, Nobuyuki Mitsukawa, Takane Suzuki, Shinsuke Akita, Yoshimichi Imai, Koichi Omori, Naoki Morimoto
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Surgery
Itaru Tsuge, Maria Chiara Munisso, Tomoko Kosaka, Ayako Takaya, Yoshihiro Sowa, Chang Liu, Goshiro Yamamoto, Susumu Saito, Naoki Morimoto
Summary: This study successfully visualized subcutaneous arteries using photoacoustic tomography and compared the results with intraoperative fluorescence angiography, with a matching rate of 71.3-82.1%. The results of this study demonstrate that photoacoustic tomography can aid in selecting perforators for abdominal flap surgery.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Article
Cell & Tissue Engineering
Takashi Nakano, Hiroki Yamanaka, Michiharu Sakamoto, Itaru Tsuge, Yasuhiro Katayama, Susumu Saito, Jiro Ono, Tetsuji Yamaoka, Naoki Morimoto
Summary: This study successfully developed a self-assembled, cell-based dermal substitute derived from human dermal fibroblasts through long-term three-dimensional culture. The scaffold-free cultured dermis exhibited superior properties, such as sufficient tensile strength, high biocompatibility, and efficacy in promoting wound healing when compared to the collagen-based artificial dermis.
TISSUE ENGINEERING PART A
(2023)
Article
Cell & Tissue Engineering
Qiannan Zhao, Shuichi Ogino, Sunghee Lee, Yuki Kato, Yuanjiaozi Li, Michiharu Sakamoto, Hiroki Yamanaka, Takashi Nakano, Eiichi Sawaragi, Naoki Morimoto
Summary: Poly-L-lactic acid (PLLA) mesh implants combined with collagen sponge (CS) were replaced with autologous adipose tissue for regeneration. The study compared different combinations of external frames (P (LA/CL), PLLA, LMWPLLA) and internal fillings (PGA nanosheets, CS) and found that PLLA served as a promising external frame material while PGA nanosheets were an effective alternative internal filling material for adipose tissue regeneration.
REGENERATIVE THERAPY
(2023)
Article
Cell & Tissue Engineering
Motoki Katsube, Natsuko Utsunomiya, Yasuhiro Katayama, Hiroki Yamanaka, Itaru Tsuge, Yoshihiro Sowa, Michiharu Sakamoto, Naoki Morimoto
Summary: This study demonstrates that the use of bFGF-CGS in primary palatoplasty can significantly reduce the occurrence of post-operative oronasal fistulas.
REGENERATIVE THERAPY
(2023)
Article
Cell & Tissue Engineering
Tien Minh Le, Naoki Morimoto, Nhung Thi My Ly, Toshihito Mitsui, Sharon Claudia Notodihardjo, Shuichi Ogino, Jun Arata, Natsuko Kakudo, Kenji Kusumoto
Summary: MSCs have become a focus of attention in tissue repair and wound healing. Recent studies have shown the importance of apoptosis in MSC-mediated immunomodulation. High hydrostatic pressure treatment induced complete apoptosis in MSCs, offering potential for manipulated products in cell-based therapies.
STEM CELL REVIEWS AND REPORTS
(2021)