Article
Oncology
Hui Li, Yuan Feng, Chang Liu, Jiawang Li, Jiaxin Li, Hong Wu, Genshu Wang, Dewei Li
Summary: The study revealed that elevated preoperative CA19-9 that normalized after surgery does not lead to a poor prognosis in ICC patients, while those with persistently elevated postoperative CA19-9 are at higher risk of recurrence and death.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Si-Young Kim, Hee-Seung Lee, Seung-Min Bang, Dai-Hoon Han, Ho-Kyoung Hwang, Gi-Hong Choi, Moon-Jae Chung, Seung-Up Kim
Summary: Cholangiocarcinoma (CCC) is a rare cancer with poor prognosis when diagnosed in advanced stages. Dickkopf-related protein 1 (DKK-1) has been shown to have diagnostic and prognostic value in intrahepatic CCC (ICC) patients, and its combination with carbohydrate antigen 19-9 (CA 19-9) can improve diagnostic performance. High levels of DKK-1 and CA 19-9 are associated with shorter overall survival in CCC patients, indicating their potential as prognostic markers.
Article
Gastroenterology & Hepatology
Zhifang Zheng, Xiaojie Wang, Xingrong Lu, Ying Huang, Pan Chi
Summary: This study found that in patients with LARC treated with nCRT, the number of elevated post-nCRT tumor markers is an independent prognostic factor. For patients with elevated pre-nCRT tumor markers, normalization of post-nCRT markers is a protective factor. Furthermore, persistent elevation of tumor markers post-surgery is associated with increased risk of recurrence and death, while normalization of these markers is linked to better survival outcomes.
COLORECTAL DISEASE
(2021)
Article
Oncology
Leijuan Gan, Shaohua Ren, Mengran Lang, Guangtao Li, Feng Fang, Lu Chen, Yayue Liu, Ruyu Han, Kangwei Zhu, Tianqiang Song
Summary: This study aimed to investigate the relationship between tumor marker score (TMS) and postoperative recurrence of single small hepatocellular carcinoma (HCC). The results showed that TMS can divide patients into groups with different prognoses, and high TMS was associated with worse recurrence-free survival. TMS was identified as an independent prognostic factor for postoperative recurrence and could be used for risk stratification.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Article
Gastroenterology & Hepatology
Zeyuan Qiang, Wenhua Zhang, Shuai Jin, Kunfu Dai, Yuting He, Lianyuan Tao, Haibo Yu
Summary: This study investigated the expression levels and prognostic roles of AFP, CEA, and Ki67 in ICC patients, finding that they are closely correlated with prognosis and can be used to evaluate the biological behavior and prognosis of ICC.
ANNALS OF HEPATOLOGY
(2021)
Article
Oncology
Quan-Yu Cai, Ping Yang, Xiao-Liang Yang, Xiang-Hua Zhang, Lie-Ping Guo, Xin-Yuan Lu, Lei Huo, Hong-Bin Ma, Xiang-Dong Wang, Hua-Bang Zhou, Lu Wu, Ning-Yang Jia
Summary: This study aimed to investigate the role of carbohydrate antigen 19-9 (CA 19-9) in evaluating response among patients with intrahepatic cholangiocarcinoma (iCCA). The authors found that CA 19-9 response was associated with radiologic response and improved outcomes in iCCA patients. Achieving a CA 19-9 response should be a therapeutic objective for patients with iCCA after systemic therapies.
Article
Surgery
Sang Hun Park, Jun Ho Shin, Kyung Uk Jung, Sung Ryol Lee
Summary: This study assessed the role of preoperative serum CA 19-9 and CEA concentrations in the survival prognosis of patients with periampullary carcinoma and found that CA 19-9 may be a useful marker in predicting prognosis at the time of diagnosis.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Artem Boyev, Laura R. Prakash, Yi-Ju Chiang, Timothy E. Newhook, Morgan L. Bruno, Elsa M. Arvide, Whitney L. Dewhurst, Michael P. Kim, Naruhiko Ikoma, Jeffrey E. Lee, Rebecca A. Snyder, Ching-Wei D. Tzeng, Matthew H. G. Katz, Jessica E. Maxwell
Summary: This study evaluated the association between initial tumor marker levels and survival in patients with resected ampullary adenocarcinoma. The study found that preoperative CA 19-9 levels greater than 100 U/mL were associated with shorter overall survival.
SURGICAL ONCOLOGY-OXFORD
(2023)
Article
Gastroenterology & Hepatology
Tao Jiang, Shao-Cheng Lyu, Lin Zhou, Jing Wang, Han Li, Qiang He, Ren Lang
Summary: This study aimed to determine the associations between CA19-9/GGT levels and postoperative neoplasm recurrence and long-term outcome of DCC patients. The high CA19-9/GGT ratio group showed higher CA19-9 levels and lymphatic metastasis rate compared to the low-ratio group, indicating a correlation with poor clinical outcomes. Multivariate analysis identified CA19-9/GGT, lymphatic metastasis, and tumor differentiation as independent risk factors for tumor recurrence and long-term prognosis of DCC.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Biophysics
Guichun Mo, Xuanming He, Dongmiao Qin, Shuo Meng, Yusheng Wu, Biyang Deng
Summary: A new ECL immunosensor based on spatially-resolved dual-potential technology was developed for simultaneous detection of CA 19-9 and CA 242, showing high selectivity and stability in real sample analysis.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Oncology
Hua-qiang Zhu, Dong-ye Wang, Lin-shen Xu, Jian-le Chen, Er-wei Chu, Cai-jin Zhou
Summary: This study aimed to investigate the diagnostic value of enhanced magnetic resonance imaging (MRI) combined with carcinoembryonic antigen (CEA) and carbohydrate antigen in detecting liver metastasis of colorectal cancer. The results showed that the combination of MRI and CEA had high specificity and positive predictive value, while the combination of MRI and parallel CEA had high sensitivity and negative predictive value. These combinations can exclude non-metastatic patients and identify colorectal cancer patients with liver metastasis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Kenjiro Okada, Tsuyoshi Kobayashi, Shintaro Kuroda, Hiroaki Mashima, Masakazu Hashimoto, Hiroyuki Tahara, Masahiro Ohira, Kenichiro Uemura, Shinya Takahashi, Hideki Ohdan
Summary: The impact of pre- and postoperative tumor markers on the survival of patients with intrahepatic cholangiocarcinoma was assessed in this study. Medical records of 73 patients were reviewed and the levels of carcinoembryonic antigen and carbohydrate antigen 19-9 were assessed. Patient characteristics, clinicopathological factors, and prognostic factors were analyzed.
Article
Chemistry, Analytical
Hayati Filik, Asiye Aslihan Avan, Nilay Altas Puntar, Mustafa Ozyurek, Zeynep Banu Gungor, Mine Kucur, Handan Kamis, Diclehan Ali Dicle
Summary: A sensitive sandwich-model immunoassay was designed for simultaneous electrochemical measurement of alphafetoprotein and carcinoembryonic antigen using multiple-label strategy. The immunoassay showed good linear relationship and low detection limits for both analytes. The sandwich-type immunosensor was successfully applied to real serum sample analysis.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Oncology
Jiawei Zhang, Qiming Huang, Yi Yang, Jiahui Zhang, Xueting Fang, Yubin Yang, Huifang Liang, Wei Wang, Yanjun Wang
Summary: The role of carbonic anhydrase II (CAII) in intrahepatic cholangiocarcinoma (ICC) was investigated and a novel prognostic system combining CAII and preoperative carbohydrate antigen 19-9 (CA19-9) was established to predict the survival of patients with ICC after curative resection.
Article
Endocrinology & Metabolism
Dong Zhang
Summary: This study aimed to investigate the relationship between glycemic control and serum levels of CA19-9 and CEA in patients with T2DM. The results showed that CA19-9 and CEA levels were higher in T2DM patients and closely correlated with the degree of glycemic control.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)